HK1256701A1 - 用於使rna穩定的3'utr序列 - Google Patents

用於使rna穩定的3'utr序列

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Publication number
HK1256701A1
HK1256701A1 HK18115686.7A HK18115686A HK1256701A1 HK 1256701 A1 HK1256701 A1 HK 1256701A1 HK 18115686 A HK18115686 A HK 18115686A HK 1256701 A1 HK1256701 A1 HK 1256701A1
Authority
HK
Hong Kong
Prior art keywords
rna
stabilization
utr sequences
utr
sequences
Prior art date
Application number
HK18115686.7A
Other languages
English (en)
Inventor
Von Niessen Alexandra Orlandini
Stephanie Fesser
Britta Vallazza
Tim Beissert
Andreas Kuhn
Ugur Sahin
Marco Alexander Poleganov
Original Assignee
Biontech Rna Pharmaceuticals Gmbh
Tron Translationale Onkologie An Der Univ Tsmedizin Der Johannes Gutenberg Univt Mainz Gemeinnuetzig
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biontech Rna Pharmaceuticals Gmbh, Tron Translationale Onkologie An Der Univ Tsmedizin Der Johannes Gutenberg Univt Mainz Gemeinnuetzig filed Critical Biontech Rna Pharmaceuticals Gmbh
Publication of HK1256701A1 publication Critical patent/HK1256701A1/zh

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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    • C12N15/09—Recombinant DNA-technology
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    • E—FIXED CONSTRUCTIONS
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    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
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    • F16C—SHAFTS; FLEXIBLE SHAFTS; ELEMENTS OR CRANKSHAFT MECHANISMS; ROTARY BODIES OTHER THAN GEARING ELEMENTS; BEARINGS
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    • A47B2200/0018—Nodal leg assembly for table in two parts
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    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
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  • Medicinal Chemistry (AREA)
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  • Physics & Mathematics (AREA)
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  • Communicable Diseases (AREA)
  • Reproductive Health (AREA)
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  • Developmental Biology & Embryology (AREA)
  • Architecture (AREA)
  • Immunology (AREA)
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  • Mechanical Engineering (AREA)
  • Cell Biology (AREA)
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HK18115686.7A 2015-10-07 2018-12-07 用於使rna穩定的3'utr序列 HK1256701A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2015/073180 WO2017059902A1 (en) 2015-10-07 2015-10-07 3' utr sequences for stabilization of rna
PCT/EP2016/073814 WO2017060314A2 (en) 2015-10-07 2016-10-05 3' utr sequences for stabilization of rna

Publications (1)

Publication Number Publication Date
HK1256701A1 true HK1256701A1 (zh) 2019-10-04

Family

ID=54293227

Family Applications (2)

Application Number Title Priority Date Filing Date
HK18115686.7A HK1256701A1 (zh) 2015-10-07 2018-12-07 用於使rna穩定的3'utr序列
HK19100626.1A HK1258262A1 (zh) 2015-10-07 2019-01-15 用於使rna穩定的3'utr序列

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Application Number Title Priority Date Filing Date
HK19100626.1A HK1258262A1 (zh) 2015-10-07 2019-01-15 用於使rna穩定的3'utr序列

Country Status (26)

Country Link
US (2) US11492628B2 (zh)
EP (3) EP3868885A1 (zh)
JP (5) JP7084302B2 (zh)
KR (3) KR20240118189A (zh)
CN (1) CN108291230B (zh)
AU (3) AU2016335029B2 (zh)
BR (2) BR112018003486B1 (zh)
CA (2) CA3223575A1 (zh)
CY (2) CY1122347T1 (zh)
DK (2) DK3636764T3 (zh)
ES (2) ES2753201T3 (zh)
HK (2) HK1256701A1 (zh)
HR (2) HRP20191907T1 (zh)
HU (2) HUE046982T2 (zh)
IL (3) IL293020A (zh)
LT (2) LT3337902T (zh)
MX (2) MX2018004160A (zh)
NZ (1) NZ740946A (zh)
PL (2) PL3636764T3 (zh)
PT (2) PT3337902T (zh)
RS (2) RS61684B1 (zh)
RU (1) RU2720934C2 (zh)
SG (1) SG10201912558YA (zh)
SI (2) SI3337902T1 (zh)
WO (2) WO2017059902A1 (zh)
ZA (1) ZA201800835B (zh)

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WO2017059902A1 (en) * 2015-10-07 2017-04-13 Biontech Rna Pharmaceuticals Gmbh 3' utr sequences for stabilization of rna
AU2017296195A1 (en) 2016-07-11 2019-01-24 Translate Bio Ma, Inc. Nucleic acid conjugates and uses thereof
MX2020001821A (es) * 2017-08-15 2020-09-18 Intellia Therapeutics Inc Ácidos nucleicos estabilizados que codifican el ácido ribonucleico mensajero (arnm).
JP7505984B2 (ja) 2018-02-12 2024-06-25 バイオエヌテック エスエー サイトカインをコードするｒｎａを用いた治療
WO2019213257A1 (en) * 2018-05-01 2019-11-07 Wake Forest University Health Sciences Lentiviral-based vectors and related systems and methods for eukaryotic gene editing
WO2020020783A1 (en) 2018-07-24 2020-01-30 Biontech Rna Pharmaceuticals Gmbh Il2 agonists
MX2021008434A (es) 2019-01-14 2021-09-23 Genentech Inc Metodos para tratar el cancer con un antagonista de union al eje de pd-1 y una vacuna de arn.
US20220125836A1 (en) 2019-02-08 2022-04-28 Biontech Cell & Gene Therapies Gmbh Treatment involving car-engineered t cells and cytokines
MX2021011258A (es) 2019-03-18 2021-12-10 Biontech Cell & Gene Therapies Gmbh Variantes de interleucina-2 (il2) y receptor de interleucina-2 (il2r) para la activacion especifica de celulas efectoras inmunitarias.
WO2020200481A1 (en) 2019-04-05 2020-10-08 Biontech Rna Pharmaceuticals Gmbh Treatment involving interleukin-2 (il2) and interferon (ifn)
TW202115105A (zh) 2019-06-24 2021-04-16 德商拜恩迪克Ｒｎａ製藥有限公司 Ｉｌ２激動劑
JP2022546417A (ja) * 2019-08-29 2022-11-04 チューリッヒ大学 最小ｍＲＮＡおよびその使用
EP4048789A4 (en) * 2019-10-22 2022-12-14 The Regents of The University of California MODULATION OF TRANSLATION OF GM CELLS USING NON-CODING SEQUENCE ELEMENTS
AU2021212197A1 (en) 2020-01-31 2022-08-04 BioNTech SE Methods of inducing neoepitope-specific T cells with a PD-1 axis binding antagonist and an RNA vaccine
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