MX378273B - Compuestos activos hacia bromodominios. - Google Patents

Compuestos activos hacia bromodominios.

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Publication number
MX378273B
MX378273B MX2017001512A MX2017001512A MX378273B MX 378273 B MX378273 B MX 378273B MX 2017001512 A MX2017001512 A MX 2017001512A MX 2017001512 A MX2017001512 A MX 2017001512A MX 378273 B MX378273 B MX 378273B
Authority
MX
Mexico
Prior art keywords
bromodomains
active compounds
compounds towards
towards
compounds
Prior art date
Application number
MX2017001512A
Other languages
English (en)
Spanish (es)
Other versions
MX2017001512A (es
Inventor
Gitte Friberg
Seitzberg Jimmi Gerner
Lene Teuber
Akinleminu Kronborg Tine Titilola
Visnja Poljak
Original Assignee
Nuevolution As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nuevolution As filed Critical Nuevolution As
Publication of MX2017001512A publication Critical patent/MX2017001512A/es
Publication of MX378273B publication Critical patent/MX378273B/es

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    • A61K31/47Quinolines; Isoquinolines
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Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2990403A1 (en) 2014-08-29 2016-03-02 Novartis Tiergesundheit AG Anthranilamides, sulfonamides and nitro analogues derived therefrom as anthelmintics
MX2018000599A (es) 2015-07-17 2018-05-28 Fujifilm Corp Compuesto heterociclico que contiene nitrogeno.
CN109153647A (zh) * 2016-02-15 2019-01-04 分子医学研究中心责任有限公司 用于治疗癌症的taf1抑制剂
KR20180132682A (ko) * 2016-04-07 2018-12-12 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 브로모도메인 억제제로서의 피리딜 유도체
CN116478132A (zh) 2016-07-12 2023-07-25 锐新医药公司 作为变构shp2抑制剂的2,5-双取代型及2,5,6-三取代型3-甲基吡嗪
WO2018075908A1 (en) * 2016-10-21 2018-04-26 University Of Miami Materials and methods for treating ophthalmic inflammation
WO2018124180A1 (ja) 2016-12-27 2018-07-05 富士フイルム株式会社 抗腫瘍剤およびブロモドメイン阻害剤
CN110446709B (zh) 2017-01-23 2023-09-12 锐新医药公司 作为变构shp2抑制剂的二环化合物
AU2018210196B2 (en) 2017-01-23 2022-06-02 Revolution Medicines, Inc. Pyridine compounds as allosteric SHP2 inhibitors
AU2018217664B2 (en) * 2017-02-07 2022-03-03 Janssen Pharmaceutica Nv Sulphamoylaryl derivatives and use thereof as medicaments for the treatment of liver fibrosis
JP2020525490A (ja) 2017-06-27 2020-08-27 ヤンセン ファーマシューティカ エヌ.ベー. ヘテロアリールジヒドロピリミジン誘導体及びb型肝炎感染を治療する方法
CA3078565A1 (en) * 2017-10-12 2019-04-18 Revolution Medicines, Inc. Pyridine, pyrazine, and triazine compounds as allosteric shp2 inhibitors
BR112020009757A2 (pt) 2017-12-15 2020-11-03 Revolution Medicines, Inc. compostos policíclicos como inibidores alostéricos de shp2
US20210261539A1 (en) * 2018-02-06 2021-08-26 Shanghai Haihe Pharmaceutical Co., Ltd. Compound having bet inhibitory activity and preparation method and use therefor
EP3782995B1 (en) * 2018-04-20 2023-11-22 Shanghai Institute of Materia Medica, Chinese Academy of Sciences Spiro condensed imidazoline-2,4-dione derivatives as histone acetyltransferase inhibitors for the treatment of cancer diseases
CN109053542A (zh) * 2018-07-25 2018-12-21 南通大学 一种6-溴-5-羟基异吲哚啉-1-酮的化学合成方法
AU2019315444B2 (en) * 2018-07-31 2024-10-31 The Trustees Of Princeton University Tetrahydroquinolino derivatives for the treatment of metastatic and chemoresistant cancers
US11053235B2 (en) 2018-08-09 2021-07-06 Janssen Sciences Ireland Unlimited Company Substituted 1,4-dihydropyrimidines for the treatment of HBV infection or HBV-induced diseases
SG11202104326TA (en) * 2018-11-02 2021-05-28 Merck Sharp & Dohme 2-amino-n-heteroaryl-nicotinamides as nav1.8 inhibitors
CA3123042A1 (en) 2018-12-20 2020-06-25 Amgen Inc. Kif18a inhibitors
CA3123227A1 (en) 2018-12-20 2020-06-25 Amgen Inc. Heteroaryl amides useful as kif18a inhibitors
ES2997190T3 (en) 2018-12-20 2025-02-14 Amgen Inc Heteroaryl amides useful as kif18a inhibitors
PE20211733A1 (es) 2019-01-11 2021-09-06 Gruenenthal Chemie Amidas de pirrolidina sustituidas
CN114391012B (zh) * 2019-08-02 2025-10-31 美国安进公司 作为kif18a抑制剂的吡啶衍生物
CN114401953A (zh) 2019-08-02 2022-04-26 美国安进公司 Kif18a抑制剂
WO2021032934A1 (en) * 2019-08-21 2021-02-25 Kalvista Pharmaceuticals Limited Enzyme inhibitors
CN114728936A (zh) * 2019-10-29 2022-07-08 豪夫迈·罗氏有限公司 用于治疗癌症的双功能化合物
GB201918587D0 (en) * 2019-12-17 2020-01-29 Artios Pharma Ltd Novel compounds
EP4093400A4 (en) * 2020-01-24 2024-03-13 The Trustees of Princeton University Heterocyclic compounds and uses thereof
MX2023005436A (es) * 2020-11-10 2023-07-25 Foghorn Therapeutics Inc Compuestos y usos de estos.
GB202019475D0 (en) * 2020-12-10 2021-01-27 Cancer Research Tech Ltd Therapeutic compounds and their use
US20250092014A1 (en) * 2021-01-19 2025-03-20 Metrea Biosciences, Inc. Compounds and methods of activating lipoprotein lipase
US20240216362A1 (en) * 2021-04-19 2024-07-04 Shanghai Yao Yuan Biotechnology Co., Ltd. Benzothiazole and quinoline derivatives for use in treating kawasaki disease
MX2023012435A (es) 2021-04-22 2024-02-08 Kayothera Inc Compuestos heterociclicos y usos de los mismos.
WO2023274418A1 (zh) * 2021-07-02 2023-01-05 南京明德新药研发有限公司 蛋白降解靶向嵌合体类化合物
WO2023006893A1 (en) * 2021-07-30 2023-02-02 Confo Therapeutics N.V. Compounds for the treatment of pain, in particular neuropathic pain, and/or other diseases or disorders that are associated with at2r and/or at2r mediated signaling
CN119365455A (zh) 2022-04-19 2025-01-24 纽韦卢森公司 对溴结构域有活性的化合物
EP4511035A1 (en) * 2022-04-21 2025-02-26 Nimbus Clotho, Inc. Ctps1 inhibitors and uses thereof
AR129299A1 (es) 2022-05-11 2024-08-07 Foghorn Therapeutics Inc Compuestos para modular complejos de factores asociados a brg1 o brm (baf)
US20250387385A1 (en) * 2022-06-24 2025-12-25 Zydus Lifesciences Limited Treatment for glomerular diseases
CN119768400A (zh) * 2022-11-11 2025-04-04 苏州信诺维医药科技股份有限公司 一种稠环化合物、其用途及含其的药物组合物

Family Cites Families (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5328935B2 (enExample) 1972-01-20 1978-08-17
JPS56104333A (en) 1980-01-23 1981-08-20 Fuji Photo Film Co Ltd Color photographic sensitive material
DE3445669A1 (de) 1984-12-14 1986-06-19 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JPS6232459A (ja) 1985-08-05 1987-02-12 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料
JPS6238463A (ja) 1985-08-14 1987-02-19 Fuji Photo Film Co Ltd ハロゲン化銀カラ−感光材料の画像形成方法
JPH067250B2 (ja) 1985-10-18 1994-01-26 富士写真フイルム株式会社 ハロゲン化銀カラ−写真感光材料
JPS6292939A (ja) 1985-10-19 1987-04-28 Fuji Photo Film Co Ltd 熱現像感光材料
JPH0756566B2 (ja) 1985-11-06 1995-06-14 富士写真フイルム株式会社 ハロゲン化銀カラ−写真感光材料の処理方法
JPS62129853A (ja) 1985-11-30 1987-06-12 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料
JPS62153953A (ja) 1985-12-27 1987-07-08 Fuji Photo Film Co Ltd カラ−写真感光材料
JPS62173466A (ja) 1986-01-28 1987-07-30 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料
JPS62222251A (ja) 1986-02-17 1987-09-30 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料の処理方法
JPS62257158A (ja) 1986-04-30 1987-11-09 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料
DE3788600T2 (de) 1986-07-22 1994-04-28 Fuji Photo Film Co Ltd Verfahren zur Behandlung eines farbphotographischen Silberhalogenidmaterials.
DE3803775A1 (de) 1988-02-09 1989-08-17 Boehringer Mannheim Gmbh Neue substituierte lactame, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
JPH02234158A (ja) 1989-03-07 1990-09-17 Fuji Photo Film Co Ltd カラー感光材料
JPH02264946A (ja) 1989-04-05 1990-10-29 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料
JPH02267548A (ja) 1989-04-10 1990-11-01 Fuji Photo Film Co Ltd 画像形成法
DE3925584A1 (de) 1989-08-02 1991-02-07 Boehringer Mannheim Gmbh Neue n-(dimethyloxophosphinylmethyl-)-lactame, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE4027592A1 (de) 1990-08-31 1992-03-05 Beiersdorf Ag Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
JPH04315148A (ja) 1991-04-15 1992-11-06 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料
GB9205702D0 (en) 1992-03-16 1992-04-29 Fujisawa Pharmaceutical Co A new use of a quinazoline derivative
DE69310098T2 (de) 1992-10-15 1997-07-31 Fuji Photo Film Co., Ltd., Minami-Ashigara, Kanagawa Verarbeitungsverfahren für farbphotographisches Silberhalogenidmaterial
DE69528829T2 (de) 1994-05-27 2003-08-07 Merck & Co., Inc. Präparate zur hemmung der durch osteoklasten vermittelten knochenresorption
US5756502A (en) 1994-08-08 1998-05-26 Warner-Lambert Company Quinazolinone derivatives as cholyecystokinin (CCK) ligands
TW381092B (en) * 1995-07-07 2000-02-01 Otsuka Pharma Co Ltd Novel benzimidazole derivatives for use in treating arteriosclerotic diseases
US5747235A (en) 1996-01-26 1998-05-05 Eastman Kodak Company Silver halide light sensitive emulsion layer having enhanced photographic sensitivity
AU712082B2 (en) 1996-02-28 1999-10-28 Merck & Co., Inc. Fibrinogen receptor antagonists
US5780480A (en) 1996-02-28 1998-07-14 Merck & Co., Inc. Fibrinogen receptor antagonists
CA2276081A1 (en) 1996-12-30 1998-07-09 Lekhanh O. Tran Inhibitors of farnesyl-protein transferase
UA71555C2 (en) 1997-10-06 2004-12-15 Zentaris Gmbh Methods for modulating function of serine/threonine protein kinases by 5-azaquinoline derivatives
CA2313125A1 (en) 1997-12-12 1999-06-24 Laramie Mary Gaster Quinolinepiperazine and quinolinepiperidine derivatives, their preparation and their use as combined 5-ht1a, 5-ht1b and 5-ht1d receptor antagonists
ES2153809T3 (es) 1997-12-22 2005-07-16 Bayer Pharmaceuticals Corporation Inhibicion de la cinasa raf por uso de difnil-ureas sustituidas simetrica y asimetricamente.
DE19839499A1 (de) 1998-08-29 2000-03-02 Merck Patent Gmbh 2-Oxo-2H-chinolinderivate
EP1255741A2 (en) 2000-02-01 2002-11-13 Cor Therapeutics, Inc. 2- 1H]-QUINOLONE AND 2- 1H]-QUINOXALONE INHIBITORS OF FACTOR Xa
JP2002341484A (ja) 2001-03-12 2002-11-27 Fuji Photo Film Co Ltd 熱現像感光材料
JP2002296731A (ja) 2001-03-30 2002-10-09 Fuji Photo Film Co Ltd 熱現像カラー画像記録材料
WO2002090347A1 (en) 2001-04-30 2002-11-14 Fujisawa Pharmaceutical Co., Ltd. Amide compounds
JP2004529943A (ja) 2001-05-15 2004-09-30 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 殺菌・殺カビ剤としてのピリジニル縮合二環式アミド
JP2003321472A (ja) 2002-02-26 2003-11-11 Takeda Chem Ind Ltd Grk阻害剤
EP1388342A1 (en) 2002-08-07 2004-02-11 Aventis Pharma Deutschland GmbH Acylated, heteroaryl-condensed cycloalkenylamines and their use as pharmaceuticals
JP4613130B2 (ja) 2002-08-23 2011-01-12 ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド ベンゾイミダゾールキノリノンおよびそれらの使用
US7825132B2 (en) 2002-08-23 2010-11-02 Novartis Vaccines And Diagnostics, Inc. Inhibition of FGFR3 and treatment of multiple myeloma
EP1545526A4 (en) 2002-09-17 2009-09-23 Merck & Co Inc REMOVAL OF ALDEHYDE POLLUTION BY REACTIVE POLYSTYRENE RESIN
EP1572212A2 (en) 2002-12-11 2005-09-14 7TM Pharma A/S Quinoline compounds for use in mch receptor related disorders
US20040142950A1 (en) 2003-01-17 2004-07-22 Bunker Amy Mae Amide and ester matrix metalloproteinase inhibitors
US7205318B2 (en) 2003-03-18 2007-04-17 Bristol-Myers Squibb Company Lactam-containing cyclic diamines and derivatives as a factor Xa inhibitors
JP4847868B2 (ja) 2003-05-14 2011-12-28 ニューロジェネティック ファーマシューティカルズ、 インコーポレイテッド 化合物、及び、アミロイドベータの調節におけるその使用
AU2004249664A1 (en) 2003-05-19 2004-12-29 Irm Llc Immunosuppressant compounds and compositions
MXPA06004194A (es) 2003-11-07 2006-06-28 Chiron Corp Inhibicion de fgfr3 y tratamiento de mieloma multiple.
WO2005087742A1 (en) 2004-03-08 2005-09-22 Exelixis, Inc. Metabolic kinase modulators and methods of use as pesticides
WO2005094805A1 (ja) 2004-04-01 2005-10-13 Institute Of Medicinal Molecular Design. Inc. イミン誘導体及びアミド誘導体
US7312335B2 (en) 2004-06-03 2007-12-25 Brandeis University Asymmetric Michael and Aldol additions using bifunctional cinchona-alkaloid-based catalysts
GB0416730D0 (en) 2004-07-27 2004-09-01 Novartis Ag Organic compounds
EP1655295A1 (en) * 2004-11-03 2006-05-10 Schering Aktiengesellschaft Anthranilamide pyridinureas as VEGF receptor kinase inhibitors
UY29198A1 (es) 2004-11-09 2006-05-31 Cancer Rec Tech Ltd Derivados sustituidos de quinazolinona y derivados sustituidos de quinazolina-2, 4-diona, composiciones conteniéndolos, procedimientos de preparación y aplicaciones
US20060281763A1 (en) 2005-03-25 2006-12-14 Axon Jonathan R Carboxamide inhibitors of TGFbeta
GB0509227D0 (en) 2005-05-05 2005-06-15 Chroma Therapeutics Ltd Intracellular enzyme inhibitors
GB0509224D0 (en) 2005-05-05 2005-06-15 Chroma Therapeutics Ltd Inhibitors of intracellular enzymatic activity
WO2006130437A2 (en) 2005-05-27 2006-12-07 Brandeis University Asymmetric carbon-carbon-bond-forming reactions catalyzed by bifunctional cinchona alkaloids
CA2623541A1 (en) 2005-09-23 2007-03-29 Coley Pharmaceutical Group, Inc. Method for 1h-imidazo[4,5-c]pyridines and analogs thereof
JP2009526798A (ja) 2006-02-16 2009-07-23 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト 二環式ビスアミド構造を含む殺虫剤
GB0605689D0 (en) 2006-03-21 2006-05-03 Novartis Ag Organic compounds
US7601716B2 (en) 2006-05-01 2009-10-13 Cephalon, Inc. Pyridopyrazines and derivatives thereof as ALK and c-Met inhibitors
ATE528002T1 (de) 2006-05-19 2011-10-15 Bayer Pharma AG Pyridoncarboxamidderivate zur behandlung hyperproliferativer und angiogenese-vermittelter leiden
WO2008029152A2 (en) 2006-09-08 2008-03-13 Summit Corporation Plc Treatment of duchenne muscular dystrophy
US9987277B2 (en) 2006-10-04 2018-06-05 Janssen Sciences Ireland Uc Carboxamide 4-[(4-pyridyl)amino] pryimidines for the treatment of hepatitis C
US20080186971A1 (en) 2007-02-02 2008-08-07 Tarari, Inc. Systems and methods for processing access control lists (acls) in network switches using regular expression matching logic
WO2008103277A2 (en) 2007-02-16 2008-08-28 Amgen Inc. Nitrogen-containing heterocyclyl ketones and their use as c-met inhibitors
WO2008109180A2 (en) * 2007-03-07 2008-09-12 Alantos Pharmaceuticals Holding, Inc. Metalloprotease inhibitors containing a heterocyclic moiety
US8039505B2 (en) 2007-04-11 2011-10-18 University Of Utah Research Foundation Compounds for modulating T-cells
JP2008280341A (ja) 2007-04-12 2008-11-20 Sumitomo Chemical Co Ltd ヒドラジド化合物およびその防除用途
WO2009020677A2 (en) 2007-04-27 2009-02-12 University Of Rochester Compositions and methods for inhibiting g protein signaling
EP2008658A1 (en) 2007-06-28 2008-12-31 Bayer Schering Pharma Aktiengesellschaft Synergistic combination of anthranilamide pyridinureas and benzamide derivatives
TWI534137B (zh) 2007-09-17 2016-05-21 艾伯維巴哈馬有限公司 抗感染劑及其用途
JP2011524365A (ja) 2008-06-11 2011-09-01 アイアールエム・リミテッド・ライアビリティ・カンパニー マラリアの処置に有用な化合物および組成物
US20100068204A1 (en) 2008-09-12 2010-03-18 Wyeth 4-aryloxyquinolin-2(1h)-ones as mtor kinase and pi3 kinase inhibitors, for use as anti-cancer agents
WO2010045374A1 (en) 2008-10-15 2010-04-22 Gilead Palo Alto, Inc. 3-hydroquinazolin-4-one derivatives for use as stearoyl coa desaturase inhibitors
CA2745864A1 (en) 2008-12-23 2010-07-01 F.Hoffmann-La Roche Ag Dihydropyridone amides as p2x7 modulators
BRPI1011477A2 (pt) 2009-03-02 2016-03-22 Sirtris Pharmaceuticals Inc quinolinas 8-substituidas e analogos relacionados como moduladores de sirtuina
US8278302B2 (en) 2009-04-08 2012-10-02 Boehringer Ingelheim International Gmbh Substituted piperidines as CCR3 antagonists
US8362249B2 (en) 2009-04-27 2013-01-29 Boehringer Ingelheim International Gmbh CXCR3 receptor antagonists
UA107360C2 (en) 2009-08-05 2014-12-25 Biogen Idec Inc Bicyclic aryl sphingosine 1-phosphate analogs
BR112012010706A2 (pt) * 2009-11-05 2016-03-29 Glaxosmithkline Llc composto, composição farmacêutica, combinação do produto farmacêutico, uso de um composto, e, métodos para o tratamento de uma doença ou condição, e para inibir um bromodomínio
US20130109672A1 (en) 2010-04-29 2013-05-02 The United States Of America,As Represented By The Secretary, Department Of Health And Human Service Activators of human pyruvate kinase
AU2011254242B2 (en) 2010-05-17 2015-10-29 Incozen Therapeutics Pvt. Ltd. Novel 3,5-disubstitued-3H-imidazo[4,5-b]pyridine and 3,5- disubstitued -3H-[1,2,3]triazolo[4,5-b] pyridine compounds as modulators of protein kinases
WO2011156632A2 (en) 2010-06-09 2011-12-15 Georgetown University Compositions and methods of treatment for tumors in the nervous system
EP2604602A4 (en) 2010-08-11 2013-12-18 Taisho Pharmaceutical Co Ltd HETEROARYL PYRAZOLE DERIVATIVE
AR084070A1 (es) * 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
EA026115B1 (ru) 2010-12-17 2017-03-31 Ф. Хоффманн-Ля Рош Аг Замещенные 6,6-конденсированные азотсодержащие гетероциклические соединения и их применение
TW201309639A (zh) 2011-02-17 2013-03-01 Lg Life Sciences Ltd 作為gpr119促效劑之肟衍生物
WO2012125668A1 (en) 2011-03-17 2012-09-20 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
GB201106750D0 (en) * 2011-04-21 2011-06-01 Glaxosmithkline Llc Novel compounds
GB201106743D0 (en) 2011-04-21 2011-06-01 Glaxosmithkline Llc Novel compounds
JP5742439B2 (ja) 2011-05-02 2015-07-01 信越化学工業株式会社 蛍光性化合物及び蛍光性樹脂組成物
US9278910B2 (en) 2011-05-31 2016-03-08 Receptos, Inc. GLP-1 receptor stabilizers and modulators
CN102887895B (zh) 2011-07-22 2016-08-24 山东轩竹医药科技有限公司 吡啶并嘧啶类mTOR抑制剂
EP2736330A4 (en) 2011-07-29 2015-05-27 Tempero Pharmaceuticals Inc COMPOUNDS AND METHODS
WO2013027168A1 (en) * 2011-08-22 2013-02-28 Pfizer Inc. Novel heterocyclic compounds as bromodomain inhibitors
EP2766345B1 (en) * 2011-10-14 2016-03-16 Bristol-Myers Squibb Company Substituted tetrahydroisoquinoline compounds as factor xia inhibitors
CN104080452A (zh) 2011-10-26 2014-10-01 美国政府健康及人类服务部 用小分子chk2抑制剂治疗hcv感染的方法
CA2870992C (en) 2012-04-25 2020-07-14 Raqualia Pharma Inc. Amide derivatives as ttx-s blockers
JPWO2014034719A1 (ja) 2012-08-29 2016-08-08 興和株式会社 Tlr阻害作用を有するキノリン誘導体
CN105229002A (zh) 2012-12-20 2016-01-06 拜耳医药股份有限公司 抑制bet蛋白的二氢吡啶并吡嗪酮
JP2016509576A (ja) 2012-12-20 2016-03-31 バイエル ファーマ アクチエンゲゼルシャフト Betタンパク質阻害性ジヒドロキノキザリノン類

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