MX371228B - Anticuerpos antiperiostina, kits, composiciones y su uso en la medición de periostina total. - Google Patents
Anticuerpos antiperiostina, kits, composiciones y su uso en la medición de periostina total.Info
- Publication number
- MX371228B MX371228B MX2017015918A MX2017015918A MX371228B MX 371228 B MX371228 B MX 371228B MX 2017015918 A MX2017015918 A MX 2017015918A MX 2017015918 A MX2017015918 A MX 2017015918A MX 371228 B MX371228 B MX 371228B
- Authority
- MX
- Mexico
- Prior art keywords
- inhibition
- diagnosis
- treatments relating
- methods
- treatments
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6884—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from lung
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39566—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against immunoglobulins, e.g. anti-idiotypic antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/12—Pulmonary diseases
- G01N2800/122—Chronic or obstructive airway disorders, e.g. asthma COPD
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a un anticuerpo antiperiostina capaz de detectar periostina Total, que comprende las secuencias de región hipervariable (HVR) de las secuencias de región hipervariable (HVR) de la secuencia del domino variable de la cadena pesada (VH) de SEQ ID NO: 1 y las secuencias HVR de la secuencia del dominio variable de la cadena ligera (VL) de SEQ ID NO: 2; o las secuencias HVR de la secuencia VH de SEQ ID NO: 3 y las secuencia HVR de la secuencia VL de SEQ ID NO: 4. Un kit para medir Periostina Total en una muestra biológica de un paciente, y un composición que comprende el anticuerpo antiperiostina.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45976010P | 2010-12-16 | 2010-12-16 | |
US201161465425P | 2011-03-18 | 2011-03-18 | |
US201161484650P | 2011-05-10 | 2011-05-10 | |
US201161574485P | 2011-08-02 | 2011-08-02 | |
US201161557295P | 2011-11-08 | 2011-11-08 | |
PCT/US2011/065410 WO2012083132A2 (en) | 2010-12-16 | 2011-12-16 | Diagnosis and treatments relating to th2 inhibition |
Publications (1)
Publication Number | Publication Date |
---|---|
MX371228B true MX371228B (es) | 2020-01-10 |
Family
ID=46234723
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013006712A MX352789B (es) | 2010-12-16 | 2011-12-16 | Anticuerpo anti-il-13 para usarse en tratar un asma o un trastorno respiratorio. |
MX2017015918A MX371228B (es) | 2010-12-16 | 2011-12-16 | Anticuerpos antiperiostina, kits, composiciones y su uso en la medición de periostina total. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013006712A MX352789B (es) | 2010-12-16 | 2011-12-16 | Anticuerpo anti-il-13 para usarse en tratar un asma o un trastorno respiratorio. |
Country Status (19)
Country | Link |
---|---|
US (4) | US20120156194A1 (es) |
EP (2) | EP3447491A3 (es) |
JP (4) | JP6005657B2 (es) |
KR (4) | KR101616260B1 (es) |
CN (4) | CN103688171B (es) |
AR (1) | AR084342A1 (es) |
AU (1) | AU2011343570B2 (es) |
BR (2) | BR122020012255B1 (es) |
CA (2) | CA3040095C (es) |
HK (2) | HK1215711A1 (es) |
IL (2) | IL226821B (es) |
MX (2) | MX352789B (es) |
MY (1) | MY188365A (es) |
NZ (2) | NZ609493A (es) |
RU (2) | RU2737245C2 (es) |
SG (3) | SG10201401746TA (es) |
TW (4) | TWI666447B (es) |
WO (1) | WO2012083132A2 (es) |
ZA (1) | ZA201302979B (es) |
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SG10201404273QA (en) | 2003-12-23 | 2014-10-30 | Genentech Inc | Novel anti-il 13 antibodies and uses thereof |
NZ588853A (en) * | 2008-03-31 | 2013-07-26 | Genentech Inc | Compositions and methods for treating and diagnosing asthma |
EP3447491A3 (en) * | 2010-12-16 | 2019-06-05 | F. Hoffmann-La Roche AG | Diagnosis and treatments relating to th2 inhibition |
JP6404208B2 (ja) * | 2012-03-27 | 2018-10-10 | ジェネンテック, インコーポレイテッド | 特発性肺線維症の予後予測、診断および処置の方法 |
JO3623B1 (ar) | 2012-05-18 | 2020-08-27 | Amgen Inc | البروتينات المرتبطة بمولد المستضاد st2 |
WO2014151648A1 (en) * | 2013-03-15 | 2014-09-25 | Coronado Biosciences, Inc. | Treatment of autoimmune disease using helminthic parasites |
KR20150131177A (ko) | 2013-03-15 | 2015-11-24 | 제넨테크, 인크. | 항-CRTh2 항체 및 그의 용도 |
AU2014306956B2 (en) | 2013-08-12 | 2019-11-21 | Astrazeneca Ab | Methods for reducing exacerbation rates of asthma using benralizumab |
KR102337601B1 (ko) * | 2013-08-12 | 2021-12-10 | 아스트라제네카 아베 | 벤랄리주맙을 이용하여 천식 증상을 개선시키는 방법 |
EP3875487A1 (en) * | 2013-08-12 | 2021-09-08 | Astrazeneca AB | Methods for increasing forced expiratory volume in asthmatics using benralizumab |
KR102332302B1 (ko) | 2013-09-13 | 2021-12-01 | 제넨테크, 인크. | 세포주에서 숙주 세포 단백질 및 재조합 폴리펩티드 생성물을 검출 및 정량화하기 위한 조성물 및 방법 |
EP3683232A1 (en) | 2013-09-13 | 2020-07-22 | F. Hoffmann-La Roche AG | Methods and compositions comprising purified recombinant polypeptides |
JP6250351B2 (ja) * | 2013-09-30 | 2017-12-20 | シスメックス株式会社 | 好酸球性気道炎症に関する情報の取得方法およびそのような情報を取得するためのマーカー |
US20150104447A1 (en) * | 2013-10-15 | 2015-04-16 | Medimmune, Llc | Methods for treating chronic obstructive pulmonary disease using benralizumab |
EP3060685B1 (en) * | 2013-10-23 | 2019-05-01 | F. Hoffmann-La Roche AG | Method of predicting the response of an asthma patient to therapy |
RU2019118984A (ru) | 2014-01-10 | 2019-08-06 | Анаптисбайо, Инк. | Антитела, направленные против интерлейкина-33 (il-33) |
BR112016017192A2 (pt) | 2014-01-27 | 2017-10-10 | Medimmune Llc | dipeptidil peptidase-4 (dpp4/cd26) como um biomarcador periférico da ativação de il-13 no pulmão asmático |
WO2015120185A1 (en) | 2014-02-07 | 2015-08-13 | Medimmune, Llc | Novel assay to detect human periostin |
WO2015126750A1 (en) * | 2014-02-19 | 2015-08-27 | Array Biopharma Inc. | BIOMARKERS PREDICTIVE OF RESPONSIVENESS TO TREATMENT WITH A CRTh2 INHIBITOR |
KR20160124165A (ko) * | 2014-02-21 | 2016-10-26 | 제넨테크, 인크. | 항-il-13/il-17 이중특이적 항체 및 그의 용도 |
EP3129497B1 (en) | 2014-04-11 | 2021-09-08 | Novartis AG | Methods of selectively treating asthma using il-13 antagonists |
TW201628647A (zh) | 2014-06-27 | 2016-08-16 | 賽諾菲公司 | 抗-il4-il13雙特異性抗體 |
MA40164A (fr) * | 2014-06-27 | 2017-05-03 | Sanofi Sa | Anticorps bispécifiques anti-il4-il13 |
CA2962944A1 (en) * | 2014-09-08 | 2016-03-17 | Guy BRUSSELLE | Use of reslizumab to treat moderate to severe eosinophilic asthma |
JP7095990B2 (ja) | 2014-09-18 | 2022-07-05 | シーダーズ-サイナイ メディカル センター | 線維症を治療するための組成物及び方法 |
EA201791029A1 (ru) | 2014-11-10 | 2017-12-29 | Дженентек, Инк. | Антитела против интерлейкина-33 и их применение |
CN107109494B (zh) * | 2014-11-10 | 2023-10-27 | 豪夫迈·罗氏有限公司 | Il-33介导型疾病的治疗方法和诊断方法 |
JP2018508183A (ja) | 2014-12-23 | 2018-03-29 | ジェネンテック, インコーポレイテッド | 化学療法耐性癌を治療及び診断する組成物及び方法 |
BR112017011724A2 (pt) | 2015-01-09 | 2018-05-15 | Medimmune, Llc | ensaio para detectar dpp-4 humana |
MX2017011486A (es) * | 2015-03-16 | 2018-06-15 | Genentech Inc | Métodos de detección y cuantificación de il-13 y sus usos en el diagnóstico y tratamiento de enfermedades asociadas a th2. |
WO2017077391A2 (en) | 2015-11-04 | 2017-05-11 | Astrazeneca Ab | Dipeptidyl peptidase-4 and periostin as predictors of clinical response to eosinophil-targeted therapeutic agents in eosinophilic diseases |
EP3417079A4 (en) * | 2016-02-17 | 2019-07-10 | Icahn School of Medicine at Mount Sinai | NASAL BIOMARKERS FOR ASTHMA |
PE20181952A1 (es) | 2016-04-27 | 2018-12-17 | Pfizer | Anticuerpos anti-ll-33, composiciones, metodos y usos de los mismos |
JP6871948B2 (ja) * | 2016-04-27 | 2021-05-19 | アッヴィ・インコーポレイテッド | 抗il−13抗体を使用する、il−13活性が有害である疾患の治療方法 |
AU2017330405B2 (en) * | 2016-09-23 | 2024-02-01 | Genentech, Inc. | Uses of IL-13 antagonists for treating atopic dermatitis |
AR110873A1 (es) | 2017-02-10 | 2019-05-08 | Genentech Inc | Anticuerpos contra triptasa, composiciones de estos y usos de estos |
KR102417088B1 (ko) | 2018-02-09 | 2022-07-07 | 제넨테크, 인크. | 비만 세포 매개 염증성 질환에 대한 치료 및 진단 방법 |
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IL296256A (en) | 2020-03-13 | 2022-11-01 | Genentech Inc | Antibodies against interleukin-33 and uses thereof |
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EP3447491A3 (en) * | 2010-12-16 | 2019-06-05 | F. Hoffmann-La Roche AG | Diagnosis and treatments relating to th2 inhibition |
EP2754672B1 (en) | 2011-09-06 | 2019-02-27 | Shino-Test Corporation | Antibody capable of binding to specific region of periostin, and method of measuring periostin using the same |
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