EA201101568A1 - Лечение ex vivo иммунологических нарушений с помощью ингибиторов pkc-teta - Google Patents

Лечение ex vivo иммунологических нарушений с помощью ингибиторов pkc-teta

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Publication number
EA201101568A1
EA201101568A1 EA201101568A EA201101568A EA201101568A1 EA 201101568 A1 EA201101568 A1 EA 201101568A1 EA 201101568 A EA201101568 A EA 201101568A EA 201101568 A EA201101568 A EA 201101568A EA 201101568 A1 EA201101568 A1 EA 201101568A1
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EA
Eurasian Patent Office
Prior art keywords
pkc
teta
inhibitors
treatment
treating
Prior art date
Application number
EA201101568A
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English (en)
Inventor
Мэрианне Браун
Майкл Дастин
Александра Занин-Жоров
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Бёрингер Ингельхайм Интернациональ Гмбх
Нью-Йорк Юниверсити
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42332785&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201101568(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх, Нью-Йорк Юниверсити filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA201101568A1 publication Critical patent/EA201101568A1/ru

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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

В заявке описан способ лечения различных заболеваний и нарушений, которые опосредуются или поддерживаются активностью PKC-тета, включая иммунологические нарушения и атеросклероз. Конкретно, в заявке описан способ лечения иммунологического нарушения или атеросклероза у пациента, заключающийся в том, что обрабатывают ex vivo кровь, взятую у пациента, или определенный компонент этой крови ингибитором PKC-тета и затем снова вводят обработанную кровь пациенту.
EA201101568A 2009-04-28 2010-04-28 Лечение ex vivo иммунологических нарушений с помощью ингибиторов pkc-teta EA201101568A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17323709P 2009-04-28 2009-04-28
PCT/US2010/032707 WO2010126967A1 (en) 2009-04-28 2010-04-28 Ex-vivo treatment of immunological disorders with pkc-theta inhibitors

Publications (1)

Publication Number Publication Date
EA201101568A1 true EA201101568A1 (ru) 2012-05-30

Family

ID=42332785

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201101568A EA201101568A1 (ru) 2009-04-28 2010-04-28 Лечение ex vivo иммунологических нарушений с помощью ингибиторов pkc-teta

Country Status (14)

Country Link
US (1) US20120196919A1 (ru)
EP (1) EP2445503A1 (ru)
JP (1) JP2012525403A (ru)
KR (1) KR20120005460A (ru)
CN (1) CN102421435A (ru)
AU (1) AU2010241701A1 (ru)
BR (1) BRPI1014775A2 (ru)
CA (1) CA2760305A1 (ru)
CL (1) CL2011002690A1 (ru)
EA (1) EA201101568A1 (ru)
IL (1) IL215939A0 (ru)
MX (1) MX2011011290A (ru)
NZ (1) NZ595331A (ru)
WO (1) WO2010126967A1 (ru)

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EP2446022A4 (en) * 2009-05-18 2013-06-26 Therakos Inc PROCESS FOR THE EX-VIVO EXPANSION OF REGULATORY T CELLS WITH IMPROVED SUPPRESSION FUNCTION FOR CLINICAL APPLICATION IN IMMUNE-MEDIATED DISEASES
WO2012006060A1 (en) 2010-06-28 2012-01-12 Vertex Pharmaceuticals Incorporated Compounds and methods for the treatment or prevention of flavivirus infections
AR081691A1 (es) 2010-06-28 2012-10-10 Vertex Pharma Derivados de tiofeno, metodos para su preparacion y su uso en el tratamiento o la prevencion de infecciones por flavivirus
WO2012024363A2 (en) 2010-08-17 2012-02-23 Vertex Pharmaceuticals Incorporated Compounds and methods for the treatment or prevention of flaviviridae viral infections
CN103260670A (zh) 2010-10-15 2013-08-21 塞托弗尔克斯股份有限公司 细胞分离灌流器及其用途
EP2720705A4 (en) * 2011-06-16 2015-02-18 Jolla Inst Allergy Immunolog PKC-THETA TARGETING COMPOSITIONS AND USES AND METHODS FOR TREATING PKC-THETA PATHOLOGIES, RESPONSES, AND ADVERSE IMMUNE DISEASES
TW201317223A (zh) 2011-07-26 2013-05-01 Vertex Pharma 噻吩化合物
WO2013016499A1 (en) 2011-07-26 2013-01-31 Vertex Pharmaceuticals Incorporated Methods for preparation of thiophene compounds
JP2015503418A (ja) 2012-01-09 2015-02-02 エイチ． デビッド ヒュームズ 心筋機能を向上させるためのカートリッジおよび方法
US9012427B2 (en) 2012-03-22 2015-04-21 Alios Biopharma, Inc. Pharmaceutical combinations comprising a thionucleotide analog
DK2953634T3 (da) 2013-02-07 2021-08-30 Massachusetts Gen Hospital Fremgangsmåder til udvidelse eller udtømning af regulerende t-celler
US20150065439A1 (en) 2013-02-28 2015-03-05 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions
CN107207470B (zh) 2014-11-21 2019-12-03 F2G有限公司 抗真菌剂
CN107849142B (zh) 2015-05-15 2022-04-26 综合医院公司 拮抗性抗肿瘤坏死因子受体超家族抗体
WO2017041002A1 (en) * 2015-09-04 2017-03-09 Blazar Bruce R Methods and compositions for increasing the suppressive function of regulatory t-cells (tregs)
EP3355914B1 (en) 2015-09-29 2024-03-06 The General Hospital Corporation A composition comprising bcg for reducing cholesterol.
KR20240095471A (ko) 2016-05-13 2024-06-25 더 제너럴 하스피탈 코포레이션 길항성 항-종양 괴사 인자 수용체 슈퍼패밀리 항체
GB201609222D0 (en) 2016-05-25 2016-07-06 F2G Ltd Pharmaceutical formulation
WO2020113094A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
US11819503B2 (en) 2019-04-23 2023-11-21 F2G Ltd Method of treating coccidioides infection

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE50212771D1 (de) * 2001-10-17 2008-10-23 Boehringer Ingelheim Pharma Pyrimidinderivate, arzneimittel enthaltend diese verbindungen, deren verwendung und verfahren zu ihrer herstellung
JP2006508191A (ja) * 2002-11-08 2006-03-09 トーラーレックス， インク． エフェクタｔ細胞に優先的に関連する分子及びそれらの使用法
DE602004022633D1 (de) * 2003-01-30 2009-10-01 Boehringer Ingelheim Pharma 2,4-diaminopyrimidinderivate, die sich als inhibitoren von pkc-theta eignen
EP1765791A1 (en) * 2004-07-08 2007-03-28 Boehringer Ingelheim Pharmaceuticals Inc. Pyrimidine derivatives useful as inhibitors of pkc-theta

Also Published As

Publication number Publication date
WO2010126967A1 (en) 2010-11-04
JP2012525403A (ja) 2012-10-22
CN102421435A (zh) 2012-04-18
EP2445503A1 (en) 2012-05-02
CA2760305A1 (en) 2010-11-04
MX2011011290A (es) 2012-02-13
AU2010241701A1 (en) 2011-10-13
CL2011002690A1 (es) 2012-04-27
US20120196919A1 (en) 2012-08-02
BRPI1014775A2 (pt) 2016-04-19
NZ595331A (en) 2013-08-30
IL215939A0 (en) 2012-01-31
KR20120005460A (ko) 2012-01-16

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