BRPI1014775A2 - tratamento ex vivo de distúrbios imunológicos com inibidores de pkc-teta - Google Patents
tratamento ex vivo de distúrbios imunológicos com inibidores de pkc-tetaInfo
- Publication number
- BRPI1014775A2 BRPI1014775A2 BRPI1014775A BRPI1014775A BRPI1014775A2 BR PI1014775 A2 BRPI1014775 A2 BR PI1014775A2 BR PI1014775 A BRPI1014775 A BR PI1014775A BR PI1014775 A BRPI1014775 A BR PI1014775A BR PI1014775 A2 BRPI1014775 A2 BR PI1014775A2
- Authority
- BR
- Brazil
- Prior art keywords
- pkc
- immune disorders
- vivo treatment
- theta inhibitors
- theta
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17323709P | 2009-04-28 | 2009-04-28 | |
PCT/US2010/032707 WO2010126967A1 (en) | 2009-04-28 | 2010-04-28 | Ex-vivo treatment of immunological disorders with pkc-theta inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI1014775A2 true BRPI1014775A2 (pt) | 2016-04-19 |
Family
ID=42332785
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI1014775A BRPI1014775A2 (pt) | 2009-04-28 | 2010-04-28 | tratamento ex vivo de distúrbios imunológicos com inibidores de pkc-teta |
Country Status (14)
Country | Link |
---|---|
US (1) | US20120196919A1 (pt) |
EP (1) | EP2445503A1 (pt) |
JP (1) | JP2012525403A (pt) |
KR (1) | KR20120005460A (pt) |
CN (1) | CN102421435A (pt) |
AU (1) | AU2010241701A1 (pt) |
BR (1) | BRPI1014775A2 (pt) |
CA (1) | CA2760305A1 (pt) |
CL (1) | CL2011002690A1 (pt) |
EA (1) | EA201101568A1 (pt) |
IL (1) | IL215939A0 (pt) |
MX (1) | MX2011011290A (pt) |
NZ (1) | NZ595331A (pt) |
WO (1) | WO2010126967A1 (pt) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102908690A (zh) | 2007-08-31 | 2013-02-06 | 密执安州立大学董事会 | 选择性细胞隔离装置及其相关方法 |
JP5937003B2 (ja) * | 2009-05-18 | 2016-06-22 | セラコス・インコーポレイテッドTherakos, Inc. | 免疫介在性疾患における臨床応用のための、抑制機能の高められた制御性t細胞のエクスビボ増加方法 |
UY33473A (es) | 2010-06-28 | 2012-01-31 | Vertex Pharma | Compuestos y métodos para el tratamiento o la prevencion de infecciones por flavivirus |
EP2585448A1 (en) | 2010-06-28 | 2013-05-01 | Vertex Pharmaceuticals Incorporated | Compounds and methods for the treatment or prevention of flavivirus infections |
AU2011292040A1 (en) | 2010-08-17 | 2013-03-07 | Vertex Pharmaceuticals Incorporated | Compounds and methods for the treatment or prevention of Flaviviridae viral infections |
US20130288370A1 (en) | 2010-10-15 | 2013-10-31 | Cytopherx, Inc. | Cytopheresis cartridges and use thereof |
US20140186372A1 (en) * | 2011-06-16 | 2014-07-03 | La Jolla Institute For Allergy And Immunology | Compositions targeting pkc-theta and uses and methods of treating pkc-theta pathologies, adverse immune responses and diseases |
WO2013016499A1 (en) | 2011-07-26 | 2013-01-31 | Vertex Pharmaceuticals Incorporated | Methods for preparation of thiophene compounds |
WO2013016492A1 (en) | 2011-07-26 | 2013-01-31 | Vertex Pharmaceuticals Incorporated | Thiophene compounds |
CA2852220A1 (en) | 2011-10-14 | 2013-07-18 | Cytopherx, Inc. | Cartridge and method for increasing myocardial function |
WO2013142157A1 (en) | 2012-03-22 | 2013-09-26 | Alios Biopharma, Inc. | Pharmaceutical combinations comprising a thionucleotide analog |
DK2953634T3 (da) * | 2013-02-07 | 2021-08-30 | Massachusetts Gen Hospital | Fremgangsmåder til udvidelse eller udtømning af regulerende t-celler |
WO2014134251A1 (en) | 2013-02-28 | 2014-09-04 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions |
ES2694637T3 (es) | 2014-11-21 | 2018-12-26 | F2G Limited | Agentes antifúngicos |
CN115043943A (zh) | 2015-05-15 | 2022-09-13 | 综合医院公司 | 拮抗性抗肿瘤坏死因子受体超家族抗体 |
US10993959B2 (en) | 2015-09-04 | 2021-05-04 | Regents Of The University Of Minnesota | Methods and compositions for increasing the suppressive function of regulatory T-cells (Tregs) |
US11266730B2 (en) | 2015-09-29 | 2022-03-08 | The General Hospital Corporation | Methods of treating and diagnosing disease using biomarkers for BCG therapy |
KR102410778B1 (ko) | 2016-05-13 | 2022-06-21 | 더 제너럴 하스피탈 코포레이션 | 길항성 항-종양 괴사 인자 수용체 슈퍼패밀리 항체 |
GB201609222D0 (en) | 2016-05-25 | 2016-07-06 | F2G Ltd | Pharmaceutical formulation |
WO2020113094A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
US11819503B2 (en) | 2019-04-23 | 2023-11-21 | F2G Ltd | Method of treating coccidioides infection |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UY27487A1 (es) * | 2001-10-17 | 2003-05-30 | Boehringer Ingelheim Pharma | Derivados de pirimidina, medicamentos que contienen estos compuestos, su empleo y procedimiento para su preparación |
CA2505546A1 (en) * | 2002-11-08 | 2004-05-27 | Tolerrx, Inc. | Molecules preferentially associated with effector t cells and methods of their use |
WO2004067516A1 (en) * | 2003-01-30 | 2004-08-12 | Boehringer Ingelheim Pharmaceuticals, Inc. | 2,4-diaminopyrimidine derivatives useful as inhibitors of pkc-theta |
WO2006014482A1 (en) * | 2004-07-08 | 2006-02-09 | Boehringer Ingelheim Pharmaceuticals, Inc. | Pyrimidine derivatives useful as inhibitors of pkc-theta |
-
2010
- 2010-04-28 MX MX2011011290A patent/MX2011011290A/es not_active Application Discontinuation
- 2010-04-28 BR BRPI1014775A patent/BRPI1014775A2/pt not_active IP Right Cessation
- 2010-04-28 CN CN2010800185205A patent/CN102421435A/zh active Pending
- 2010-04-28 CA CA2760305A patent/CA2760305A1/en not_active Abandoned
- 2010-04-28 WO PCT/US2010/032707 patent/WO2010126967A1/en active Application Filing
- 2010-04-28 EP EP10717377A patent/EP2445503A1/en not_active Withdrawn
- 2010-04-28 EA EA201101568A patent/EA201101568A1/ru unknown
- 2010-04-28 JP JP2012508629A patent/JP2012525403A/ja active Pending
- 2010-04-28 US US13/266,757 patent/US20120196919A1/en not_active Abandoned
- 2010-04-28 AU AU2010241701A patent/AU2010241701A1/en not_active Abandoned
- 2010-04-28 NZ NZ595331A patent/NZ595331A/xx not_active IP Right Cessation
- 2010-04-28 KR KR1020117023974A patent/KR20120005460A/ko not_active Application Discontinuation
-
2011
- 2011-10-26 IL IL215939A patent/IL215939A0/en unknown
- 2011-10-27 CL CL2011002690A patent/CL2011002690A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
AU2010241701A1 (en) | 2011-10-13 |
US20120196919A1 (en) | 2012-08-02 |
IL215939A0 (en) | 2012-01-31 |
KR20120005460A (ko) | 2012-01-16 |
CL2011002690A1 (es) | 2012-04-27 |
WO2010126967A1 (en) | 2010-11-04 |
CN102421435A (zh) | 2012-04-18 |
EP2445503A1 (en) | 2012-05-02 |
MX2011011290A (es) | 2012-02-13 |
EA201101568A1 (ru) | 2012-05-30 |
NZ595331A (en) | 2013-08-30 |
JP2012525403A (ja) | 2012-10-22 |
CA2760305A1 (en) | 2010-11-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |