DOP2011000397A - Nuevos derivados de fenilimidazol como inhibidores de la enzima pde10a - Google Patents
Nuevos derivados de fenilimidazol como inhibidores de la enzima pde10aInfo
- Publication number
- DOP2011000397A DOP2011000397A DO2011000397A DO2011000397A DOP2011000397A DO P2011000397 A DOP2011000397 A DO P2011000397A DO 2011000397 A DO2011000397 A DO 2011000397A DO 2011000397 A DO2011000397 A DO 2011000397A DO P2011000397 A DOP2011000397 A DO P2011000397A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- phenylimidazol
- inhibitors
- new derivatives
- pde10a
- enzyme
- Prior art date
Links
- ZCUJYXPAKHMBAZ-UHFFFAOYSA-N 2-phenyl-1h-imidazole Chemical class C1=CNC(C=2C=CC=CC=2)=N1 ZCUJYXPAKHMBAZ-UHFFFAOYSA-N 0.000 title 1
- 101001072037 Homo sapiens cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/DK2009/050134 WO2009152825A1 (en) | 2008-06-20 | 2009-06-19 | Novel phenylimidazole derivatives as pde10a enzyme inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DOP2011000397A true DOP2011000397A (es) | 2012-07-15 |
Family
ID=42321053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2011000397A DOP2011000397A (es) | 2009-06-19 | 2011-12-19 | Nuevos derivados de fenilimidazol como inhibidores de la enzima pde10a |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP2443105B1 (es) |
| JP (1) | JP5768044B2 (es) |
| AR (1) | AR077144A1 (es) |
| AU (1) | AU2010262190B2 (es) |
| CA (1) | CA2765750A1 (es) |
| CR (1) | CR20110654A (es) |
| CY (1) | CY1115971T1 (es) |
| DK (1) | DK2443105T3 (es) |
| DO (1) | DOP2011000397A (es) |
| ES (1) | ES2527216T3 (es) |
| GE (1) | GEP20146100B (es) |
| GT (1) | GT201100322A (es) |
| HR (1) | HRP20141222T1 (es) |
| IL (1) | IL216684A (es) |
| MA (1) | MA33367B1 (es) |
| MX (1) | MX2011013400A (es) |
| MY (1) | MY156785A (es) |
| NZ (1) | NZ597203A (es) |
| PL (1) | PL2443105T3 (es) |
| PT (1) | PT2443105E (es) |
| SG (1) | SG176680A1 (es) |
| SI (1) | SI2443105T1 (es) |
| SM (1) | SMT201500003B (es) |
| TW (1) | TW201100430A (es) |
| UA (2) | UA102693C2 (es) |
| WO (1) | WO2010145668A1 (es) |
| ZA (1) | ZA201109271B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8133897B2 (en) | 2008-06-20 | 2012-03-13 | H. Lundbeck A/S | Phenylimidazole derivatives as PDE10A enzyme inhibitors |
| TWI501965B (zh) | 2008-06-20 | 2015-10-01 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑之新穎苯基咪唑衍生物 |
| TWI485151B (zh) | 2009-12-17 | 2015-05-21 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族苯基咪唑衍生物 |
| US8552045B2 (en) | 2010-11-19 | 2013-10-08 | H. Lundbeck A/S | Tricyclic imidazole compounds as PDE10 inhibitors |
| JO3089B1 (ar) * | 2010-11-19 | 2017-03-15 | H Lundbeck As | مشتقات ايميدازول كمثبطات لانزيمات pde10a |
| KR20140009372A (ko) | 2011-02-18 | 2014-01-22 | 알러간, 인코포레이티드 | 포스포다이에스테라제 10(pde10a)의 억제제로서의 치환된 6,7-다이알콕시-3-아이소퀴놀리놀 유도체 |
| WO2013034758A1 (en) * | 2011-09-09 | 2013-03-14 | H. Lundbeck A/S | Substituted triazolopyrazines and uses thereof |
| WO2013034761A1 (en) * | 2011-09-09 | 2013-03-14 | H. Lundbeck A/S | Pyridine compounds and uses thereof |
| CN103874701A (zh) * | 2011-09-09 | 2014-06-18 | H.隆德贝克有限公司 | 吡啶化合物和其用途 |
| WO2013034755A1 (en) * | 2011-09-09 | 2013-03-14 | H. Lundbeck A/S | Triazolopyrazine derivatives and their use for treating neurological and psychiatric disorders |
| TWI570124B (zh) | 2011-12-21 | 2017-02-11 | Ｈ 朗德貝克公司 | 作為ｐｄｅ１０ａ酵素抑制劑的喹啉衍生物 |
| WO2013107856A1 (en) * | 2012-01-20 | 2013-07-25 | H. Lundbeck A/S | Imidazole derivatives as pde10a enzyme inhibitors |
| WO2013127817A1 (en) | 2012-02-27 | 2013-09-06 | H. Lundbeck A/S | Imidazole derivatives as pde10a enzyme inhibitors |
| WO2014071044A1 (en) | 2012-11-01 | 2014-05-08 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
| US9200016B2 (en) | 2013-12-05 | 2015-12-01 | Allergan, Inc. | Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A) |
| WO2020094590A1 (en) * | 2018-11-06 | 2020-05-14 | H. Lundbeck A/S | 5,8-dimethyl-2-[2-(1-methyl-4-phenyl-1h-imidazol-2-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyrazine hemiadipate |
| BR112020013697A2 (pt) * | 2018-11-06 | 2020-12-01 | H. Lundbeck A/S | compostos para tratamento de sintomas negativos e comprometimentos cognitivos |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4826833A (en) | 1984-01-30 | 1989-05-02 | Pfizer Inc. | 6-(Substituted)methylene-penicillanic and 6-(substituted)hydroxymethylpenicillanic acids and derivatives thereof |
| US20030032579A1 (en) | 2001-04-20 | 2003-02-13 | Pfizer Inc. | Therapeutic use of selective PDE10 inhibitors |
| IL149106A0 (en) | 2001-04-20 | 2002-11-10 | Pfizer Prod Inc | Therapeutic use of selective pde10 inhibitors |
| FR2824065A1 (fr) | 2001-04-26 | 2002-10-31 | Neuro3D | Composes inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations |
| WO2004024705A1 (ja) | 2002-09-10 | 2004-03-25 | Takeda Pharmaceutical Company Limited | ５員複素環化合物 |
| US20060128695A1 (en) | 2002-10-30 | 2006-06-15 | Neuro3D | Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses |
| TW200510407A (en) * | 2003-06-30 | 2005-03-16 | Altana Pharma Ag | Novel pyrrolodihydroisoquinolines as PDE 10 inhibitors |
| ATE438398T1 (de) | 2003-06-30 | 2009-08-15 | Nycomed Gmbh | Pyrrolo-dihydroisochinolin-derivate als pde10- inhibitoren |
| WO2005012485A2 (en) | 2003-07-31 | 2005-02-10 | Bayer Pharmaceuticals Corporation | Methods for treating diabetes and related disorders using pde10a inhibitors |
| JP2007523152A (ja) | 2004-02-18 | 2007-08-16 | ファイザー・プロダクツ・インク | キナゾリンおよびイソキノリンのテトラヒドロイソキノリニル誘導体 |
| FR2870539B1 (fr) | 2004-05-19 | 2006-08-04 | Greenpharma Sa Sa | Nouvelles methodes et medicaments |
| EP1755611A1 (en) | 2004-06-07 | 2007-02-28 | Pfizer Products Inc. | Phosphodiesterase 10 inhibition as treatment for obesity-related and metabolic syndrome-related conditions |
| US20060019975A1 (en) | 2004-07-23 | 2006-01-26 | Pfizer Inc | Novel piperidyl derivatives of quinazoline and isoquinoline |
| JP2008512375A (ja) | 2004-09-03 | 2008-04-24 | メモリ ファーマセチカル コーポレーション | 精神医学的又は神経学的症候群の治療用のホスホジエステラーゼ１０阻害剤としての４−置換４，６−ジアルコキシ−シンノリン誘導体 |
| US20060183763A1 (en) * | 2004-12-31 | 2006-08-17 | Pfizer Inc | Novel pyrrolidyl derivatives of heteroaromatic compounds |
| AU2007217750A1 (en) * | 2006-02-21 | 2007-08-30 | Amgen Inc. | Cinnoline derivatives as phosphodiesterase 10 inhibitors |
| TWI501965B (zh) | 2008-06-20 | 2015-10-01 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑之新穎苯基咪唑衍生物 |
-
2009
- 2009-06-19 UA UAA201015420A patent/UA102693C2/ru unknown
-
2010
- 2010-06-17 WO PCT/DK2010/050147 patent/WO2010145668A1/en not_active Ceased
- 2010-06-17 UA UAA201200499A patent/UA106378C2/ru unknown
- 2010-06-17 PT PT107253734T patent/PT2443105E/pt unknown
- 2010-06-17 AU AU2010262190A patent/AU2010262190B2/en not_active Ceased
- 2010-06-17 CA CA2765750A patent/CA2765750A1/en not_active Abandoned
- 2010-06-17 ES ES10725373.4T patent/ES2527216T3/es active Active
- 2010-06-17 JP JP2012515356A patent/JP5768044B2/ja not_active Expired - Fee Related
- 2010-06-17 GE GEAP201012536A patent/GEP20146100B/en unknown
- 2010-06-17 NZ NZ597203A patent/NZ597203A/xx not_active IP Right Cessation
- 2010-06-17 PL PL10725373T patent/PL2443105T3/pl unknown
- 2010-06-17 DK DK10725373.4T patent/DK2443105T3/en active
- 2010-06-17 MX MX2011013400A patent/MX2011013400A/es unknown
- 2010-06-17 MA MA34464A patent/MA33367B1/fr unknown
- 2010-06-17 MY MYPI2011005865A patent/MY156785A/en unknown
- 2010-06-17 SG SG2011089919A patent/SG176680A1/en unknown
- 2010-06-17 EP EP10725373.4A patent/EP2443105B1/en active Active
- 2010-06-17 HR HRP20141222AT patent/HRP20141222T1/hr unknown
- 2010-06-17 SI SI201030841T patent/SI2443105T1/sl unknown
- 2010-06-18 TW TW099119840A patent/TW201100430A/zh unknown
- 2010-06-18 AR ARP100102165A patent/AR077144A1/es active IP Right Grant
-
2011
- 2011-11-29 IL IL216684A patent/IL216684A/en active IP Right Grant
- 2011-12-08 CR CR20110654A patent/CR20110654A/es unknown
- 2011-12-14 GT GT201100322A patent/GT201100322A/es unknown
- 2011-12-15 ZA ZA2011/09271A patent/ZA201109271B/en unknown
- 2011-12-19 DO DO2011000397A patent/DOP2011000397A/es unknown
-
2014
- 2014-12-19 CY CY20141101071T patent/CY1115971T1/el unknown
-
2015
- 2015-01-05 SM SM201500003T patent/SMT201500003B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG176680A1 (en) | 2012-01-30 |
| GEP20146100B (en) | 2014-05-27 |
| ZA201109271B (en) | 2013-02-27 |
| HRP20141222T1 (hr) | 2015-02-27 |
| MX2011013400A (es) | 2012-02-21 |
| NZ597203A (en) | 2013-03-28 |
| IL216684A (en) | 2016-03-31 |
| TW201100430A (en) | 2011-01-01 |
| DK2443105T3 (en) | 2015-01-12 |
| PT2443105E (pt) | 2015-01-14 |
| AU2010262190A1 (en) | 2012-01-19 |
| ES2527216T3 (es) | 2015-01-21 |
| UA102693C2 (ru) | 2013-08-12 |
| MY156785A (en) | 2016-03-31 |
| JP2012530086A (ja) | 2012-11-29 |
| AU2010262190B2 (en) | 2013-01-31 |
| WO2010145668A1 (en) | 2010-12-23 |
| MA33367B1 (fr) | 2012-06-01 |
| UA106378C2 (ru) | 2014-08-26 |
| SMT201500003B (it) | 2015-03-05 |
| SI2443105T1 (sl) | 2015-02-27 |
| EP2443105B1 (en) | 2014-10-29 |
| CA2765750A1 (en) | 2010-12-23 |
| JP5768044B2 (ja) | 2015-08-26 |
| CR20110654A (es) | 2012-03-09 |
| CY1115971T1 (el) | 2017-01-25 |
| EP2443105A1 (en) | 2012-04-25 |
| GT201100322A (es) | 2014-02-06 |
| AR077144A1 (es) | 2011-08-03 |
| IL216684A0 (en) | 2012-02-29 |
| PL2443105T3 (pl) | 2015-03-31 |
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