MX345238B - (aralquilamino y heteroarilalquilamino alfa-substituidos)pirimidin ilo y 1,3,5-triazinilbenzimidazoles, composiciones farmacéuticas que los contienen, y estos compuestos para su uso en el tratamiento de enfermedades proliferativas. - Google Patents

(aralquilamino y heteroarilalquilamino alfa-substituidos)pirimidin ilo y 1,3,5-triazinilbenzimidazoles, composiciones farmacéuticas que los contienen, y estos compuestos para su uso en el tratamiento de enfermedades proliferativas.

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Publication number
MX345238B
MX345238B MX2013011086A MX2013011086A MX345238B MX 345238 B MX345238 B MX 345238B MX 2013011086 A MX2013011086 A MX 2013011086A MX 2013011086 A MX2013011086 A MX 2013011086A MX 345238 B MX345238 B MX 345238B
Authority
MX
Mexico
Prior art keywords
heteroarylalkylamino
pyrimidinyl
alpha
pharmaceutical compositions
proliferative diseases
Prior art date
Application number
MX2013011086A
Other languages
English (en)
Spanish (es)
Other versions
MX2013011086A (es
Inventor
David Brown S
J Matthews David
Original Assignee
Mei Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mei Pharma Inc filed Critical Mei Pharma Inc
Publication of MX2013011086A publication Critical patent/MX2013011086A/es
Publication of MX345238B publication Critical patent/MX345238B/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • C12N9/10—Transferases (2.)
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MX2013011086A 2011-03-28 2012-03-27 (aralquilamino y heteroarilalquilamino alfa-substituidos)pirimidin ilo y 1,3,5-triazinilbenzimidazoles, composiciones farmacéuticas que los contienen, y estos compuestos para su uso en el tratamiento de enfermedades proliferativas. MX345238B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161468502P 2011-03-28 2011-03-28
US201161530859P 2011-09-02 2011-09-02
US201161560699P 2011-11-16 2011-11-16
PCT/US2012/030640 WO2012135160A1 (en) 2011-03-28 2012-03-27 (alpha- substituted aralkylamino and heteroarylalkylamino) pyrimidinyl and 1,3,5 -triazinyl benzimidazoles, pharmaceutical compositions containing them, and these compounds for use in treating proliferative diseases

Publications (2)

Publication Number Publication Date
MX2013011086A MX2013011086A (es) 2014-04-14
MX345238B true MX345238B (es) 2017-01-23

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MX2013011086A MX345238B (es) 2011-03-28 2012-03-27 (aralquilamino y heteroarilalquilamino alfa-substituidos)pirimidin ilo y 1,3,5-triazinilbenzimidazoles, composiciones farmacéuticas que los contienen, y estos compuestos para su uso en el tratamiento de enfermedades proliferativas.

Country Status (17)

Country Link
US (6) US9056852B2 (OSRAM)
EP (1) EP2691384B1 (OSRAM)
JP (1) JP6042406B2 (OSRAM)
KR (1) KR101940831B1 (OSRAM)
CN (2) CN103582636B (OSRAM)
AU (2) AU2012236834B2 (OSRAM)
BR (1) BR112013024907A2 (OSRAM)
CA (1) CA2831582C (OSRAM)
DK (1) DK2691384T3 (OSRAM)
ES (1) ES2608967T3 (OSRAM)
IL (1) IL228600B (OSRAM)
MX (1) MX345238B (OSRAM)
RU (1) RU2608742C2 (OSRAM)
SG (1) SG193982A1 (OSRAM)
TW (1) TWI572599B (OSRAM)
WO (1) WO2012135160A1 (OSRAM)
ZA (1) ZA201307224B (OSRAM)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013024907A2 (pt) 2011-03-28 2016-12-20 Mei Pharma Inc composto, composição farmacêutica, método para o tratamento, prevenção ou atenuação de um ou mais sintomas de um distúrbio, doença ou condição mediada por pi3k em um sujeito, método para modular a atividade enzimática de pi3k
JP2014509648A (ja) * 2011-03-28 2014-04-21 メイ プハルマ，インコーポレーテッド （α−置換シクロアルキルアミノ及びヘテロシクリルアミノ）ピリミジニル及び１，３，５−トリアジニルベンズイミダゾール、その医薬組成物、並びに増殖性疾患の治療におけるそれらの使用
KR20150079745A (ko) 2012-11-08 2015-07-08 리젠 파마슈티컬스 소시에떼 아노님 Pde4 억제제 및 pi3 델타 또는 이중 pi3 델타-감마 키나아제 억제제를 함유하는 약제학적 조성물
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CN107501241A (zh) 2017-12-22
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