EA202092154A1 - Комбинированная терапия - Google Patents
Комбинированная терапияInfo
- Publication number
- EA202092154A1 EA202092154A1 EA202092154A EA202092154A EA202092154A1 EA 202092154 A1 EA202092154 A1 EA 202092154A1 EA 202092154 A EA202092154 A EA 202092154A EA 202092154 A EA202092154 A EA 202092154A EA 202092154 A1 EA202092154 A1 EA 202092154A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- combination therapy
- inhibitor
- effective amount
- methods
- kinase
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Изобретение относится к способам лечения заболеваний, таких как рак, с применением комбинированной терапии. В конкретных вариантах выполнения изобретения способы включают введение пациенту эффективного количества ингибитора фосфоинозитид-3-киназы (PI3K) и эффективного количества ингибитора тирозинкиназы Брутона (БТК).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862646314P | 2018-03-21 | 2018-03-21 | |
PCT/US2019/023172 WO2019183226A1 (en) | 2018-03-21 | 2019-03-20 | Combination therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202092154A1 true EA202092154A1 (ru) | 2021-03-22 |
Family
ID=67988025
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202092154A EA202092154A1 (ru) | 2018-03-21 | 2019-03-20 | Комбинированная терапия |
Country Status (16)
Country | Link |
---|---|
US (1) | US20210000838A1 (ru) |
EP (1) | EP3768258A4 (ru) |
JP (1) | JP2021517116A (ru) |
KR (1) | KR20200135439A (ru) |
CN (1) | CN112165939A (ru) |
AU (1) | AU2019238207A1 (ru) |
BR (1) | BR112020019082A2 (ru) |
CA (1) | CA3093847A1 (ru) |
EA (1) | EA202092154A1 (ru) |
IL (1) | IL277336A (ru) |
MA (1) | MA52090A (ru) |
MX (1) | MX2020009773A (ru) |
SG (1) | SG11202009137PA (ru) |
TW (1) | TW202002983A (ru) |
WO (1) | WO2019183226A1 (ru) |
ZA (1) | ZA202005661B (ru) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2691384B1 (en) | 2011-03-28 | 2016-10-26 | MEI Pharma, Inc. | (alpha-substituted aralkylamino and heteroarylalkylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, pharmaceutical compositions containing them, and these compounds for use in treating proliferative diseases |
SG11201601844TA (en) | 2013-09-13 | 2016-04-28 | Beigene Ltd | Anti-pd1 antibodies and their use as therapeutics and diagnostics |
JP6526189B2 (ja) | 2014-07-03 | 2019-06-05 | ベイジーン リミテッド | 抗pd−l1抗体並びにその治療及び診断のための使用 |
CA3033827A1 (en) | 2016-08-16 | 2018-02-22 | Beigene, Ltd. | Crystalline form of (s)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl )-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide,preparation, and uses thereof |
EP4353747A3 (en) | 2016-08-19 | 2024-06-26 | BeiGene Switzerland GmbH | Combination of zanubrutinib with an anti-cd20 or an anti-pd-1 antibody for use in treating cancer |
KR20200009088A (ko) | 2017-05-23 | 2020-01-29 | 메이 파마, 아이엔씨. | 병용 요법 |
EP3645569A4 (en) | 2017-06-26 | 2021-03-24 | BeiGene, Ltd. | IMMUNOTHERAPY FOR LIVER CELL CARCINOMA |
CN111212643A (zh) | 2017-08-14 | 2020-05-29 | 梅制药公司 | 联合疗法 |
US11786529B2 (en) | 2017-11-29 | 2023-10-17 | Beigene Switzerland Gmbh | Treatment of indolent or aggressive B-cell lymphomas using a combination comprising BTK inhibitors |
JP2022538215A (ja) * | 2019-06-10 | 2022-09-01 | ベイジーン スウィッツァーランド ゲーエムベーハー | 経口カプセルおよびその調製方法 |
CN113939289A (zh) * | 2019-06-10 | 2022-01-14 | 百济神州瑞士有限责任公司 | 一种含有布鲁顿氏酪氨酸激酶抑制剂的口服固体片剂及其制备方法 |
CN110922409A (zh) * | 2019-12-19 | 2020-03-27 | 武汉九州钰民医药科技有限公司 | 制备btk抑制剂泽布替尼的方法 |
KR20210115375A (ko) * | 2020-03-12 | 2021-09-27 | 보령제약 주식회사 | Pi3 키나아제 저해제 및 btk 저해제를 포함하는 조성물 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2691384B1 (en) * | 2011-03-28 | 2016-10-26 | MEI Pharma, Inc. | (alpha-substituted aralkylamino and heteroarylalkylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, pharmaceutical compositions containing them, and these compounds for use in treating proliferative diseases |
KR20150141971A (ko) * | 2013-04-08 | 2015-12-21 | 파마싸이클릭스 엘엘씨 | 이브루티닙 병용 요법 |
JP2016540053A (ja) * | 2013-12-05 | 2016-12-22 | アセルタ ファーマ ビー.ブイ. | Pi3k阻害剤とbtk阻害剤の治療的組み合わせ |
US9949971B2 (en) * | 2014-06-17 | 2018-04-24 | Acerta Pharma B.V. | Therapeutic combinations of a BTK inhibitor, a PI3K inhibitor and/or a JAK-2 inhibitor |
TW201618774A (zh) * | 2014-08-11 | 2016-06-01 | 艾森塔製藥公司 | 使用btk抑制劑透過調變腫瘤微環境來治療實體腫瘤及其他疾病之方法 |
-
2019
- 2019-03-20 MX MX2020009773A patent/MX2020009773A/es unknown
- 2019-03-20 JP JP2020545770A patent/JP2021517116A/ja active Pending
- 2019-03-20 WO PCT/US2019/023172 patent/WO2019183226A1/en unknown
- 2019-03-20 EA EA202092154A patent/EA202092154A1/ru unknown
- 2019-03-20 KR KR1020207030110A patent/KR20200135439A/ko not_active Application Discontinuation
- 2019-03-20 EP EP19770484.4A patent/EP3768258A4/en not_active Withdrawn
- 2019-03-20 US US16/981,780 patent/US20210000838A1/en not_active Abandoned
- 2019-03-20 AU AU2019238207A patent/AU2019238207A1/en not_active Abandoned
- 2019-03-20 BR BR112020019082-9A patent/BR112020019082A2/pt not_active IP Right Cessation
- 2019-03-20 SG SG11202009137PA patent/SG11202009137PA/en unknown
- 2019-03-20 MA MA052090A patent/MA52090A/fr unknown
- 2019-03-20 CA CA3093847A patent/CA3093847A1/en active Pending
- 2019-03-20 CN CN201980034008.0A patent/CN112165939A/zh active Pending
- 2019-03-21 TW TW108109853A patent/TW202002983A/zh unknown
-
2020
- 2020-09-11 ZA ZA2020/05661A patent/ZA202005661B/en unknown
- 2020-09-14 IL IL277336A patent/IL277336A/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP2021517116A (ja) | 2021-07-15 |
CA3093847A1 (en) | 2019-09-26 |
SG11202009137PA (en) | 2020-10-29 |
AU2019238207A1 (en) | 2020-10-01 |
US20210000838A1 (en) | 2021-01-07 |
WO2019183226A1 (en) | 2019-09-26 |
MX2020009773A (es) | 2020-10-08 |
KR20200135439A (ko) | 2020-12-02 |
IL277336A (en) | 2020-10-29 |
BR112020019082A2 (pt) | 2020-12-29 |
EP3768258A1 (en) | 2021-01-27 |
MA52090A (fr) | 2021-04-21 |
CN112165939A (zh) | 2021-01-01 |
EP3768258A4 (en) | 2022-01-12 |
TW202002983A (zh) | 2020-01-16 |
ZA202005661B (en) | 2023-05-31 |
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