CN103582636B - (α‑取代的芳烷基氨基和杂芳基烷基氨基)嘧啶基和1,3,5‑三嗪基苯并咪唑、含有其的药物组合物以及这些化合物在治疗增生性疾病中的用途 - Google Patents
(α‑取代的芳烷基氨基和杂芳基烷基氨基)嘧啶基和1,3,5‑三嗪基苯并咪唑、含有其的药物组合物以及这些化合物在治疗增生性疾病中的用途 Download PDFInfo
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- 0 CCC(**)NCC[U]* Chemical compound CCC(**)NCC[U]* 0.000 description 6
- NTDNEOWLKYXXQX-UHFFFAOYSA-N C1NCC[U]C1 Chemical compound C1NCC[U]C1 NTDNEOWLKYXXQX-UHFFFAOYSA-N 0.000 description 1
- NSRPHDHJTJWXMN-UHFFFAOYSA-N CCCC1=CCC(CC)C1 Chemical compound CCCC1=CCC(CC)C1 NSRPHDHJTJWXMN-UHFFFAOYSA-N 0.000 description 1
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- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710749933.4A CN107501241B (zh) | 2011-03-28 | 2012-03-27 | 化合物、含有其的药物组合物以及它们在治疗增生性疾病中的用途 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161468502P | 2011-03-28 | 2011-03-28 | |
| US61/468,502 | 2011-03-28 | ||
| US201161530859P | 2011-09-02 | 2011-09-02 | |
| US61/530,859 | 2011-09-02 | ||
| US201161560699P | 2011-11-16 | 2011-11-16 | |
| US61/560,699 | 2011-11-16 | ||
| PCT/US2012/030640 WO2012135160A1 (en) | 2011-03-28 | 2012-03-27 | (alpha- substituted aralkylamino and heteroarylalkylamino) pyrimidinyl and 1,3,5 -triazinyl benzimidazoles, pharmaceutical compositions containing them, and these compounds for use in treating proliferative diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710749933.4A Division CN107501241B (zh) | 2011-03-28 | 2012-03-27 | 化合物、含有其的药物组合物以及它们在治疗增生性疾病中的用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103582636A CN103582636A (zh) | 2014-02-12 |
| CN103582636B true CN103582636B (zh) | 2017-08-18 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280026047.4A Active CN103582636B (zh) | 2011-03-28 | 2012-03-27 | (α‑取代的芳烷基氨基和杂芳基烷基氨基)嘧啶基和1,3,5‑三嗪基苯并咪唑、含有其的药物组合物以及这些化合物在治疗增生性疾病中的用途 |
| CN201710749933.4A Active CN107501241B (zh) | 2011-03-28 | 2012-03-27 | 化合物、含有其的药物组合物以及它们在治疗增生性疾病中的用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710749933.4A Active CN107501241B (zh) | 2011-03-28 | 2012-03-27 | 化合物、含有其的药物组合物以及它们在治疗增生性疾病中的用途 |
Country Status (17)
| Country | Link |
|---|---|
| US (6) | US9056852B2 (OSRAM) |
| EP (1) | EP2691384B1 (OSRAM) |
| JP (1) | JP6042406B2 (OSRAM) |
| KR (1) | KR101940831B1 (OSRAM) |
| CN (2) | CN103582636B (OSRAM) |
| AU (2) | AU2012236834B2 (OSRAM) |
| BR (1) | BR112013024907A2 (OSRAM) |
| CA (1) | CA2831582C (OSRAM) |
| DK (1) | DK2691384T3 (OSRAM) |
| ES (1) | ES2608967T3 (OSRAM) |
| IL (1) | IL228600B (OSRAM) |
| MX (1) | MX345238B (OSRAM) |
| RU (1) | RU2608742C2 (OSRAM) |
| SG (1) | SG193982A1 (OSRAM) |
| TW (1) | TWI572599B (OSRAM) |
| WO (1) | WO2012135160A1 (OSRAM) |
| ZA (1) | ZA201307224B (OSRAM) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112013024909A2 (pt) * | 2011-03-28 | 2019-09-24 | Mei Pharma Inc | composto, composição farmacêutica, método para o tratamento, prevenção ou melhoria de um ou mais sintomas de desordem, doença, ou condição mediada por pi3k, e método para modular a atividade enzimática de pi3k |
| DK2691384T3 (en) | 2011-03-28 | 2017-01-16 | Mei Pharma Inc | (ALPHA-SUBSTITUTED ARALKYLAMINO AND HETEROARYLALKYLAMINO) PYRIMIDINYL AND 1,3,5-TRIAZINYL BENZIMIDAZOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEMSELVES AND THEIR SUBSTANCES CONCERNING THE USE OF THE USE |
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