MX2020010607A - Compuestos y metodos para inhibir el transporte de fosfato. - Google Patents

Compuestos y metodos para inhibir el transporte de fosfato.

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Publication number
MX2020010607A
MX2020010607A MX2020010607A MX2020010607A MX2020010607A MX 2020010607 A MX2020010607 A MX 2020010607A MX 2020010607 A MX2020010607 A MX 2020010607A MX 2020010607 A MX2020010607 A MX 2020010607A MX 2020010607 A MX2020010607 A MX 2020010607A
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MX
Mexico
Prior art keywords
methods
compounds
phosphate transport
inhibiting phosphate
inhibiting
Prior art date
Application number
MX2020010607A
Other languages
English (en)
Inventor
Jason G Lewis
Jeffrey W Jacobs
Dominique Charmot
Christopher Carreras
Ingrid Langsetmo
Original Assignee
Ardelyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ardelyx Inc filed Critical Ardelyx Inc
Publication of MX2020010607A publication Critical patent/MX2020010607A/es

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    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
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    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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Abstract

La presente invención se refiere a agentes de no unión a NHE3 que tienen actividad como inhibidores de transporte/captación de fosfato en el tracto gastrointestinal, que incluye en el intestino delgado, métodos para su uso como agentes terapéuticos o profilácticos, y métodos relacionados de descubrimiento de fármacos.
MX2020010607A 2013-08-09 2016-02-08 Compuestos y metodos para inhibir el transporte de fosfato. MX2020010607A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361864215P 2013-08-09 2013-08-09
US201461936715P 2014-02-06 2014-02-06

Publications (1)

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MX2020010607A true MX2020010607A (es) 2020-10-20

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MX2016001714A MX2016001714A (es) 2013-08-09 2014-08-08 Compuestos y metodos para inhibir el transporte de fosfato.
MX2020010607A MX2020010607A (es) 2013-08-09 2016-02-08 Compuestos y metodos para inhibir el transporte de fosfato.

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US (2) US20160184387A1 (es)
EP (3) EP3884935B1 (es)
JP (3) JP6694385B2 (es)
KR (3) KR102456567B1 (es)
CN (2) CN105979959B (es)
AU (3) AU2014305843B2 (es)
BR (1) BR112016002789A2 (es)
CA (1) CA2920856A1 (es)
HK (1) HK1225628A1 (es)
IL (3) IL280864B2 (es)
MX (2) MX2016001714A (es)
WO (1) WO2015021358A2 (es)
ZA (1) ZA201601603B (es)

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EP3712254A1 (en) 2014-05-28 2020-09-23 Children's Hospital Medical Center Methods and systems for converting precursor cells into gastric tissues through directed differentiation
EP3194386A2 (en) * 2014-09-17 2017-07-26 Ironwood Pharmaceuticals, Inc. Sgc stimulators
US11584916B2 (en) 2014-10-17 2023-02-21 Children's Hospital Medical Center Method of making in vivo human small intestine organoids from pluripotent stem cells
EP4177335A1 (en) 2016-05-05 2023-05-10 Children's Hospital Medical Center Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same
SG10202105768WA (en) 2016-12-05 2021-06-29 Childrens Hospital Med Ct Colonic organoids and methods of making and using same
JP2018127435A (ja) * 2017-02-10 2018-08-16 国立大学法人東北大学 尿毒症の予防又は改善剤
CN108654695B (zh) * 2017-03-29 2021-04-06 天津大学 吲哚[3,2-a]恶唑烷标记的钌卡宾催化剂及制备方法及应用
CN109745317A (zh) * 2017-11-08 2019-05-14 俞为群 腺苷受体激动剂的应用及评价方法及治疗膀胱泌尿功能障碍的药物
JP7137376B2 (ja) * 2018-06-28 2022-09-14 株式会社トクヤマ セラミックス製造用顆粒の製造方法
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