MX2019008185A - Composiciones anti-cgrp y uso de las mismas. - Google Patents
Composiciones anti-cgrp y uso de las mismas.Info
- Publication number
- MX2019008185A MX2019008185A MX2019008185A MX2019008185A MX2019008185A MX 2019008185 A MX2019008185 A MX 2019008185A MX 2019008185 A MX2019008185 A MX 2019008185A MX 2019008185 A MX2019008185 A MX 2019008185A MX 2019008185 A MX2019008185 A MX 2019008185A
- Authority
- MX
- Mexico
- Prior art keywords
- cgrp
- antibodies
- binding fragments
- fragments
- binding
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Abstract
La presente invención se dirige a anticuerpos y fragmentos de los mimos que tienen especificidad de unión con CGRP. Otra realización de esta invención se refiere a anticuerpos descritos en la presente, y fragmentos de unión de los mismos, que comprenden las secuencias de los Polipéptidos de VH, VL y CDR descritos en la presente y los polinucleótidos que los codifican. La invención también contempla conjugados de anticuerpos anti-CGRP y fragmentos de unión de los mismos conjugados con uno o más restos funcionales o detectables. La invención contempla además métodos para producir dichos anticuerpos anti-CGRP y fragmentos de unión de los mismos. Realizaciones de la invención se refieren al uso de anticuerpos anti-CGRP y fragmentos de unión de los mismos para el diagnóstico, evaluación y tratamiento de enfermedades o trastornos asociados con CGRP.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161488660P | 2011-05-20 | 2011-05-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019008185A true MX2019008185A (es) | 2019-09-09 |
Family
ID=47175055
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013013535A MX370749B (es) | 2011-05-20 | 2012-05-21 | Composiciones de anti-cgrp y uso de las mismas. |
MX2019015745A MX2019015745A (es) | 2011-05-20 | 2013-11-19 | Composiciones de anti-cgrp y uso de las mismas. |
MX2019008185A MX2019008185A (es) | 2011-05-20 | 2013-11-19 | Composiciones anti-cgrp y uso de las mismas. |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013013535A MX370749B (es) | 2011-05-20 | 2012-05-21 | Composiciones de anti-cgrp y uso de las mismas. |
MX2019015745A MX2019015745A (es) | 2011-05-20 | 2013-11-19 | Composiciones de anti-cgrp y uso de las mismas. |
Country Status (35)
Country | Link |
---|---|
US (9) | US9745373B2 (es) |
EP (5) | EP2710039B1 (es) |
JP (3) | JP6282584B2 (es) |
KR (1) | KR102128627B1 (es) |
CN (5) | CN107602700B (es) |
AP (1) | AP2013007259A0 (es) |
AR (3) | AR086516A1 (es) |
AU (3) | AU2012258966C1 (es) |
BR (2) | BR112013029932A2 (es) |
CA (3) | CA3079978A1 (es) |
CL (3) | CL2013003336A1 (es) |
CO (1) | CO6870005A2 (es) |
CY (2) | CY1124209T1 (es) |
DK (3) | DK2710039T3 (es) |
EA (3) | EA039905B1 (es) |
ES (3) | ES2873837T3 (es) |
FR (1) | FR22C1032I2 (es) |
HR (3) | HRP20190640T1 (es) |
HU (4) | HUE054437T2 (es) |
IL (4) | IL229431B (es) |
LT (4) | LT3662932T (es) |
MX (3) | MX370749B (es) |
NL (1) | NL301181I2 (es) |
NZ (1) | NZ733060A (es) |
PE (2) | PE20180502A1 (es) |
PH (1) | PH12018500521A1 (es) |
PL (3) | PL3662932T3 (es) |
PT (3) | PT3495392T (es) |
RS (3) | RS58621B1 (es) |
SG (2) | SG194938A1 (es) |
SI (3) | SI2710039T1 (es) |
TR (1) | TR201904088T4 (es) |
TW (4) | TWI646111B (es) |
WO (1) | WO2012162243A2 (es) |
ZA (1) | ZA201308637B (es) |
Families Citing this family (37)
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WO2012162243A2 (en) * | 2011-05-20 | 2012-11-29 | Alderbio Holdings Llc | Anti-cgrp compositions and use thereof |
WO2012162253A2 (en) | 2011-05-20 | 2012-11-29 | Alderbio Holdings Llc | Use of anti-cgrp or anti-cgrp-r antibodies or antibody fragments to treat or prevent chronic and acute forms of diarrhea |
CN108014334B (zh) * | 2011-05-20 | 2021-11-30 | H.伦德贝克公司 | 抗cgrp抗体和抗体片段用于在有需要的受试者中预防或抑制畏光或厌光的用途 |
EP3754012A1 (en) | 2013-03-15 | 2020-12-23 | Alder Biopharmaceuticals, Inc. | Antibody purification and purity monitoring |
MX2016000220A (es) * | 2013-07-03 | 2016-08-18 | Alder Biopharmaceuticals Inc | Regulacion del metabolismo de glucosa usando anticuerpos anti-cgrp. |
US10556945B2 (en) | 2014-03-21 | 2020-02-11 | Teva Pharmaceuticals International Gmbh | Antagonist antibodies directed against calcitonin gene-related peptide and methods using same |
HRP20240159T1 (hr) | 2014-03-21 | 2024-04-12 | Teva Pharmaceuticals International Gmbh | Antagonistička protutijela usmjerena protiv peptida povezanog s genom kalcitonina i postupci koji ih koriste |
TWI721976B (zh) | 2015-04-16 | 2021-03-21 | 美商艾爾德生物製藥股份有限公司 | 抗pacap抗體及其用途 |
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AR104847A1 (es) * | 2015-06-17 | 2017-08-16 | Lilly Co Eli | Formulación de anticuerpo anti-cgrp |
KR20180058777A (ko) * | 2015-09-24 | 2018-06-01 | 테바 파마슈티컬스 인터내셔널 게엠베하 | (지속성) 외상후 두통의 예방, 치료 및 감소 |
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WO2017132062A1 (en) * | 2016-01-28 | 2017-08-03 | Eli Lilly And Company | Cgrp antibodies and uses thereof |
CN108601833B (zh) | 2016-02-01 | 2022-11-15 | 伊莱利利公司 | 甲状旁腺激素-抗rankl抗体融合化合物 |
KR102444717B1 (ko) | 2016-04-15 | 2022-09-16 | 하. 룬드벡 아크티에셀스카브 | 인간화 항-pacap 항체 및 그의 용도 |
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KR20190067181A (ko) | 2016-09-23 | 2019-06-14 | 테바 파마슈티컬스 인터내셔널 게엠베하 | 군발성 두통의 치료 |
WO2018160896A1 (en) * | 2017-03-02 | 2018-09-07 | Beth Israel Deaconess Medical Center | Selecting headache patients responsive to antibodies directed against calcitonin gene related peptide |
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WO2022185224A1 (en) | 2021-03-02 | 2022-09-09 | Mark Hasleton | Treatment and/or reduction of occurrence of migraine |
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