HRP20210777T1 - Pripravci protiv cgrp-a njihova upotreba - Google Patents
Pripravci protiv cgrp-a njihova upotreba Download PDFInfo
- Publication number
- HRP20210777T1 HRP20210777T1 HRP20210777TT HRP20210777T HRP20210777T1 HR P20210777 T1 HRP20210777 T1 HR P20210777T1 HR P20210777T T HRP20210777T T HR P20210777TT HR P20210777 T HRP20210777 T HR P20210777T HR P20210777 T1 HRP20210777 T1 HR P20210777T1
- Authority
- HR
- Croatia
- Prior art keywords
- cells
- antibody
- cgrp
- pharmaceutical composition
- headache
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
- 238000000034 method Methods 0.000 claims 14
- 208000019695 Migraine disease Diseases 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 210000004962 mammalian cell Anatomy 0.000 claims 3
- 206010027599 migraine Diseases 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 210000005253 yeast cell Anatomy 0.000 claims 3
- 108090000932 Calcitonin Gene-Related Peptide Proteins 0.000 claims 2
- 102100025588 Calcitonin gene-related peptide 1 Human genes 0.000 claims 2
- 206010019233 Headaches Diseases 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 231100000869 headache Toxicity 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 238000011321 prophylaxis Methods 0.000 claims 2
- 208000006561 Cluster Headache Diseases 0.000 claims 1
- 241000235058 Komagataella pastoris Species 0.000 claims 1
- 241000235648 Pichia Species 0.000 claims 1
- 238000001042 affinity chromatography Methods 0.000 claims 1
- 238000012870 ammonium sulfate precipitation Methods 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 208000018912 cluster headache syndrome Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Claims (14)
1. Postupak za proizvodnju protutijela protiv CGRP, postupak koji obuhvaća ekspresiju polinukleotida iz SEQ ID NO: 192 i SEQ ID NO: 194 u kvaščevim stanicama ili u sisavačkim stanicama.
2. Postupak prema zahtjevu 1, naznačen time što su kvaščeve stanice Pichia stanice, a sisavačke stanice su CHO, NSO ili HEK293 stanice.
3. Postupak prema bilo kojem od prethodnih zahtjeva, naznačen time što su kvaščeve stanice Pichia pastoris stanice.
4. Postupak prema bilo kojem od zahtjeva 1 ili 2, naznačen time što su sisavačke stanice CHO stanice.
5. Postupak prema bilo kojem od prethodnih zahtjeva, naznačen time što su polinukleotidi ugrađeni u ekspresijski vektor.
6. Postupak prema bilo kojem od prethodnih zahtjeva, naznačen time što je vektor plazmid ili rekombinantni virusni vektor.
7. Postupak prema bilo kojem od prethodnih zahtjeva, nadalje obuhvaća pročišćavanje protutijela.
8. Postupak prema zahtjevu 7, naznačen time što pročišćavanje protutijela sadrži filtriranje u presjeku, taloženje amonij sulfata ili afinitetnu kolonsku kromatografiju.
9. Postupak prema bilo kojem od prethodnih zahtjeva, postupak nadalje obuhvaća formuliranje navedenog protutijela u farmaceutskom pripravku.
10. Postupak prema zahtjevu 9, naznačen time što farmaceutski pripravak sadrži farmaceutski prihvatljiv nosač, i izborno barem jedan stabilizator.
11. Protutijelo protiv CGRP koje se može dobiti postupkom prema bilo kojem od zahtjeva 1-8, ili farmaceutski pripravak koje se može dobiti postupkom prema zahtjevu 9 ili 10.
12. Protutijelo protiv CGRP ili farmaceutski pripravak prema zahtjevu 11, za upotrebu u ublažavanju ili smanjenju simptoma, ili liječenju, ili prevenciji migrene, ili glavobolje.
13. Protutijelo protiv GCRP ili farmaceutski pripravak prema patentnom zahtjevu 11, za uporabu u akutnom ili profilaktičkom liječenju glavobolje, uključujući migrenu i klaster glavobolju.
14. Protutijelo protiv GCRP ili farmaceutski pripravak prema patentnom zahtjevu 11, za uporabu u akutnom ili profilaktičkom liječenju migrene.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161488660P | 2011-05-20 | 2011-05-20 | |
EP19215303.9A EP3662932B1 (en) | 2011-05-20 | 2012-05-21 | Anti-cgrp compositions and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20210777T1 true HRP20210777T1 (hr) | 2021-06-25 |
Family
ID=47175055
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20190640TT HRP20190640T1 (hr) | 2011-05-20 | 2019-04-03 | Pripravci protiv cgrp-a njihova upotreba |
HRP20210777TT HRP20210777T1 (hr) | 2011-05-20 | 2021-05-14 | Pripravci protiv cgrp-a njihova upotreba |
HRP20211395TT HRP20211395T1 (hr) | 2011-05-20 | 2021-09-02 | Pripravci protutijela protiv cgrp |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20190640TT HRP20190640T1 (hr) | 2011-05-20 | 2019-04-03 | Pripravci protiv cgrp-a njihova upotreba |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20211395TT HRP20211395T1 (hr) | 2011-05-20 | 2021-09-02 | Pripravci protutijela protiv cgrp |
Country Status (35)
Country | Link |
---|---|
US (9) | US9745373B2 (hr) |
EP (5) | EP2710039B1 (hr) |
JP (3) | JP6282584B2 (hr) |
KR (1) | KR102128627B1 (hr) |
CN (5) | CN107602700B (hr) |
AP (1) | AP2013007259A0 (hr) |
AR (3) | AR086516A1 (hr) |
AU (3) | AU2012258966C1 (hr) |
BR (2) | BR112013029932A2 (hr) |
CA (3) | CA3079978A1 (hr) |
CL (3) | CL2013003336A1 (hr) |
CO (1) | CO6870005A2 (hr) |
CY (2) | CY1124209T1 (hr) |
DK (3) | DK2710039T3 (hr) |
EA (3) | EA039905B1 (hr) |
ES (3) | ES2873837T3 (hr) |
FR (1) | FR22C1032I2 (hr) |
HR (3) | HRP20190640T1 (hr) |
HU (4) | HUE054437T2 (hr) |
IL (4) | IL229431B (hr) |
LT (4) | LT3662932T (hr) |
MX (3) | MX370749B (hr) |
NL (1) | NL301181I2 (hr) |
NZ (1) | NZ733060A (hr) |
PE (2) | PE20180502A1 (hr) |
PH (1) | PH12018500521A1 (hr) |
PL (3) | PL3662932T3 (hr) |
PT (3) | PT3495392T (hr) |
RS (3) | RS58621B1 (hr) |
SG (2) | SG194938A1 (hr) |
SI (3) | SI2710039T1 (hr) |
TR (1) | TR201904088T4 (hr) |
TW (4) | TWI646111B (hr) |
WO (1) | WO2012162243A2 (hr) |
ZA (1) | ZA201308637B (hr) |
Families Citing this family (37)
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GEP20115333B (en) | 2005-11-14 | 2011-11-25 | Rinat Neuroscience Corp | Antagonist antibodies directed against calcitonin generelated peptide and using same |
CN107296957A (zh) | 2008-03-04 | 2017-10-27 | 梯瓦制药国际有限责任公司 | 治疗慢性疼痛的方法 |
WO2012162243A2 (en) * | 2011-05-20 | 2012-11-29 | Alderbio Holdings Llc | Anti-cgrp compositions and use thereof |
WO2012162253A2 (en) | 2011-05-20 | 2012-11-29 | Alderbio Holdings Llc | Use of anti-cgrp or anti-cgrp-r antibodies or antibody fragments to treat or prevent chronic and acute forms of diarrhea |
CN108014334B (zh) * | 2011-05-20 | 2021-11-30 | H.伦德贝克公司 | 抗cgrp抗体和抗体片段用于在有需要的受试者中预防或抑制畏光或厌光的用途 |
EP3754012A1 (en) | 2013-03-15 | 2020-12-23 | Alder Biopharmaceuticals, Inc. | Antibody purification and purity monitoring |
MX2016000220A (es) * | 2013-07-03 | 2016-08-18 | Alder Biopharmaceuticals Inc | Regulacion del metabolismo de glucosa usando anticuerpos anti-cgrp. |
US10556945B2 (en) | 2014-03-21 | 2020-02-11 | Teva Pharmaceuticals International Gmbh | Antagonist antibodies directed against calcitonin gene-related peptide and methods using same |
HRP20240159T1 (hr) | 2014-03-21 | 2024-04-12 | Teva Pharmaceuticals International Gmbh | Antagonistička protutijela usmjerena protiv peptida povezanog s genom kalcitonina i postupci koji ih koriste |
TWI721976B (zh) | 2015-04-16 | 2021-03-21 | 美商艾爾德生物製藥股份有限公司 | 抗pacap抗體及其用途 |
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KR20180058777A (ko) * | 2015-09-24 | 2018-06-01 | 테바 파마슈티컬스 인터내셔널 게엠베하 | (지속성) 외상후 두통의 예방, 치료 및 감소 |
TW201725212A (zh) | 2015-12-10 | 2017-07-16 | 第一三共股份有限公司 | 特異性於降鈣素基因相關胜肽的新穎蛋白 |
WO2017132062A1 (en) * | 2016-01-28 | 2017-08-03 | Eli Lilly And Company | Cgrp antibodies and uses thereof |
CN108601833B (zh) | 2016-02-01 | 2022-11-15 | 伊莱利利公司 | 甲状旁腺激素-抗rankl抗体融合化合物 |
KR102444717B1 (ko) | 2016-04-15 | 2022-09-16 | 하. 룬드벡 아크티에셀스카브 | 인간화 항-pacap 항체 및 그의 용도 |
SG10201913032TA (en) | 2016-09-23 | 2020-02-27 | Teva Pharmaceuticals Int Gmbh | Treating refractory migraine |
KR20190067181A (ko) | 2016-09-23 | 2019-06-14 | 테바 파마슈티컬스 인터내셔널 게엠베하 | 군발성 두통의 치료 |
WO2018160896A1 (en) * | 2017-03-02 | 2018-09-07 | Beth Israel Deaconess Medical Center | Selecting headache patients responsive to antibodies directed against calcitonin gene related peptide |
CA3087951A1 (en) | 2018-01-12 | 2019-07-18 | Amgen Inc. | Pac1 antibodies and uses thereof |
US11274158B2 (en) * | 2018-01-30 | 2022-03-15 | Flagship Pioneering Innovations V, Inc. | Methods and compositions for treating inflammatory or autoimmune diseases or conditions using calcitonin receptor activators |
JP2021518748A (ja) * | 2018-02-23 | 2021-08-05 | アールイーエムディー バイオセラピューティクス,インコーポレイテッドREMD Biotherapeutics,Inc | カルシトニン遺伝子関連ペプチド(cgrp)アンタゴニスト抗体 |
WO2019231800A1 (en) * | 2018-05-31 | 2019-12-05 | Eli Lilly And Company | Anti-cgrp antibodies for treating menstrual-related migraines |
US10899826B1 (en) * | 2018-09-13 | 2021-01-26 | Teva Pharmaceuticals International Gmbh | Pharmaceutical compositions for an anti-CGRP antagonist antibody |
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KR20240049275A (ko) | 2021-08-27 | 2024-04-16 | 하. 룬드벡 아크티에셀스카브 | 항-cgrp 항체를 사용한 군발성 두통의 치료 |
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- 2022-06-22 HU HUS2200031C patent/HUS2200031I1/hu unknown
- 2022-06-29 FR FR22C1032C patent/FR22C1032I2/fr active Active
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