CO6870005A2 - Composición anti-cgrp y uso de las mismas - Google Patents
Composición anti-cgrp y uso de las mismasInfo
- Publication number
- CO6870005A2 CO6870005A2 CO13275276A CO13275276A CO6870005A2 CO 6870005 A2 CO6870005 A2 CO 6870005A2 CO 13275276 A CO13275276 A CO 13275276A CO 13275276 A CO13275276 A CO 13275276A CO 6870005 A2 CO6870005 A2 CO 6870005A2
- Authority
- CO
- Colombia
- Prior art keywords
- cgrp
- composition
- cgrp composition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161488660P | 2011-05-20 | 2011-05-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6870005A2 true CO6870005A2 (es) | 2014-02-20 |
Family
ID=47175055
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO13275276A CO6870005A2 (es) | 2011-05-20 | 2013-11-22 | Composición anti-cgrp y uso de las mismas |
Country Status (35)
Country | Link |
---|---|
US (9) | US9745373B2 (es) |
EP (5) | EP3875115A1 (es) |
JP (3) | JP6282584B2 (es) |
KR (1) | KR102128627B1 (es) |
CN (5) | CN108373502B (es) |
AP (1) | AP2013007259A0 (es) |
AR (3) | AR086516A1 (es) |
AU (3) | AU2012258966C1 (es) |
BR (2) | BR122022012930B1 (es) |
CA (3) | CA3079978A1 (es) |
CL (3) | CL2013003336A1 (es) |
CO (1) | CO6870005A2 (es) |
CY (2) | CY1124209T1 (es) |
DK (3) | DK3662932T3 (es) |
EA (3) | EA031065B1 (es) |
ES (3) | ES2715001T3 (es) |
FR (1) | FR22C1032I2 (es) |
HR (3) | HRP20190640T1 (es) |
HU (4) | HUE055505T2 (es) |
IL (4) | IL229431B (es) |
LT (4) | LT3495392T (es) |
MX (3) | MX370749B (es) |
NL (1) | NL301181I2 (es) |
NZ (1) | NZ733060A (es) |
PE (2) | PE20141787A1 (es) |
PH (1) | PH12018500521A1 (es) |
PL (3) | PL3495392T3 (es) |
PT (3) | PT2710039T (es) |
RS (3) | RS61793B1 (es) |
SG (2) | SG10201604040PA (es) |
SI (3) | SI3495392T1 (es) |
TR (1) | TR201904088T4 (es) |
TW (4) | TWI646111B (es) |
WO (1) | WO2012162243A2 (es) |
ZA (1) | ZA201308637B (es) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2664421T3 (es) | 2005-11-14 | 2018-04-19 | Teva Pharmaceuticals International Gmbh | Anticuerpo antagonista dirigido contra un péptido relacionado con el gen de la calcitonina |
US8293239B2 (en) | 2008-03-04 | 2012-10-23 | Pfizer Limited | Methods of treating chronic pain |
KR102098546B1 (ko) | 2011-05-20 | 2020-04-07 | 앨더바이오 홀딩스 엘엘씨 | 필요한 대상체, 특히 편두통 환자의 광선공포증 또는 광선 혐오증을 예방 또는 억제하기 위한 항-cgrp 항체 및 항체 단편의 용도 |
CN103957935B (zh) | 2011-05-20 | 2018-04-03 | 奥尔德生物控股有限责任公司 | 抗cgrp或抗cgrp‑r抗体或抗体片段用于治疗或预防慢性和急性形式的腹泻的用途 |
CN108373502B (zh) | 2011-05-20 | 2022-03-22 | H.伦德贝克公司 | 抗cgrp组合物及其用途 |
US9518082B2 (en) * | 2013-03-15 | 2016-12-13 | Alderbio Holdings Llc | Antibody purification and purity monitoring |
MX2016000220A (es) * | 2013-07-03 | 2016-08-18 | Alder Biopharmaceuticals Inc | Regulacion del metabolismo de glucosa usando anticuerpos anti-cgrp. |
US10556945B2 (en) | 2014-03-21 | 2020-02-11 | Teva Pharmaceuticals International Gmbh | Antagonist antibodies directed against calcitonin gene-related peptide and methods using same |
DK3119431T3 (da) | 2014-03-21 | 2024-03-18 | Teva Pharmaceuticals Int Gmbh | Antagonistantistoffer rettet mod calcitoningen-relateret peptid og fremgangsmåder til anvendelse deraf |
WO2016168768A2 (en) | 2015-04-16 | 2016-10-20 | Alder Biopharmaceuticals, Inc. | Anti-pacap antibodies and uses thereof |
JOP20200116A1 (ar) | 2015-04-24 | 2017-06-16 | Amgen Inc | طرق لعلاج أو الوقاية من الصداع النصفي |
AR104847A1 (es) * | 2015-06-17 | 2017-08-16 | Lilly Co Eli | Formulación de anticuerpo anti-cgrp |
EP3353202B1 (en) * | 2015-09-24 | 2020-11-04 | Teva Pharmaceuticals International GmbH | Preventing, treating, and reducing (persistent) post-traumatic headache |
TW201725212A (zh) * | 2015-12-10 | 2017-07-16 | 第一三共股份有限公司 | 特異性於降鈣素基因相關胜肽的新穎蛋白 |
KR20180091930A (ko) * | 2016-01-28 | 2018-08-16 | 일라이 릴리 앤드 캄파니 | Cgrp 항체 및 그의 용도 |
AU2017214277B2 (en) | 2016-02-01 | 2020-02-27 | Eli Lilly And Company | Parathyroid hormone – anti-RANKL antibody fusion compounds |
US10202435B2 (en) | 2016-04-15 | 2019-02-12 | Alder Biopharmaceuticals, Inc. | Anti-PACAP antibodies and uses thereof |
EP3515937A1 (en) | 2016-09-23 | 2019-07-31 | Teva Pharmaceuticals International GmbH | Treating refractory migraine |
EA201990548A1 (ru) | 2016-09-23 | 2019-09-30 | Тева Фармасьютикалз Интернэшнл Гмбх | Лечение кластерной головной боли |
KR20190133174A (ko) * | 2017-03-02 | 2019-12-02 | 베쓰 이스라엘 디코니스 메디칼 센터 인크 | 칼시토닌 유전자 관련 펩티드에 대해 지시되는 항체에 반응하는 두통 환자를 선택하는 방법 |
MX2020006976A (es) | 2018-01-12 | 2020-10-05 | Amgen Inc | Anticuerpos del receptor de tipo i del polipeptido activador de la adenilato?ciclasa hipofisaria (pac1) y sus usos. |
US11274158B2 (en) * | 2018-01-30 | 2022-03-15 | Flagship Pioneering Innovations V, Inc. | Methods and compositions for treating inflammatory or autoimmune diseases or conditions using calcitonin receptor activators |
EP3755327A4 (en) * | 2018-02-23 | 2021-11-24 | REMD Biotherapeutics, Inc. | CALCITONIN GENE-RELATED PEPTIDE ANTAGONIST ANTIBODIES (CGRP) |
WO2019231800A1 (en) * | 2018-05-31 | 2019-12-05 | Eli Lilly And Company | Anti-cgrp antibodies for treating menstrual-related migraines |
US10899826B1 (en) * | 2018-09-13 | 2021-01-26 | Teva Pharmaceuticals International Gmbh | Pharmaceutical compositions for an anti-CGRP antagonist antibody |
EP3674418A1 (en) * | 2018-12-26 | 2020-07-01 | Life Length S.L. | Method for measuring telomere associated variables and uses thereof for the diagnosis and/or prognosis of telomeric-associated diseases |
US11639380B2 (en) | 2019-01-08 | 2023-05-02 | H. Lundbeck A/S | Acute treatment and rapid treatment of headache using anti-CGRP antibodies |
JOP20210166A1 (ar) * | 2019-01-08 | 2023-01-30 | H Lundbeck As | علاج الصداع الناتج عن فرط استعمال الأدوية باستخدام أجسام مضادة لـcgrp أو أجسام مضادة لـcgrp-r |
WO2020175936A1 (ko) * | 2019-02-28 | 2020-09-03 | 단디바이오사이언스 주식회사 | 항균활성을 갖는 폴리펩타이드, 이를 포함하는 패혈증 예방 또는 치료용 조성물, 및 항균용 조성물 |
JP2022533030A (ja) * | 2019-05-02 | 2022-07-21 | ハー・ルンドベック・アクチエゼルスカベット | 抗cgrp抗体を用いた頭痛の治療 |
CN114127110B (zh) * | 2019-05-30 | 2022-07-01 | 山东博安生物技术股份有限公司 | 抗cgrp抗体及其应用 |
AU2020202454A1 (en) | 2020-04-06 | 2021-10-21 | H. Lundbeck A/S | Treatment of most bothersome symptom (MBS) associated with migraine using anti-CGRP antibodies |
EP4301362A1 (en) | 2021-03-02 | 2024-01-10 | CGRP Diagnostics GmbH | Treatment and/or reduction of occurrence of migraine |
WO2023026205A1 (en) | 2021-08-24 | 2023-03-02 | Cgrp Diagnostics Gmbh | Preventative treatment of migraine |
WO2023026245A1 (en) | 2021-08-27 | 2023-03-02 | H. Lundbeck A/S | Treatment of cluster headache using anti-cgrp antibodies |
WO2023161526A1 (en) | 2022-02-28 | 2023-08-31 | Tridem Bioscience Gmbh & Co Kg | A CONJUGATE CONSISTING OF OR COMPRISING AT LEAST A ß-GLUCAN OR A MANNAN |
CN117586390A (zh) * | 2022-08-11 | 2024-02-23 | 上海君实生物医药科技股份有限公司 | 抗cgrp抗体及用途 |
Family Cites Families (121)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3662333A (en) | 1970-09-08 | 1972-05-09 | Bendix Corp | Hydraulic accumulator charge detector and indicating system |
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
JPS5123197A (ja) | 1974-08-21 | 1976-02-24 | Hitachi Ltd | Purosesugasukuromatogurafuno ondoseigyohoshiki |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US5374618A (en) * | 1983-06-15 | 1994-12-20 | Celltech Limited | Calcitonin peptides, and gene related pharmaceutical compositions |
JPS62129297A (ja) | 1985-08-09 | 1987-06-11 | Toyo Jozo Co Ltd | カルシトニン遺伝子関連ペプチド誘導体 |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
EP0307434B2 (en) | 1987-03-18 | 1998-07-29 | Scotgen Biopharmaceuticals, Inc. | Altered antibodies |
GB8725529D0 (en) | 1987-10-30 | 1987-12-02 | Delta Biotechnology Ltd | Polypeptides |
US5266561A (en) | 1988-01-11 | 1993-11-30 | Amylin Pharmaceuticals, Inc. | Treatment of type 2 diabetes mellitus |
US5364841A (en) | 1988-01-11 | 1994-11-15 | Amylin Pharmaceuticals, Inc. | Treatment of obesity and essential hypertension and related disorders |
DE68925966T2 (de) | 1988-12-22 | 1996-08-29 | Kirin Amgen Inc | Chemisch modifizierte granulocytenkolonie erregender faktor |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
US5766883A (en) | 1989-04-29 | 1998-06-16 | Delta Biotechnology Limited | Polypeptides |
FR2650598B1 (fr) | 1989-08-03 | 1994-06-03 | Rhone Poulenc Sante | Derives de l'albumine a fonction therapeutique |
US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
CA2090126C (en) | 1990-08-02 | 2002-10-22 | John W. Schrader | Methods for the production of proteins with a desired function |
FR2669336B1 (fr) | 1990-11-20 | 1993-01-22 | Adir | Nouveaux derives d'oxazolo pyridines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
ES2206447T3 (es) | 1991-06-14 | 2004-05-16 | Genentech, Inc. | Anticuerpo humanizado para heregulina. |
WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
DE4227454C1 (de) * | 1992-08-19 | 1994-02-03 | Henning Berlin Gmbh | Verfahren zur Früherkennung, zur Erkennung des Schweregrads sowie zur therapiebegleitenden Verlaufsbeurteilung einer Sepsis sowie Mittel zur Durchführung des Verfahrens |
US5604260A (en) | 1992-12-11 | 1997-02-18 | Merck Frosst Canada Inc. | 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2 |
US5409944A (en) | 1993-03-12 | 1995-04-25 | Merck Frosst Canada, Inc. | Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase |
AU6445894A (en) | 1993-03-19 | 1994-10-11 | Duke University | Method of treatment of tumors with an antibody binding to tenascin |
US5474995A (en) | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
US5436265A (en) | 1993-11-12 | 1995-07-25 | Merck Frosst Canada, Inc. | 1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents |
US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
US5475995A (en) | 1994-05-16 | 1995-12-19 | Livingston; George G. | Truck spare tire locking rod |
US5616601A (en) | 1994-07-28 | 1997-04-01 | Gd Searle & Co | 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation |
ATE306930T1 (de) | 1994-08-12 | 2005-11-15 | Immunomedics Inc | Für b-zell-lymphom und leukämiezellen spezifische immunkonjugate und humane antikörper |
AU7953194A (en) | 1994-08-16 | 1996-03-07 | Human Genome Sciences, Inc. | Calcitonin receptor |
US5521213A (en) | 1994-08-29 | 1996-05-28 | Merck Frosst Canada, Inc. | Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2 |
US5593994A (en) | 1994-09-29 | 1997-01-14 | The Dupont Merck Pharmaceutical Company | Prostaglandin synthase inhibitors |
US5552422A (en) | 1995-01-11 | 1996-09-03 | Merck Frosst Canada, Inc. | Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents |
FR2732221B1 (fr) | 1995-03-28 | 1997-04-25 | Oreal | Utilisation d'un antagoniste de cgrp pour traiter les rougeurs cutanees d'origine neurogene et composition obtenue |
US5604253A (en) | 1995-05-22 | 1997-02-18 | Merck Frosst Canada, Inc. | N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors |
US5639780A (en) | 1995-05-22 | 1997-06-17 | Merck Frosst Canada, Inc. | N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors |
US5510368A (en) | 1995-05-22 | 1996-04-23 | Merck Frosst Canada, Inc. | N-benzyl-3-indoleacetic acids as antiinflammatory drugs |
JPH11512396A (ja) | 1995-09-05 | 1999-10-26 | スミスクライン・ビーチャム・コーポレイション | 化合物および方法 |
US5710024A (en) * | 1996-07-23 | 1998-01-20 | Smithkline Beecham Corporation | Polynucleotides that encode the calcitonin gene-related peptide receptor coponent factor (HOUNDC44) |
EP0934068A1 (en) | 1996-09-09 | 1999-08-11 | Smithkline Beecham Corporation | Compounds and methods |
BR9712023A (pt) | 1996-09-10 | 1999-08-31 | Thomae Gmbh Dr K | Aminoácidos derivados, medicamentos contendo esses compostos e processos para a sua preparação. |
US6653104B2 (en) | 1996-10-17 | 2003-11-25 | Immunomedics, Inc. | Immunotoxins, comprising an internalizing antibody, directed against malignant and normal cells |
WO1998056779A1 (en) | 1997-06-13 | 1998-12-17 | Smithkline Beecham Corporation | 4-sulfinyl benzamides as calcitonin gene-related peptide receptor antagonists |
US6956107B2 (en) | 1998-02-20 | 2005-10-18 | Tanox, Inc. | Inhibitors of complement activation |
WO2000018764A1 (en) | 1998-09-30 | 2000-04-06 | Merck Sharp & Dohme Limited | Benzimidazolinyl piperidines as cgrp ligands |
US20010036647A1 (en) | 1998-10-22 | 2001-11-01 | Prabhakara V. Choudary | Functionally assembled antigen-specific intact recombinant antibody and a method for production thereof |
US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
EP1031350A1 (en) | 1999-02-23 | 2000-08-30 | Warner-Lambert Company | Use of a gabapentin-analog for the manufacture of a medicament for preventing and treating visceral pain |
US6313097B1 (en) | 1999-03-02 | 2001-11-06 | Boehringer Ingelheim Pharma Kg | Antagonists of calcitonin gene-related peptide |
US6521609B1 (en) | 1999-08-10 | 2003-02-18 | Boehringer Ingelheim Pharma Kg | Use of CGRP antagonists and CGRP release inhibitors for combating menopausal hot flushes |
AP1775A (en) | 1999-09-25 | 2007-08-28 | Univ Iowa Res Found | Immunostimulatory nucleic acids. |
ES2390761T3 (es) | 2000-03-01 | 2012-11-16 | Medimmune, Llc | Anticuerpos recombinantes de alta potencia y método para producción de los mismos |
US6406863B1 (en) | 2000-06-23 | 2002-06-18 | Genetastix Corporation | High throughput generation and screening of fully human antibody repertoire in yeast |
US20020162125A1 (en) | 2001-03-06 | 2002-10-31 | Anne-Marie Salmon | Methods and compositions for the modulation of neurogenic inflammatory pain and physical opiate withdrawal |
US20030181462A1 (en) | 2001-08-17 | 2003-09-25 | Boehringer Ingelheim Pharma Kg | Use of BIBN4096 in combination with other antimigraine drugs for the treatment of migraine |
CA2471833A1 (en) | 2001-11-26 | 2003-06-05 | Protemix Corporation Limited | Methods of compositions for normalizing lipid levels in mammalian tissues |
ES2327830T3 (es) | 2002-03-29 | 2009-11-04 | Schering Corporation | Anticuerpos monoclonales humanos anti-interleuquina-5 y metodos y composiciones que los contienen. |
EP1501929B1 (de) | 2002-05-06 | 2013-03-27 | Noxxon Pharma AG | Cgrp bindende nukleinsäuren |
US20040110170A1 (en) | 2002-05-18 | 2004-06-10 | The Regents Of The University Of California | Cloning and characterization of calcitonin gene related peptide receptors |
US7345065B2 (en) | 2002-05-21 | 2008-03-18 | Allergan, Inc. | Methods and compositions for alleviating pain |
JP4490809B2 (ja) | 2002-06-05 | 2010-06-30 | ブリストル−マイヤーズ スクイブ カンパニー | カルシトニン遺伝子関連ペプチド受容体拮抗薬 |
PT1517921E (pt) | 2002-06-28 | 2006-09-29 | Domantis Ltd | Ligandos duplamente especificos com semi-vida no soro aumentada |
BR0313388A (pt) | 2002-08-12 | 2005-07-05 | Birkir Sveinsson | Método para tratar, remediar ou evitar a psorìase em um paciente, uso de um composto de antagonista de cgrp, composição farmacêutica para tratamento da psorìase, e, método para identificar um composto candidato para o uso em um medicamento para tratar a psorìase |
UA80447C2 (en) | 2002-10-08 | 2007-09-25 | Methods for treating pain by administering nerve growth factor antagonist and opioid analgesic | |
DE10250082A1 (de) | 2002-10-25 | 2004-05-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
AU2003298816C1 (en) | 2002-12-02 | 2010-12-16 | Amgen Fremont, Inc. | Antibodies directed to Tumor Necrosis Factor and uses thereof |
PT1575517E (pt) | 2002-12-24 | 2012-05-28 | Rinat Neuroscience Corp | Anticorpos anti-ngf e métodos de utilização dos mesmos |
JP4690313B2 (ja) | 2003-03-14 | 2011-06-01 | メルク・シャープ・エンド・ドーム・コーポレイション | カルボキサミドスピロヒダントインcgrp受容体アンタゴニスト |
JP4673295B2 (ja) | 2003-03-14 | 2011-04-20 | メルク・シャープ・エンド・ドーム・コーポレイション | 単環式アニリドスピロヒダントインcgrp受容体拮抗物質 |
WO2004087649A2 (en) | 2003-03-14 | 2004-10-14 | Merck & Co., Inc. | Benodiazepine spirohydantoin cgrp receptor antagonists |
EP1608627B1 (en) | 2003-03-14 | 2008-05-07 | Merck & Co. Inc. | Bicyclic anilide spirohydantoin cgrp receptor antagonists |
JP4673296B2 (ja) | 2003-03-14 | 2011-04-20 | メルク・シャープ・エンド・ドーム・コーポレイション | アリールスピロヒダントインcgrp受容体拮抗物質 |
JO2355B1 (en) | 2003-04-15 | 2006-12-12 | ميرك شارب اند دوم كوربوريشن | Hereditary calcitonin polypeptide receptor antagonists |
WO2004091514A2 (en) | 2003-04-15 | 2004-10-28 | Merck & Co., Inc. | Cgrp receptor antagonists |
WO2004097421A2 (en) | 2003-04-29 | 2004-11-11 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with calcitonin receptor-like receptor (calcrl) |
EP1646611A1 (en) | 2003-07-15 | 2006-04-19 | Merck & Co., Inc. | Hydroxypyridine cgrp receptor antagonists |
SI1678314T1 (sl) * | 2003-10-22 | 2013-01-31 | Keck Graduate Institute | Metode za sintetiziranje heteromultimernih polipeptidov pri kvasovkah s strategijo razmnoĺ˝evanja haploidnih celic |
US20080070239A1 (en) | 2003-10-29 | 2008-03-20 | University Of Rochester | Detection of neureopeptides associated with pelvic pain disorders and uses thereof |
JP2007517911A (ja) | 2004-01-13 | 2007-07-05 | バソジェニックス ファーマシューティカルズ, インコーポレイテッド | 心臓血管の適応症および腎臓の適応症に対してcgrpを使用する方法 |
DE102004015723A1 (de) | 2004-03-29 | 2005-10-20 | Boehringer Ingelheim Pharma | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
DE102004018794A1 (de) | 2004-04-15 | 2005-10-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
US7279471B2 (en) | 2004-04-15 | 2007-10-09 | Boehringer Ingelheim International Gmbh | Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions |
TWI432196B (zh) | 2005-01-18 | 2014-04-01 | Euro Celtique Sa | 內臟痛的治療 |
EP1770091A1 (de) | 2005-09-29 | 2007-04-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
ITRM20050290A1 (it) | 2005-06-07 | 2006-12-08 | Lay Line Genomics Spa | Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato. |
CA2619856A1 (en) | 2005-08-25 | 2007-03-01 | Wex Pharmaceuticals Inc. | Use of sodium channel blockers for the treatment of visceral pain or pain caused by cancer treatment |
US8168592B2 (en) | 2005-10-21 | 2012-05-01 | Amgen Inc. | CGRP peptide antagonists and conjugates |
US20070108378A1 (en) | 2005-11-14 | 2007-05-17 | Toru Terabayashi | High pressure optical cell for a downhole optical fluid analyzer |
ES2664421T3 (es) | 2005-11-14 | 2018-04-19 | Teva Pharmaceuticals International Gmbh | Anticuerpo antagonista dirigido contra un péptido relacionado con el gen de la calcitonina |
JP2009515971A (ja) | 2005-11-18 | 2009-04-16 | メルク エンド カムパニー インコーポレーテッド | スピロヒダントインアリールcgrp受容体アンタゴニスト |
WO2007076336A1 (en) | 2005-12-22 | 2007-07-05 | Eli Lilly And Company | Treatment of migraine with anti-cgrp antibodies |
US9074352B2 (en) | 2006-03-27 | 2015-07-07 | John R. Ramun | Universal control scheme for mobile hydraulic equipment and method for achieving the same |
MX2008014692A (es) | 2006-05-19 | 2009-08-18 | Alder Biopharmaceuticals Inc | Metodo de cultivo para obtener una poblacion clonal de celulas b especificas de antigeno. |
EP2029234A1 (en) | 2006-06-08 | 2009-03-04 | Boehringer Ingelheim International GmbH | Treatment of gastrointestinal disorders with cgrp-antagonists |
WO2008011190A1 (en) | 2006-07-21 | 2008-01-24 | Vertex Pharmaceuticals Incorporated | Cgrp receptor antagonists |
US8075902B2 (en) * | 2007-01-03 | 2011-12-13 | Michael Powell | Diagnosis and treatment of cancer related to human dormancy |
US20090104187A1 (en) | 2007-05-21 | 2009-04-23 | Alder Biopharmaceuticals, Inc. | Novel Rabbit Antibody Humanization Methods and Humanized Rabbit Antibodies |
WO2008144753A2 (en) | 2007-05-21 | 2008-11-27 | Alder Biopharmaceuticals, Inc. | Antibodies to tnf alpha and use thereof |
DK2164514T3 (en) | 2007-05-21 | 2017-02-27 | Alderbio Holdings Llc | Antibodies to IL-6 and its use |
GB0725103D0 (en) * | 2007-12-21 | 2008-01-30 | Glaxo Group Ltd | Novel compounds |
US8293239B2 (en) | 2008-03-04 | 2012-10-23 | Pfizer Limited | Methods of treating chronic pain |
ES2584907T3 (es) | 2008-03-04 | 2016-09-30 | Labrys Biologics Inc. | Métodos para tratamiento del dolor inflamatorio |
JO3382B1 (ar) | 2008-12-23 | 2019-03-13 | Amgen Inc | أجسام مضادة ترتبط مع مستقبل cgrp بشري |
WO2011024113A1 (en) | 2009-08-28 | 2011-03-03 | Rinat Neuroscience Corporation | Methods for treating visceral pain by administering antagonist antibodies directed against calcitonin gene-related peptide |
AR081434A1 (es) | 2010-06-10 | 2012-08-29 | Lilly Co Eli | Anticuerpo del peptido relacionado con el gen calcitonina (cgrp), composicion farmaceutica que lo comprende, uso de dicho anticuerpo para preparar un medicamento util para tratar dolor de osteoartritis o migranas y fragmento de union a antigeno de dicho anticuerpo |
US11214610B2 (en) * | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
KR102098546B1 (ko) | 2011-05-20 | 2020-04-07 | 앨더바이오 홀딩스 엘엘씨 | 필요한 대상체, 특히 편두통 환자의 광선공포증 또는 광선 혐오증을 예방 또는 억제하기 위한 항-cgrp 항체 및 항체 단편의 용도 |
CN108373502B (zh) * | 2011-05-20 | 2022-03-22 | H.伦德贝克公司 | 抗cgrp组合物及其用途 |
CN103957935B (zh) | 2011-05-20 | 2018-04-03 | 奥尔德生物控股有限责任公司 | 抗cgrp或抗cgrp‑r抗体或抗体片段用于治疗或预防慢性和急性形式的腹泻的用途 |
US20170114122A1 (en) | 2015-10-23 | 2017-04-27 | Alderbio Holdings Llc | Regulation of glucose metabolism using anti-cgrp antibodies |
EP3353202B1 (en) | 2015-09-24 | 2020-11-04 | Teva Pharmaceuticals International GmbH | Preventing, treating, and reducing (persistent) post-traumatic headache |
KR20190133174A (ko) * | 2017-03-02 | 2019-12-02 | 베쓰 이스라엘 디코니스 메디칼 센터 인크 | 칼시토닌 유전자 관련 펩티드에 대해 지시되는 항체에 반응하는 두통 환자를 선택하는 방법 |
US11752099B2 (en) * | 2017-03-27 | 2023-09-12 | W. L. Gore & Associates, Inc. | Injectable and biodegradable polymer formulations for controlled release of bioactive agents |
WO2018236873A1 (en) * | 2017-06-19 | 2018-12-27 | President And Fellows Of Harvard College | METHODS AND COMPOSITIONS FOR THE TREATMENT OF MICROBIAL INFECTION |
TWI754772B (zh) * | 2017-09-06 | 2022-02-11 | 美商美國禮來大藥廠 | 用於治療偏頭痛之拉米迪坦(lasmiditan)與cgrp拮抗劑之組合療法 |
JOP20210166A1 (ar) | 2019-01-08 | 2023-01-30 | H Lundbeck As | علاج الصداع الناتج عن فرط استعمال الأدوية باستخدام أجسام مضادة لـcgrp أو أجسام مضادة لـcgrp-r |
US11639380B2 (en) * | 2019-01-08 | 2023-05-02 | H. Lundbeck A/S | Acute treatment and rapid treatment of headache using anti-CGRP antibodies |
-
2012
- 2012-05-21 CN CN201810269354.4A patent/CN108373502B/zh active Active
- 2012-05-21 SI SI201231944T patent/SI3495392T1/sl unknown
- 2012-05-21 DK DK19215303.9T patent/DK3662932T3/da active
- 2012-05-21 EP EP21159270.4A patent/EP3875115A1/en active Pending
- 2012-05-21 AR ARP120101804A patent/AR086516A1/es active IP Right Grant
- 2012-05-21 TW TW101118029A patent/TWI646111B/zh active
- 2012-05-21 HU HUE18203518A patent/HUE055505T2/hu unknown
- 2012-05-21 CA CA3079978A patent/CA3079978A1/en active Pending
- 2012-05-21 SG SG10201604040PA patent/SG10201604040PA/en unknown
- 2012-05-21 PL PL18203518T patent/PL3495392T3/pl unknown
- 2012-05-21 TW TW109110803A patent/TWI719869B/zh active
- 2012-05-21 PE PE2013002534A patent/PE20141787A1/es active IP Right Grant
- 2012-05-21 MX MX2013013535A patent/MX370749B/es active IP Right Grant
- 2012-05-21 KR KR1020137033843A patent/KR102128627B1/ko active IP Right Grant
- 2012-05-21 RS RS20210554A patent/RS61793B1/sr unknown
- 2012-05-21 ES ES12789693T patent/ES2715001T3/es active Active
- 2012-05-21 CN CN201810269398.7A patent/CN108424452B/zh active Active
- 2012-05-21 US US13/476,465 patent/US9745373B2/en active Active
- 2012-05-21 ES ES19215303T patent/ES2873837T3/es active Active
- 2012-05-21 AP AP2013007259A patent/AP2013007259A0/xx unknown
- 2012-05-21 JP JP2014512923A patent/JP6282584B2/ja active Active
- 2012-05-21 CN CN201280035733.8A patent/CN103748111B/zh active Active
- 2012-05-21 EA EA201301295A patent/EA031065B1/ru unknown
- 2012-05-21 WO PCT/US2012/038844 patent/WO2012162243A2/en active Application Filing
- 2012-05-21 EP EP22178673.4A patent/EP4115905A1/en active Pending
- 2012-05-21 PL PL12789693T patent/PL2710039T3/pl unknown
- 2012-05-21 BR BR122022012930-7A patent/BR122022012930B1/pt active IP Right Grant
- 2012-05-21 EA EA201891284A patent/EA201891284A1/ru unknown
- 2012-05-21 EA EA201592042A patent/EA039905B1/ru unknown
- 2012-05-21 SI SI201231586T patent/SI2710039T1/sl unknown
- 2012-05-21 RS RS20190430A patent/RS58621B1/sr unknown
- 2012-05-21 SI SI201231916T patent/SI3662932T1/sl unknown
- 2012-05-21 BR BR112013029932A patent/BR112013029932A2/pt not_active Application Discontinuation
- 2012-05-21 EP EP18203518.8A patent/EP3495392B1/en active Active
- 2012-05-21 EP EP19215303.9A patent/EP3662932B1/en active Active
- 2012-05-21 LT LTEP18203518.8T patent/LT3495392T/lt unknown
- 2012-05-21 PL PL19215303T patent/PL3662932T3/pl unknown
- 2012-05-21 CN CN201710902899.XA patent/CN107602700B/zh active Active
- 2012-05-21 LT LTEP19215303.9T patent/LT3662932T/lt unknown
- 2012-05-21 EP EP12789693.4A patent/EP2710039B1/en active Active
- 2012-05-21 RS RS20211095A patent/RS62306B1/sr unknown
- 2012-05-21 NZ NZ733060A patent/NZ733060A/en unknown
- 2012-05-21 CN CN201710917266.6A patent/CN107586338B/zh active Active
- 2012-05-21 PT PT12789693T patent/PT2710039T/pt unknown
- 2012-05-21 TR TR2019/04088T patent/TR201904088T4/tr unknown
- 2012-05-21 DK DK18203518.8T patent/DK3495392T3/da active
- 2012-05-21 HU HUE12789693A patent/HUE044062T2/hu unknown
- 2012-05-21 PT PT192153039T patent/PT3662932T/pt unknown
- 2012-05-21 DK DK12789693.4T patent/DK2710039T3/en active
- 2012-05-21 TW TW107143050A patent/TWI692485B/zh active
- 2012-05-21 CA CA3080000A patent/CA3080000A1/en active Pending
- 2012-05-21 TW TW106121803A patent/TWI685505B/zh active
- 2012-05-21 CA CA2836649A patent/CA2836649C/en active Active
- 2012-05-21 HU HUE19215303A patent/HUE054437T2/hu unknown
- 2012-05-21 ES ES18203518T patent/ES2893073T3/es active Active
- 2012-05-21 LT LTEP12789693.4T patent/LT2710039T/lt unknown
- 2012-05-21 SG SG2013084058A patent/SG194938A1/en unknown
- 2012-05-21 PE PE2018000036A patent/PE20180502A1/es unknown
- 2012-05-21 AU AU2012258966A patent/AU2012258966C1/en active Active
- 2012-05-21 PT PT182035188T patent/PT3495392T/pt unknown
-
2013
- 2013-11-14 IL IL229431A patent/IL229431B/en active IP Right Grant
- 2013-11-18 ZA ZA2013/08637A patent/ZA201308637B/en unknown
- 2013-11-19 MX MX2019015745A patent/MX2019015745A/es unknown
- 2013-11-19 MX MX2019008185A patent/MX2019008185A/es unknown
- 2013-11-20 CL CL2013003336A patent/CL2013003336A1/es unknown
- 2013-11-22 CO CO13275276A patent/CO6870005A2/es unknown
-
2016
- 2016-09-06 US US15/257,562 patent/US10066009B2/en active Active
-
2017
- 2017-05-30 CL CL2017001379A patent/CL2017001379A1/es unknown
- 2017-06-08 AU AU2017203890A patent/AU2017203890B2/en active Active
- 2017-08-24 JP JP2017160778A patent/JP6527563B2/ja active Active
-
2018
- 2018-02-09 US US15/892,858 patent/US10214582B2/en active Active
- 2018-02-09 US US15/892,956 patent/US10189895B2/en active Active
- 2018-02-09 US US15/892,804 patent/US10179809B2/en active Active
- 2018-02-09 US US15/892,892 patent/US10208112B2/en active Active
- 2018-03-09 PH PH12018500521A patent/PH12018500521A1/en unknown
- 2018-05-30 CL CL2018001452A patent/CL2018001452A1/es unknown
- 2018-08-30 US US16/117,401 patent/US10533048B2/en active Active
- 2018-09-25 IL IL26192718A patent/IL261927B/en active IP Right Grant
-
2019
- 2019-01-15 US US16/248,284 patent/US11111289B2/en active Active
- 2019-04-03 HR HRP20190640TT patent/HRP20190640T1/hr unknown
- 2019-05-09 JP JP2019088960A patent/JP6952736B2/ja active Active
- 2019-08-04 IL IL268464A patent/IL268464B/en active IP Right Grant
- 2019-09-06 AU AU2019226231A patent/AU2019226231B2/en active Active
- 2019-11-03 IL IL270382A patent/IL270382B/en active IP Right Grant
-
2020
- 2020-01-13 US US16/740,699 patent/US20210047391A1/en not_active Abandoned
- 2020-04-06 AR ARP200100966A patent/AR118605A2/es unknown
-
2021
- 2021-05-11 CY CY20211100403T patent/CY1124209T1/el unknown
- 2021-05-14 HR HRP20210777TT patent/HRP20210777T1/hr unknown
- 2021-09-02 HR HRP20211395TT patent/HRP20211395T1/hr unknown
- 2021-09-21 CY CY20211100830T patent/CY1124515T1/el unknown
- 2021-10-21 AR ARP210102914A patent/AR123876A2/es unknown
-
2022
- 2022-06-13 NL NL301181C patent/NL301181I2/nl unknown
- 2022-06-20 LT LTPA2022511C patent/LTPA2022511I1/lt unknown
- 2022-06-22 HU HUS2200031C patent/HUS2200031I1/hu unknown
- 2022-06-29 FR FR22C1032C patent/FR22C1032I2/fr active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO6870005A2 (es) | Composición anti-cgrp y uso de las mismas | |
CO6950471A2 (es) | Pirimidinas anilladas sustituidas y uso de las mismas | |
BR112013007506A2 (pt) | piridinonas/pirazinonas - métodos de criação e de uso | |
CO7020870A2 (es) | Anticuerpos anti-htra1 y métodos de uso | |
BR112014010175A2 (pt) | unidades de filtro, componentes e recursos destas e métodos de uso e construção | |
BR112014012137A2 (pt) | anticorpos anti-fgfr2 e suas utilizações | |
CO6930362A2 (es) | Compuesto heterocíclico y su uso | |
BR112012021065A2 (pt) | artigo de uso descartável | |
CL2015001266A1 (es) | Anticuerpos de antihemaglutinina y métodos de uso. | |
CO6862148A2 (es) | Composiciones transdérmicas de ibuprofeno y métodos de uso de las mismas | |
BR112013023776A2 (pt) | composição e abertura vedada com selante | |
BR112013010988A2 (pt) | composição fluída e uso | |
CO7000747A2 (es) | Anticuerpos anti-lrp5 y métodos de uso | |
BR112014002716A2 (pt) | anticorpos anti-poliubiquitina e métodos de uso | |
BR112014012590A2 (pt) | anticorpos anti-cd98 e métodos de uso dos mesmos | |
BR112014010450A2 (pt) | composição e método | |
BR112014003051A2 (pt) | novas composições e uso das mesmas | |
CO6940436A2 (es) | Composicion de control de fitoenfermedades y su uso | |
BR112012028633A2 (pt) | composição reticulada e artigo | |
CO6781486A2 (es) | Compuestos y su uso | |
CR20130133A (es) | Composiciones de anticuerpo y mètodos de uso | |
BR112014005406A2 (pt) | composição de vacina e respectivo uso | |
BR112014014504A2 (pt) | uso de partícula | |
CR20140362A (es) | Fenilimidazopirazoles sustituidos y su uso | |
CO6900119A2 (es) | Uso de proteína cristalina insecticida dig3 en combinación con cry1ab |