CY1124209T1 - Συνθεσεις anti-cgrp και χρησεις αυτων - Google Patents
Συνθεσεις anti-cgrp και χρησεις αυτωνInfo
- Publication number
- CY1124209T1 CY1124209T1 CY20211100403T CY211100403T CY1124209T1 CY 1124209 T1 CY1124209 T1 CY 1124209T1 CY 20211100403 T CY20211100403 T CY 20211100403T CY 211100403 T CY211100403 T CY 211100403T CY 1124209 T1 CY1124209 T1 CY 1124209T1
- Authority
- CY
- Cyprus
- Prior art keywords
- cgrp
- antibodies
- binding fragments
- fragments
- relates
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Abstract
Η παρούσα εφεύρεση αφορά αντισώματα και θραύσματα αυτών που έχουν εξειδίκευση δέσμευσης για CGRP. Άλλη υλοποίηση αυτής της εφεύρεσης σχετίζεται με τα αντισώματα που περιγράφονται εδώ, και δεσμευόμενα θραύσματα αυτών, που περιλαμβάνουν τις αλληλουχίες των πολυπεπτιδίων VH, VL και CDR που περιγράφονται εδώ, και των πολυνουκλεοτιδίων που τα κωδικοποιούν. Η εφεύρεση επίσης εξετάζει συζεύγματα αντισωμάτων αντι-CGRP και δεσμευόμενων θραυσμάτων αυτών συζευγμένων με ένα ή περισσότερα λειτουργικά ή ανιχνεύσιμα τμήματα. Η εφεύρεση επίσης εξετάζει μεθόδους παρασκευής αυτών των αντισωμάτων αντι-CGRP και δεσμευόμενων θραυσμάτων αυτών. Υλοποιήσεις της εφεύρεσης αφορούν επίσης την χρήση αντισωμάτων αντι- CGRP, και δεσμευόμενων θραυσμάτων αυτών, για την διάγνωση, εκτίμηση και θεραπευτική αγωγή ασθενειών και διαταραχών που σχετίζονται με CGRP.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161488660P | 2011-05-20 | 2011-05-20 | |
EP12789693.4A EP2710039B1 (en) | 2011-05-20 | 2012-05-21 | Anti-cgrp compositions and use thereof |
EP18203518.8A EP3495392B1 (en) | 2011-05-20 | 2012-05-21 | Anti-cgrp compositions and use thereof |
PCT/US2012/038844 WO2012162243A2 (en) | 2011-05-20 | 2012-05-21 | Anti-cgrp compositions and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1124209T1 true CY1124209T1 (el) | 2022-05-27 |
Family
ID=47175055
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20211100403T CY1124209T1 (el) | 2011-05-20 | 2021-05-11 | Συνθεσεις anti-cgrp και χρησεις αυτων |
CY20211100830T CY1124515T1 (el) | 2011-05-20 | 2021-09-21 | Συνθεσεις αντι-cgrp και χρησεις αυτων |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20211100830T CY1124515T1 (el) | 2011-05-20 | 2021-09-21 | Συνθεσεις αντι-cgrp και χρησεις αυτων |
Country Status (35)
Country | Link |
---|---|
US (9) | US9745373B2 (el) |
EP (5) | EP2710039B1 (el) |
JP (3) | JP6282584B2 (el) |
KR (1) | KR102128627B1 (el) |
CN (5) | CN107602700B (el) |
AP (1) | AP2013007259A0 (el) |
AR (3) | AR086516A1 (el) |
AU (3) | AU2012258966C1 (el) |
BR (2) | BR112013029932A2 (el) |
CA (3) | CA3079978A1 (el) |
CL (3) | CL2013003336A1 (el) |
CO (1) | CO6870005A2 (el) |
CY (2) | CY1124209T1 (el) |
DK (3) | DK2710039T3 (el) |
EA (3) | EA039905B1 (el) |
ES (3) | ES2873837T3 (el) |
FR (1) | FR22C1032I2 (el) |
HR (3) | HRP20190640T1 (el) |
HU (4) | HUE054437T2 (el) |
IL (4) | IL229431B (el) |
LT (4) | LT3662932T (el) |
MX (3) | MX370749B (el) |
NL (1) | NL301181I2 (el) |
NZ (1) | NZ733060A (el) |
PE (2) | PE20180502A1 (el) |
PH (1) | PH12018500521A1 (el) |
PL (3) | PL3662932T3 (el) |
PT (3) | PT3495392T (el) |
RS (3) | RS58621B1 (el) |
SG (2) | SG194938A1 (el) |
SI (3) | SI2710039T1 (el) |
TR (1) | TR201904088T4 (el) |
TW (4) | TWI646111B (el) |
WO (1) | WO2012162243A2 (el) |
ZA (1) | ZA201308637B (el) |
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WO2012162243A2 (en) * | 2011-05-20 | 2012-11-29 | Alderbio Holdings Llc | Anti-cgrp compositions and use thereof |
WO2012162253A2 (en) | 2011-05-20 | 2012-11-29 | Alderbio Holdings Llc | Use of anti-cgrp or anti-cgrp-r antibodies or antibody fragments to treat or prevent chronic and acute forms of diarrhea |
CN108014334B (zh) * | 2011-05-20 | 2021-11-30 | H.伦德贝克公司 | 抗cgrp抗体和抗体片段用于在有需要的受试者中预防或抑制畏光或厌光的用途 |
EP3754012A1 (en) | 2013-03-15 | 2020-12-23 | Alder Biopharmaceuticals, Inc. | Antibody purification and purity monitoring |
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KR102444717B1 (ko) | 2016-04-15 | 2022-09-16 | 하. 룬드벡 아크티에셀스카브 | 인간화 항-pacap 항체 및 그의 용도 |
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KR20190067181A (ko) | 2016-09-23 | 2019-06-14 | 테바 파마슈티컬스 인터내셔널 게엠베하 | 군발성 두통의 치료 |
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JP2021518748A (ja) * | 2018-02-23 | 2021-08-05 | アールイーエムディー バイオセラピューティクス,インコーポレイテッドREMD Biotherapeutics,Inc | カルシトニン遺伝子関連ペプチド(cgrp)アンタゴニスト抗体 |
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