MX2015000190A - Purificacion de iduronato-2-sulfatasa. - Google Patents
Purificacion de iduronato-2-sulfatasa.Info
- Publication number
- MX2015000190A MX2015000190A MX2015000190A MX2015000190A MX2015000190A MX 2015000190 A MX2015000190 A MX 2015000190A MX 2015000190 A MX2015000190 A MX 2015000190A MX 2015000190 A MX2015000190 A MX 2015000190A MX 2015000190 A MX2015000190 A MX 2015000190A
- Authority
- MX
- Mexico
- Prior art keywords
- iduronate
- sulfatase
- purification
- present
- protein
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/095—Oxytocins; Vasopressins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/06—Sulfuric ester hydrolases (3.1.6)
- C12Y301/06013—Iduronate-2-sulfatase (3.1.6.13)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención proporciona, entre otras cosas, métodos mejorados para purificar la proteína I2S producida de forma recombinante para la terapia de reemplazo enzimática; la presente invención, se basa en parte sobre el sorpresivo descubrimiento referido a que la proteína I2S recombinante se puede purificar a partir de materiales biológicos no procesados, tal como, un medio de cultivo celular que contiene I2S, usando un proceso que involucra tan poco como cuatro columnas de cromatografía.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261666733P | 2012-06-29 | 2012-06-29 | |
PCT/US2013/048561 WO2014005014A2 (en) | 2012-06-29 | 2013-06-28 | Purification of iduronate-2-sulfatase |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015000190A true MX2015000190A (es) | 2015-04-08 |
MX336715B MX336715B (es) | 2016-01-28 |
Family
ID=49778401
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015000190A MX336715B (es) | 2012-06-29 | 2013-06-28 | Purificacion de iduronato-2-sulfatasa. |
MX2016001228A MX366906B (es) | 2012-06-29 | 2013-06-28 | Purificacion de iduronato-2-sulfatasa. |
MX2019008914A MX2019008914A (es) | 2012-06-29 | 2015-01-07 | Purificacion de iduronato-2-sulfatasa. |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016001228A MX366906B (es) | 2012-06-29 | 2013-06-28 | Purificacion de iduronato-2-sulfatasa. |
MX2019008914A MX2019008914A (es) | 2012-06-29 | 2015-01-07 | Purificacion de iduronato-2-sulfatasa. |
Country Status (38)
Country | Link |
---|---|
US (6) | US9051556B2 (es) |
EP (2) | EP2867245B1 (es) |
JP (4) | JP6171007B2 (es) |
KR (5) | KR101380740B1 (es) |
CN (3) | CN104583225A (es) |
AR (1) | AR091647A1 (es) |
AU (3) | AU2013282395C1 (es) |
BR (1) | BR112014032567B1 (es) |
CA (2) | CA3008945A1 (es) |
CL (1) | CL2014003567A1 (es) |
CO (1) | CO7240396A2 (es) |
CR (1) | CR20140588A (es) |
CY (1) | CY1121519T1 (es) |
DK (1) | DK2867245T3 (es) |
DO (1) | DOP2014000294A (es) |
EA (2) | EA202090044A1 (es) |
ES (1) | ES2689468T3 (es) |
GT (1) | GT201400303A (es) |
HK (4) | HK1209431A1 (es) |
HR (1) | HRP20181897T1 (es) |
HU (1) | HUE040769T2 (es) |
IL (4) | IL236315A (es) |
LT (1) | LT2867245T (es) |
MX (3) | MX336715B (es) |
MY (3) | MY157087A (es) |
NZ (3) | NZ703093A (es) |
PE (1) | PE20150720A1 (es) |
PH (3) | PH12014502871A1 (es) |
PL (1) | PL2867245T3 (es) |
PT (1) | PT2867245T (es) |
RS (1) | RS58005B1 (es) |
SG (2) | SG10201703489VA (es) |
SI (1) | SI2867245T1 (es) |
TR (1) | TR201815811T4 (es) |
TW (2) | TWI587869B (es) |
UA (1) | UA121959C2 (es) |
WO (1) | WO2014005014A2 (es) |
ZA (2) | ZA201409397B (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5901877B2 (ja) | 2007-07-27 | 2016-04-13 | アーメイゲン・テクノロジーズ・インコーポレイテッドArmagen Technologies, Inc. | 中枢神経系のα−L−イデュロニダーゼ活性を増加させるための方法および組成物 |
KR101158673B1 (ko) | 2011-06-24 | 2012-07-03 | 주식회사 지씨바이오 | 재조합 인간 이듀로네이트-2-설파타아제를 포함하는 조성물, 제제 및 이의 제조방법 |
US20160145589A1 (en) | 2011-06-24 | 2016-05-26 | Green Cross Corporation | Composition and formulation comprising recombinant human iduronate-2-sulfatase and preparation method thereof |
US9150841B2 (en) | 2012-06-29 | 2015-10-06 | Shire Human Genetic Therapies, Inc. | Cells for producing recombinant iduronate-2-sulfatase |
KR101380740B1 (ko) | 2012-06-29 | 2014-04-11 | 쉐어 휴먼 제네텍 세러피스, 인코포레이티드 | 이듀로네이트-2-설파타제의 정제 |
KR102318480B1 (ko) | 2016-08-25 | 2021-10-28 | 제이씨알 파마 가부시키가이샤 | 항체 융합 단백질의 제조 방법 |
CN106282231B (zh) * | 2016-09-06 | 2020-01-03 | 陕西慧康生物科技有限责任公司 | 粘多糖贮积症ii型动物模型的构建方法及应用 |
CN106428420B (zh) * | 2016-10-17 | 2018-08-21 | 上海江南长兴造船有限责任公司 | 一种用于超大型集装箱船止裂钢舱口围的安装的方法 |
JP2021500857A (ja) | 2017-10-02 | 2021-01-14 | デナリ セラピューティクス インコーポレイテッドDenali Therapeutics Inc. | 酵素補充療法用酵素を含む融合タンパク質 |
US20220002688A1 (en) * | 2018-12-20 | 2022-01-06 | Armagen, Inc. | Purification of iduronate-2-sulfatase immunoglobulin fusion protein |
JP2023546682A (ja) * | 2020-10-23 | 2023-11-07 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | アルカリホスファターゼの製造中に総シアル酸含量(tsac)を制御する方法 |
Family Cites Families (45)
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DK6488D0 (da) | 1988-01-07 | 1988-01-07 | Novo Industri As | Enzymer |
US5310646A (en) | 1988-05-13 | 1994-05-10 | Regents Of The University Of Minnesota | Method for the detection of mucopolysaccharide storage diseases |
US5932211A (en) * | 1991-11-12 | 1999-08-03 | Women's And Children's Hospital | Glycosylation variants of iduronate 2-sulfatase |
AU700369B2 (en) | 1994-03-16 | 1999-01-07 | Regents Of The University Of California, The | Treating inflammation via the administration of specific sulfatase enzymes and/or sulfation inhibitor |
US5863782A (en) | 1995-04-19 | 1999-01-26 | Women's And Children's Hospital | Synthetic mammalian sulphamidase and genetic sequences encoding same |
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US7368531B2 (en) | 1997-03-07 | 2008-05-06 | Human Genome Sciences, Inc. | Human secreted proteins |
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US20030148920A1 (en) | 2000-12-27 | 2003-08-07 | Steven Rosen | Sulfatases and methods of use thereof |
AU2002317700A1 (en) | 2001-06-07 | 2002-12-16 | Hemebiotech A/S | Production of recombinant human arylsulfatase a |
JP4319979B2 (ja) | 2002-04-26 | 2009-08-26 | ジェネンテック・インコーポレーテッド | タンパク質の非アフィニティ精製 |
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TWI312368B (en) | 2002-12-23 | 2009-07-21 | Bristol Myers Squibb Compan | Mammalian cell culture processes for protein production |
JP4606712B2 (ja) * | 2003-01-08 | 2011-01-05 | マサチューセッツ インスティテュート オブ テクノロジー | 2−oスルファターゼ組成物および関連の方法 |
EP2325301B1 (en) | 2003-02-11 | 2015-09-02 | Shire Human Genetic Therapies, Inc. | Diagnosis and treatment of multiple sulfatase deficiency and others using a formylglycine generating enzyme (FGE) |
US20050019914A1 (en) | 2003-07-24 | 2005-01-27 | Aventis Pharma Deutschland Gmbh | Perfusion process for producing erythropoietin |
CA2554883C (en) | 2004-01-30 | 2013-10-01 | Zymenex A/S | Production and purification of recombinant arylsulfatase a |
WO2005113765A2 (en) | 2004-05-06 | 2005-12-01 | Biomarin Pharmaceutical Inc. | Methods of activation of sulfatases and methods and compositions of using the same |
PT1885753E (pt) | 2005-06-03 | 2011-10-06 | Ares Trading Sa | Produção de proteína recombinante de ligação a il-18 |
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US20130195888A1 (en) | 2007-11-30 | 2013-08-01 | Abbvie | Ultrafiltration and diafiltration formulation methods for protein processing |
LT2245145T (lt) * | 2008-01-18 | 2017-04-10 | Biomarin Pharmaceutical Inc. | Aktyvių gausiai fosforilintų žmogaus lizosominės sulfatazės fermentų gamyba ir jų panaudojimas |
EP2485761B1 (en) | 2009-10-09 | 2019-02-27 | Armagen, Inc. | Methods and compositions for increasing iduronate 2-sulfatase activity in the cns |
WO2011108451A1 (ja) * | 2010-03-01 | 2011-09-09 | 日本ケミカルリサーチ株式会社 | 遺伝子ノックアウト細胞を用いた組換え体リソソーム酵素の製造方法 |
MX2013000324A (es) * | 2010-06-25 | 2013-02-01 | Shire Human Genetic Therapies | Tratamiento del sindrome de sanfilippo tipo b. |
WO2011163649A2 (en) | 2010-06-25 | 2011-12-29 | Shire Human Genetic Therapies, Inc | Methods and compositions for cns delivery of iduronate-2-sulfatase |
AR082319A1 (es) | 2010-07-22 | 2012-11-28 | Biomarin Pharm Inc | Produccion de una n-acetilgalactosamina-6-sulfatasa humana activa altamente fosforilada y sus usos |
JP5865839B2 (ja) * | 2010-09-28 | 2016-02-17 | 共立製薬株式会社 | 粘膜アジュバント組成物 |
WO2012101671A1 (en) * | 2011-01-25 | 2012-08-02 | Jcr Pharmaceuticals Co., Ltd. | Method for production of human recombinant iduronate 2-sulfatase |
KR20130114704A (ko) | 2011-01-31 | 2013-10-17 | 휴렛-팩커드 디벨롭먼트 컴퍼니, 엘.피. | 동적으로 튜닝 가능한 산란각을 갖는 산광기 |
KR101158673B1 (ko) | 2011-06-24 | 2012-07-03 | 주식회사 지씨바이오 | 재조합 인간 이듀로네이트-2-설파타아제를 포함하는 조성물, 제제 및 이의 제조방법 |
US9150841B2 (en) | 2012-06-29 | 2015-10-06 | Shire Human Genetic Therapies, Inc. | Cells for producing recombinant iduronate-2-sulfatase |
US20140004097A1 (en) | 2012-06-29 | 2014-01-02 | Shire Human Genetic Therapies, Inc. | Method of producing recombinant iduronate-2-sulfatase |
KR101380740B1 (ko) | 2012-06-29 | 2014-04-11 | 쉐어 휴먼 제네텍 세러피스, 인코포레이티드 | 이듀로네이트-2-설파타제의 정제 |
KR20190062745A (ko) | 2017-11-29 | 2019-06-07 | 주식회사 위니플 | 쇼핑몰 모바일앱 빌더 |
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2012
- 2012-09-07 KR KR1020120099511A patent/KR101380740B1/ko active IP Right Grant
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2013
- 2013-03-14 US US13/829,706 patent/US9051556B2/en active Active
- 2013-06-28 PE PE2014002539A patent/PE20150720A1/es active IP Right Grant
- 2013-06-28 CA CA3008945A patent/CA3008945A1/en not_active Abandoned
- 2013-06-28 NZ NZ703093A patent/NZ703093A/en unknown
- 2013-06-28 SI SI201331176T patent/SI2867245T1/sl unknown
- 2013-06-28 WO PCT/US2013/048561 patent/WO2014005014A2/en active Application Filing
- 2013-06-28 EA EA202090044A patent/EA202090044A1/ru unknown
- 2013-06-28 TW TW105120026A patent/TWI587869B/zh active
- 2013-06-28 SG SG10201703489VA patent/SG10201703489VA/en unknown
- 2013-06-28 CN CN201380042665.2A patent/CN104583225A/zh active Pending
- 2013-06-28 DK DK13809853.8T patent/DK2867245T3/en active
- 2013-06-28 NZ NZ733366A patent/NZ733366A/en unknown
- 2013-06-28 LT LTEP13809853.8T patent/LT2867245T/lt unknown
- 2013-06-28 NZ NZ743910A patent/NZ743910A/en unknown
- 2013-06-28 TR TR2018/15811T patent/TR201815811T4/tr unknown
- 2013-06-28 AU AU2013282395A patent/AU2013282395C1/en active Active
- 2013-06-28 MY MYPI2014003472A patent/MY157087A/en unknown
- 2013-06-28 CN CN201710840314.6A patent/CN107596357A/zh active Pending
- 2013-06-28 EP EP13809853.8A patent/EP2867245B1/en active Active
- 2013-06-28 UA UAA201413826A patent/UA121959C2/uk unknown
- 2013-06-28 MX MX2015000190A patent/MX336715B/es unknown
- 2013-06-28 ES ES13809853.8T patent/ES2689468T3/es active Active
- 2013-06-28 CA CA2877517A patent/CA2877517C/en active Active
- 2013-06-28 RS RS20181324A patent/RS58005B1/sr unknown
- 2013-06-28 HU HUE13809853A patent/HUE040769T2/hu unknown
- 2013-06-28 MY MYPI2019006401A patent/MY192068A/en unknown
- 2013-06-28 EP EP18193801.0A patent/EP3441398A1/en active Pending
- 2013-06-28 CN CN201710840704.3A patent/CN107596358A/zh active Pending
- 2013-06-28 MY MYPI2016000157A patent/MY180287A/en unknown
- 2013-06-28 BR BR112014032567-7A patent/BR112014032567B1/pt active IP Right Grant
- 2013-06-28 PT PT13809853T patent/PT2867245T/pt unknown
- 2013-06-28 JP JP2015520567A patent/JP6171007B2/ja active Active
- 2013-06-28 TW TW102123353A patent/TWI553120B/zh active
- 2013-06-28 MX MX2016001228A patent/MX366906B/es unknown
- 2013-06-28 PL PL13809853T patent/PL2867245T3/pl unknown
- 2013-06-28 SG SG11201408761VA patent/SG11201408761VA/en unknown
- 2013-06-28 EA EA201492177A patent/EA034549B1/ru active IP Right Maintenance
- 2013-07-01 AR ARP130102350 patent/AR091647A1/es not_active Application Discontinuation
- 2013-09-26 KR KR1020130114704A patent/KR20140004603A/ko active Search and Examination
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2014
- 2014-12-17 CR CR20140588A patent/CR20140588A/es unknown
- 2014-12-17 IL IL236315A patent/IL236315A/en active IP Right Grant
- 2014-12-19 ZA ZA201409397A patent/ZA201409397B/en unknown
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