CO7240396A2 - Purificación de iduronato-2-sulfatasa - Google Patents
Purificación de iduronato-2-sulfatasaInfo
- Publication number
- CO7240396A2 CO7240396A2 CO14284199A CO14284199A CO7240396A2 CO 7240396 A2 CO7240396 A2 CO 7240396A2 CO 14284199 A CO14284199 A CO 14284199A CO 14284199 A CO14284199 A CO 14284199A CO 7240396 A2 CO7240396 A2 CO 7240396A2
- Authority
- CO
- Colombia
- Prior art keywords
- protein
- iduronate
- sulfatase
- purification
- present
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/095—Oxytocins; Vasopressins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/06—Sulfuric ester hydrolases (3.1.6)
- C12Y301/06013—Iduronate-2-sulfatase (3.1.6.13)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención proporciona, entre otras cosas, métodos mejorados para purificar la proteína I2S producida de forma recombinante para la terapia de reemplazo enzimática. La presente invención, se basa en parte sobre el sorpresivo descubrimiento referido a que la proteína I2S recombinante se puede purificar a partir de materiales biológicos no procesador, tal como, un medio de cultivo celular que contiene I2S, usando un proceso que involucra tan poco como cuatro columnas de cromatografía.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261666733P | 2012-06-29 | 2012-06-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO7240396A2 true CO7240396A2 (es) | 2015-04-17 |
Family
ID=49778401
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO14284199A CO7240396A2 (es) | 2012-06-29 | 2014-12-26 | Purificación de iduronato-2-sulfatasa |
Country Status (38)
Country | Link |
---|---|
US (6) | US9051556B2 (es) |
EP (2) | EP3441398A1 (es) |
JP (4) | JP6171007B2 (es) |
KR (5) | KR101380740B1 (es) |
CN (3) | CN107596357A (es) |
AR (1) | AR091647A1 (es) |
AU (3) | AU2013282395C1 (es) |
BR (1) | BR112014032567B1 (es) |
CA (2) | CA3008945A1 (es) |
CL (1) | CL2014003567A1 (es) |
CO (1) | CO7240396A2 (es) |
CR (1) | CR20140588A (es) |
CY (1) | CY1121519T1 (es) |
DK (1) | DK2867245T3 (es) |
DO (1) | DOP2014000294A (es) |
EA (2) | EA034549B1 (es) |
ES (1) | ES2689468T3 (es) |
GT (1) | GT201400303A (es) |
HK (4) | HK1209431A1 (es) |
HR (1) | HRP20181897T1 (es) |
HU (1) | HUE040769T2 (es) |
IL (4) | IL236315A (es) |
LT (1) | LT2867245T (es) |
MX (3) | MX336715B (es) |
MY (3) | MY157087A (es) |
NZ (3) | NZ733366A (es) |
PE (1) | PE20150720A1 (es) |
PH (3) | PH12014502871A1 (es) |
PL (1) | PL2867245T3 (es) |
PT (1) | PT2867245T (es) |
RS (1) | RS58005B1 (es) |
SG (2) | SG11201408761VA (es) |
SI (1) | SI2867245T1 (es) |
TR (1) | TR201815811T4 (es) |
TW (2) | TWI553120B (es) |
UA (1) | UA121959C2 (es) |
WO (1) | WO2014005014A2 (es) |
ZA (2) | ZA201409397B (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2997976A1 (en) | 2007-07-27 | 2016-03-23 | Armagen Technologies, Inc. | Methods and compositions for increasing alpha-l-iduronidase activity in the cns |
US20160145589A1 (en) | 2011-06-24 | 2016-05-26 | Green Cross Corporation | Composition and formulation comprising recombinant human iduronate-2-sulfatase and preparation method thereof |
KR101158673B1 (ko) | 2011-06-24 | 2012-07-03 | 주식회사 지씨바이오 | 재조합 인간 이듀로네이트-2-설파타아제를 포함하는 조성물, 제제 및 이의 제조방법 |
US9150841B2 (en) | 2012-06-29 | 2015-10-06 | Shire Human Genetic Therapies, Inc. | Cells for producing recombinant iduronate-2-sulfatase |
KR101380740B1 (ko) * | 2012-06-29 | 2014-04-11 | 쉐어 휴먼 제네텍 세러피스, 인코포레이티드 | 이듀로네이트-2-설파타제의 정제 |
WO2018038243A1 (ja) | 2016-08-25 | 2018-03-01 | Jcrファーマ株式会社 | 抗体融合蛋白質の製造方法 |
CN106282231B (zh) * | 2016-09-06 | 2020-01-03 | 陕西慧康生物科技有限责任公司 | 粘多糖贮积症ii型动物模型的构建方法及应用 |
CN106428420B (zh) * | 2016-10-17 | 2018-08-21 | 上海江南长兴造船有限责任公司 | 一种用于超大型集装箱船止裂钢舱口围的安装的方法 |
EP3692070A1 (en) | 2017-10-02 | 2020-08-12 | Denali Therapeutics Inc. | Fusion proteins comprising enzyme replacement therapy enzymes |
WO2020132452A1 (en) * | 2018-12-20 | 2020-06-25 | Shire Human Genetic Therapies, Inc. | Purification of iduronate-2-sulfatase immunoglobulin fusion protein |
AU2021364779A1 (en) * | 2020-10-23 | 2023-06-01 | Alexion Pharmaceuticals, Inc. | Method of controlling total sialic acid content (tsac) during manufacturing of alkaline phosphatase |
Family Cites Families (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK6488D0 (da) | 1988-01-07 | 1988-01-07 | Novo Industri As | Enzymer |
US5310646A (en) | 1988-05-13 | 1994-05-10 | Regents Of The University Of Minnesota | Method for the detection of mucopolysaccharide storage diseases |
US5932211A (en) | 1991-11-12 | 1999-08-03 | Women's And Children's Hospital | Glycosylation variants of iduronate 2-sulfatase |
EP0750511B1 (en) | 1994-03-16 | 2003-06-11 | The Regents Of The University Of California | Treating inflammation via the administration of specific sulfatase enzymes and/or sulfation inhibitor |
US5863782A (en) | 1995-04-19 | 1999-01-26 | Women's And Children's Hospital | Synthetic mammalian sulphamidase and genetic sequences encoding same |
DE19527054A1 (de) | 1995-07-26 | 1997-01-30 | Behringwerke Ag | Verfahren zur Charakterisierung der Glycosylierung von Glycoproteinen sowie zur in-vitro Bestimmung der Bioverfügbarkeit von Glycoproteinen |
EP2243827B2 (en) | 1996-08-30 | 2017-11-22 | Life Technologies Corporation | Serum-free mammalian cell culture medium, and uses thereof |
US7368531B2 (en) | 1997-03-07 | 2008-05-06 | Human Genome Sciences, Inc. | Human secreted proteins |
WO2000050443A2 (en) | 1999-02-26 | 2000-08-31 | Millennium Pharmaceutcals, Inc. | Secreted proteins and uses thereof |
US7083793B2 (en) | 1999-02-26 | 2006-08-01 | Millennium Pharmaceuticals, Inc. | Tango 243 polypeptides and uses thereof |
ATE348173T1 (de) | 1999-04-26 | 2007-01-15 | Genentech Inc | Zellenzuchtverfahren für glycoproteine |
JP2002017376A (ja) | 1999-07-08 | 2002-01-22 | Herikkusu Kenkyusho:Kk | 分泌蛋白質、または膜蛋白質 |
AU7099200A (en) | 1999-09-03 | 2001-04-10 | Human Genome Sciences, Inc. | 52 human secreted proteins |
US6780627B1 (en) | 2000-01-31 | 2004-08-24 | Millennium Pharmaceuticals, Inc. | 22438, 23553, 25278, and 26212 novel human sulfatases |
JP2004502404A (ja) | 2000-02-17 | 2004-01-29 | インサイト・ゲノミックス・インコーポレイテッド | ヒトキナーゼ |
AU2001252917A1 (en) | 2000-03-17 | 2001-10-03 | Human Genome Sciences, Inc. | 7 human ovarian and ovarian cancer associated proteins |
AU2001259063A1 (en) | 2000-04-12 | 2001-10-30 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US20030148920A1 (en) | 2000-12-27 | 2003-08-07 | Steven Rosen | Sulfatases and methods of use thereof |
AU2002317700A1 (en) | 2001-06-07 | 2002-12-16 | Hemebiotech A/S | Production of recombinant human arylsulfatase a |
AU2003265235A1 (en) | 2002-04-26 | 2003-12-19 | Genetech, Inc. | Non-affinity purification of proteins |
US6890736B1 (en) | 2002-09-20 | 2005-05-10 | Immunex Corporation | Methods for producing proteins in cultured cells |
EP1575998A4 (en) * | 2002-12-23 | 2007-07-25 | Bristol Myers Squibb Co | PROCESS FOR CULTIVATING MAMMALIAN CELLS FOR PROTEIN PRODUCTION |
JP4606712B2 (ja) * | 2003-01-08 | 2011-01-05 | マサチューセッツ インスティテュート オブ テクノロジー | 2−oスルファターゼ組成物および関連の方法 |
WO2004072275A2 (en) | 2003-02-11 | 2004-08-26 | Transkaryotic Therapies, Inc. | Diagnosis and treatment of multiple sulfatase deficiency and other using a formylglycine generating enzyme (fge) |
US20050019914A1 (en) | 2003-07-24 | 2005-01-27 | Aventis Pharma Deutschland Gmbh | Perfusion process for producing erythropoietin |
EP1713904B1 (en) | 2004-01-30 | 2016-06-29 | Shire Pharmaceuticals Ireland Limited | Production and purification of recombinant arylsulfatase a |
WO2005113765A2 (en) | 2004-05-06 | 2005-12-01 | Biomarin Pharmaceutical Inc. | Methods of activation of sulfatases and methods and compositions of using the same |
CA2609060C (en) | 2005-06-03 | 2014-07-15 | Urs Weber | Production of recombinant il-18 binding protein |
CA2645739A1 (en) | 2006-03-20 | 2007-09-27 | Medarex, Inc. | Protein purification |
JP4458377B2 (ja) | 2007-06-29 | 2010-04-28 | キヤノン株式会社 | プロセスカートリッジ及び電子写真画像形成装置 |
US20130195888A1 (en) | 2007-11-30 | 2013-08-01 | Abbvie | Ultrafiltration and diafiltration formulation methods for protein processing |
KR101744142B1 (ko) * | 2008-01-18 | 2017-06-07 | 바이오마린 파머수티컬 인크. | 활성이고 높은 정도로 인산화된 인간 리소좀 술파타아제 효소의 제조 및 그 용도 |
DK2485761T3 (da) | 2009-10-09 | 2019-05-06 | Armagen Inc | Fremgangsmåder og sammensætninger til øgning af iduronat-2-sulfatase-aktivitet i CNS |
WO2011108451A1 (ja) * | 2010-03-01 | 2011-09-09 | 日本ケミカルリサーチ株式会社 | 遺伝子ノックアウト細胞を用いた組換え体リソソーム酵素の製造方法 |
NZ605871A (en) * | 2010-06-25 | 2015-02-27 | Shire Human Genetic Therapies | Treatment of sanfilippo syndrome type b |
JP6045492B2 (ja) | 2010-06-25 | 2016-12-14 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | イズロン酸−2−スルファターゼのcns送達のための方法および組成物 |
AR082319A1 (es) | 2010-07-22 | 2012-11-28 | Biomarin Pharm Inc | Produccion de una n-acetilgalactosamina-6-sulfatasa humana activa altamente fosforilada y sus usos |
CN103153337A (zh) * | 2010-09-28 | 2013-06-12 | 共立制药股份有限公司 | 黏膜佐剂组合物 |
WO2012101671A1 (en) * | 2011-01-25 | 2012-08-02 | Jcr Pharmaceuticals Co., Ltd. | Method for production of human recombinant iduronate 2-sulfatase |
KR20130114704A (ko) | 2011-01-31 | 2013-10-17 | 휴렛-팩커드 디벨롭먼트 컴퍼니, 엘.피. | 동적으로 튜닝 가능한 산란각을 갖는 산광기 |
KR101158673B1 (ko) | 2011-06-24 | 2012-07-03 | 주식회사 지씨바이오 | 재조합 인간 이듀로네이트-2-설파타아제를 포함하는 조성물, 제제 및 이의 제조방법 |
KR101380740B1 (ko) | 2012-06-29 | 2014-04-11 | 쉐어 휴먼 제네텍 세러피스, 인코포레이티드 | 이듀로네이트-2-설파타제의 정제 |
US20140004097A1 (en) | 2012-06-29 | 2014-01-02 | Shire Human Genetic Therapies, Inc. | Method of producing recombinant iduronate-2-sulfatase |
US9150841B2 (en) | 2012-06-29 | 2015-10-06 | Shire Human Genetic Therapies, Inc. | Cells for producing recombinant iduronate-2-sulfatase |
KR20190062745A (ko) | 2017-11-29 | 2019-06-07 | 주식회사 위니플 | 쇼핑몰 모바일앱 빌더 |
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2012
- 2012-09-07 KR KR1020120099511A patent/KR101380740B1/ko active IP Right Grant
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2013
- 2013-03-14 US US13/829,706 patent/US9051556B2/en active Active
- 2013-06-28 SG SG11201408761VA patent/SG11201408761VA/en unknown
- 2013-06-28 CA CA3008945A patent/CA3008945A1/en not_active Abandoned
- 2013-06-28 EA EA201492177A patent/EA034549B1/ru active IP Right Maintenance
- 2013-06-28 CN CN201710840314.6A patent/CN107596357A/zh active Pending
- 2013-06-28 CA CA2877517A patent/CA2877517C/en active Active
- 2013-06-28 PE PE2014002539A patent/PE20150720A1/es active IP Right Grant
- 2013-06-28 PT PT13809853T patent/PT2867245T/pt unknown
- 2013-06-28 PL PL13809853T patent/PL2867245T3/pl unknown
- 2013-06-28 BR BR112014032567-7A patent/BR112014032567B1/pt active IP Right Grant
- 2013-06-28 TW TW102123353A patent/TWI553120B/zh active
- 2013-06-28 CN CN201710840704.3A patent/CN107596358A/zh active Pending
- 2013-06-28 UA UAA201413826A patent/UA121959C2/uk unknown
- 2013-06-28 AU AU2013282395A patent/AU2013282395C1/en active Active
- 2013-06-28 WO PCT/US2013/048561 patent/WO2014005014A2/en active Application Filing
- 2013-06-28 NZ NZ733366A patent/NZ733366A/en unknown
- 2013-06-28 HU HUE13809853A patent/HUE040769T2/hu unknown
- 2013-06-28 DK DK13809853.8T patent/DK2867245T3/en active
- 2013-06-28 NZ NZ743910A patent/NZ743910A/en unknown
- 2013-06-28 SI SI201331176T patent/SI2867245T1/sl unknown
- 2013-06-28 ES ES13809853.8T patent/ES2689468T3/es active Active
- 2013-06-28 EP EP18193801.0A patent/EP3441398A1/en active Pending
- 2013-06-28 MY MYPI2014003472A patent/MY157087A/en unknown
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- 2013-06-28 CN CN201380042665.2A patent/CN104583225A/zh active Pending
- 2013-06-28 EP EP13809853.8A patent/EP2867245B1/en active Active
- 2013-06-28 TR TR2018/15811T patent/TR201815811T4/tr unknown
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- 2013-06-28 NZ NZ703093A patent/NZ703093A/en unknown
- 2013-06-28 MX MX2015000190A patent/MX336715B/es unknown
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- 2013-06-28 JP JP2015520567A patent/JP6171007B2/ja active Active
- 2013-06-28 EA EA202090044A patent/EA202090044A1/ru unknown
- 2013-06-28 LT LTEP13809853.8T patent/LT2867245T/lt unknown
- 2013-06-28 TW TW105120026A patent/TWI587869B/zh active
- 2013-06-28 MY MYPI2019006401A patent/MY192068A/en unknown
- 2013-07-01 AR ARP130102350 patent/AR091647A1/es not_active Application Discontinuation
- 2013-09-26 KR KR1020130114704A patent/KR20140004603A/ko active Search and Examination
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2014
- 2014-12-17 IL IL236315A patent/IL236315A/en active IP Right Grant
- 2014-12-17 CR CR20140588A patent/CR20140588A/es unknown
- 2014-12-19 ZA ZA201409397A patent/ZA201409397B/en unknown
- 2014-12-19 DO DO2014000294A patent/DOP2014000294A/es unknown
- 2014-12-22 PH PH12014502871A patent/PH12014502871A1/en unknown
- 2014-12-26 CO CO14284199A patent/CO7240396A2/es unknown
- 2014-12-29 GT GT201400303A patent/GT201400303A/es unknown
- 2014-12-29 CL CL2014003567A patent/CL2014003567A1/es unknown
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2015
- 2015-01-07 MX MX2019008914A patent/MX2019008914A/es unknown
- 2015-03-30 US US14/673,607 patent/US9492511B2/en active Active
- 2015-10-14 HK HK15110042.0A patent/HK1209431A1/xx unknown
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2016
- 2016-01-27 AU AU2016200469A patent/AU2016200469B2/en active Active
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2018
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2019
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2020
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2021
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2022
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