MX336715B - Purificacion de iduronato-2-sulfatasa. - Google Patents

Purificacion de iduronato-2-sulfatasa.

Info

Publication number
MX336715B
MX336715B MX2015000190A MX2015000190A MX336715B MX 336715 B MX336715 B MX 336715B MX 2015000190 A MX2015000190 A MX 2015000190A MX 2015000190 A MX2015000190 A MX 2015000190A MX 336715 B MX336715 B MX 336715B
Authority
MX
Mexico
Prior art keywords
sulfatase
purified recombinant
iduronate
purification
seq
Prior art date
Application number
MX2015000190A
Other languages
English (en)
Other versions
MX2015000190A (es
Inventor
Dave Nichols
Original Assignee
Shire Human Genetic Therapies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49778401&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX336715(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Shire Human Genetic Therapies filed Critical Shire Human Genetic Therapies
Publication of MX2015000190A publication Critical patent/MX2015000190A/es
Publication of MX336715B publication Critical patent/MX336715B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/095—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/06—Sulfuric ester hydrolases (3.1.6)
    • C12Y301/06013—Iduronate-2-sulfatase (3.1.6.13)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención se refiere a una composición, caracterizada porque comprende uduronato-2-sulfatasa (I2S) recombinante purificada que tiene la secuencia de aminoácidos de la SEQ ID NO: 1, en donde la I2S recombinante purificada comprende por lo menos 70% de conversión del residuo cisteína que corresponde a Cys59 de la SEQ ID NO: 1 a C?-formilglicina (FGly), en donde la I2S recombinante purificada contiene de 150 ng/mg de Proteína de Célula Huésped (HCP) .
MX2015000190A 2012-06-29 2013-06-28 Purificacion de iduronato-2-sulfatasa. MX336715B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261666733P 2012-06-29 2012-06-29
PCT/US2013/048561 WO2014005014A2 (en) 2012-06-29 2013-06-28 Purification of iduronate-2-sulfatase

Publications (2)

Publication Number Publication Date
MX2015000190A MX2015000190A (es) 2015-04-08
MX336715B true MX336715B (es) 2016-01-28

Family

ID=49778401

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2019008914A MX393364B (es) 2012-06-29 2013-06-28 Purificacion de iduronato-2-sulfatasa
MX2015000190A MX336715B (es) 2012-06-29 2013-06-28 Purificacion de iduronato-2-sulfatasa.
MX2016001228A MX366906B (es) 2012-06-29 2013-06-28 Purificacion de iduronato-2-sulfatasa.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2019008914A MX393364B (es) 2012-06-29 2013-06-28 Purificacion de iduronato-2-sulfatasa

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2016001228A MX366906B (es) 2012-06-29 2013-06-28 Purificacion de iduronato-2-sulfatasa.

Country Status (39)

Country Link
US (7) US9051556B2 (es)
EP (2) EP3441398A1 (es)
JP (4) JP6171007B2 (es)
KR (5) KR101380740B1 (es)
CN (3) CN104583225A (es)
AR (1) AR091647A1 (es)
AU (3) AU2013282395C1 (es)
BR (1) BR112014032567B1 (es)
CA (2) CA3008945A1 (es)
CL (1) CL2014003567A1 (es)
CO (1) CO7240396A2 (es)
CR (1) CR20140588A (es)
CY (1) CY1121519T1 (es)
DK (1) DK2867245T3 (es)
DO (1) DOP2014000294A (es)
EA (2) EA202090044A1 (es)
ES (1) ES2689468T3 (es)
GT (1) GT201400303A (es)
HK (3) HK1209431A1 (es)
HR (1) HRP20181897T1 (es)
HU (1) HUE040769T2 (es)
IL (4) IL236315A (es)
LT (1) LT2867245T (es)
MX (3) MX393364B (es)
MY (3) MY157087A (es)
NZ (3) NZ733366A (es)
PE (1) PE20150720A1 (es)
PH (3) PH12014502871A1 (es)
PL (1) PL2867245T3 (es)
PT (1) PT2867245T (es)
RS (1) RS58005B1 (es)
SG (2) SG11201408761VA (es)
SI (1) SI2867245T1 (es)
SM (1) SMT201800612T1 (es)
TR (1) TR201815811T4 (es)
TW (2) TWI587869B (es)
UA (2) UA121959C2 (es)
WO (1) WO2014005014A2 (es)
ZA (2) ZA201409397B (es)

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DOP2014000294A (es) 2015-03-15
ES2689468T3 (es) 2018-11-14
JP2016119911A (ja) 2016-07-07
MY180287A (en) 2020-11-27
IL236315A (en) 2016-11-30
SI2867245T1 (sl) 2018-12-31
KR101380740B1 (ko) 2014-04-11
MX2019008914A (es) 2019-09-26
EA202090044A1 (ru) 2020-07-31
ZA201803289B (en) 2021-04-28
HUE040769T2 (hu) 2019-03-28
BR112014032567A2 (pt) 2017-08-01
NZ743910A (en) 2019-12-20
DK2867245T3 (en) 2018-11-26
JP2015523072A (ja) 2015-08-13
SG11201408761VA (en) 2015-01-29
PE20150720A1 (es) 2015-05-16
US11530393B2 (en) 2022-12-20
TWI587869B (zh) 2017-06-21
MY157087A (en) 2016-04-19
PH12015502408A1 (en) 2018-03-26
TW201703794A (zh) 2017-02-01
MX366906B (es) 2019-07-30
PH12015502408B1 (en) 2020-02-14
CL2014003567A1 (es) 2015-04-24
US20240043817A1 (en) 2024-02-08
CY1121519T1 (el) 2020-05-29
PH12014502871B1 (en) 2015-02-23
KR20140002451A (ko) 2014-01-08
IL261264A (en) 2018-10-31
JP2020105209A (ja) 2020-07-09
HK1209431A1 (en) 2016-04-01
PH12020500027A1 (en) 2021-03-15
KR20220002227A (ko) 2022-01-06
MY192068A (en) 2022-07-25
AU2018200230B2 (en) 2020-01-02
TWI553120B (zh) 2016-10-11
AU2018200230A1 (en) 2018-02-01
PH12014502871A1 (en) 2015-02-23
TW201410868A (zh) 2014-03-16
US20150313972A1 (en) 2015-11-05
RS58005B1 (sr) 2019-02-28
CA2877517A1 (en) 2014-01-03
HK1209767A1 (en) 2016-04-08
IL248727A0 (en) 2017-01-31
WO2014005014A3 (en) 2014-02-27
NZ703093A (en) 2017-08-25
AU2016200469A1 (en) 2016-02-18
US20170073652A1 (en) 2017-03-16
KR20140004603A (ko) 2014-01-13
EP2867245A2 (en) 2015-05-06
NZ733366A (en) 2019-12-20
UA129561C2 (uk) 2025-06-04
BR112014032567B1 (pt) 2022-09-13
CA2877517C (en) 2018-07-31
US20140004096A1 (en) 2014-01-02
US10344270B2 (en) 2019-07-09
TR201815811T4 (tr) 2018-11-21
LT2867245T (lt) 2018-11-12
HRP20181897T1 (hr) 2019-01-11
HK1249026A1 (zh) 2018-10-26
JP2018121645A (ja) 2018-08-09
ZA201409397B (en) 2019-10-30
AU2013282395B2 (en) 2015-12-03
PT2867245T (pt) 2018-11-26
US20210317426A1 (en) 2021-10-14
KR20190064542A (ko) 2019-06-10
CA3008945A1 (en) 2014-01-03
KR20200143339A (ko) 2020-12-23
AU2016200469B2 (en) 2017-10-12
CO7240396A2 (es) 2015-04-17
PL2867245T3 (pl) 2019-02-28
UA121959C2 (uk) 2020-08-25
US12359178B2 (en) 2025-07-15
MX2015000190A (es) 2015-04-08
AR091647A1 (es) 2015-02-18
IL236315A0 (en) 2015-02-26
WO2014005014A2 (en) 2014-01-03
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IL287057A (en) 2021-12-01
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US20190359958A1 (en) 2019-11-28
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AU2013282395A1 (en) 2015-01-29
EP2867245A4 (en) 2016-03-09
GT201400303A (es) 2017-08-31
AU2013282395C1 (en) 2016-03-24
EA034549B1 (ru) 2020-02-19
EP2867245B1 (en) 2018-09-12
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JP7594365B2 (ja) 2024-12-04
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US9492511B2 (en) 2016-11-15
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