SG11201408761VA - Purification of iduronate-2-sulfatase - Google Patents

Purification of iduronate-2-sulfatase

Info

Publication number
SG11201408761VA
SG11201408761VA SG11201408761VA SG11201408761VA SG11201408761VA SG 11201408761V A SG11201408761V A SG 11201408761VA SG 11201408761V A SG11201408761V A SG 11201408761VA SG 11201408761V A SG11201408761V A SG 11201408761VA SG 11201408761V A SG11201408761V A SG 11201408761VA
Authority
SG
Singapore
Prior art keywords
international
lllll
llll
massachusetts
publication
Prior art date
Application number
SG11201408761VA
Inventor
Dave Nichols
Original Assignee
Shire Human Genetic Therapies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49778401&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201408761V(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Shire Human Genetic Therapies filed Critical Shire Human Genetic Therapies
Publication of SG11201408761VA publication Critical patent/SG11201408761VA/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/095—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/06—Sulfuric ester hydrolases (3.1.6)
    • C12Y301/06013—Iduronate-2-sulfatase (3.1.6.13)

Abstract

(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 3 January 2014 (03.01.2014) WIPOIPCT (10) International Publication Number WO 2014/005014 A3 (51) International Patent Classification: C07K1/00 (2006.01) A61K38/17 (2006.01) C07K16/00 (2006.01) (21) International Application Number: (22) International Filing Date: (25) (26) Publication (30) Priority Filing Language: Language: PCT/US2013/048561 28 June 2013 (28.06.2013) English Data: 61/666,733 29 June 2012 (29.06.2012) English US (71) Applicant: SHIRE HUMAN GENETIC THERAPIES, INC. [US/US]; 300 Shire Way, Lexington, Massachusetts 02421 (US). (72) Inventor: NICHOLS, Dave; 300 Shire Way, Lexington, Massachusetts 02421 (US). (74) Agent: HUDDLESON, Justin P.; Choate, Hall & Stewart LLP, Two International Place, Boston, Massachusetts 02110 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, [Continued on next page] (54) Title: PURIFICATION OF IDURONATE-2-SULFATASE < o © o (57) Abstract: The present invention provides, among other things, im­ proved methods for purifying 12 S protein produced recombinantly for enzyme replacement therapy. The present invention is, in part, based on the surprising discovery that recombinant I2S protein can be purified from unprocessed biological materials, such as, I2S-containing cell culture me­ dium, using a process involving as few as four chromatography columns. FIG. 1 WO 2014/005014 A3 I lllll llllllll II llllll III III lllll lllll lllll llll lllll III III lllll lllll llll lllllll llll llll llll KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — with sequence listing part of description (Rule 5.2(a)) (88) Date of publication of the international search report: 27 February 2014
SG11201408761VA 2012-06-29 2013-06-28 Purification of iduronate-2-sulfatase SG11201408761VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261666733P 2012-06-29 2012-06-29
PCT/US2013/048561 WO2014005014A2 (en) 2012-06-29 2013-06-28 Purification of iduronate-2-sulfatase

Publications (1)

Publication Number Publication Date
SG11201408761VA true SG11201408761VA (en) 2015-01-29

Family

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SG11201408761VA SG11201408761VA (en) 2012-06-29 2013-06-28 Purification of iduronate-2-sulfatase
SG10201703489VA SG10201703489VA (en) 2012-06-29 2013-06-28 Purification of iduronate-2-sulfatase

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Country Status (38)

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US (6) US9051556B2 (en)
EP (2) EP3441398A1 (en)
JP (4) JP6171007B2 (en)
KR (5) KR101380740B1 (en)
CN (3) CN107596357A (en)
AR (1) AR091647A1 (en)
AU (3) AU2013282395C1 (en)
BR (1) BR112014032567B1 (en)
CA (2) CA2877517C (en)
CL (1) CL2014003567A1 (en)
CO (1) CO7240396A2 (en)
CR (1) CR20140588A (en)
CY (1) CY1121519T1 (en)
DK (1) DK2867245T3 (en)
DO (1) DOP2014000294A (en)
EA (2) EA034549B1 (en)
ES (1) ES2689468T3 (en)
GT (1) GT201400303A (en)
HK (4) HK1209431A1 (en)
HR (1) HRP20181897T1 (en)
HU (1) HUE040769T2 (en)
IL (4) IL236315A (en)
LT (1) LT2867245T (en)
MX (3) MX336715B (en)
MY (3) MY180287A (en)
NZ (3) NZ743910A (en)
PE (1) PE20150720A1 (en)
PH (3) PH12014502871B1 (en)
PL (1) PL2867245T3 (en)
PT (1) PT2867245T (en)
RS (1) RS58005B1 (en)
SG (2) SG11201408761VA (en)
SI (1) SI2867245T1 (en)
TR (1) TR201815811T4 (en)
TW (2) TWI587869B (en)
UA (1) UA121959C2 (en)
WO (1) WO2014005014A2 (en)
ZA (2) ZA201409397B (en)

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TW201410868A (en) 2014-03-16
KR20190064542A (en) 2019-06-10
AU2018200230B2 (en) 2020-01-02
AU2013282395C1 (en) 2016-03-24
JP2018121645A (en) 2018-08-09
DOP2014000294A (en) 2015-03-15
CA3008945A1 (en) 2014-01-03
EP2867245A2 (en) 2015-05-06
TWI553120B (en) 2016-10-11
US11530393B2 (en) 2022-12-20
US20140004096A1 (en) 2014-01-02
US20210317426A1 (en) 2021-10-14
HK1209767A1 (en) 2016-04-08
SG10201703489VA (en) 2017-05-30
PH12015502408A1 (en) 2018-03-26
CN107596358A (en) 2018-01-19
TR201815811T4 (en) 2018-11-21
EA202090044A1 (en) 2020-07-31
EP3441398A1 (en) 2019-02-13
SI2867245T1 (en) 2018-12-31
WO2014005014A3 (en) 2014-02-27
JP2016119911A (en) 2016-07-07
PE20150720A1 (en) 2015-05-16
BR112014032567A2 (en) 2017-08-01
IL261264B (en) 2021-10-31
IL236315A (en) 2016-11-30
JP2020105209A (en) 2020-07-09
HRP20181897T1 (en) 2019-01-11
RS58005B1 (en) 2019-02-28
US20170073652A1 (en) 2017-03-16
MX2015000190A (en) 2015-04-08
PL2867245T3 (en) 2019-02-28
AU2016200469B2 (en) 2017-10-12
IL236315A0 (en) 2015-02-26
CY1121519T1 (en) 2020-05-29
AU2016200469A1 (en) 2016-02-18
HK1249027A1 (en) 2018-10-26
EA034549B1 (en) 2020-02-19
AU2013282395A1 (en) 2015-01-29
CN104583225A (en) 2015-04-29
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US10344270B2 (en) 2019-07-09
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