ME03442B - Stabilizovani rastvorljivi pre-fuzioni rsv f polipeptidi - Google Patents
Stabilizovani rastvorljivi pre-fuzioni rsv f polipeptidiInfo
- Publication number
- ME03442B ME03442B MEP-2019-73A MEP201973A ME03442B ME 03442 B ME03442 B ME 03442B ME P201973 A MEP201973 A ME P201973A ME 03442 B ME03442 B ME 03442B
- Authority
- ME
- Montenegro
- Prior art keywords
- polypeptides
- soluble rsv
- stabilized prefusion
- prefusion
- stabilized
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/115—Paramyxoviridae, e.g. parainfluenza virus
- C07K14/135—Respiratory syncytial virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13165402 | 2013-04-25 | ||
| EP14719022.7A EP2988780B1 (en) | 2013-04-25 | 2014-04-24 | Stabilized soluble prefusion rsv f polypeptides |
| PCT/EP2014/058353 WO2014174018A1 (en) | 2013-04-25 | 2014-04-24 | Stabilized soluble prefusion rsv f polypeptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME03442B true ME03442B (me) | 2020-01-20 |
Family
ID=48326107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2019-73A ME03442B (me) | 2013-04-25 | 2014-04-24 | Stabilizovani rastvorljivi pre-fuzioni rsv f polipeptidi |
Country Status (33)
| Country | Link |
|---|---|
| US (3) | US10899800B2 (me) |
| EP (2) | EP2988780B1 (me) |
| JP (1) | JP6469081B2 (me) |
| KR (1) | KR102236497B1 (me) |
| CN (2) | CN110590916A (me) |
| AP (1) | AP2015008815A0 (me) |
| AR (1) | AR096113A1 (me) |
| AU (1) | AU2014259474B2 (me) |
| CA (1) | CA2910067C (me) |
| CL (1) | CL2015003124A1 (me) |
| CY (1) | CY1121600T1 (me) |
| DK (1) | DK2988780T3 (me) |
| EA (2) | EA035522B1 (me) |
| ES (1) | ES2715378T3 (me) |
| HR (1) | HRP20190175T1 (me) |
| HU (1) | HUE041659T2 (me) |
| IL (1) | IL242186B (me) |
| LT (1) | LT2988780T (me) |
| ME (1) | ME03442B (me) |
| MX (1) | MX361774B (me) |
| MY (2) | MY181066A (me) |
| PE (1) | PE20151867A1 (me) |
| PH (1) | PH12015502377B1 (me) |
| PL (1) | PL2988780T3 (me) |
| PT (1) | PT2988780T (me) |
| RS (1) | RS58436B1 (me) |
| SG (1) | SG11201508567XA (me) |
| SI (1) | SI2988780T1 (me) |
| SM (1) | SMT201900138T1 (me) |
| TR (1) | TR201902513T4 (me) |
| TW (1) | TWI663175B (me) |
| WO (1) | WO2014174018A1 (me) |
| ZA (1) | ZA201507912B (me) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11446374B2 (en) | 2008-12-09 | 2022-09-20 | Novavax, Inc. | Modified RSV F proteins and methods of their use |
| WO2010077717A1 (en) | 2008-12-09 | 2010-07-08 | Novavax, Inc. | Modified rsv f proteins and methods of their use |
| CN105473604B (zh) | 2013-03-13 | 2021-01-22 | 美国政府(由卫生和人类服务部的部长所代表) | 融合前rsv f蛋白和其用途 |
| US9738689B2 (en) | 2013-03-13 | 2017-08-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Prefusion RSV F proteins and their use |
| CN110590916A (zh) * | 2013-04-25 | 2019-12-20 | 扬森疫苗与预防公司 | 稳定化的可溶性融合前rsv f多肽 |
| KR102313153B1 (ko) | 2013-06-17 | 2021-10-15 | 얀센 백신스 앤드 프리벤션 비.브이. | 안정화된 가용성 예비융합 ｒｓｖ ｆ 폴리펩타이드 |
| WO2016160166A1 (en) * | 2015-03-30 | 2016-10-06 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Immunogenic rsv polypeptides |
| JP7189014B2 (ja) | 2015-07-07 | 2022-12-13 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | Ｒｓｖに対するワクチン |
| US10457708B2 (en) * | 2015-07-07 | 2019-10-29 | Janssen Vaccines & Prevention B.V. | Stabilized soluble pre-fusion RSV F polypeptides |
| AU2016316723B2 (en) * | 2015-09-02 | 2021-03-25 | Janssen Vaccines & Prevention B.V. | Stabilized viral class I fusion proteins |
| MX2018002728A (es) * | 2015-09-03 | 2018-09-05 | Novavax Inc | Composiciones de vacuna que tienen estabilidad e inmunogenicidad mejoradas. |
| MY205060A (en) | 2015-12-23 | 2024-09-30 | Pfizer | Rsv f protein mutants |
| EA202092250A1 (ru) | 2016-02-03 | 2020-12-11 | Янссен Сайенсиз Айрлэнд Юси | Комбинированные продукты для лечения rsv |
| CN115960263A (zh) | 2016-03-29 | 2023-04-14 | 美国政府(由卫生和人类服务部的部长所代表) | 取代修饰的融合前rsv f蛋白及其用途 |
| BR112018070323A2 (pt) | 2016-04-05 | 2019-01-29 | Janssen Vaccines & Prevention Bv | vacina contra rsv |
| KR20220041966A (ko) * | 2016-04-05 | 2022-04-01 | 얀센 백신스 앤드 프리벤션 비.브이. | 안정화된 용해성 융합-전 rsv f 단백질 |
| WO2017207477A1 (en) | 2016-05-30 | 2017-12-07 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion rsv f proteins |
| IL264119B2 (en) * | 2016-05-30 | 2023-04-01 | Janssen Vaccines Prevention B V | f proteins of rsv are stabilized before fusion |
| CN108265079A (zh) * | 2017-01-02 | 2018-07-10 | 刘昕 | 一种新型呼吸道合胞体病毒pre-F融合蛋白载体的制备方法 |
| WO2018170260A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Respiratory syncytial virus vaccine |
| EP3595676A4 (en) | 2017-03-17 | 2021-05-05 | Modernatx, Inc. | RNA VACCINES AGAINST ZOONOSES |
| CN110603262A (zh) | 2017-04-04 | 2019-12-20 | 华盛顿大学 | 显示副粘病毒和/或肺炎病毒f蛋白的自组装蛋白纳米结构及其用途 |
| AU2018267971A1 (en) * | 2017-05-17 | 2019-11-07 | Janssen Vaccines & Prevention B.V. | Methods and compositions for inducing protective immunity against RSV infection |
| CN111148509A (zh) | 2017-07-24 | 2020-05-12 | 诺瓦瓦克斯股份有限公司 | 治疗呼吸系统疾病的方法和组合物 |
| SG11202001458SA (en) * | 2017-09-15 | 2020-03-30 | Janssen Vaccines & Prevention Bv | Method for the safe induction of immunity against rsv |
| KR102700187B1 (ko) * | 2017-09-29 | 2024-08-28 | 에스케이바이오사이언스(주) | 가용성 변형 호흡기 융합세포 바이러스 (ｒｓｖ) ｆ 단백질 항원 |
| WO2019148101A1 (en) | 2018-01-29 | 2019-08-01 | Modernatx, Inc. | Rsv rna vaccines |
| IL277274B2 (en) | 2018-03-19 | 2024-02-01 | Novavax Inc | Multifunctional nanoparticle vaccines for influenza |
| EP3873517A4 (en) * | 2018-10-29 | 2022-09-28 | Emory University | RSV VIRUS-LIKE PARTICLES AND METHODS OF PRODUCTION THEREOF |
| JOP20210106A1 (ar) | 2018-11-13 | 2023-01-30 | Janssen Vaccines And Prevention B V | بروتينات rsv f سابقة الاندماج مستقرة |
| CN109851678A (zh) * | 2019-03-07 | 2019-06-07 | 苏州宇之波生物科技有限公司 | 一种改良的亚稳定态牛呼吸道合胞病毒融合前体f蛋白质及编码的dna分子和其应用 |
| KR20220008816A (ko) | 2019-05-15 | 2022-01-21 | 얀센 백신스 앤드 프리벤션 비.브이. | 아데노바이러스 기반 백신을 사용한 호흡기 세포융합 바이러스 감염의 예방적 치료 |
| BR112021022087A2 (pt) | 2019-05-15 | 2021-12-28 | Janssen Vaccines & Prevention Bv | Coadministração de vacina sazonal contra influenza e vacina contra vírus respiratório sincicial à base de adenovírus |
| US20220306697A1 (en) | 2019-09-04 | 2022-09-29 | University Of Washington | Self-Assembling Protein Nanostructures Displaying Paramyxovirus and/or Pneumovirus F Proteins and Their Use |
| CN111303245B (zh) * | 2020-02-21 | 2023-06-27 | 成都奥达生物科技有限公司 | 一种抗合胞病毒膜融合抑制剂 |
| CN115461076A (zh) | 2020-04-02 | 2022-12-09 | 扬森疫苗与预防公司 | 稳定化的疫苗组合物 |
| JP2023531554A (ja) | 2020-06-29 | 2023-07-24 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | 呼吸器合胞体ウイルス感染に対するワクチンの組み合わせ |
| CN112220921B (zh) | 2020-08-25 | 2022-08-16 | 北京交通大学 | 一种针对呼吸道合胞病毒感染的组合疫苗 |
| JP7822149B2 (ja) | 2020-10-02 | 2026-03-02 | ファイザー・インク | Ｒｓｖ ｆタンパク質生産のための細胞培養工程 |
| WO2022175479A1 (en) | 2021-02-19 | 2022-08-25 | Janssen Vaccines & Prevention B.V. | Vaccine combinations against respiratory syncytial virus strain a and b infections |
| CN114195867B (zh) * | 2021-12-15 | 2024-05-03 | 北京交通大学 | 一种rsv融合前f蛋白、表达质粒、细胞株和rsv疫苗组合物 |
| EP4448802A1 (en) | 2021-12-16 | 2024-10-23 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion hmpv fusion proteins |
| JP2025532706A (ja) * | 2022-09-29 | 2025-10-01 | 北京百邑无憂科技発展有限公司 | 融合前コンフォメーションを持つ呼吸器合胞体ウイルス組み換え融合タンパク質、その調製方法及び使用 |
| KR20250054810A (ko) | 2022-09-29 | 2025-04-23 | 화이자 인코포레이티드 | Rsv f 단백질 삼량체를 포함하는 면역원성 조성물 |
| CN116478296B (zh) * | 2022-10-17 | 2024-02-23 | 厦门大学 | 截短的呼吸道合胞病毒f蛋白及其用途 |
| WO2024089633A1 (en) | 2022-10-27 | 2024-05-02 | Pfizer Inc. | Rna molecules encoding rsv-f and vaccines containing them |
| EP4608441A1 (en) | 2022-10-27 | 2025-09-03 | Pfizer Inc. | Immunogenic compositions against influenza and rsv |
| CN116284266B (zh) * | 2022-11-21 | 2024-01-19 | 怡道生物科技(苏州)有限公司 | 突变型呼吸道合胞病毒融合前f蛋白及其应用 |
| EP4630049A1 (en) | 2022-12-11 | 2025-10-15 | Pfizer Inc. | Immunogenic compositions against influenza and rsv |
| WO2024155561A2 (en) * | 2023-01-17 | 2024-07-25 | The Scripps Research Institute | Engineered paramyxovirus soluble fusion (f) proteins and related vaccines |
| EP4651889A1 (en) | 2023-01-18 | 2025-11-26 | Pfizer Inc. | Vaccines against respiratory diseases |
| JP2026504603A (ja) * | 2023-02-06 | 2026-02-05 | サイアンバック エルエルシー | 修飾ｐｉｖ５ワクチンベクター：作製方法及び使用方法 |
| CN118108812B (zh) * | 2023-05-04 | 2025-04-15 | 国药中生生物技术研究院有限公司 | Rsv f蛋白的突变体 |
| CN117050149B (zh) * | 2023-05-19 | 2025-12-12 | 珠海丽凡达生物技术有限公司 | 包含人呼吸道合胞病毒抗原的免疫组合物及其制备方法和应用 |
| KR20260023012A (ko) | 2023-06-07 | 2026-02-20 | 시추안 클로버 바이오파마슈티컬스, 인크. | Rsv 백신 조성물, 방법 및 이의 용도 |
| TW202515531A (zh) | 2023-07-07 | 2025-04-16 | 美商輝瑞股份有限公司 | 兩親性ｔｌｒ７／８佐劑及其用途 |
| CN119462859A (zh) * | 2023-08-09 | 2025-02-18 | 深圳瑞吉生物科技有限公司 | 呼吸道合胞病毒抗原性多肽、疫苗及其应用 |
| CN116785421B (zh) * | 2023-08-21 | 2024-01-09 | 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） | 一种牛呼吸道合胞体病毒的mRNA疫苗及其应用 |
| WO2025051250A1 (zh) * | 2023-09-07 | 2025-03-13 | 北京科兴中维生物技术有限公司 | 呼吸道合胞病毒f蛋白及其应用 |
| AR133824A1 (es) * | 2023-09-15 | 2025-11-05 | Icosavax Inc | Proteínas virales y nanoestructuras y usos de estas |
| WO2025126071A1 (en) | 2023-12-14 | 2025-06-19 | Pfizer Inc. | Rna molecules |
| CN117736278B (zh) * | 2023-12-25 | 2025-02-07 | 英诺特（唐山）生物技术有限公司 | 一种用于检测呼吸道合胞病毒感染的试剂盒及检测方法 |
| WO2025149032A1 (en) * | 2024-01-11 | 2025-07-17 | Immorna (hangzhou) Biotechnology Co., Ltd. | Respiratory syncytial virus vaccine compositions and their use |
| CN117586357B (zh) * | 2024-01-19 | 2024-07-09 | 北京安百胜生物科技有限公司 | 一种具有免疫原性的呼吸道合胞病毒（rsv）多肽 |
| WO2025163460A2 (en) | 2024-01-30 | 2025-08-07 | Pfizer Inc. | Vaccines against respiratory diseases |
| WO2025186719A1 (en) | 2024-03-06 | 2025-09-12 | Pfizer Inc. | Immunogenic compositions and uses thereof |
| CN121022942A (zh) * | 2024-05-27 | 2025-11-28 | 广州国家实验室 | 腺相关病毒载体在制备防治rsv感染和/或rsv引起的疾病的药物中的应用 |
| WO2026018181A1 (en) | 2024-07-17 | 2026-01-22 | Pfizer Inc. | Immunogenic compositions and uses thereof |
| WO2026038177A1 (en) | 2024-08-16 | 2026-02-19 | Pfizer Inc. | Immunogenic compositions and uses thereof |
| CN118725053B (zh) * | 2024-09-03 | 2024-12-24 | 北京民海生物科技有限公司 | 呼吸道合胞病毒融合前f蛋白突变体及其应用 |
| CN120192385B (zh) * | 2025-02-07 | 2025-11-11 | 复星安特金(成都)生物制药有限公司 | Rsv f蛋白突变体及其应用 |
Family Cites Families (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235877A (en) | 1979-06-27 | 1980-11-25 | Merck & Co., Inc. | Liposome particle containing viral or bacterial antigenic subunit |
| US4372945A (en) | 1979-11-13 | 1983-02-08 | Likhite Vilas V | Antigen compounds |
| IL61904A (en) | 1981-01-13 | 1985-07-31 | Yeda Res & Dev | Synthetic vaccine against influenza virus infections comprising a synthetic peptide and process for producing same |
| DE3584341D1 (de) | 1984-08-24 | 1991-11-14 | Upjohn Co | Rekombinante dna-verbindungen und expression von polypeptiden wie tpa. |
| US5168062A (en) | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
| US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| NZ230747A (en) | 1988-09-30 | 1992-05-26 | Bror Morein | Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina |
| JPH0832638B2 (ja) | 1989-05-25 | 1996-03-29 | カイロン コーポレイション | サブミクロン油滴乳剤を含んで成るアジュバント製剤 |
| FR2705686B1 (fr) | 1993-05-28 | 1995-08-18 | Transgene Sa | Nouveaux adénovirus défectifs et lignées de complémentation correspondantes. |
| US5851806A (en) | 1994-06-10 | 1998-12-22 | Genvec, Inc. | Complementary adenoviral systems and cell lines |
| ATE336587T1 (de) | 1994-06-10 | 2006-09-15 | Genvec Inc | Adenoviren-vektor systeme und zelllinien |
| US5846782A (en) | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
| US5965541A (en) | 1995-11-28 | 1999-10-12 | Genvec, Inc. | Vectors and methods for gene transfer to cells |
| US5559099A (en) | 1994-09-08 | 1996-09-24 | Genvec, Inc. | Penton base protein and methods of using same |
| US5786464C1 (en) | 1994-09-19 | 2012-04-24 | Gen Hospital Corp | Overexpression of mammalian and viral proteins |
| AUPM873294A0 (en) | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
| US5837520A (en) | 1995-03-07 | 1998-11-17 | Canji, Inc. | Method of purification of viral vectors |
| ATE445705T1 (de) | 1995-06-15 | 2009-10-15 | Crucell Holland Bv | Verpackungssysteme für humane rekombinante adenoviren zur gentherapie |
| US5837511A (en) | 1995-10-02 | 1998-11-17 | Cornell Research Foundation, Inc. | Non-group C adenoviral vectors |
| CA2177085C (en) | 1996-04-26 | 2007-08-14 | National Research Council Of Canada | Adenovirus e1-complementing cell lines |
| CZ438398A3 (cs) | 1996-07-01 | 1999-03-17 | Rhone-Poulenc Rorer S. A. | Způsob přípravy rekombinantních adenovirů |
| FR2751343B1 (fr) | 1996-07-16 | 1998-12-18 | Transgene Sa | Procede de conservation de virus recombinants infectieux, suspension aqueuse virale et utilisation comme medicament |
| AU4255397A (en) | 1996-09-06 | 1998-03-26 | Trustees Of The University Of Pennsylvania, The | Chimpanzee adenovirus vectors |
| JP4492826B2 (ja) | 1996-11-20 | 2010-06-30 | イントロジェン セラピューティクス，インコーポレイテッド | アデノウイルスベクターの産生および精製のための改良された方法 |
| US7732129B1 (en) | 1998-12-01 | 2010-06-08 | Crucell Holland B.V. | Method for the production and purification of adenoviral vectors |
| US6261823B1 (en) | 1996-12-13 | 2001-07-17 | Schering Corporation | Methods for purifying viruses |
| EP0973866A4 (en) | 1997-03-04 | 2000-04-19 | Baxter Int | ADENOVIRUS E1-COMPLEMENTING CELL LINES |
| US6020191A (en) | 1997-04-14 | 2000-02-01 | Genzyme Corporation | Adenoviral vectors capable of facilitating increased persistence of transgene expression |
| US6210683B1 (en) | 1997-09-05 | 2001-04-03 | Merck & Co., Inc. | Stabilizers containing recombinant human serum albumin for live virus vaccines |
| DK1054955T3 (da) | 1998-02-17 | 2007-01-15 | Schering Corp | Sammensætninger omfattende vira og fremgangsmåde til at opkoncentrere viruspræparater |
| US5981225A (en) | 1998-04-16 | 1999-11-09 | Baylor College Of Medicine | Gene transfer vector, recombinant adenovirus particles containing the same, method for producing the same and method of use of the same |
| US6113913A (en) | 1998-06-26 | 2000-09-05 | Genvec, Inc. | Recombinant adenovirus |
| ES2323991T3 (es) | 1998-11-16 | 2009-07-28 | Introgen Therapeutics, Inc. | Formulacion de adenovirus para terapia genica. |
| US6225289B1 (en) | 1998-12-10 | 2001-05-01 | Genvec, Inc. | Methods and compositions for preserving adenoviral vectors |
| DK1818408T3 (da) | 1999-05-17 | 2011-10-17 | Crucell Holland Bv | Rekombinant adenovirus af serotypen Ad11 |
| US6492169B1 (en) | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
| US6913922B1 (en) | 1999-05-18 | 2005-07-05 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
| DE19955558C2 (de) | 1999-11-18 | 2003-03-20 | Stefan Kochanek | Permanente Amniozyten-Zelllinie, ihre Herstellung und Verwendung zur Herstellung von Gentransfervektoren |
| CA2799545A1 (en) | 2000-03-07 | 2001-09-13 | Merck Sharp & Dohme Corp. | Adenovirus formulations |
| EP1287159A4 (en) | 2000-05-08 | 2005-02-09 | Davisco Foods Int Inc | Enzymatic treatment of whey proteins for the production of antihypertensive peptides, the resulting products and treatment of hypertension in mammals |
| AUPR878401A0 (en) | 2001-11-09 | 2001-12-06 | Biota Holdings Ltd | Methods for identifying or screening anti-viral agents |
| JP4550421B2 (ja) | 2001-12-12 | 2010-09-22 | メイン・ファ−マ・インタ−ナショナル・プロプライエタリ−・リミテッド | ウイルスの保存のための組成物 |
| BR0306925A (pt) | 2002-01-18 | 2004-11-09 | Schering Ag | Formulações estabilizadas de adenovìrus |
| US20030180936A1 (en) | 2002-03-15 | 2003-09-25 | Memarzadeh Bahram Eric | Method for the purification, production and formulation of oncolytic adenoviruses |
| PT1497438E (pt) | 2002-04-25 | 2010-02-04 | Crucell Holland Bv | Meios e métodos para a produção de vectores de adenovírus |
| DK1497440T3 (da) | 2002-04-25 | 2008-12-01 | Crucell Holland Bv | Stabile adenovirale vektorer og fremgangsmåder til propagering deraf |
| ES2285120T3 (es) | 2002-05-14 | 2007-11-16 | MERCK & CO., INC. | Procedimientos de purificacion de adenovirus. |
| SE0202110D0 (sv) | 2002-07-05 | 2002-07-05 | Isconova Ab | Iscom preparation and use thereof |
| CA2496918A1 (en) | 2002-08-28 | 2004-03-11 | Introgen Therapeutics Inc. | Chromatographic methods for adenovirus purification |
| SE0301998D0 (sv) | 2003-07-07 | 2003-07-07 | Isconova Ab | Quil A fraction with low toxicity and use thereof |
| DK1711518T3 (da) | 2004-01-23 | 2010-04-06 | Angeletti P Ist Richerche Bio | Vaccinebærere for chimpanse-adenovirus |
| CN1922308A (zh) | 2004-02-23 | 2007-02-28 | 克鲁塞尔荷兰公司 | 病毒纯化方法 |
| CA2602944C (en) | 2005-04-11 | 2015-08-11 | Crucell Holland B.V. | Virus purification using ultrafiltration |
| WO2007104792A2 (en) | 2006-03-16 | 2007-09-20 | Crucell Holland B.V. | Recombinant adenoviruses based on serotype 26 and 48, and use thereof |
| EP1998804B1 (en) | 2006-03-27 | 2014-04-16 | Crucell Holland B.V. | Compositions comprising a recombinant adenovirus and an adjuvant |
| US8772256B2 (en) | 2006-11-30 | 2014-07-08 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Codon modified immunogenic compositions and methods of use |
| US7901388B2 (en) | 2007-07-13 | 2011-03-08 | Bacoustics, Llc | Method of treating wounds by creating a therapeutic solution with ultrasonic waves |
| JP5711972B2 (ja) | 2007-12-24 | 2015-05-07 | アイディー バイオメディカル コーポレイション オブ ケベック | 組換えｒｓｖ抗原 |
| WO2010014975A2 (en) | 2008-08-01 | 2010-02-04 | Academia Sinica | Use of microrna signatures for assessing risk levels of neuroblastoma patients |
| WO2010060719A1 (en) | 2008-11-03 | 2010-06-03 | Crucell Holland B.V. | Method for the production of adenoviral vectors |
| AU2010209938A1 (en) | 2009-02-02 | 2011-08-25 | Glaxosmithkline Biologicals Sa | Simian adenovirus nucleic acid- and amino acid-sequences, vectors containing same, and uses thereof |
| SG176807A1 (en) | 2009-06-24 | 2012-01-30 | Id Biomedical Corp Quebec | Vaccine |
| PT2445526T (pt) | 2009-06-24 | 2016-08-16 | Glaxosmithkline Biologicals Sa | Antigénios de rsv recombinantes |
| PL3178490T3 (pl) | 2009-07-15 | 2022-08-01 | Glaxosmithkline Biologicals S.A. | Kompozycje białka f rsv i sposoby ich wytwarzania |
| ES2553440T3 (es) | 2009-08-13 | 2015-12-09 | Crucell Holland B.V. | Anticuerpos contra el virus sincitial respiratorio humano (VSR) y método de uso |
| CN102791852B (zh) | 2009-10-15 | 2014-05-07 | 克鲁塞尔荷兰公司 | 纯化腺病毒颗粒的方法 |
| KR101805938B1 (ko) | 2009-10-15 | 2018-01-10 | 얀센 백신스 앤드 프리벤션 비.브이. | 고밀도 세포 배양액에서 아데노바이러스의 정제 방법 |
| US20120315270A1 (en) | 2009-10-21 | 2012-12-13 | The United States Of America, As Represented By The | Rsv immunogens, antibodies and compositions thereof |
| EP2536829B1 (en) | 2010-02-15 | 2016-04-06 | Crucell Holland B.V. | Method for the production of Ad26 adenoviral vectors |
| TWI627964B (zh) | 2010-07-09 | 2018-07-01 | 傑森疫苗防護公司 | 抗-人類呼吸道融合性病毒（ｒｓｖ）抗體及其使用方法 |
| ES2651143T3 (es) | 2011-05-13 | 2018-01-24 | Glaxosmithkline Biologicals Sa | Antígenos de F de prefusión del VRS |
| CA2864956C (en) | 2012-03-12 | 2021-11-09 | Crucell Holland B.V. | Batches of recombinant adenovirus with altered terminal ends |
| US8932607B2 (en) | 2012-03-12 | 2015-01-13 | Crucell Holland B.V. | Batches of recombinant adenovirus with altered terminal ends |
| AP2014007993A0 (en) | 2012-03-22 | 2014-10-31 | Crucell Holland Bv | Vaccine against RSV |
| JP2013247240A (ja) | 2012-05-25 | 2013-12-09 | Gigaphoton Inc | レーザ装置 |
| WO2014005643A1 (en) | 2012-07-05 | 2014-01-09 | Okairos Ag | Novel prime-boosting regimens involving immunogenic polypeptides encoded by polynucleotides |
| CN105473604B (zh) | 2013-03-13 | 2021-01-22 | 美国政府(由卫生和人类服务部的部长所代表) | 融合前rsv f蛋白和其用途 |
| US9738689B2 (en) * | 2013-03-13 | 2017-08-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Prefusion RSV F proteins and their use |
| KR102201555B1 (ko) | 2013-04-15 | 2021-01-12 | 얀센 백신스 앤드 프리벤션 비.브이. | Ｒｓｖ ｇ 단백질에 결합하는 인간 항체 |
| JP6412107B2 (ja) | 2013-04-15 | 2018-10-24 | ヤンセン ファッシンズ アンド プリベンション ベーフェーＪａｎｓｓｅｎ Ｖａｃｃｉｎｅｓ ＆ Ｐｒｅｖｅｎｔｉｏｎ Ｂ．Ｖ． | Ｒｓｖｇタンパク質に結合するヒト抗体 |
| CN110590916A (zh) | 2013-04-25 | 2019-12-20 | 扬森疫苗与预防公司 | 稳定化的可溶性融合前rsv f多肽 |
| KR102313153B1 (ko) * | 2013-06-17 | 2021-10-15 | 얀센 백신스 앤드 프리벤션 비.브이. | 안정화된 가용성 예비융합 ｒｓｖ ｆ 폴리펩타이드 |
| JP6685903B2 (ja) | 2013-07-25 | 2020-04-22 | アバター・メディカル・エルエルシー | 立体構造的に安定化されたｒｓｖ融合前ｆタンパク質 |
| TR201900274T4 (tr) | 2013-09-19 | 2019-02-21 | Janssen Vaccines & Prevention Bv | Geliştirilmiş adenovirüs formülasyonları. |
| BR112018070323A2 (pt) | 2016-04-05 | 2019-01-29 | Janssen Vaccines & Prevention Bv | vacina contra rsv |
| KR20220041966A (ko) * | 2016-04-05 | 2022-04-01 | 얀센 백신스 앤드 프리벤션 비.브이. | 안정화된 용해성 융합-전 rsv f 단백질 |
-
2014
- 2014-04-24 CN CN201910911639.8A patent/CN110590916A/zh active Pending
- 2014-04-24 WO PCT/EP2014/058353 patent/WO2014174018A1/en not_active Ceased
- 2014-04-24 SM SM20190138T patent/SMT201900138T1/it unknown
- 2014-04-24 JP JP2016509467A patent/JP6469081B2/ja not_active Expired - Fee Related
- 2014-04-24 ME MEP-2019-73A patent/ME03442B/me unknown
- 2014-04-24 LT LTEP14719022.7T patent/LT2988780T/lt unknown
- 2014-04-24 TR TR2019/02513T patent/TR201902513T4/tr unknown
- 2014-04-24 HR HRP20190175TT patent/HRP20190175T1/hr unknown
- 2014-04-24 MY MYPI2015703748A patent/MY181066A/en unknown
- 2014-04-24 RS RS20190170A patent/RS58436B1/sr unknown
- 2014-04-24 PL PL14719022T patent/PL2988780T3/pl unknown
- 2014-04-24 HU HUE14719022A patent/HUE041659T2/hu unknown
- 2014-04-24 US US14/786,955 patent/US10899800B2/en active Active
- 2014-04-24 EA EA201592048A patent/EA035522B1/ru unknown
- 2014-04-24 EP EP14719022.7A patent/EP2988780B1/en active Active
- 2014-04-24 EA EA202090675A patent/EA039803B1/ru unknown
- 2014-04-24 SG SG11201508567XA patent/SG11201508567XA/en unknown
- 2014-04-24 KR KR1020157032796A patent/KR102236497B1/ko not_active Expired - Fee Related
- 2014-04-24 EP EP18205858.6A patent/EP3488864A1/en active Pending
- 2014-04-24 MX MX2015014890A patent/MX361774B/es active IP Right Grant
- 2014-04-24 ES ES14719022T patent/ES2715378T3/es active Active
- 2014-04-24 PE PE2015002278A patent/PE20151867A1/es unknown
- 2014-04-24 SI SI201431056T patent/SI2988780T1/sl unknown
- 2014-04-24 CN CN201480023229.5A patent/CN105188745B/zh active Active
- 2014-04-24 AP AP2015008815A patent/AP2015008815A0/xx unknown
- 2014-04-24 DK DK14719022.7T patent/DK2988780T3/en active
- 2014-04-24 PT PT14719022T patent/PT2988780T/pt unknown
- 2014-04-24 CA CA2910067A patent/CA2910067C/en active Active
- 2014-04-24 AU AU2014259474A patent/AU2014259474B2/en not_active Ceased
- 2014-04-25 AR ARP140101738A patent/AR096113A1/es not_active Application Discontinuation
- 2014-04-25 TW TW103115087A patent/TWI663175B/zh active
-
2015
- 2015-10-13 PH PH12015502377A patent/PH12015502377B1/en unknown
- 2015-10-20 IL IL242186A patent/IL242186B/en active IP Right Grant
- 2015-10-22 CL CL2015003124A patent/CL2015003124A1/es unknown
- 2015-10-23 ZA ZA2015/07912A patent/ZA201507912B/en unknown
-
2018
- 2018-11-29 MY MYPI2018002243A patent/MY201791A/en unknown
-
2019
- 2019-03-13 CY CY20191100303T patent/CY1121600T1/el unknown
-
2020
- 2020-12-18 US US17/126,128 patent/US20210101940A1/en not_active Abandoned
-
2022
- 2022-08-23 US US17/821,694 patent/US20230265127A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ME03442B (me) | Stabilizovani rastvorljivi pre-fuzioni rsv f polipeptidi | |
| DK3342773T3 (da) | Syk-hæmmere | |
| DK3613453T3 (da) | Fordamper | |
| EP2989885A4 (en) | HARVESTER | |
| DK3077047T3 (da) | Aramcholsalte | |
| DK3052081T3 (da) | Pastil | |
| DK3060460T3 (da) | Saddel | |
| DK2956698T5 (da) | Bindestrimler | |
| PL2945641T3 (pl) | Cykloalkinowe pochodne sacharydów | |
| DK2946640T3 (da) | Langmuir-probe | |
| EP2943489A4 (en) | DEUTERATED MOMELOTINIB | |
| DE102013106534B8 (de) | Chromatographiepipettenspitze | |
| EP2991647A4 (en) | DEUTERED AMLEXANOX | |
| CL2014000068S1 (es) | Hebilla | |
| EP2970310A4 (en) | 5-BROMO-indirubins | |
| EP2853297A4 (en) | kendama | |
| DK3071227T3 (da) | Fiskevaccine | |
| HUE050917T2 (hu) | Hidrokortizon-tartalmú készítmény | |
| DE112014001252A5 (de) | Aufbissschiene | |
| DK3086679T3 (da) | Sportssko | |
| DK2981168T3 (da) | Laminitiskile | |
| FR3008288B1 (fr) | 2sap | |
| FI10138U1 (fi) | Kelkkateltta | |
| DE112014005422A5 (de) | Friktionsfalschdrallaggregat | |
| UA25711S (uk) | Серветка |