SG11201508567XA - Stabilized soluble prefusion rsv f polypeptides - Google Patents

Stabilized soluble prefusion rsv f polypeptides

Info

Publication number
SG11201508567XA
SG11201508567XA SG11201508567XA SG11201508567XA SG11201508567XA SG 11201508567X A SG11201508567X A SG 11201508567XA SG 11201508567X A SG11201508567X A SG 11201508567XA SG 11201508567X A SG11201508567X A SG 11201508567XA SG 11201508567X A SG11201508567X A SG 11201508567XA
Authority
SG
Singapore
Prior art keywords
polypeptides
stabilized soluble
prefusion rsv
soluble prefusion
rsv
Prior art date
Application number
SG11201508567XA
Inventor
Johannes Petrus Maria Langedijk
Anders Krarup
Original Assignee
Crucell Holland Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48326107&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201508567X(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Crucell Holland Bv filed Critical Crucell Holland Bv
Publication of SG11201508567XA publication Critical patent/SG11201508567XA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/155Paramyxoviridae, e.g. parainfluenza virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08RNA viruses
    • C07K14/115Paramyxoviridae, e.g. parainfluenza virus
    • C07K14/135Respiratory syncytial virus
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55561CpG containing adjuvants; Oligonucleotide containing adjuvants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/18011Paramyxoviridae
    • C12N2760/18511Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18522New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/18011Paramyxoviridae
    • C12N2760/18511Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18534Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SG11201508567XA 2013-04-25 2014-04-24 Stabilized soluble prefusion rsv f polypeptides SG11201508567XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13165402 2013-04-25
PCT/EP2014/058353 WO2014174018A1 (en) 2013-04-25 2014-04-24 Stabilized soluble prefusion rsv f polypeptides

Publications (1)

Publication Number Publication Date
SG11201508567XA true SG11201508567XA (en) 2015-11-27

Family

ID=48326107

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201508567XA SG11201508567XA (en) 2013-04-25 2014-04-24 Stabilized soluble prefusion rsv f polypeptides

Country Status (33)

Country Link
US (3) US10899800B2 (en)
EP (2) EP3488864A1 (en)
JP (1) JP6469081B2 (en)
KR (1) KR102236497B1 (en)
CN (2) CN105188745B (en)
AP (1) AP2015008815A0 (en)
AR (1) AR096113A1 (en)
AU (1) AU2014259474B2 (en)
CA (1) CA2910067C (en)
CL (1) CL2015003124A1 (en)
CY (1) CY1121600T1 (en)
DK (1) DK2988780T3 (en)
EA (2) EA035522B1 (en)
ES (1) ES2715378T3 (en)
HK (1) HK1220124A1 (en)
HR (1) HRP20190175T1 (en)
HU (1) HUE041659T2 (en)
IL (1) IL242186B (en)
LT (1) LT2988780T (en)
ME (1) ME03442B (en)
MX (1) MX361774B (en)
MY (2) MY181066A (en)
PE (1) PE20151867A1 (en)
PH (1) PH12015502377B1 (en)
PL (1) PL2988780T3 (en)
PT (1) PT2988780T (en)
RS (1) RS58436B1 (en)
SG (1) SG11201508567XA (en)
SI (1) SI2988780T1 (en)
TR (1) TR201902513T4 (en)
TW (1) TWI663175B (en)
WO (1) WO2014174018A1 (en)
ZA (1) ZA201507912B (en)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11446374B2 (en) 2008-12-09 2022-09-20 Novavax, Inc. Modified RSV F proteins and methods of their use
DK2370099T3 (en) 2008-12-09 2016-08-01 Novavax Inc Rsv f modified proteins and methods of their use
DK2970398T3 (en) 2013-03-13 2024-08-05 Us Health PREFUSION RSV-F PROTEINS AND USE THEREOF
US9738689B2 (en) 2013-03-13 2017-08-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Prefusion RSV F proteins and their use
AP2015008815A0 (en) 2013-04-25 2015-10-31 Crucell Holland Bv Stabilized soluble prefusion rsv f polypeptides
MY171210A (en) 2013-06-17 2019-10-02 Janssen Vaccines & Prevention Bv Stabilized soluble pre-fusion rsv f polypeptides
WO2016160166A1 (en) 2015-03-30 2016-10-06 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Immunogenic rsv polypeptides
EP3319634B1 (en) * 2015-07-07 2019-08-21 Janssen Vaccines & Prevention B.V. Stabilized soluble pre-fusion rsv f polypeptides
JP7189014B2 (en) * 2015-07-07 2022-12-13 ヤンセン ファッシンズ アンド プリベンション ベーフェー Vaccine against RSV
EP3344288A1 (en) 2015-09-02 2018-07-11 Janssen Vaccines & Prevention B.V. Stabilized viral class i fusion proteins
CN114617959A (en) 2015-09-03 2022-06-14 诺瓦瓦克斯股份有限公司 Vaccine compositions with improved stability and immunogenicity
AU2016379097C1 (en) 2015-12-23 2021-04-08 Pfizer Inc. RSV F protein mutants
MY197217A (en) 2016-02-03 2023-06-01 Janssen Sciences Ireland Uc Combination products for the treatment of rsv
WO2017172890A1 (en) 2016-03-29 2017-10-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Substitutions-modified prefusion rsv f proteins and their use
JP7233928B2 (en) * 2016-04-05 2023-03-07 ヤンセン ファッシンズ アンド プリベンション ベーフェー Vaccine against RSV
DK3439672T3 (en) 2016-04-05 2021-02-15 Janssen Vaccines & Prevention Bv STABILIZED SOLUBLE PREFUSION RSV-F PROTEINS
WO2017207477A1 (en) 2016-05-30 2017-12-07 Janssen Vaccines & Prevention B.V. Stabilized pre-fusion rsv f proteins
ES2836598T3 (en) * 2016-05-30 2021-06-25 Janssen Vaccines & Prevention Bv Stabilized prefusion RSV F proteins
CN108265079A (en) * 2017-01-02 2018-07-10 刘昕 A kind of preparation method of novel respiratory tract syncytial virus pre-F fusion protein carriers
EP3595713A4 (en) 2017-03-15 2021-01-13 ModernaTX, Inc. Respiratory syncytial virus vaccine
MA47790A (en) 2017-03-17 2021-05-05 Modernatx Inc RNA-BASED VACCINES AGAINST ZOONOTIC DISEASES
WO2018187325A1 (en) 2017-04-04 2018-10-11 University Of Washington Self-assembling protein nanostructures displaying paramyxovirus and/or pneumovirus f proteins and their use
JP2020519663A (en) * 2017-05-17 2020-07-02 ヤンセン ファッシンズ アンド プリベンション ベーフェーJanssen Vaccines & Prevention B.V. Methods and compositions for inducing protective immunity against RSV infection
US12083228B2 (en) 2017-07-24 2024-09-10 Novavax, Inc. Methods and compositions for treating respiratory disease
SG11202001458SA (en) * 2017-09-15 2020-03-30 Janssen Vaccines & Prevention Bv Method for the safe induction of immunity against rsv
KR102700187B1 (en) * 2017-09-29 2024-08-28 에스케이바이오사이언스(주) Modified soluble RSV F protein antigen
MA54676A (en) 2018-01-29 2021-11-17 Modernatx Inc RSV RNA VACCINES
BR112020019108A2 (en) 2018-03-19 2020-12-29 Novavax, Inc. POLLVALENT NANOPARTICLE VACCINES OF INFLUENZA
US20210401969A1 (en) * 2018-10-29 2021-12-30 Emory University Rsv virus-like particles and methods of use thereof
WO2020099383A1 (en) 2018-11-13 2020-05-22 Janssen Vaccines & Prevention B.V. Stabilized pre-fusion rsv f proteins
CN109851678A (en) * 2019-03-07 2019-06-07 苏州宇之波生物科技有限公司 A kind of inferior stable state bovine respiratory syncytial virus of improvement merges DNA molecular and its application of precursor F protein matter and coding
AU2020275455A1 (en) 2019-05-15 2021-12-09 Janssen Vaccines & Prevention B.V. Co-administration of seasonal influenza vaccine and an adenovirus based respiratory syncytial virus vaccine
CN113950333A (en) 2019-05-15 2022-01-18 扬森疫苗与预防公司 Prophylactic treatment of respiratory syncytial virus infection using adenovirus-based vaccines
US20220306697A1 (en) 2019-09-04 2022-09-29 University Of Washington Self-Assembling Protein Nanostructures Displaying Paramyxovirus and/or Pneumovirus F Proteins and Their Use
CN111303245B (en) * 2020-02-21 2023-06-27 成都奥达生物科技有限公司 Anti-syncytial virus membrane fusion inhibitor
EP4126023A1 (en) 2020-04-02 2023-02-08 Janssen Vaccines & Prevention B.V. Stabilized vaccine compositions
IL299515A (en) 2020-06-29 2023-02-01 Janssen Vaccines & Prevention Bv Vaccine combination against respiratory syncytial virus infection
CN112220921B (en) * 2020-08-25 2022-08-16 北京交通大学 Combined vaccine for respiratory syncytial virus infection
JP2022060169A (en) 2020-10-02 2022-04-14 ファイザー・インク Cell culture process for rsv f protein production
WO2022175479A1 (en) 2021-02-19 2022-08-25 Janssen Vaccines & Prevention B.V. Vaccine combinations against respiratory syncytial virus strain a and b infections
CN114195867B (en) * 2021-12-15 2024-05-03 北京交通大学 RSV pre-fusion F protein, expression plasmid, cell strain and RSV vaccine composition
WO2023110618A1 (en) 2021-12-16 2023-06-22 Janssen Vaccines & Prevention B.V. Stabilized pre-fusion hmpv fusion proteins
WO2024069420A2 (en) 2022-09-29 2024-04-04 Pfizer Inc. Immunogenic compositions comprising an rsv f protein trimer
WO2024067725A1 (en) * 2022-09-29 2024-04-04 北京百邑无忧科技发展有限公司 Respiratory syncytial virus recombinant fusion protein with prefusion conformation, and preparation method therefor and use thereof
CN116478296B (en) * 2022-10-17 2024-02-23 厦门大学 Truncated respiratory syncytial virus F proteins and uses thereof
WO2024089634A1 (en) 2022-10-27 2024-05-02 Pfizer Inc. Immunogenic compositions against influenza and rsv
WO2024089633A1 (en) 2022-10-27 2024-05-02 Pfizer Inc. Rna molecules encoding rsv-f and vaccines containing them
CN116284266B (en) * 2022-11-21 2024-01-19 怡道生物科技(苏州)有限公司 Mutant respiratory syncytial virus pre-fusion F protein and application thereof
WO2024127181A1 (en) 2022-12-11 2024-06-20 Pfizer Inc. Immunogenic compositions against influenza and rsv
WO2024155561A2 (en) * 2023-01-17 2024-07-25 The Scripps Research Institute Engineered paramyxovirus soluble fusion (f) proteins and related vaccines
US20240252614A1 (en) 2023-01-18 2024-08-01 Pfizer Inc. Vaccines against respiratory diseases
CN116785421B (en) * 2023-08-21 2024-01-09 中国农业科学院哈尔滨兽医研究所(中国动物卫生与流行病学中心哈尔滨分中心) mRNA vaccine of bovine respiratory syncytial virus and application thereof
CN117736278A (en) * 2023-12-25 2024-03-22 英诺特(唐山)生物技术有限公司 Kit and detection method for detecting respiratory syncytial virus infection
CN117586357B (en) * 2024-01-19 2024-07-09 北京安百胜生物科技有限公司 Respiratory Syncytial Virus (RSV) polypeptides having immunogenicity

Family Cites Families (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235877A (en) 1979-06-27 1980-11-25 Merck & Co., Inc. Liposome particle containing viral or bacterial antigenic subunit
US4372945A (en) 1979-11-13 1983-02-08 Likhite Vilas V Antigen compounds
IL61904A (en) 1981-01-13 1985-07-31 Yeda Res & Dev Synthetic vaccine against influenza virus infections comprising a synthetic peptide and process for producing same
DE3584341D1 (en) 1984-08-24 1991-11-14 Upjohn Co RECOMBINANT DNA COMPOUNDS AND EXPRESSION OF POLYPEPTIDES LIKE TPA.
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
NZ230747A (en) 1988-09-30 1992-05-26 Bror Morein Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina
HU212924B (en) 1989-05-25 1996-12-30 Chiron Corp Adjuvant formulation comprising a submicron oil droplet emulsion
FR2705686B1 (en) 1993-05-28 1995-08-18 Transgene Sa New defective adenoviruses and corresponding complementation lines.
US5851806A (en) 1994-06-10 1998-12-22 Genvec, Inc. Complementary adenoviral systems and cell lines
CA2192442C (en) 1994-06-10 2007-09-25 Imre Kovesdi Complementary adenoviral vector systems and cell lines
US5965541A (en) 1995-11-28 1999-10-12 Genvec, Inc. Vectors and methods for gene transfer to cells
US5559099A (en) 1994-09-08 1996-09-24 Genvec, Inc. Penton base protein and methods of using same
US5846782A (en) 1995-11-28 1998-12-08 Genvec, Inc. Targeting adenovirus with use of constrained peptide motifs
US5786464C1 (en) 1994-09-19 2012-04-24 Gen Hospital Corp Overexpression of mammalian and viral proteins
AUPM873294A0 (en) 1994-10-12 1994-11-03 Csl Limited Saponin preparations and use thereof in iscoms
US5837520A (en) 1995-03-07 1998-11-17 Canji, Inc. Method of purification of viral vectors
IL122614A0 (en) 1995-06-15 1998-08-16 Introgene Bv Packaging systems for human recombinant adenovirus to be used in gene therapy
US5837511A (en) 1995-10-02 1998-11-17 Cornell Research Foundation, Inc. Non-group C adenoviral vectors
CA2177085C (en) 1996-04-26 2007-08-14 National Research Council Of Canada Adenovirus e1-complementing cell lines
AU3447097A (en) 1996-07-01 1998-01-21 Rhone-Poulenc Rorer S.A. Method for producing recombinant adenovirus
FR2751343B1 (en) 1996-07-16 1998-12-18 Transgene Sa PROCESS FOR THE PRESERVATION OF INFECTIOUS RECOMBINANT VIRUSES, AQUEOUS VIRAL SUSPENSION, AND USE AS A MEDICAMENT
US6083716A (en) 1996-09-06 2000-07-04 The Trustees Of The University Of Pennsylvania Chimpanzee adenovirus vectors
DE69737107T2 (en) 1996-11-20 2007-07-12 Introgen Therapeutics Inc., Austin AN IMPROVED PROCESS FOR THE PRODUCTION AND CLEANING OF ADENOVIRAL VECTORS
US7732129B1 (en) 1998-12-01 2010-06-08 Crucell Holland B.V. Method for the production and purification of adenoviral vectors
US6261823B1 (en) 1996-12-13 2001-07-17 Schering Corporation Methods for purifying viruses
JP2000509614A (en) 1997-03-04 2000-08-02 バクスター インターナショナル インコーポレイテッド Adenovirus E1-complementation cell line
US6020191A (en) 1997-04-14 2000-02-01 Genzyme Corporation Adenoviral vectors capable of facilitating increased persistence of transgene expression
US6210683B1 (en) 1997-09-05 2001-04-03 Merck & Co., Inc. Stabilizers containing recombinant human serum albumin for live virus vaccines
KR100912362B1 (en) 1998-02-17 2009-08-19 쉐링 코포레이션 Methods for purifying virus preparations
US5981225A (en) 1998-04-16 1999-11-09 Baylor College Of Medicine Gene transfer vector, recombinant adenovirus particles containing the same, method for producing the same and method of use of the same
US6113913A (en) 1998-06-26 2000-09-05 Genvec, Inc. Recombinant adenovirus
ATE421337T1 (en) 1998-11-16 2009-02-15 Introgen Therapeutics Inc ADENOVIRUS FORMULATIONS FOR GENE THERAPY
US6225289B1 (en) 1998-12-10 2001-05-01 Genvec, Inc. Methods and compositions for preserving adenoviral vectors
AU777041B2 (en) 1999-05-17 2004-09-30 Crucell Holland B.V. Adenovirus derived gene delivery vehicles comprising at least one element of adenovirus type 35
US6492169B1 (en) 1999-05-18 2002-12-10 Crucell Holland, B.V. Complementing cell lines
US6913922B1 (en) 1999-05-18 2005-07-05 Crucell Holland B.V. Serotype of adenovirus and uses thereof
DE19955558C2 (en) 1999-11-18 2003-03-20 Stefan Kochanek Permanent amniocyte cell line, its production and use for the production of gene transfer vectors
US20020041884A1 (en) 2000-03-07 2002-04-11 Evans Robert K. Adenovirus formulations
CA2415688A1 (en) 2000-05-08 2001-11-15 Anand Rao Enzymatic treatment of whey proteins for the production of antihypertensive peptides, the resulting products and treatment of hypertension in mammals
AUPR878401A0 (en) 2001-11-09 2001-12-06 Biota Holdings Ltd Methods for identifying or screening anti-viral agents
JP4550421B2 (en) 2001-12-12 2010-09-22 メイン・ファ−マ・インタ−ナショナル・プロプライエタリ−・リミテッド Composition for the preservation of viruses
US20030232018A1 (en) 2002-01-18 2003-12-18 Berlex Biosciences Stabilized formulations of adenovirus
US20030180936A1 (en) 2002-03-15 2003-09-25 Memarzadeh Bahram Eric Method for the purification, production and formulation of oncolytic adenoviruses
ES2335657T3 (en) 2002-04-25 2010-03-31 Crucell Holland B.V. MEANS AND METHODS FOR THE PRODUCTION OF ADENOVIRUS VECTORS.
ATE405663T1 (en) 2002-04-25 2008-09-15 Crucell Holland Bv STABLE ADENOVIRAL VECTORS AND METHODS FOR THEIR PROPAGATION
DE60335672D1 (en) 2002-05-14 2011-02-17 Merck Sharp & Dohme PROCESS FOR CLEANING ADENOVIRUS
SE0202110D0 (en) 2002-07-05 2002-07-05 Isconova Ab Iscom preparation and use thereof
EP1585964A4 (en) 2002-08-28 2008-07-16 Introgen Therapeutics Inc Chromatographic methods for adenovirus purification
SE0301998D0 (en) 2003-07-07 2003-07-07 Isconova Ab Quil A fraction with low toxicity and use thereof
CA2880061C (en) 2004-01-23 2018-03-13 Agostino Cirillo Chimpanzee adenovirus vaccine carriers
ES2329607T3 (en) 2004-02-23 2009-11-27 Crucell Holland B.V. VIRUS PURIFICATION METHODS
ATE412737T1 (en) 2005-04-11 2008-11-15 Crucell Holland Bv VIRUS CLEANING WITH ULTRAFILTRATION
US20100143302A1 (en) 2006-03-16 2010-06-10 Crucell Holland B.V. Recombinant Adenoviruses Based on Serotype 26 and 48, and Use Thereof
WO2007110409A1 (en) 2006-03-27 2007-10-04 Crucell Holland B.V. Compositions comprising a recombinant adenovirus and an adjuvant
EP2099486A2 (en) 2006-11-30 2009-09-16 Government Of The United States Of America, As Represented by the Secretary Codon modified immunogenic compositions and methods of use
US7901388B2 (en) 2007-07-13 2011-03-08 Bacoustics, Llc Method of treating wounds by creating a therapeutic solution with ultrasonic waves
PL2222710T3 (en) * 2007-12-24 2017-01-31 Id Biomedical Corporation Of Quebec Recombinant rsv antigens
WO2010014975A2 (en) 2008-08-01 2010-02-04 Academia Sinica Use of microrna signatures for assessing risk levels of neuroblastoma patients
PL2350268T3 (en) 2008-11-03 2015-05-29 Crucell Holland Bv Method for the production of adenoviral vectors
RU2604815C2 (en) 2009-02-02 2016-12-10 ГлаксоСмитКлайн Байолоджикалз с.а. Simian adenovirus nucleic acid- and amino acid-sequences, vectors containing same, and use thereof
BRPI1015917A2 (en) 2009-06-24 2019-08-27 Glaxosmithkline Biologicals Sa recombinant rsv antigens.
US8889146B2 (en) 2009-06-24 2014-11-18 Glaxosmithkline Biologicals, Sa Vaccine
HUE058971T2 (en) 2009-07-15 2022-09-28 Glaxosmithkline Biologicals Sa Rsv f protein compositions and methods for making same
BR112012003064B8 (en) 2009-08-13 2021-05-25 Crucell Holland Bv antibody or antigen-binding fragment thereof, combination comprising them, method of detecting rsv infection, nucleic acid molecules, and method of producing an antibody or antigen-binding fragment thereof
ES2445713T3 (en) 2009-10-15 2014-03-04 Crucell Holland B.V. Process for adenovirus purification from high cell density cultures
WO2011045378A1 (en) 2009-10-15 2011-04-21 Crucell Holland B.V. Method for the purification of adenovirus particles
US20120315270A1 (en) 2009-10-21 2012-12-13 The United States Of America, As Represented By The Rsv immunogens, antibodies and compositions thereof
NZ601424A (en) 2010-02-15 2014-07-25 Crucell Holland Bv Method for the production of ad26 adenoviral vectors
JP5744196B2 (en) * 2010-07-09 2015-07-08 クルセル ホランド ベー ヴェー Anti-human respiratory polynuclear virus (RSV) antibodies and methods of use
ES2651143T3 (en) 2011-05-13 2018-01-24 Glaxosmithkline Biologicals Sa RS prefusion F antigens
SG11201405228VA (en) 2012-03-12 2014-11-27 Crucell Holland Bv Batches of recombinant adenovirus with altered terminal ends
US8932607B2 (en) 2012-03-12 2015-01-13 Crucell Holland B.V. Batches of recombinant adenovirus with altered terminal ends
EP2827895B1 (en) 2012-03-22 2017-08-09 Janssen Vaccines & Prevention B.V. Vaccine against rsv
JP2013247240A (en) 2012-05-25 2013-12-09 Gigaphoton Inc Laser device
WO2014005643A1 (en) 2012-07-05 2014-01-09 Okairos Ag Novel prime-boosting regimens involving immunogenic polypeptides encoded by polynucleotides
US9738689B2 (en) * 2013-03-13 2017-08-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Prefusion RSV F proteins and their use
DK2970398T3 (en) 2013-03-13 2024-08-05 Us Health PREFUSION RSV-F PROTEINS AND USE THEREOF
EP2986637A1 (en) 2013-04-15 2016-02-24 Crucell Holland B.V. Human antibodies binding to rsv g protein
WO2014170258A1 (en) 2013-04-15 2014-10-23 Crucell Holland B.V. Human antibodies binding to rsv g proteins
AP2015008815A0 (en) 2013-04-25 2015-10-31 Crucell Holland Bv Stabilized soluble prefusion rsv f polypeptides
MY171210A (en) * 2013-06-17 2019-10-02 Janssen Vaccines & Prevention Bv Stabilized soluble pre-fusion rsv f polypeptides
EP3024483B1 (en) 2013-07-25 2020-01-15 Calder Biosciences Inc. Conformationally stabilized rsv pre-fusion f proteins
ES2711115T3 (en) 2013-09-19 2019-04-30 Janssen Vaccines & Prevention Bv Improved adenovirus formulations
DK3439672T3 (en) * 2016-04-05 2021-02-15 Janssen Vaccines & Prevention Bv STABILIZED SOLUBLE PREFUSION RSV-F PROTEINS
JP7233928B2 (en) * 2016-04-05 2023-03-07 ヤンセン ファッシンズ アンド プリベンション ベーフェー Vaccine against RSV

Also Published As

Publication number Publication date
AU2014259474A1 (en) 2015-11-05
MY181066A (en) 2020-12-17
MX361774B (en) 2018-12-17
HK1220124A1 (en) 2017-04-28
HRP20190175T1 (en) 2019-03-22
US20230265127A1 (en) 2023-08-24
SI2988780T1 (en) 2019-05-31
JP2016520039A (en) 2016-07-11
EA035522B1 (en) 2020-06-29
PE20151867A1 (en) 2016-01-07
PT2988780T (en) 2019-03-25
TWI663175B (en) 2019-06-21
EP2988780B1 (en) 2018-12-26
AR096113A1 (en) 2015-12-09
CN110590916A (en) 2019-12-20
WO2014174018A1 (en) 2014-10-30
PL2988780T3 (en) 2019-06-28
CL2015003124A1 (en) 2016-05-13
TR201902513T4 (en) 2019-03-21
KR20160002938A (en) 2016-01-08
EA201592048A1 (en) 2016-04-29
AP2015008815A0 (en) 2015-10-31
EA202090675A2 (en) 2020-06-30
US20160102123A1 (en) 2016-04-14
ZA201507912B (en) 2022-03-30
DK2988780T3 (en) 2019-04-08
US20210101940A1 (en) 2021-04-08
IL242186B (en) 2020-07-30
LT2988780T (en) 2019-03-12
JP6469081B2 (en) 2019-02-13
EP2988780A1 (en) 2016-03-02
NZ713371A (en) 2021-02-26
ME03442B (en) 2020-01-20
PH12015502377A1 (en) 2016-02-22
CY1121600T1 (en) 2020-05-29
KR102236497B1 (en) 2021-04-06
EA202090675A3 (en) 2020-08-31
CA2910067A1 (en) 2014-10-30
US10899800B2 (en) 2021-01-26
CN105188745A (en) 2015-12-23
CN105188745B (en) 2019-10-18
TW201520221A (en) 2015-06-01
CA2910067C (en) 2023-10-17
AU2014259474B2 (en) 2018-09-13
EP3488864A1 (en) 2019-05-29
PH12015502377B1 (en) 2016-02-22
EA039803B1 (en) 2022-03-15
ES2715378T3 (en) 2019-06-04
MY201791A (en) 2024-03-18
HUE041659T2 (en) 2019-05-28
MX2015014890A (en) 2016-03-09
RS58436B1 (en) 2019-04-30

Similar Documents

Publication Publication Date Title
HRP20190175T1 (en) Stabilized soluble prefusion rsv f polypeptides
HK1223949A1 (en) Stabilized soluble pre-fusion rsv f polypeptides rsv f
HK1252317A1 (en) Novel amino pyrimidine derivatives
GB201401167D0 (en) Position sensor
GB201301543D0 (en) Sensor
GB201306097D0 (en) Sensor
AP2015008892A0 (en) Stabilized soluble pre-fusion rsv f polypeptides
PL3014234T3 (en) Sensor
GB201314490D0 (en) Position Sensor
GB201305210D0 (en) Component sensor
GB201311400D0 (en) Position Sensor
GB201313025D0 (en) Sensor