MD4801B1 - Antagonişti ai activin-ActRII şi utilizarea lor pentru tratamentul sindroamelor mielodisplazice - Google Patents

Antagonişti ai activin-ActRII şi utilizarea lor pentru tratamentul sindroamelor mielodisplazice Download PDF

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Publication number
MD4801B1
MD4801B1 MDA20180012A MD20180012A MD4801B1 MD 4801 B1 MD4801 B1 MD 4801B1 MD A20180012 A MDA20180012 A MD A20180012A MD 20180012 A MD20180012 A MD 20180012A MD 4801 B1 MD4801 B1 MD 4801B1
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MD
Moldova
Prior art keywords
activin
myelodysplastic syndromes
actrii antagonists
treating myelodysplastic
subject
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MDA20180012A
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English (en)
Russian (ru)
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MD4801C1 (ro
MD20180012A2 (ro
Inventor
Кеннет М. АТТИ
Кристофер РОВАЛДИ
Абдеррахман ЛААДЕМ
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Celgene Corporation
Acceleron Pharma Inc.
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Publication date
Application filed by Celgene Corporation, Acceleron Pharma Inc. filed Critical Celgene Corporation
Publication of MD20180012A2 publication Critical patent/MD20180012A2/ro
Publication of MD4801B1 publication Critical patent/MD4801B1/ro
Publication of MD4801C1 publication Critical patent/MD4801C1/ro

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/49Blood
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Ecology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Invenţia se referă la metode pentru tratamentul la un subiect al sindroamelor mielodisplazice (SMD) cu risc scăzut sau intermediar-1 la mamifere, în care metodele cuprind administrarea inhibitorilor semnalizării Activin-ActRII la un subiect, care necesită tratament.Secvenţe: 47
MDA20180012A 2014-12-03 2015-12-03 Antagonişti ai activin-ActRII şi utilizarea lor pentru tratamentul sindroamelor mielodisplazice MD4801C1 (ro)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201462086977P 2014-12-03 2014-12-03
US201462088478P 2014-12-05 2014-12-05
US201562153872P 2015-04-28 2015-04-28
US201562173782P 2015-06-10 2015-06-10
US201562218728P 2015-09-15 2015-09-15
PCT/US2015/063595 WO2016090077A1 (en) 2014-12-03 2015-12-03 Activin-actrii antagonists and uses for treating anemia

Publications (3)

Publication Number Publication Date
MD20180012A2 MD20180012A2 (ro) 2018-05-31
MD4801B1 true MD4801B1 (ro) 2022-03-31
MD4801C1 MD4801C1 (ro) 2022-10-31

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20180012A MD4801C1 (ro) 2014-12-03 2015-12-03 Antagonişti ai activin-ActRII şi utilizarea lor pentru tratamentul sindroamelor mielodisplazice

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Country Link
US (1) US11471510B2 (ro)
EP (2) EP4233889A3 (ro)
JP (2) JP2018501307A (ro)
KR (1) KR102556991B1 (ro)
CN (2) CN114675039B (ro)
AU (2) AU2015358469B2 (ro)
BR (1) BR112017011722A2 (ro)
CA (1) CA2969572A1 (ro)
CY (1) CY1126033T1 (ro)
DK (1) DK3227675T3 (ro)
ES (1) ES2946160T3 (ro)
FI (1) FI3227675T3 (ro)
HR (1) HRP20230504T1 (ro)
HU (1) HUE062189T2 (ro)
IL (1) IL252631B2 (ro)
LT (1) LT3227675T (ro)
MD (1) MD4801C1 (ro)
NZ (1) NZ770419A (ro)
PL (1) PL3227675T3 (ro)
PT (1) PT3227675T (ro)
RS (1) RS64214B1 (ro)
SI (1) SI3227675T1 (ro)
SM (1) SMT202300166T1 (ro)
TW (2) TWI773117B (ro)
WO (1) WO2016090077A1 (ro)

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JP2022517951A (ja) * 2019-01-10 2022-03-11 スミトモ ダイニッポン ファーマ オンコロジー, インコーポレイテッド 骨髄異形成症候群を処置するためのalk5阻害剤
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