HRP20230504T1 - Antagonisti aktivin-actrii i upotreba u liječenju mijelodisplastičnog sindroma - Google Patents
Antagonisti aktivin-actrii i upotreba u liječenju mijelodisplastičnog sindroma Download PDFInfo
- Publication number
- HRP20230504T1 HRP20230504T1 HRP20230504TT HRP20230504T HRP20230504T1 HR P20230504 T1 HRP20230504 T1 HR P20230504T1 HR P20230504T T HRP20230504T T HR P20230504TT HR P20230504 T HRP20230504 T HR P20230504T HR P20230504 T1 HRP20230504 T1 HR P20230504T1
- Authority
- HR
- Croatia
- Prior art keywords
- signaling inhibitor
- subject
- actrii signaling
- use according
- months
- Prior art date
Links
- 201000003793 Myelodysplastic syndrome Diseases 0.000 title claims 3
- 239000005557 antagonist Substances 0.000 title 1
- 239000003112 inhibitor Substances 0.000 claims 41
- 230000011664 signaling Effects 0.000 claims 41
- 210000003924 normoblast Anatomy 0.000 claims 13
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 102000001554 Hemoglobins Human genes 0.000 claims 11
- 108010054147 Hemoglobins Proteins 0.000 claims 11
- 230000007774 longterm Effects 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 101100437153 Rattus norvegicus Acvr2b gene Proteins 0.000 claims 2
- 210000003743 erythrocyte Anatomy 0.000 claims 2
- 230000002489 hematologic effect Effects 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 102000005606 Activins Human genes 0.000 claims 1
- 108010059616 Activins Proteins 0.000 claims 1
- 239000000488 activin Substances 0.000 claims 1
- 238000004820 blood count Methods 0.000 claims 1
- 238000005534 hematocrit Methods 0.000 claims 1
- 238000010606 normalization Methods 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- Epidemiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Ecology (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Claims (18)
1. Inhibitor signalizacije receptora aktivina tipa II (ActRII) za upotrebu u postupku liječenja mijelodisplastičnih sindroma (MDS) kod subjekta, pri čemu postupak obuhvaća:
(a) određivanje postotka eritroblasta kod subjekta koji su prstenasti sideroblasti; i
(b) davanje subjektu farmaceutski učinkovite doze inhibitora signalizacije ActRII između 0,1 mg/kg i 2,0 mg/kg, ako je najmanje 15%, 16%, 17%, 18%, 19% ili 20% od eritroblasta kod subjekta prstenasti sideroblasti,
pri čemu je navedeni inhibitor signalizacije ActRII polipeptid koji sadrži:
(i) aminokiselinsku sekvencu koja je najmanje 90% identična sa SEQ ID NO:7;
(ii) aminokiselinsku sekvencu koja je najmanje 95% identična sa SEQ ID NO:7;
(iii) aminokiselinsku sekvencu koja je najmanje 98% identična sa SEQ ID NO:7;
(iv) aminokiselinsku sekvencu SEQ ID NO:7;
(v) aminokiselinsku sekvencu koja je najmanje 90% identična sa SEQ ID NO:25;
(vi) aminokiselinsku sekvencu koja je najmanje 95% identična sa SEQ ID NO:25;
(vii) aminokiselinsku sekvencu koja je najmanje 98% identična sa SEQ ID NO:25;
(viii) aminokiselinsku sekvencu SEQ ID NO:25; ili
(ix) fragment izvanstanične domene ActRIIB, pri čemu se fragment sastoji od aminokiselinske sekvence SEQ ID NO:23; poveznice; i Fc od IgG.
2. Inhibitor signalizacije ActRII za upotrebu prema zahtjevu 1, naznačen time što se postupkom postiže:
(a) dugoročno smanjenje postotka eritroblasta kod subjekta koji su prstenasti sideroblasti u usporedbi s početnim postotkom eritroblasta kod subjekta koji su prstenasti sideroblasti, pri čemu dugoročno smanjenje je smanjenje postotka eritroblasta koje se održava najmanje 1, 2, 3, 4, 5, 6, 12, 18 ili 24 mjeseca nakon razdoblja primjene inhibitora signalizacije ActRII; i/ili
(b) dugotrajno povećanje razine hemoglobina kod subjekta u usporedbi s početnom razinom hemoglobina kod subjekta, pri čemu je početna razina hemoglobina kod subjekta razina hemoglobina kod subjekta u vremenskom razdoblju prije davanja subjektu početne dozu inhibitora signalizacije ActRII; pri čemu dugoročno povećanje je povećanje razine hemoglobina koje se održava najmanje 3, 4, 5, 6, 12, 18 ili 24 mjeseca nakon vremenskog razdoblja primjene inhibitora signalizacije ActRII.
3. Inhibitor signalizacije ActRII za upotrebu prema zahtjevu 1 ili 2, naznačen time što se inhibitor signalizacije ActRII primjenjuje u kratkom vremenskom periodu, i pri čemu je kratki vremenski period 1, 2, 3, 4 ili 5 mjeseci.
4. Inhibitor signalizacije ActRII za upotrebu prema zahtjevu 1 ili 2, naznačen time što postupak nadalje obuhvaća:
(c) određivanje drugog postotka eritroblasta kod subjekta koji su prstenasti sideroblasti nakon određenog vremenskog razdoblja, izborno pri čemu je vremenski period 1, 2, 3, 4, 5 ili 6 mjeseci; i
(d) izborno davanje subjektu prilagođene doze inhibitora signalizacije ActRII.
5. Inhibitor signalizacije ActRII za upotrebu prema zahtjevu 1 ili 2, naznačen time što postupak nadalje obuhvaća:
(c) određivanje razine hemoglobina kod subjekta nakon što je subjektu primijenjen inhibitor signalizacije ActRII, izborno pri čemu se razina hemoglobina određuje unutar 6, 12, 18 i/ili 24 mjeseca nakon što je primijenjen inhibitor signalizacije ActRII; i
(d) prekid primjene inhibitora signalizacije ActRII subjektu, ako je razina hemoglobina kod subjekta najmanje 11 g/dL.
6. Inhibitor signalizacije ActRII za upotrebu prema zahtjevu 1, naznačen time što se postotak eritroblasta kod subjekta koji su prstenasti sideroblasti određuje unutar 1 dana, 2 dana, 3 dana, 4 dana, 5 dana, 6 dana, 1 tjedna, 2 tjedana, 3 tjedna, 4 tjedna, 5 tjedana, 6 tjedana, 7 tjedana, 8 tjedana, 3 mjeseca, 4 mjeseca, 5 mjeseci ili 6 mjeseci davanja subjektu farmaceutski učinkovite doze inhibitora signalizacije ActRII.
7. Inhibitor signalizacije ActRII za upotrebu prema zahtjevu 2, naznačen time što je dugoročno smanjenje postotka eritroblasta kod subjekta koji su prstenasti sideroblasti najmanje 1,5, 2,5, 5,0, 7,5 ili 10,0 puta ispod početnog postotka eritroblasta kod subjekta koji su prstenasti sideroblasti najmanje 6, 12, 18 ili 24 mjeseca nakon razdoblja primjene inhibitora signalizacije ActRII.
8. Inhibitor signalizacije ActRII za upotrebu prema zahtjevu 2, naznačen time što je dugotrajno povećanje razine hemoglobina kod subjekta razina hemoglobina između oko 11 g/dL i 18 g/dL kod subjekta tijekom najmanje 3, 4 , 5, 6, 12, 18 ili 24 mjeseca nakon razdoblja primjene inhibitora signalizacije ActRII.
9. Inhibitor signalizacije ActRII za upotrebu prema zahtjevu 3, naznačen time što
(i) prvi postotak eritroblasta koji su prstenasti sideroblasti kod subjekta kojemu je primijenjen inhibitor signalizacije ActRII tijekom kratkog vremenskog razdoblja smanjen je na manje od 10%, 9%, 8%, 7%, 6%, 5%, 4 %, 3%, 2% ili manje od 1% tijekom najmanje 6, 12, 18 ili 24 mjeseca nakon kratkog vremenskog razdoblja primjene inhibitora signalizacije ActRII; i/ili
(ii) razina hemoglobina kod subjekta kojem je primijenjen inhibitor signalizacije ActRII u kratkom vremenskom razdoblju je između oko 11 g/dL i 18 g/dL tijekom najmanje 3, 4, 5, 6, 12, 18 ili 24 mjeseca nakon razdoblja primjene inhibitora signalizacije ActRII.
10. Inhibitor signalizacije ActRII za upotrebu prema bilo kojem od zahtjeva 1 do 9, naznačen time što subjekt ima povećanu vjerojatnost postizanja normalizacije jednog ili više hematoloških parametara, ako je najmanje 15%, 16%, 17%, 18%, 19 % ili 20% eritroblasta kod subjekta, prstenasti sideroblasti u usporedbi sa subjektom koji ima najviše 15% eritroblasta koji su prstenasti sideroblasti.
11. Inhibitor signalizacije ActRII za upotrebu prema zahtjevu 10, naznačen time što je hematološki parametar razina hemoglobina, hematokrit, broj crvenih krvnih stanica ili postotak eritroblasta kod subjekta koji su prstenasti sideroblasti.
12. Inhibitor signalizacije ActRII za upotrebu prema bilo kojem od zahtjeva 1 do 11, naznačen time što kod subjekta nije potrebna transfuzija crvenih krvnih stanica najmanje 3, 4, 5, 6, 12, 18 ili 24 mjeseca nakon vremenskog razdoblja primjene inhibitora signalizacije ActRII.
13. Inhibitor signalizacije ActRII za upotrebu prema bilo kojem od zahtjeva 1 do 12, naznačen time što se inhibitor signalizacije ActRII primjenjuje:
(i) jednom svaka tri tjedna;
(ii) jednom svakih 28 dana; ili
(iii) jednom svaka 42 dana.
14. Inhibitor signalizacije ActRII za upotrebu prema bilo kojem od zahtjeva 1 do 13, naznačen time što se inhibitor signalizacije ActRII primjenjuje putem injekcije, po izboru pri čemu je injekcija potkožna.
15. Inhibitor signalizacije ActRII za upotrebu prema bilo kojem od zahtjeva 1 do 14, naznačen time što je inhibitor signalizacije ActRII polipeptid koji sadrži aminokiselinsku sekvencu SEQ ID NO:25.
16. Inhibitor signalizacije ActRII za upotrebu prema bilo kojem od zahtjeva 1 do 14, naznačen time što je inhibitor signalizacije ActRII polipeptid koji sadrži aminokiselinsku sekvencu SEQ ID NO:7.
17. Inhibitor signalizacije ActRII za upotrebu prema bilo kojem od zahtjeva 1 do 14, naznačen time što je inhibitor signalizacije ActRII polipeptid koji sadrži fragment izvanstanične domene od ActRIIB, pri čemu se fragment sadrži aminokiselinsku sekvencu SEQ ID NO:23; poveznicu; i Fc od IgG.
18. Inhibitor signalizacije ActRII za upotrebu prema bilo kojem od zahtjeva 1 do 17, pri čemu je subjekt čovjek.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462086977P | 2014-12-03 | 2014-12-03 | |
US201462088478P | 2014-12-05 | 2014-12-05 | |
US201562153872P | 2015-04-28 | 2015-04-28 | |
US201562173782P | 2015-06-10 | 2015-06-10 | |
US201562218728P | 2015-09-15 | 2015-09-15 | |
EP15865213.1A EP3227675B1 (en) | 2014-12-03 | 2015-12-03 | Activin-actrii antagonists and uses for treating myelodysplastic syndrome |
PCT/US2015/063595 WO2016090077A1 (en) | 2014-12-03 | 2015-12-03 | Activin-actrii antagonists and uses for treating anemia |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20230504T1 true HRP20230504T1 (hr) | 2023-09-15 |
Family
ID=56092426
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20230504TT HRP20230504T1 (hr) | 2014-12-03 | 2015-12-03 | Antagonisti aktivin-actrii i upotreba u liječenju mijelodisplastičnog sindroma |
Country Status (24)
Country | Link |
---|---|
US (1) | US11471510B2 (hr) |
EP (2) | EP4233889A3 (hr) |
JP (2) | JP2018501307A (hr) |
KR (1) | KR102556991B1 (hr) |
CN (2) | CN114675039A (hr) |
AU (2) | AU2015358469B2 (hr) |
BR (1) | BR112017011722A2 (hr) |
CA (1) | CA2969572A1 (hr) |
CY (1) | CY1126033T1 (hr) |
DK (1) | DK3227675T3 (hr) |
ES (1) | ES2946160T3 (hr) |
FI (1) | FI3227675T3 (hr) |
HK (2) | HK1245397A1 (hr) |
HR (1) | HRP20230504T1 (hr) |
HU (1) | HUE062189T2 (hr) |
IL (1) | IL252631B1 (hr) |
LT (1) | LT3227675T (hr) |
MD (1) | MD4801C1 (hr) |
PL (1) | PL3227675T3 (hr) |
PT (1) | PT3227675T (hr) |
RS (1) | RS64214B1 (hr) |
SI (1) | SI3227675T1 (hr) |
TW (2) | TWI730949B (hr) |
WO (1) | WO2016090077A1 (hr) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
CA2890217C (en) | 2012-11-02 | 2021-07-20 | Yifu FANG | Activin-actrii antagonists and uses for treating bone and other disorders |
MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
BR112017011722A2 (pt) | 2014-12-03 | 2018-02-27 | Acceleron Pharma Inc | antagonistas de activina-actrii e usos para o tratamento de anemia |
MA41119A (fr) | 2014-12-03 | 2017-10-10 | Acceleron Pharma Inc | Méthodes de traitement de syndromes myélodysplasiques et d'anémie sidéroblastique |
PL3286206T3 (pl) | 2015-04-22 | 2021-09-13 | Biogen Ma Inc. | Nowe hybrydowe białka pułapki na ligand actriib do leczenia chorób powodujących zanik mięśni |
JP2018522579A (ja) | 2015-05-20 | 2018-08-16 | セルジーン コーポレイション | アクチビンII型受容体リガンドトラップを使用するβ−サラセミアのインビトロ細胞培養法 |
EP3370754A4 (en) | 2015-11-04 | 2019-10-23 | Acceleron Pharma Inc. | METHODS FOR INCREASING ERYTHROCYTE RATES AND TREATING INEFFECTIVE ERYTHROPOISIS |
KR20180096645A (ko) | 2015-11-23 | 2018-08-29 | 악셀레론 파마 인코포레이티드 | 눈 질환의 치료 방법 |
WO2018022982A1 (en) * | 2016-07-29 | 2018-02-01 | Trustees Of Boston University | Age-associated clonal hematopoiesis accelerates cardio-metabolic disease development |
WO2018089706A2 (en) | 2016-11-10 | 2018-05-17 | Keros Therapeutics, Inc. | Activin receptor type iia variants and methods of use thereof |
EP3638243A4 (en) | 2017-06-14 | 2021-03-17 | Celgene Corporation | METHOD OF TREATMENT OF MYELOPROLIFERATIVE NEOPLASM ASSOCIATED MYELOFIBROSIS AND ANEMIA |
JP7258021B2 (ja) | 2017-11-09 | 2023-04-14 | ケロス セラピューティクス インコーポレイテッド | アクチビンIIa型受容体変異体を含む医薬組成物 |
AU2019206634A1 (en) | 2018-01-12 | 2020-07-23 | Keros Therapeutics, Inc. | Activin receptor type IIB variants and methods of use thereof |
WO2019213016A1 (en) * | 2018-04-30 | 2019-11-07 | The Children's Hospital Of Philadelphia | Methods of improving anemias by combining agents |
US20210346464A1 (en) * | 2018-10-31 | 2021-11-11 | Celgene Corporation | TREATMENT OF ANEMIA DUE TO VERY LOW, LOW, OR INTERMEDIATE RISK MYELODYSPLASTIC SYNDROMES IN SUBJECTS WITH RING SIDEROBLASTS USING ACTIVIN-ACTRll LIGAND TRAPS |
WO2021189010A1 (en) * | 2020-03-20 | 2021-09-23 | Keros Therapeutics, Inc. | Methods of using activin receptor type iib variants |
WO2021189006A1 (en) * | 2020-03-20 | 2021-09-23 | Keros Therapeutics, Inc. | Methods of using activin receptor type iia variants |
US20230270821A1 (en) * | 2020-11-06 | 2023-08-31 | Acceleron Pharma Inc. | Formulations comprising actrii polypeptide variants |
Family Cites Families (194)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0637520B2 (ja) | 1985-07-03 | 1994-05-18 | 味の素株式会社 | ポリペプチド |
JPS63502716A (ja) | 1986-03-07 | 1988-10-13 | マサチューセッツ・インステチュート・オブ・テクノロジー | 糖タンパク安定性の強化方法 |
US4973577A (en) | 1986-04-04 | 1990-11-27 | The Salk Institute For Biological Studies | FSH-releasing peptides |
US5080891A (en) | 1987-08-03 | 1992-01-14 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5198346A (en) | 1989-01-06 | 1993-03-30 | Protein Engineering Corp. | Generation and selection of novel DNA-binding proteins and polypeptides |
US5096815A (en) | 1989-01-06 | 1992-03-17 | Protein Engineering Corporation | Generation and selection of novel dna-binding proteins and polypeptides |
EP0548276A4 (en) | 1990-09-13 | 1993-12-29 | Children's Hospital Medical Center Of Northern California | Method for increasing red blood cell production by treatment with activin or activin-related peptides |
US5118667A (en) | 1991-05-03 | 1992-06-02 | Celtrix Pharmaceuticals, Inc. | Bone growth factors and inhibitors of bone resorption for promoting bone formation |
US5885794A (en) | 1991-05-10 | 1999-03-23 | The Salk Institute For Biological Studies | Recombinant production of vertebrate activin receptor polypeptides and identification of receptor DNAs in the activin/TGF-β superfamily |
AU654724B2 (en) | 1991-05-10 | 1994-11-17 | Salk Institute For Biological Studies, The | Cloning and recombinant production of receptor(s) of the activin/TGF-beta superfamily |
US6162896A (en) | 1991-05-10 | 2000-12-19 | The Salk Institute For Biological Studies | Recombinant vertebrate activin receptors |
US20050186593A1 (en) | 1991-05-10 | 2005-08-25 | The Salk Institute For Biological Studies | Cloning and recombinant production of CRF receptor(s) |
US6287816B1 (en) | 1991-06-25 | 2001-09-11 | Genetics Institute, Inc. | BMP-9 compositions |
CA2108770C (en) | 1991-06-25 | 2007-04-03 | John M. Wozney | Bmp-9 compositions |
US6692925B1 (en) | 1992-11-17 | 2004-02-17 | Ludwig Institute For Cancer Research | Proteins having serine/threonine kinase domains, corresponding nucleic acid molecules, and their use |
CA2153652A1 (en) | 1993-01-12 | 1994-07-21 | Se-Jin Lee | Growth differentiation factor-3 |
US5637480A (en) | 1993-05-12 | 1997-06-10 | Genetics Institute, Inc. | DNA molecules encoding bone morphogenetic protein-10 |
EP0698095B1 (en) | 1993-05-12 | 2004-04-28 | Genetics Institute, LLC | Bmp-10 compositions |
US5677196A (en) | 1993-05-18 | 1997-10-14 | University Of Utah Research Foundation | Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays |
US5831050A (en) | 1993-06-07 | 1998-11-03 | Creative Biomolecules, Inc. | Morphogen cell surface receptor |
CA2174098C (en) | 1993-10-14 | 2011-01-25 | Douglas A. Melton | Method of inducing and maintaining neuronal cells |
US5525490A (en) | 1994-03-29 | 1996-06-11 | Onyx Pharmaceuticals, Inc. | Reverse two-hybrid method |
US5658876A (en) | 1994-04-28 | 1997-08-19 | The General Hospital Corporation | Activin antagonists as novel contraceptives |
US5885574A (en) | 1994-07-26 | 1999-03-23 | Amgen Inc. | Antibodies which activate an erythropoietin receptor |
US5760010A (en) | 1995-01-01 | 1998-06-02 | Klein; Ira | Method of treating liver disorders with a macrolide antibiotic |
US5814565A (en) | 1995-02-23 | 1998-09-29 | University Of Utah Research Foundation | Integrated optic waveguide immunosensor |
NZ502795A (en) | 1995-04-11 | 2001-09-28 | Gen Hospital Corp | Method of identifying molecular interactions employing counterselection and at least two hybrid molecules or two hybrid systems |
US6132988A (en) | 1995-10-27 | 2000-10-17 | Takeda Chemical Industries, Ltd. | DNA encoding a neuronal cell-specific receptor protein |
GB9526131D0 (en) | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Recombinant chimeric receptors |
US6004780A (en) | 1996-03-26 | 1999-12-21 | Human Genome Sciences, Inc. | Growth factor HTTER36 |
US20050244867A1 (en) | 1996-03-26 | 2005-11-03 | Human Genome Sciences, Inc. | Growth factor HTTER36 |
CN1234073A (zh) | 1996-10-25 | 1999-11-03 | G·D·瑟尔公司 | 环状变更的促红细胞生成素受体激动剂 |
US6605699B1 (en) | 1997-01-21 | 2003-08-12 | Human Genome Sciences, Inc. | Galectin-11 polypeptides |
US6231880B1 (en) | 1997-05-30 | 2001-05-15 | Susan P. Perrine | Compositions and administration of compositions for the treatment of blood disorders |
US6300127B1 (en) | 1997-07-30 | 2001-10-09 | Emory University | Bone mineralization proteins, DNA, vectors, expression systems |
US6696260B1 (en) | 1997-08-01 | 2004-02-24 | The Johns Hopkins University School Of Medicine | Methods to identify growth differentiation factor (GDF) binding proteins |
US6656475B1 (en) | 1997-08-01 | 2003-12-02 | The Johns Hopkins University School Of Medicine | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
WO1999006559A1 (en) | 1997-08-01 | 1999-02-11 | The Johns Hopkins University School Of Medicine | Methods to identify growth differentiation factor (gdf) receptors |
US6891082B2 (en) | 1997-08-01 | 2005-05-10 | The Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a truncated activintype II receptor |
JP2001513982A (ja) | 1997-08-29 | 2001-09-11 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | フォリスタチン−3 |
US6953662B2 (en) | 1997-08-29 | 2005-10-11 | Human Genome Sciences, Inc. | Follistatin-3 |
US6696411B1 (en) | 1998-04-22 | 2004-02-24 | Cornell Research Foundation, Inc. | Canine erythropoietin gene and recombinant protein |
US6440930B1 (en) | 1998-09-17 | 2002-08-27 | Eli Lilly And Company | Protein formulations |
US6656708B1 (en) | 1998-09-22 | 2003-12-02 | Long Yu | Human growth differentiation factor encoding sequence and polypeptide encoded by such DNA sequence and producing method thereof |
US6472179B2 (en) | 1998-09-25 | 2002-10-29 | Regeneron Pharmaceuticals, Inc. | Receptor based antagonists and methods of making and using |
US6548634B1 (en) | 1998-09-30 | 2003-04-15 | Chiron Corporation | Synthetic peptides having FGF receptor affinity |
US6777205B1 (en) | 1998-11-06 | 2004-08-17 | Sterrenbeld Biotechnologie North America, Inc. | Host cells expressing recombinant human erythropoietin |
US20040009535A1 (en) | 1998-11-27 | 2004-01-15 | Celltech R&D, Inc. | Compositions and methods for increasing bone mineralization |
CA2359242C (en) | 1999-01-21 | 2009-12-08 | Metamorphix, Inc. | Growth differentiation factor inhibitors and uses therefor |
WO2000062809A1 (fr) | 1999-04-19 | 2000-10-26 | Kyowa Hakko Kogyo Co., Ltd. | Inhibiteur de proliferation cellulaire pour tumeurs androgeno-independantes |
US6468543B1 (en) | 1999-05-03 | 2002-10-22 | Zymogenetics, Inc. | Methods for promoting growth of bone using ZVEGF4 |
CA2390292A1 (en) | 1999-11-12 | 2001-05-25 | Maxygen Holdings Ltd. | Interferon gamma conjugates |
CA2394576A1 (en) | 1999-12-15 | 2001-06-21 | Research Development Foundation | Betaglycan as an inhibin receptor and uses thereof |
JP4487376B2 (ja) | 2000-03-31 | 2010-06-23 | 味の素株式会社 | 腎疾患治療剤 |
US6627424B1 (en) | 2000-05-26 | 2003-09-30 | Mj Bioworks, Inc. | Nucleic acid modifying enzymes |
WO2002008277A2 (en) | 2000-07-19 | 2002-01-31 | Eli Lilly And Company | Nucleic acids, vectors, host cells, polypeptides, and uses thereof |
US6632180B1 (en) | 2000-09-07 | 2003-10-14 | John H. Laragh | Method for evaluating and treating hypertension |
DE10045591A1 (de) | 2000-09-15 | 2002-04-04 | Klaus Pfizenmaier | Ortsspezifische, antikörpervermittelte Aktivierung proapoptotischer Zytokine - AMAIZe (Antibody-Mediated Apoptosis Inducing Zytokine) |
CA2418835A1 (en) | 2000-10-16 | 2002-04-25 | Phylos, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
US7087224B2 (en) | 2000-10-31 | 2006-08-08 | Amgen Inc. | Method of treating anemia by administering IL-1ra |
JP4303468B2 (ja) | 2000-11-20 | 2009-07-29 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシテイ オブ イリノイ | 膜スカホールドタンパク質 |
US20030082233A1 (en) | 2000-12-01 | 2003-05-01 | Lyons Karen M. | Method and composition for modulating bone growth |
AU2002236558A1 (en) | 2000-12-01 | 2002-06-11 | Regents Of The University Of California | Method and composition for modulating bone growth |
US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
TWI329129B (en) | 2001-02-08 | 2010-08-21 | Wyeth Corp | Modified and stabilized gdf propeptides and uses thereof |
US20040132675A1 (en) | 2002-02-08 | 2004-07-08 | Calvin Kuo | Method for treating cancer and increasing hematocrit levels |
US7294472B2 (en) | 2001-03-14 | 2007-11-13 | Caden Biosciences | Method for identifying modulators of G protein coupled receptor signaling |
WO2002074340A1 (fr) | 2001-03-16 | 2002-09-26 | Takeda Chemical Industries, Ltd. | Procede de fabrication d'une preparation a liberation continue |
AU2002256371B2 (en) | 2001-04-26 | 2008-01-10 | Amgen Mountain View Inc. | Combinatorial libraries of monomer domains |
EA007275B1 (ru) | 2001-05-24 | 2006-08-25 | Займодженетикс, Инк. | Слитые белки taci-иммуноглобулина |
US7074901B2 (en) | 2001-05-25 | 2006-07-11 | Serono Genetics Institute S.A. | Isolated human vCOL16A1 polypeptide and fragments thereof |
AUPR638101A0 (en) | 2001-07-13 | 2001-08-09 | Bioa Pty Limited | Composition and method for treatment of disease |
DE60234348D1 (de) | 2001-07-17 | 2009-12-24 | Teijin Ltd | Selektionsverfahren für eine durch das austesten einer ppard aktivierenden wirkung charakterisierten substanz und arzneistoff |
US6855344B2 (en) | 2001-07-17 | 2005-02-15 | Integrated Chinese Medicine Holdings, Ltd. | Compositions and methods for prostate and kidney health and disorders, an herbal preparation |
KR100453877B1 (ko) | 2001-07-26 | 2004-10-20 | 메덱스젠 주식회사 | 연쇄체화에 의한 면역 글로블린 융합 단백질의 제조 방법 및 이 방법에 의해 제조된 TNFR/Fc 융합 단백질, 상기 단백질을 코딩하는 DNA, 상기 DNA를 포함하는벡터, 및 상기 벡터에 의한 형질전환체 |
US7320789B2 (en) | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
US6784154B2 (en) | 2001-11-01 | 2004-08-31 | University Of Utah Research Foundation | Method of use of erythropoietin to treat ischemic acute renal failure |
US20030144203A1 (en) | 2001-12-19 | 2003-07-31 | Voyager Pharmaceutical Corporation | Methods for slowing senescence and treating and preventing diseases associated with senescence |
US6998118B2 (en) | 2001-12-21 | 2006-02-14 | The Salk Institute For Biological Studies | Targeted retrograde gene delivery for neuronal protection |
MXPA04007583A (es) | 2002-02-11 | 2005-04-25 | Genentech Inc | Variantes de anticuerpo con tasas mas rapidas de asociacion a antigeno. |
PL375045A1 (en) | 2002-02-21 | 2005-11-14 | Wyeth | Gasp1: a follistatin domain containing protein |
US20030219846A1 (en) | 2002-02-28 | 2003-11-27 | Pfizer Inc. | Assay for activity of the ActRIIB kinase |
AU2003232485A1 (en) | 2002-04-18 | 2003-10-27 | Mtm Laboratories Ag | Neopeptides and methods useful for detection and treatment of cancer |
AU2003261246A1 (en) | 2002-08-16 | 2004-03-03 | Wyeth | Bmp-2 estrogen responsive element and methods of using the same |
WO2004034962A2 (en) | 2002-10-15 | 2004-04-29 | Celgene Corporation | Selective cytokine inhibitory drugs for treating myelodysplastic syndrome |
AR047392A1 (es) | 2002-10-22 | 2006-01-18 | Wyeth Corp | Neutralizacion de anticuerpos contra gdf 8 y su uso para tales fines |
US20040223966A1 (en) | 2002-10-25 | 2004-11-11 | Wolfman Neil M. | ActRIIB fusion polypeptides and uses therefor |
AU2002953327A0 (en) | 2002-12-12 | 2003-01-09 | Monash University | Methods of diagnosing prognosing and treating activin associated diseases and conditions |
DE602004018902D1 (de) | 2003-02-07 | 2009-02-26 | Prometic Biosciences Inc | Fettsäuren mittlerer kettenlänge, glyceride und analoga als stimulatoren der erythropoiese |
US20040197828A1 (en) | 2003-03-26 | 2004-10-07 | Gaddy Dana P. | Method for diagnosis and treatment of bone turnover |
US20070184052A1 (en) | 2003-05-09 | 2007-08-09 | Lin Herbert Y | Soluble tgf-b type III receptor fusion proteins |
MXPA05012965A (es) | 2003-06-02 | 2006-03-09 | Wyeth Corp | Uso de inhibidores de miostatina (gdf8) en conjuncion con corticoesteroides para el tratamiento de desordenes neuromusculares y composiciones farmaceuticas para ello. |
MEP2808A (xx) | 2003-06-16 | 2010-02-10 | Celltech R & D Inc | Antitijela specifična za sklerositin i metode za povećanje mineralizacije kostiju |
US7611465B2 (en) | 2003-07-15 | 2009-11-03 | Board Of Regents, The University Of Texas System | Rapid and accurate detection of bone quality using ultrasound critical angle reflectometry |
WO2005009460A2 (en) | 2003-07-25 | 2005-02-03 | Medexis, S.A. | Pharmaceutical composition comprising activin a, alk-4 or derivatives thereof for the treatment of ophthalmic disorders or cancer |
DE10335211A1 (de) | 2003-08-01 | 2005-02-17 | Robert Bosch Gmbh | Kraftstoff-Einspritzvorrichtung für eine Brennkraftmaschine |
WO2005025601A1 (en) | 2003-09-15 | 2005-03-24 | Monash University | Follistatin isoforms and uses thereof |
US8895540B2 (en) | 2003-11-26 | 2014-11-25 | DePuy Synthes Products, LLC | Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor |
CA2553883C (en) | 2004-01-22 | 2013-04-02 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Anti-cancer antibodies with reduced complement fixation |
US20050197292A1 (en) | 2004-01-30 | 2005-09-08 | Glennda Smithson | Compositions and methods for treating T-cell mediated pathological conditions |
AU2005229072A1 (en) | 2004-03-26 | 2005-10-13 | Acceleron Pharma Inc. | BMP-3 propeptides and related methods |
EP1730186A2 (en) | 2004-03-31 | 2006-12-13 | Xencor, Inc. | Bmp-7 variants with improved properties |
WO2005113590A2 (en) | 2004-05-12 | 2005-12-01 | Acceleron Pharma Inc. | Bmp10 propeptides and related methods |
EP1771557B1 (en) | 2004-06-24 | 2014-12-31 | Acceleron Pharma Inc. | GDF3 Propeptides and Related Methods |
ES2426005T3 (es) | 2004-07-23 | 2013-10-18 | Acceleron Pharma Inc. | Polipéptidos del receptor ACTRII, procedimientos y composiciones |
EP1778275A2 (en) | 2004-08-12 | 2007-05-02 | Wyeth | Combination therapy for diabetes, obesity, and cardiovascular diseases using gdf-8 inhibitors |
WO2006039400A2 (en) | 2004-09-29 | 2006-04-13 | Mount Sinai School Of Medicine Of New York University | Fsh and fsh receptor modulator compositions and methods for inhibiting osteoclastic bone resorption and bone loss in osteoporosis |
WO2006052842A2 (en) | 2004-11-09 | 2006-05-18 | The Trustees Of The University Of Pennsylvania | Methods for diagnosis of myelodysplastic syndromes (mds) |
US20060234299A1 (en) | 2004-11-16 | 2006-10-19 | Avidia Research Institute | Protein scaffolds and uses thereof |
NZ538097A (en) | 2005-02-07 | 2006-07-28 | Ovita Ltd | Method and compositions for improving wound healing |
EP1858541B1 (en) | 2005-02-16 | 2012-07-25 | The General Hospital Corporation | Use of bmp antagonists to regulate hepcidin-mediated iron metabolism and treat iron deficiency |
EP1884235A1 (en) | 2005-04-26 | 2008-02-06 | Ajinomoto Co., Inc. | Myeloerythroid progenitor differentiation inducer |
JP2007099764A (ja) | 2005-09-09 | 2007-04-19 | Ajinomoto Co Inc | 血糖低下剤 |
CA2621623A1 (en) | 2005-09-28 | 2007-04-05 | Zymogenetics, Inc. | Il-17a and il-17f antagonists and methods of using the same |
US8067562B2 (en) | 2005-11-01 | 2011-11-29 | Amgen Inc. | Isolated nucleic acid molecule comprising the amino acid sequence of SEQ ID NO:1 |
AU2006318449B2 (en) | 2005-11-23 | 2012-07-05 | Acceleron Pharma Inc. | Activin-actRIIa antagonists and uses for promoting bone growth |
US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
CA2856436A1 (en) | 2005-12-06 | 2007-06-14 | Amgen Inc. | Uses of myostatin antagonists |
CA2632936A1 (en) | 2005-12-20 | 2007-06-28 | Merck Frosst Canada Ltd. | Heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
US20070161578A1 (en) | 2005-12-21 | 2007-07-12 | Hwa Joyce J | Treatment of nonalcoholic fatty liver disease using cholesterol lowering agents and/or H3 receptor antagonist/inverse agonist |
EP1973909A2 (en) | 2005-12-22 | 2008-10-01 | Biogen Idec MA Inc. | Transforming growth factor modulators |
US7361512B2 (en) | 2006-01-20 | 2008-04-22 | Beckman Coulter, Inc. | Low hemoglobin concentration cell percentage and method of use in detection of iron deficiency |
EP1976377A4 (en) | 2006-01-25 | 2010-06-23 | Wellstat Therapeutics Corp | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS |
MX2008011022A (es) | 2006-02-28 | 2008-09-10 | Wellstat Therapeutics Corp | Compuestos para el tratamiento de trastornos metabolicos. |
US8008074B2 (en) | 2006-03-20 | 2011-08-30 | The Uab Research Foundation | Compositions and methods for improving bone mass through modulation of receptors of PTH and fragments thereof |
EP2007813A2 (en) | 2006-04-14 | 2008-12-31 | Amgen Inc. | Agonist erythropoietin receptor antibodies |
CA2652235A1 (en) | 2006-05-09 | 2007-11-22 | Hemaquest Pharmaceuticals, Inc. | Methods for treating blood disorders |
EP2484352B1 (en) | 2006-07-21 | 2014-07-09 | Lyne Laboratories, Inc. | Liquid compositions of calcium acetate |
GB0615129D0 (en) | 2006-07-29 | 2006-09-06 | Univ Cardiff | Anti-cancer activity of BMP-9 and BMP-10 and their use in cancer therapies |
WO2008030367A2 (en) | 2006-09-01 | 2008-03-13 | The General Hospital Corporation | Selective myostatin inhibitors |
CL2007002567A1 (es) | 2006-09-08 | 2008-02-01 | Amgen Inc | Proteinas aisladas de enlace a activina a humana. |
US7547781B2 (en) | 2006-09-11 | 2009-06-16 | Curis, Inc. | Quinazoline based EGFR inhibitors containing a zinc binding moiety |
WO2008060139A1 (en) | 2006-11-17 | 2008-05-22 | Erasmus University Medical Center Rotterdam | Methods for controlling mineralization of extracellular matrix, therapeutic methods based thereon and medicaments for use therein |
WO2008073292A2 (en) | 2006-12-08 | 2008-06-19 | Caritas St. Elizabeth's Medical Center Of Boston, Inc. | Method for protecting renal tubular epithelial cells from radiocontrast nephro parhy (rcn) |
AU2007332473B2 (en) | 2006-12-14 | 2012-09-27 | Forerunner Pharma Research Co., Ltd. | Anti-Claudin-3 monoclonal antibody, and treatment and diagnosis of cancer using the same |
US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
AU2013221910B2 (en) | 2006-12-18 | 2016-11-17 | Acceleron Pharma Inc. | Activin-ActRII antagonists and uses for increasing red blood cell levels |
US20100028332A1 (en) | 2006-12-18 | 2010-02-04 | Acceleron Pharma Inc. | Antagonists of actriib and uses for increasing red blood cell levels |
CN104524548A (zh) | 2006-12-18 | 2015-04-22 | 阿塞勒隆制药公司 | 活化素-actrii拮抗剂及在提高红细胞水平中的用途 |
CA2677007A1 (en) | 2007-02-01 | 2008-08-07 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for treating or preventing breast cancer |
TWI782836B (zh) | 2007-02-02 | 2022-11-01 | 美商艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
TWI667038B (zh) | 2007-02-09 | 2019-08-01 | 美商艾瑟勒朗法瑪公司 | 包含ActRIIa-Fc融合蛋白的醫藥組合物;ActRIIa-Fc融合蛋白於治療或預防與癌症相關的骨質流失之用途;ActRIIa-Fc融合蛋白於治療或預防多發性骨髓瘤之用途 |
TWI573802B (zh) | 2007-03-06 | 2017-03-11 | 安美基公司 | 變異之活動素受體多肽及其用途 |
MX2009012934A (es) | 2007-06-01 | 2009-12-15 | Wyeth Corp | Metodos y composiciones para modular la actividad de bmp-10. |
WO2009009059A1 (en) | 2007-07-09 | 2009-01-15 | Biogen Idec Ma Inc. | Spiro compounds as antagonists of tgf-beta |
SI2170396T1 (sl) | 2007-08-03 | 2017-04-26 | Summit (Oxford) Limited | Kombinacije zdravil za zdravljenje duchennove mišične distrofije |
GB0715087D0 (en) | 2007-08-03 | 2007-09-12 | Summit Corp Plc | Drug combinations for the treatment of duchenne muscular dystrophy |
GB0715938D0 (en) | 2007-08-15 | 2007-09-26 | Vastox Plc | Method of treatment of duchenne muscular dystrophy |
WO2009025651A1 (en) | 2007-08-17 | 2009-02-26 | University Of Maine System Board Of Trustees | Biologically active peptide and method of using the same |
US7960343B2 (en) | 2007-09-18 | 2011-06-14 | Acceleron Pharma Inc. | Activin-ActRIIa antagonists and uses for decreasing or inhibiting FSH secretion |
PE20091163A1 (es) | 2007-11-01 | 2009-08-09 | Wyeth Corp | Anticuerpos para gdf8 |
WO2009070243A2 (en) | 2007-11-21 | 2009-06-04 | Amgen Inc. | Wise binding agents and epitopes |
US8507501B2 (en) | 2008-03-13 | 2013-08-13 | The Brigham And Women's Hospital, Inc. | Inhibitors of the BMP signaling pathway |
AU2009244308A1 (en) | 2008-05-06 | 2009-11-12 | Joslin Diabetes Center, Inc. | Methods and compositions for inducing brown adipogenesis |
WO2009137075A1 (en) | 2008-05-06 | 2009-11-12 | Acceleron Pharma Inc. | Anti-activin antibodies and uses for promoting bone growth |
CN107252486B (zh) | 2008-06-26 | 2021-10-22 | 阿塞勒隆制药公司 | 激活素-actrii的拮抗剂及在提高红细胞水平中的用途 |
KR20220002710A (ko) | 2008-06-26 | 2022-01-06 | 악셀레론 파마 인코포레이티드 | 액티빈-actriia 길항물질을 투약하는 방법 및 치료된 환자의 모니터링 |
US8637611B2 (en) | 2008-08-13 | 2014-01-28 | Designer Molecules, Inc. | Amide-extended crosslinking compounds and methods for use thereof |
US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
SI3750552T1 (sl) | 2008-08-14 | 2023-10-30 | Acceleron Pharma Inc. | GDF pasti |
CA2749544A1 (en) | 2009-01-13 | 2010-07-22 | Acceleron Pharma Inc. | Methods for increasing adiponectin |
CN102307598A (zh) | 2009-02-05 | 2012-01-04 | 迪格纳生物技术公司 | TGF-β1抑制肽的药物制剂 |
EA027071B1 (ru) | 2009-04-27 | 2017-06-30 | Новартис Аг | АНТИТЕЛО К ActRIIB И СОДЕРЖАЩАЯ ЕГО КОМПОЗИЦИЯ |
EP3845239A1 (en) | 2009-06-08 | 2021-07-07 | Acceleron Pharma Inc. | Use of anti-actriib proteins for increasing thermogenic adipocytes |
CN107267520A (zh) | 2009-06-12 | 2017-10-20 | 阿塞勒隆制药公司 | 截短的actriib‑fc融合蛋白 |
CN102655872B (zh) | 2009-08-13 | 2016-01-20 | 阿塞勒隆制药公司 | Gdf捕获物和促红细胞生成素受体激活剂联合应用以增加红细胞水平 |
BR112012005225B8 (pt) | 2009-09-09 | 2023-01-10 | Acceleron Pharma Inc | Uso de uma proteína de fusão actriib-fc para o tratamento de um transtorno relacionado ao osso ou associado à perda de músculo por crescimento muscular insuficiente |
ES2869864T3 (es) | 2009-11-03 | 2021-10-26 | Acceleron Pharma Inc | Procedimientos para el tratamiento de la enfermedad del hígado graso |
US8710016B2 (en) | 2009-11-17 | 2014-04-29 | Acceleron Pharma, Inc. | ActRIIB proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy |
WO2012027065A2 (en) | 2010-08-27 | 2012-03-01 | Celgene Corporation | Combination therapy for treatment of disease |
JP6472999B2 (ja) | 2011-07-01 | 2019-02-20 | ノバルティス アーゲー | 代謝障害を治療するための方法 |
CN107693776A (zh) | 2011-10-17 | 2018-02-16 | 阿塞勒隆制药公司 | 用于治疗无效性红细胞生成的方法和组合物 |
EP2868667B1 (en) | 2012-07-02 | 2019-01-30 | Kyowa Hakko Kirin Co., Ltd. | Therapeutic agent for anemia including renal anemia and cancer-induced anemia which contains anti-bmp9 antibody as active ingredient |
CN112933223A (zh) | 2012-10-24 | 2021-06-11 | 细胞基因公司 | 用于治疗贫血的方法 |
IL267663B (en) * | 2012-10-24 | 2022-09-01 | Celgene Corp | A biomarker for use in the treatment of anemia |
CA2890217C (en) | 2012-11-02 | 2021-07-20 | Yifu FANG | Activin-actrii antagonists and uses for treating bone and other disorders |
EP3119418B1 (en) | 2014-03-21 | 2022-02-23 | Acceleron Pharma Inc. | Composition for use in a method of treating or preventing anemia by inhibiting activin b and gdf11 |
EP3131931B1 (en) | 2014-04-18 | 2020-10-21 | Acceleron Pharma Inc. | Methods for increasing red blood cell levels and treating sickle-cell disease |
WO2015192111A1 (en) | 2014-06-13 | 2015-12-17 | Acceleron Pharma, Inc. | Methods and compositions for treating ulcers |
MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
BR112017011722A2 (pt) | 2014-12-03 | 2018-02-27 | Acceleron Pharma Inc | antagonistas de activina-actrii e usos para o tratamento de anemia |
MA41119A (fr) | 2014-12-03 | 2017-10-10 | Acceleron Pharma Inc | Méthodes de traitement de syndromes myélodysplasiques et d'anémie sidéroblastique |
EP3294320A4 (en) | 2015-05-13 | 2018-12-26 | Celgene Corporation | Treatment of beta-thalassemia using actrii ligand traps |
JP2018522579A (ja) | 2015-05-20 | 2018-08-16 | セルジーン コーポレイション | アクチビンII型受容体リガンドトラップを使用するβ−サラセミアのインビトロ細胞培養法 |
CN108348578B (zh) | 2015-08-04 | 2022-08-09 | 阿塞勒隆制药公司 | 用于治疗骨髓增生性病症的方法 |
EP3370754A4 (en) | 2015-11-04 | 2019-10-23 | Acceleron Pharma Inc. | METHODS FOR INCREASING ERYTHROCYTE RATES AND TREATING INEFFECTIVE ERYTHROPOISIS |
KR20180096645A (ko) | 2015-11-23 | 2018-08-29 | 악셀레론 파마 인코포레이티드 | 눈 질환의 치료 방법 |
AU2017296040C1 (en) | 2016-07-15 | 2023-06-22 | Acceleron Pharma Inc. | Compositions and methods for treating pulmonary hypertension |
EP3490582A4 (en) | 2016-07-27 | 2020-04-01 | Acceleron Pharma Inc. | METHOD AND COMPOSITIONS FOR TREATING MYELOFIBROSE |
WO2018067874A1 (en) | 2016-10-05 | 2018-04-12 | Acceleron Pharma Inc. | Variant actriib proteins and uses thereof |
EP3638243A4 (en) | 2017-06-14 | 2021-03-17 | Celgene Corporation | METHOD OF TREATMENT OF MYELOPROLIFERATIVE NEOPLASM ASSOCIATED MYELOFIBROSIS AND ANEMIA |
US20210346464A1 (en) | 2018-10-31 | 2021-11-11 | Celgene Corporation | TREATMENT OF ANEMIA DUE TO VERY LOW, LOW, OR INTERMEDIATE RISK MYELODYSPLASTIC SYNDROMES IN SUBJECTS WITH RING SIDEROBLASTS USING ACTIVIN-ACTRll LIGAND TRAPS |
-
2015
- 2015-12-03 BR BR112017011722A patent/BR112017011722A2/pt not_active Application Discontinuation
- 2015-12-03 DK DK15865213.1T patent/DK3227675T3/da active
- 2015-12-03 SI SI201531946T patent/SI3227675T1/sl unknown
- 2015-12-03 HU HUE15865213A patent/HUE062189T2/hu unknown
- 2015-12-03 HR HRP20230504TT patent/HRP20230504T1/hr unknown
- 2015-12-03 CA CA2969572A patent/CA2969572A1/en active Pending
- 2015-12-03 LT LTEPPCT/US2015/063595T patent/LT3227675T/lt unknown
- 2015-12-03 MD MDA20180012A patent/MD4801C1/ro active IP Right Grant
- 2015-12-03 PL PL15865213.1T patent/PL3227675T3/pl unknown
- 2015-12-03 WO PCT/US2015/063595 patent/WO2016090077A1/en active Application Filing
- 2015-12-03 EP EP23160992.6A patent/EP4233889A3/en active Pending
- 2015-12-03 IL IL252631A patent/IL252631B1/en unknown
- 2015-12-03 KR KR1020177018131A patent/KR102556991B1/ko active IP Right Grant
- 2015-12-03 RS RS20230392A patent/RS64214B1/sr unknown
- 2015-12-03 FI FIEP15865213.1T patent/FI3227675T3/fi active
- 2015-12-03 US US15/532,329 patent/US11471510B2/en active Active
- 2015-12-03 EP EP15865213.1A patent/EP3227675B1/en active Active
- 2015-12-03 JP JP2017548364A patent/JP2018501307A/ja active Pending
- 2015-12-03 CN CN202210225878.XA patent/CN114675039A/zh active Pending
- 2015-12-03 AU AU2015358469A patent/AU2015358469B2/en active Active
- 2015-12-03 TW TW104140599A patent/TWI730949B/zh active
- 2015-12-03 ES ES15865213T patent/ES2946160T3/es active Active
- 2015-12-03 CN CN201580075198.2A patent/CN107533040B/zh active Active
- 2015-12-03 TW TW110103864A patent/TWI773117B/zh active
- 2015-12-03 PT PT158652131T patent/PT3227675T/pt unknown
-
2018
- 2018-04-06 HK HK18104547.0A patent/HK1245397A1/zh unknown
- 2018-06-26 HK HK18108223.2A patent/HK1248807A1/zh unknown
-
2020
- 2020-11-20 JP JP2020193117A patent/JP7092853B2/ja active Active
-
2021
- 2021-08-05 AU AU2021212084A patent/AU2021212084B2/en active Active
-
2023
- 2023-06-01 CY CY20231100261T patent/CY1126033T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20230504T1 (hr) | Antagonisti aktivin-actrii i upotreba u liječenju mijelodisplastičnog sindroma | |
JP2020515581A (ja) | T細胞受容体のシグナル伝達を阻害するまたは調節することによってt細胞の疲弊を治療する方法 | |
SI2691112T1 (en) | STABILITY FORMULATION PROTITELES FOR HUMAN PROGRAMMED DEPRESSOR RECEPTOR PD-1 AND RELATED HEALTH | |
JP2018505882A5 (hr) | ||
Garzon et al. | Use of thrombopoietin receptor agonists in childhood immune thrombocytopenia | |
RU2015116264A (ru) | Композиции и способы лечения сердечной недостаточности у пациентов с диабетом | |
RU2019106804A (ru) | Лечение и устойчивая вирусологическая ремиссия при вич-инфекции у haart-стабилизированных пациентов с помощью антител против cd4 | |
RU2015104001A (ru) | Комбинированная терапия для лечения глиобластомы | |
Heeney et al. | Sickle cell disease | |
WO2022150732A3 (en) | Chimeric receptor therapy | |
JP2015532293A5 (ja) | 糖尿病患者における心不全の治療用組成物 | |
US20210040224A1 (en) | Cd47 blockade therapy with cd38 antibody | |
Li et al. | Efficacy of low-dose rituximab in combination with recombinant human thrombopoietin in treating ITP | |
Oh et al. | Safety and efficacy of conversion from twice-daily tacrolimus to once-daily tacrolimus one month after transplantation: randomized controlled trial in adult renal transplantation | |
Nakamoto et al. | Effects of sustained‐release beraprost in patients with primary glomerular disease or nephrosclerosis: CASSIOPEIR study results | |
BR112021022503A2 (pt) | Métodos de administração de anticorpo anti-cd38 para tratar mieloma múltiplo | |
JP2009538916A5 (hr) | ||
Hill et al. | Coversin, a novel C5 complement inhibitor, is safe and effective in the treatment of PNH: results of a phase II clinical trial | |
BR112017014847A2 (pt) | "método para tratar anemia com o uso de formulação de epo de atuação prolongada" | |
Nilsson | The management of hemophilia patients with inhibitors | |
Scully et al. | Pharmacodynamic profile of a recombinant ADAMTS13 (BAX930) in hereditary thrombotic thrombocytopenic purpura (Upshaw-Schulman Syndrome (USS)) | |
MX2022001153A (es) | Regimen de dosificacion y administracion para el tratamiento o prevencion de enfermedades relacionadas con c5 mediante el uso del anticuerpo anti-c5 crovalimab. | |
Christopoulou et al. | P116 ATHENA (GOG-3020/ENGOT-ov45; EudraCT 2017–004557–17; NCT03522246): a randomised, double-blind, placebo-controlled, phase 3 study of the poly (ADP-Ribose) polymerase (PARP) inhibitor rucaparib+ the PD-1 inhibitor nivolumab following frontline platinum-based chemotherapy in ovarian cancer (OC) | |
Im et al. | Effective dosage and administration schedule of oral alendronate for non-nociceptive symptoms in rats with chronic constriction injury | |
Wood et al. | Rituximab |