CY1126033T1 - Ανταγωνιστες ακτιβινης-actrii και χρησεις για την αντιμετωπιση μυελοδυσπλαστικου συνδρομου - Google Patents

Ανταγωνιστες ακτιβινης-actrii και χρησεις για την αντιμετωπιση μυελοδυσπλαστικου συνδρομου

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Publication number
CY1126033T1
CY1126033T1 CY20231100261T CY231100261T CY1126033T1 CY 1126033 T1 CY1126033 T1 CY 1126033T1 CY 20231100261 T CY20231100261 T CY 20231100261T CY 231100261 T CY231100261 T CY 231100261T CY 1126033 T1 CY1126033 T1 CY 1126033T1
Authority
CY
Cyprus
Prior art keywords
treatment
activin
myelodysplastic syndrome
actrii antagonists
subject
Prior art date
Application number
CY20231100261T
Other languages
English (en)
Inventor
Kenneth M. Attie
Christopher ROVALDI
Abderrahmane LAADEM
Original Assignee
Celgene Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corporation filed Critical Celgene Corporation
Publication of CY1126033T1 publication Critical patent/CY1126033T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Epidemiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Ecology (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Στο παρόν παρέχονται μέθοδοι για την αντιμετώπιση σε ένα υποκείμενο της αναιμίας, της αναιμίας που απαιτεί μετάγγιση RBC, των μυελοδυσπλαστικών συνδρόμων (MDS) χαμηλού ή ενδιάμεσου 1 κινδύνου, ή/και της μη πολλαπλασιαστικής χρόνιας μυελομονοκυτταρικής λευχαιμίας (CMML) σε οποιαδήποτε θηλαστικά, όπου οι μέθοδοι περιλαμβάνουν χορήγηση αναστολέων σηματοδότησης Ακτιβίνης-ActRII σε ένα υποκείμενο το οποίο χρήζει της αγωγής.
CY20231100261T 2014-12-03 2023-06-01 Ανταγωνιστες ακτιβινης-actrii και χρησεις για την αντιμετωπιση μυελοδυσπλαστικου συνδρομου CY1126033T1 (el)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201462086977P 2014-12-03 2014-12-03
US201462088478P 2014-12-05 2014-12-05
US201562153872P 2015-04-28 2015-04-28
US201562173782P 2015-06-10 2015-06-10
US201562218728P 2015-09-15 2015-09-15
PCT/US2015/063595 WO2016090077A1 (en) 2014-12-03 2015-12-03 Activin-actrii antagonists and uses for treating anemia

Publications (1)

Publication Number Publication Date
CY1126033T1 true CY1126033T1 (el) 2023-11-15

Family

ID=56092426

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20231100261T CY1126033T1 (el) 2014-12-03 2023-06-01 Ανταγωνιστες ακτιβινης-actrii και χρησεις για την αντιμετωπιση μυελοδυσπλαστικου συνδρομου

Country Status (24)

Country Link
US (1) US11471510B2 (el)
EP (2) EP4233889A3 (el)
JP (2) JP2018501307A (el)
KR (1) KR102556991B1 (el)
CN (2) CN114675039A (el)
AU (2) AU2015358469B2 (el)
BR (1) BR112017011722A2 (el)
CA (1) CA2969572A1 (el)
CY (1) CY1126033T1 (el)
DK (1) DK3227675T3 (el)
ES (1) ES2946160T3 (el)
FI (1) FI3227675T3 (el)
HK (2) HK1245397A1 (el)
HR (1) HRP20230504T1 (el)
HU (1) HUE062189T2 (el)
IL (1) IL252631B1 (el)
LT (1) LT3227675T (el)
MD (1) MD4801C1 (el)
PL (1) PL3227675T3 (el)
PT (1) PT3227675T (el)
RS (1) RS64214B1 (el)
SI (1) SI3227675T1 (el)
TW (2) TWI730949B (el)
WO (1) WO2016090077A1 (el)

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