LV11833B - Needleless syringe using supersonic gas flow for particle deliwery - Google Patents

Needleless syringe using supersonic gas flow for particle deliwery Download PDF

Info

Publication number
LV11833B
LV11833B LVP-97-41A LV970041A LV11833B LV 11833 B LV11833 B LV 11833B LV 970041 A LV970041 A LV 970041A LV 11833 B LV11833 B LV 11833B
Authority
LV
Latvia
Prior art keywords
syringe according
nozzle
gas
membrane
syringe
Prior art date
Application number
LVP-97-41A
Other languages
English (en)
Latvian (lv)
Other versions
LV11833A (lv
Inventor
Bellhouse Brian John
Sarphie David Francis
Greenford John Christopher
Original Assignee
Powderject Res Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939307459A external-priority patent/GB9307459D0/en
Priority claimed from GB939318407A external-priority patent/GB9318407D0/en
Priority claimed from GB939321356A external-priority patent/GB9321356D0/en
Priority claimed from GB939326069A external-priority patent/GB9326069D0/en
Application filed by Powderject Res Ltd filed Critical Powderject Res Ltd
Publication of LV11833A publication Critical patent/LV11833A/xx
Publication of LV11833B publication Critical patent/LV11833B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A61M5/3015—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules for injecting a dose of particles in form of powdered drug, e.g. mounted on a rupturable membrane and accelerated by a gaseous shock wave or supersonic gas flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/89—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection
    • C12N15/895—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection using biolistic methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/42—Reducing noise
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2053—Media being expelled from injector by pressurised fluid or vacuum

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Sustainable Development (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Plant Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Mechanical Engineering (AREA)
  • Vascular Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
LVP-97-41A 1993-04-08 1997-03-17 Needleless syringe using supersonic gas flow for particle deliwery LV11833B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB939307459A GB9307459D0 (en) 1993-04-08 1993-04-08 Particle delivery apparatus
GB939318407A GB9318407D0 (en) 1993-09-06 1993-09-06 Particle delivery apparatus
GB939321356A GB9321356D0 (en) 1993-10-15 1993-10-15 Particle delivery apparatus
GB939326069A GB9326069D0 (en) 1993-12-21 1993-12-21 Particle delivery apparatus

Publications (2)

Publication Number Publication Date
LV11833A LV11833A (lv) 1997-08-20
LV11833B true LV11833B (en) 1997-12-20

Family

ID=27451010

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-97-41A LV11833B (en) 1993-04-08 1997-03-17 Needleless syringe using supersonic gas flow for particle deliwery

Country Status (32)

Country Link
US (5) US5630796A (ja)
EP (4) EP0951917A3 (ja)
JP (4) JP3260375B2 (ja)
KR (1) KR100332147B1 (ja)
CN (1) CN1109102C (ja)
AT (2) ATE329006T1 (ja)
AU (1) AU674742B2 (ja)
BG (1) BG61993B1 (ja)
BR (1) BR9406455A (ja)
CA (1) CA2159452C (ja)
CZ (1) CZ290476B6 (ja)
DE (2) DE69401651T2 (ja)
DK (2) DK0693119T3 (ja)
ES (2) ES2267106T3 (ja)
FI (1) FI120671B (ja)
GR (1) GR3022939T3 (ja)
HK (1) HK1000351A1 (ja)
HU (2) HU216308B (ja)
LV (1) LV11833B (ja)
NO (1) NO314570B1 (ja)
NZ (1) NZ263606A (ja)
OA (1) OA10234A (ja)
PL (1) PL174974B1 (ja)
PT (1) PT734737E (ja)
RO (1) RO118569B1 (ja)
RU (1) RU2129021C1 (ja)
SI (2) SI0734737T1 (ja)
SK (1) SK283855B6 (ja)
TJ (1) TJ248B (ja)
TW (2) TW360548B (ja)
UA (1) UA41360C2 (ja)
WO (1) WO1994024263A1 (ja)

Families Citing this family (311)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW360548B (en) * 1993-04-08 1999-06-11 Powderject Res Ltd Products for therapeutic use
EP0690732B1 (en) * 1994-01-21 2003-01-29 Powderject Vaccines, Inc. Gas driven gene delivery instrument
US5899880A (en) * 1994-04-08 1999-05-04 Powderject Research Limited Needleless syringe using supersonic gas flow for particle delivery
US6586006B2 (en) 1994-08-04 2003-07-01 Elan Drug Delivery Limited Solid delivery systems for controlled release of molecules incorporated therein and methods of making same
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
EP1138337A3 (en) * 1994-08-04 2003-03-26 Elan Drug Delivery Limited Solid delivery systems for controlled release of molecules incorporated therein and methods of making same
GB9416663D0 (en) * 1994-08-17 1994-10-12 Oxford Bioscience Limited Particle delivery
GB9426379D0 (en) 1994-12-23 1995-03-01 Oxford Biosciences Ltd Particle delivery
GB9502879D0 (en) * 1995-02-14 1995-04-05 Oxford Biosciences Ltd Particle delivery
US5766901A (en) * 1995-05-04 1998-06-16 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and method for delivering a nucleotide into cell nuclei
US6474369B2 (en) 1995-05-26 2002-11-05 Penjet Corporation Apparatus and method for delivering a lyophilized active with a needle-less injector
US7223739B1 (en) 1995-06-07 2007-05-29 Powderject Vaccines, Inc. Adjuvanted genetic vaccines
GB9515846D0 (en) * 1995-08-02 1995-10-04 Boc Group Plc Gas capsule
DE69628095T2 (de) * 1995-08-02 2004-02-19 The Boc Group Plc, Windlesham Gaszuführvorrichtung
US6080130A (en) * 1998-11-14 2000-06-27 Castellano; Thomas P. Gas power source for a needle-less injector
US6013050A (en) * 1995-10-20 2000-01-11 Powderject Research Limited Particle delivery
GB9605690D0 (en) * 1996-03-19 1996-05-22 Oxford Biosciences Ltd Particle delivery
EP0907718B1 (en) * 1996-06-14 2004-12-29 Powderject Vaccines, Inc. Sample delivery module for particle acceleration apparatus
US6893664B1 (en) * 1996-06-17 2005-05-17 Powderject Research Limited Particle delivery techniques
BR9710025A (pt) 1996-07-01 1999-08-10 Pharmacia & Upjohn Ab Dispositivo de distribuição de preparação processo para operar o mesmo sistema de recipientes de medicamento receipiente do tipo de cartucho de seringa sistema de marcação de leitura por máquina e dispositivo para análise de um objeto
CA2209406C (en) 1996-07-24 2007-05-15 David W. Birch Gas capsule and gas delivery system
US6468782B1 (en) 1996-12-05 2002-10-22 Quadrant Healthcare (Uk) Limited Methods of preserving prokaryotic cells and compositions obtained thereby
DE19701494A1 (de) * 1997-01-17 1998-07-23 Boehringer Mannheim Gmbh Transdermales Injektionssystem
US5947928A (en) * 1997-06-19 1999-09-07 Mile Creek Capital, Llc Drug delivery system
EP0888791A1 (en) 1997-07-04 1999-01-07 PowderJect Research Limited Syringe and drug capsule therefor
EP0888790A1 (en) * 1997-07-04 1999-01-07 PowderJect Research Limited Drug particle delivery device
US6074360A (en) 1997-07-21 2000-06-13 Boehringer Mannheim Gmbh Electromagnetic transdermal injection device and methods related thereto
US6171276B1 (en) 1997-08-06 2001-01-09 Pharmacia & Upjohn Ab Automated delivery device and method for its operation
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
DE19820172A1 (de) * 1997-09-30 2005-01-27 Wolfgang Wagner Einrichtung und einrichtungsbezogenes Verfahren zur Einbringung eines Diagnostikträgers oder einer Arznei unter die Haut eines Lebewesens
CA2310029A1 (en) * 1997-11-20 1999-06-03 Jean Haensler A method for in vivo dna delivery using a needle free apparatus
EP1035867A1 (en) * 1997-12-02 2000-09-20 Powderject Vaccines, Inc. Transdermal delivery of particulate vaccine compositions
EP1038016A2 (en) * 1997-12-16 2000-09-27 Valentis Inc. Needle-free injection of formulated nucleic acid molecules
GB9802508D0 (en) 1998-02-05 1998-04-01 Boc Group Plc Needleless medical device
GB9802506D0 (en) * 1998-02-05 1998-04-01 Boc Group Plc Needleless medical device
US6693087B1 (en) 1998-08-20 2004-02-17 Aventis Pasteur Limited Nucleic acid molecules encoding POMP91A protein of Chlamydia
US6686339B1 (en) 1998-08-20 2004-02-03 Aventis Pasteur Limited Nucleic acid molecules encoding inclusion membrane protein C of Chlamydia
AU5366099A (en) 1998-08-20 2000-03-14 Connaught Laboratories Limited Nucleic acid molecules encoding inclusion membrane protein of (chlamydia)
GB9818627D0 (en) * 1998-08-26 1998-10-21 Glaxo Group Ltd Improvements in dva vaccination
GB9819272D0 (en) * 1998-09-03 1998-10-28 Andaris Ltd Microparticles
US6602678B2 (en) 1998-09-04 2003-08-05 Powderject Research Limited Non- or minimally invasive monitoring methods
AU765050B2 (en) * 1998-09-04 2003-09-04 Powderject Research Limited Immunodiagnostics using particle delivery methods
CN1324228A (zh) * 1998-09-04 2001-11-28 鲍德杰克特研究有限公司 采用颗粒运送的监测方法
USD434848S (en) * 1998-09-08 2000-12-05 Powderject Research Limited Disposable injector
US6613360B1 (en) * 1998-10-01 2003-09-02 Powderject Research Limited Particle formation
ATE319826T1 (de) * 1998-10-19 2006-03-15 Powderject Vaccines Inc Minimale promotoren und ihre verwendung
FR2785293B1 (fr) 1998-10-30 2002-07-05 Pasteur Merieux Serums Vacc Acides nucleiques et polypeptides specifiques des souches pathogenes du genre neisseria
US6881723B1 (en) 1998-11-05 2005-04-19 Powderject Vaccines, Inc. Nucleic acid constructs
US6264629B1 (en) 1998-11-18 2001-07-24 Bioject, Inc. Single-use needle-less hypodermic jet injection apparatus and method
GB9825763D0 (en) * 1998-11-25 1999-01-20 Boc Group Plc Filling containers with gas
US20070196490A1 (en) * 1999-01-22 2007-08-23 Powderject Research Limited Method of enhancing needleless transdermal powered drug delivery
WO2000043058A1 (en) * 1999-01-22 2000-07-27 Powderject Research Limited Method of enhancing needleless transdermal powdered drug delivery
US6328714B1 (en) 1999-01-29 2001-12-11 Powderject Research Limited Particle delivery device
US6849060B1 (en) * 1999-01-29 2005-02-01 Powderject Research Limited Particle delivery device
CN1230152C (zh) * 1999-02-03 2005-12-07 鲍德杰克特研究有限公司 水凝胶颗粒制剂
US7022320B1 (en) 1999-02-09 2006-04-04 Powderject Vaccines, Inc. Mycobacterium tuberculosis immunization
US20050214227A1 (en) * 1999-03-08 2005-09-29 Powderject Research Limited Microparticle formulations for sustained-release of bioactive compounds
AU770235B2 (en) * 1999-03-08 2004-02-19 Powderject Research Limited Delivery of microparticle formulations using needleless syringe device for sustained-release of bioactive compounds
GB9905933D0 (en) * 1999-03-15 1999-05-05 Powderject Res Ltd Neeedleless syringe
US7013617B2 (en) 1999-04-01 2006-03-21 The Boc Group, Plc Method of filling and sealing
US7060048B1 (en) * 1999-04-16 2006-06-13 Powerject Research Limited Needleless syringe
JP2002542183A (ja) 1999-04-16 2002-12-10 ノボ ノルディスク アクティーゼルスカブ 成形可能な乾燥した医薬製剤
KR100702653B1 (ko) * 1999-04-16 2007-04-02 파우더젝트 리서치 리미티드 바늘없는 주사장치와 이로부터 입자를 배출하는 방법
FR2796290B1 (fr) * 1999-07-16 2001-09-14 Cross Site Technologies Seringue sans aiguille fonctionnant avec un generateur d'onde de choc a travers une paroi
FR2796288B1 (fr) * 1999-07-16 2001-08-10 Cross Site Technologies Seringue sans aiguille avec injecteur a elements emboites
GB9916800D0 (en) 1999-07-16 1999-09-22 Powderject Res Ltd Needleless syringe
US6319224B1 (en) * 1999-08-20 2001-11-20 Bioject Medical Technologies Inc. Intradermal injection system for injecting DNA-based injectables into humans
US20050027239A1 (en) * 1999-08-20 2005-02-03 Stout Richard R. Intradermal injection system for injecting DNA-based injectables into humans
US6811783B1 (en) 1999-09-07 2004-11-02 Aventis Pasteur Limited Immunogenic compositions for protection against chlamydial infection
DE19946059A1 (de) * 1999-09-25 2001-03-29 Roche Diagnostics Gmbh System zur transdermalen Gewinnung von Körperflüssigkeit
GB9923306D0 (en) 1999-10-01 1999-12-08 Isis Innovation Diagnostic and therapeutic epitope, and transgenic plant
ATE285806T1 (de) 1999-10-11 2005-01-15 Felton International Inc Universelle antiinfektionsschutzvorrichtung für nadellose injektoren
JP4540033B2 (ja) 1999-10-22 2010-09-08 サノフィ パストゥール リミテッド 腫瘍抗原に対する免疫応答を誘発および／または増強する方法
CN1182874C (zh) * 1999-10-29 2005-01-05 安增子摩祺株式会社 糖尿病性局部缺血疾病的基因治疗制剂
US20040234539A1 (en) * 1999-11-03 2004-11-25 Powderject Research Limited Nucleic acid vaccine compositions having a mammalian cd80/cd86 gene promoter driving antigen expression
US7196066B1 (en) 1999-11-03 2007-03-27 Powderject Vaccines, Inc. DNA-vaccines based on constructs derived from the genomes of human and animal pathogens
FR2800619B1 (fr) * 1999-11-05 2002-02-08 Cross Site Technologies Seringue sans aiguille avec un moyen de poussee temporairement retenu
US20040109874A1 (en) * 1999-11-10 2004-06-10 Powderject Vaccines, Inc. Induction of mucosal immunity by vaccination via the skin route
US7887506B1 (en) 1999-11-23 2011-02-15 Pulse Needlefree Systems, Inc. Safety mechanism to prevent accidental patient injection and methods of same
US7029457B2 (en) 1999-11-23 2006-04-18 Felton International, Inc. Jet injector with hand piece
US6770054B1 (en) 1999-11-23 2004-08-03 Felton International, Inc. Injector assembly with driving means and locking means
FR2802103B1 (fr) 1999-12-08 2003-10-03 Poudres & Explosifs Ste Nale Seringue sans aiguille fonctionnant avec entrainement du principe actif par effet tube a choc
FR2802102B1 (fr) 1999-12-08 2002-07-12 Poudres & Explosifs Ste Nale Seringue sans aiguille munie d'un tube d'ejection a section constante
FR2802820B1 (fr) 1999-12-27 2002-10-18 Poudres & Explosifs Ste Nale Seringue sans aiguille fonctionnant par effet tube a choc, avec maintien prealable du principe actif sur le cote
FR2804329B1 (fr) 2000-02-02 2002-12-13 Poudres & Explosifs Ste Nale Seringue sans aiguille munie d'un opercule contenant le principe actif
US6689092B2 (en) 2000-03-03 2004-02-10 Boehringer International Gmbh Needle-less injector of miniature type
GB0006263D0 (en) * 2000-03-15 2000-05-03 Powderject Res Ltd Apparatus and method for adjusting the characteristics of a needleless syringe
US6716190B1 (en) 2000-04-19 2004-04-06 Scimed Life Systems, Inc. Device and methods for the delivery and injection of therapeutic and diagnostic agents to a target site within a body
EP1792995A3 (en) 2000-05-08 2007-06-13 Sanofi Pasteur Limited Chlamydia secretory locus orf and uses thereof
ATE513913T1 (de) 2000-05-10 2011-07-15 Sanofi Pasteur Ltd Durch mage minigene kodierte immunogene polypeptide und ihre verwendungen
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
AU2001268762A1 (en) * 2000-05-26 2001-12-03 George Vizirgianakis Treatment and therapy apparatus
CN1438874A (zh) * 2000-06-08 2003-08-27 宝德杰克特疫苗有限公司 粉末组合物
US20040213798A1 (en) * 2000-06-08 2004-10-28 Powderject Vaccines, Inc. Spray-dried alum compositions
US20020120228A1 (en) * 2000-06-08 2002-08-29 Yuh-Fun Maa Powder compositions
US6706032B2 (en) * 2000-06-08 2004-03-16 Massachusetts Institute Of Technology Localized molecular and ionic transport to and from tissues
US7597692B2 (en) * 2000-06-08 2009-10-06 Massachusetts Institute Of Technology Microscission processes and procedures
GB0018035D0 (en) 2000-07-21 2000-09-13 Powderject Res Ltd Needleless syringe
AU2001290678A1 (en) * 2000-09-08 2002-03-22 Powderject Research Limited Alginate particle formulation
US6824822B2 (en) * 2001-08-31 2004-11-30 Alkermes Controlled Therapeutics Inc. Ii Residual solvent extraction method and microparticles produced thereby
US6981660B2 (en) * 2000-09-25 2006-01-03 Evit Labs Shock wave aerosolization apparatus and method
AU2001294742A1 (en) * 2000-09-25 2002-04-02 Evit Laboratories, Inc. Shock wave aerosolization apparatus and method
GB0025147D0 (en) 2000-10-13 2000-11-29 Torsana Diabetes Diagnostics A Optical sensor for in situ measurement of analytes
BR0115646A (pt) 2000-11-27 2005-12-13 Powderject Vaccines Inc Composição, dispositivo de liberação de partìculas, uso de uma composição, e, método para intensificar uma resposta imune contra um antìgeno de interesse em um paciente
US7150409B2 (en) * 2000-11-30 2006-12-19 Biovalve Technologies, Inc. Injection systems
GB0100756D0 (en) * 2001-01-11 2001-02-21 Powderject Res Ltd Needleless syringe
US6644309B2 (en) * 2001-01-12 2003-11-11 Becton, Dickinson And Company Medicament respiratory delivery device and method
US6443152B1 (en) 2001-01-12 2002-09-03 Becton Dickinson And Company Medicament respiratory delivery device
US6722364B2 (en) * 2001-01-12 2004-04-20 Becton, Dickinson And Company Medicament inhalation delivery devices and methods for using the same
ES2191528B1 (es) * 2001-02-05 2004-06-16 Danone, S.A. Dispositivo para la dosificacion de substancias liquidas.
GB0103348D0 (en) * 2001-02-10 2001-03-28 Medical Res Council Delivery of biologically active agents
CA2440983A1 (en) 2001-03-14 2002-09-26 Penjet Corporation System and method for removing dissolved gas from a solution
US20040185055A1 (en) 2001-03-19 2004-09-23 Glenn Gregory M Transcutaneous immunostimulation
US20050192530A1 (en) * 2001-04-13 2005-09-01 Penjet Corporation Method and apparatus for needle-less injection with a degassed fluid
US6613010B2 (en) 2001-04-13 2003-09-02 Penjet Corporation Modular gas-pressured needle-less injector
US6755220B2 (en) 2001-04-27 2004-06-29 Penjet Corporation Method and apparatus for filling or refilling a needle-less injector
DE10121255A1 (de) * 2001-04-30 2002-11-07 Switch Biotech Ag Verwendung von alpha 1-Antichymotrypsin Polypeptiden oder diese kodierende Nukleinsäuren, oder einer ein ACT Polypeptid oder diese kodierende Nukleinsäure exprimierende Zelle, zur Behandlung und/oder Prävention von diabetes-assoziierten und/oder arteriellen schlecht heilenden Wunden und zur Identifizierung von pharmakologisch aktiven Substanzen
US6648850B2 (en) * 2001-06-08 2003-11-18 Bioject, Inc. Durable needle-less jet injector apparatus and method
EP1399131A2 (en) * 2001-06-08 2004-03-24 Powderject Vaccines, Inc. Spray freeze-dried compositions
US8061006B2 (en) * 2001-07-26 2011-11-22 Powderject Research Limited Particle cassette, method and kit therefor
WO2003011379A1 (en) * 2001-07-26 2003-02-13 Powderject Research Limited Particle cassette, method and kit therefor
US20030019558A1 (en) * 2001-07-26 2003-01-30 Smith Edward R. Particle cassette, method and kit therefor
GB0118266D0 (en) 2001-07-26 2001-09-19 Powderject Res Ltd Silencing device and method for needleless syringe
DE10163325B4 (de) * 2001-07-30 2005-07-28 Tecpharma Licensing Ag Verriegelungssperre für eine Verbindung von Gehäuseabschnitten eines Verabreichungsgeräts
DE20112501U1 (de) * 2001-07-30 2002-12-19 Disetronic Licensing Ag, Burgdorf Verriegelungssperre für eine Verbindung von Gehäuseteilen eines Injektions- oder Infusionsgeräts
DE10163326A1 (de) * 2001-07-30 2003-02-27 Disetronic Licensing Ag Verabreichungsgerät mit Dosiervorrichtung
DE10163327A1 (de) * 2001-07-30 2003-02-27 Disetronic Licensing Ag Reservoirmodul mit Kolbenstange
DE10163328B4 (de) * 2001-07-30 2005-08-11 Tecpharma Licensing Ag Verabreichungsgerät mit Verdrehsicherung
US20050191361A1 (en) * 2001-08-03 2005-09-01 Powederject Research Ltd. Hydrogel particle formation
US6824526B2 (en) 2001-10-22 2004-11-30 Penjet Corporation Engine and diffuser for use with a needle-less injector
AU2002366267B2 (en) * 2001-11-19 2007-05-10 Becton, Dickinson And Company Pharmaceutical compositions in particulate form
WO2003052125A1 (en) 2001-12-17 2003-06-26 Powderject Research Limited Non-or minimally invasive monitoring methods
US8454997B2 (en) 2001-12-18 2013-06-04 Novo Nordisk A/S Solid dose micro implant
MXPA04005865A (es) 2001-12-19 2004-09-13 Nektar Therapeutics Suministro de aminoglucosidos a los pulmones.
DE20209051U1 (de) 2001-12-21 2003-04-24 Disetronic Licensing Ag, Burgdorf Injektionsgerät mit endpositionsblockiertem Dosiseinstellglied
US20030130614A1 (en) * 2002-01-09 2003-07-10 Johnson Lanny L. Device for delivering liquid medications or nutrients and gases to local tissue
WO2003068294A2 (en) 2002-02-18 2003-08-21 Danfoss A/S Device for administering of medication in fluid form
US20030163111A1 (en) * 2002-02-26 2003-08-28 Daellenbach Keith K. End effector for needle-free injection system
CA2380671A1 (fr) * 2002-04-05 2003-10-05 Stephane Dufresne Seringue sans aiguille pour l'injection sous-cutanee de gouttelettes medicamenteuses
EP1356820A1 (en) 2002-04-26 2003-10-29 Institut National De La Sante Et De La Recherche Medicale (Inserm) DNA vaccine combined with an inducer of tumor cell apoptosis
US8245708B2 (en) * 2002-05-07 2012-08-21 The Research Foundation Of State University Of New York Methods, devices and formulations for targeted endobronchial therapy
US7607436B2 (en) * 2002-05-06 2009-10-27 The Research Foundation Of State University Of New York Methods, devices and formulations for targeted endobronchial therapy
US7156823B2 (en) * 2002-06-04 2007-01-02 Bioject Inc. High workload needle-free injection system
GB0212885D0 (en) 2002-06-05 2002-07-17 Isis Innovation Therapeutic epitopes and uses thereof
CA2500215C (en) * 2002-09-27 2012-02-28 Powderject Research Limited Nucleic acid coated particles
CA2500713C (en) * 2002-10-04 2012-07-03 Photokinetix, Inc. Photokinetic delivery of biologically active substances using pulsed incoherent light
DE60333435D1 (de) * 2003-02-03 2010-09-02 Bioware Technology Co Ltd Genpistole mit Niederdruckgasbeschleunigung
DE10306716A1 (de) * 2003-02-17 2004-09-02 Lell, Peter, Dr.-Ing. Vorrichtung zum Injizieren eines staub-oder pulverförmigen Stoffs in ein Gewebe eines Körpers
CA2520123C (en) 2003-03-25 2010-12-21 Terry O. Herndon Drill device and method for forming microconduits
DE10316237A1 (de) * 2003-04-09 2004-11-04 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Kanüle und Verfahren zur Einführung einer Kanüle in biologisches Material
US20060184101A1 (en) * 2003-04-21 2006-08-17 Ravi Srinivasan Microjet devices and methods for drug delivery
AU2004232366A1 (en) * 2003-04-21 2004-11-04 Corium International, Inc. Apparatus and methods for repetitive microjet drug delivery
WO2004110533A1 (ja) * 2003-05-09 2004-12-23 Anges Mg, Inc. 薬剤が収容された針無注射器
DK1844765T3 (en) 2003-06-13 2015-04-27 Skendi Finance Ltd Slow release estradiol progesterone formulation
US7131961B2 (en) * 2003-10-01 2006-11-07 Bioject, Inc. Needle-free injection system
MXPA06003978A (es) * 2003-10-10 2006-06-27 Powderject Vaccines Inc Constructos de acidos nucleicos.
US7442182B2 (en) * 2003-10-24 2008-10-28 Bioject, Inc. Spring powered needle-free injection system
US8147426B2 (en) * 2003-12-31 2012-04-03 Nipro Diagnostics, Inc. Integrated diagnostic test system
US20050209554A1 (en) * 2004-03-19 2005-09-22 Sergio Landau Needle-free single-use cartridge and injection system
US20050209553A1 (en) * 2004-03-19 2005-09-22 Sergio Landau Needle-free single-use cartridge and injection system
JP4210231B2 (ja) * 2004-03-25 2009-01-14 株式会社資生堂 皮膚のシワを改善する美容方法及びシワ改善具
ATE531374T1 (de) * 2004-04-15 2011-11-15 Alkermes Inc Vorrichtung auf polymerbasis mit verzögerter freisetzung
US7456254B2 (en) 2004-04-15 2008-11-25 Alkermes, Inc. Polymer-based sustained release device
US20060110423A1 (en) * 2004-04-15 2006-05-25 Wright Steven G Polymer-based sustained release device
NZ550600A (en) 2004-04-28 2010-03-26 Btg Int Ltd Epitopes related to coeliac disease
US10105437B2 (en) 2004-04-28 2018-10-23 Btg International Limited Epitopes related to coeliac disease
AU2005244842B2 (en) 2004-05-12 2010-09-23 Baxter Healthcare S.A. Nucleic acid microspheres, production and delivery thereof
JP2007537288A (ja) 2004-05-12 2007-12-20 バクスター インターナショナル インコーポレイテッド オリゴヌクレオチド含有マイクロスフェア、１型糖尿病を処置する医薬の製造のための、その使用
US7717874B2 (en) * 2004-05-28 2010-05-18 Bioject, Inc. Needle-free injection system
US20060038044A1 (en) * 2004-08-23 2006-02-23 Van Steenkiste Thomas H Replaceable throat insert for a kinetic spray nozzle
US20060089593A1 (en) * 2004-10-26 2006-04-27 Sergio Landau Needle-free injection device for individual users
US20060089594A1 (en) * 2004-10-26 2006-04-27 Sergio Landau Needle-free injection device
WO2006058426A1 (en) 2004-12-01 2006-06-08 Wlt Distributors Inc. Needle-free injector
JP2008526229A (ja) * 2005-01-06 2008-07-24 ベニテック，インコーポレーテッド 幹細胞の維持のためのＲＮＡｉ剤
GB0507997D0 (en) * 2005-02-01 2005-05-25 Powderject Vaccines Inc Nucleic acid constructs
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
WO2006091459A2 (en) * 2005-02-24 2006-08-31 Joslin Diabetes Center, Inc. Compositions and methods for treating vascular permeability
DE102005015801A1 (de) 2005-04-06 2006-10-19 Schreiner Group Gmbh & Co. Kg Folienbasierter Schutzmechanismus
US20070118093A1 (en) * 2005-06-20 2007-05-24 Von Muhlen Marcio G High-speed jet devices for drug delivery
US8591457B2 (en) * 2005-08-10 2013-11-26 Alza Corporation Method for making a needle-free jet injection drug delivery device
EP1928537B1 (en) * 2005-09-02 2015-01-21 Intercell USA, Inc. Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs
EP1954336A4 (en) * 2005-11-29 2012-05-09 Biodesign Res & Dev ELECTROSTATIC, TRANSCUTANEOUS HYPODERMIC SPRAY (ELECTROSTATIC HYPOSPRAY)
JP4402648B2 (ja) * 2005-12-16 2010-01-20 オリンパス株式会社 被検体内導入装置
US20080161755A1 (en) * 2006-01-27 2008-07-03 Bioject Inc. Needle-free injection device and priming system
WO2007088112A1 (en) 2006-01-31 2007-08-09 Novo Nordisk A/S Seal for a prefilled medical jet injection device
GB0611443D0 (en) * 2006-06-09 2006-07-19 Powderject Res Ltd Improvements in, or relating to, particle cassettes
ES2422864T3 (es) 2006-08-09 2013-09-16 Intarcia Therapeutics, Inc Sistemas de liberación osmótica y unidades de pistón
CN100446823C (zh) * 2006-09-19 2008-12-31 宁波新芝生物科技股份有限公司 一种无创介入治疗系统
US7547293B2 (en) * 2006-10-06 2009-06-16 Bioject, Inc. Triggering mechanism for needle-free injector
WO2008043157A1 (en) 2006-10-12 2008-04-17 The University Of Queensland Compositions and methods for modulating immune responses
FR2908753B1 (fr) * 2006-11-16 2011-11-11 Becton Dickinson France Dispositif pour delivrer automatiquement des doses successives de produit
DE102007004855B4 (de) * 2007-01-31 2014-03-27 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung und Verfahren zur Deposition von biologischem Material in einem Zielsubstrat
JP2008199905A (ja) * 2007-02-16 2008-09-04 Snow Brand Milk Prod Co Ltd 乳酸菌生残性向上剤
US7744563B2 (en) * 2007-02-23 2010-06-29 Bioject, Inc. Needle-free injection devices and drug delivery systems therefor
PT2157967E (pt) 2007-04-23 2013-04-03 Intarcia Therapeutics Inc Formulações de suspensões de péptidos insulinotrópicos e suas utilizações
GB0708758D0 (en) * 2007-05-04 2007-06-13 Powderject Res Ltd Particle cassettes and process thereof
EP3000320B1 (en) 2007-05-16 2019-01-16 The Brigham and Women's Hospital, Inc. Treatment of synucleinopathies
GB2479843B (en) 2007-05-18 2012-02-29 Malvern Instr Ltd Method and apparatus for dispersing a sample of particulate material
JP4780034B2 (ja) * 2007-05-18 2011-09-28 株式会社島津製作所 針無注射器
EP2385065A1 (en) 2007-11-01 2011-11-09 Perseid Therapeutics LLC Immunosuppressive polypeptides and nucleic acids
EP2240155B1 (en) 2008-02-13 2012-06-06 Intarcia Therapeutics, Inc Devices, formulations, and methods for delivery of multiple beneficial agents
US8021873B2 (en) 2008-07-16 2011-09-20 Boston Microfluidics Portable, point-of-care, user-initiated fluidic assay methods and systems
US20110117673A1 (en) * 2008-07-16 2011-05-19 Johnson Brandon T Methods and systems to collect and prepare samples, to implement, initiate and perform assays, and to control and manage fluid flow
EP2385371B1 (en) 2008-09-22 2014-10-22 Oregon Health and Science University Methods for detecting a mycobacterium tuberculosis infection
DE102008048981A1 (de) * 2008-09-25 2010-04-15 Lts Lohmann Therapie-Systeme Ag Injektor und Zwei-Kammer-System mit sterilen Komponenten
US9207242B2 (en) 2008-10-09 2015-12-08 The University Of Hong Kong Cadherin-17 as diagnostic marker and therapeutic target for liver cancer
US9060926B2 (en) * 2008-10-31 2015-06-23 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8793075B2 (en) 2008-10-31 2014-07-29 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8545855B2 (en) * 2008-10-31 2013-10-01 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8731840B2 (en) 2008-10-31 2014-05-20 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US9050317B2 (en) 2008-10-31 2015-06-09 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8551505B2 (en) * 2008-10-31 2013-10-08 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US9060934B2 (en) 2008-10-31 2015-06-23 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US9050070B2 (en) 2008-10-31 2015-06-09 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US9072799B2 (en) 2008-10-31 2015-07-07 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8731841B2 (en) * 2008-10-31 2014-05-20 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8725420B2 (en) 2008-10-31 2014-05-13 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US20100111834A1 (en) * 2008-10-31 2010-05-06 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Compositions and methods for therapeutic delivery with frozen particles
US20100111857A1 (en) 2008-10-31 2010-05-06 Boyden Edward S Compositions and methods for surface abrasion with frozen particles
US8788211B2 (en) * 2008-10-31 2014-07-22 The Invention Science Fund I, Llc Method and system for comparing tissue ablation or abrasion data to data related to administration of a frozen particle composition
US8762067B2 (en) * 2008-10-31 2014-06-24 The Invention Science Fund I, Llc Methods and systems for ablation or abrasion with frozen particles and comparing tissue surface ablation or abrasion data to clinical outcome data
US9072688B2 (en) * 2008-10-31 2015-07-07 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8409376B2 (en) 2008-10-31 2013-04-02 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8721583B2 (en) 2008-10-31 2014-05-13 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8232093B2 (en) 2009-02-05 2012-07-31 Indian Institute Of Science Apparatus and method for genetically transforming cells
EP2405961A4 (en) * 2009-03-09 2012-08-08 Purdue Research Foundation COMPACT DEVICE FOR FAST MIXTURE AND ADMINISTRATION OF SUBSTANCES TO A PATIENT
WO2010105096A2 (en) 2009-03-11 2010-09-16 University Of Massachusetts Modulation of human cytomegalovirus replication by micro-rna 132 (mir132), micro-rna 145 (mir145) and micro-rna 212 (mir212)
EP2411519B1 (en) 2009-03-27 2015-07-22 Institut National de la Santé et de la Recherche Médicale Kanamycin antisense nucleic acid for the treatment of cancer
EP2756845B1 (en) 2009-04-03 2017-03-15 Dicerna Pharmaceuticals, Inc. Methods and compositions for the specific inhibition of KRAS by asymmetric double-stranded RNA
GB0906215D0 (en) 2009-04-09 2009-05-20 Lalvani Ajit Diagnostic test
TWI439302B (zh) 2009-07-14 2014-06-01 Chien Lung Chen 傳輸裝置
CN101987218B (zh) * 2009-07-30 2013-07-10 陈建龙 传输装置
KR101823699B1 (ko) 2009-09-28 2018-01-30 인타르시아 세라퓨틱스 인코포레이티드 실질 항정상태 약물 전달의 신속 확립 및/또는 종결
EP2942060A1 (en) 2009-09-29 2015-11-11 Joslin Diabetes Center, Inc. Use of Protein Kinase C Delta (PKCD) Inhibitors to Treat Diabetes, Obesity and, Hepatic Steatosis
WO2011063349A1 (en) * 2009-11-20 2011-05-26 Talima Therapeutics, Inc. Devices for implanting compositions and methods and kits therefor
EP3360566B1 (en) 2009-11-20 2019-12-25 Oregon Health&Science University Methods for detecting a mycobacterium tuberculosis infection
CN102178990B (zh) * 2010-01-08 2013-10-09 江苏丞宇米特医疗科技有限公司 无针注射器
WO2011098518A2 (en) 2010-02-11 2011-08-18 Ablynx Nv Delivery of immunoglobulin variable domains and constructs thereof
CN101797411B (zh) * 2010-03-18 2011-12-07 傅雅芬 一种气压式无针注射器动力头
WO2011123762A1 (en) * 2010-04-01 2011-10-06 Glucago Llc Method and device for mixing substances
WO2011154863A1 (en) 2010-06-07 2011-12-15 Pfizer Inc. Her-2 peptides and vaccines
US8821434B2 (en) * 2010-10-07 2014-09-02 Massachusetts Institute Of Technology Delivery of a solid body and/or a fluid using a linear Lorentz-force actuated needle-free jet injection system
US9211378B2 (en) 2010-10-22 2015-12-15 Cequr Sa Methods and systems for dosing a medicament
EP2635596B8 (en) 2010-11-01 2020-03-11 University of Technology Sydney Immune-modulating agents and uses therefor
GB201021881D0 (en) * 2010-12-23 2011-02-02 Profibrix Bv Powder delivery device
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
US8388569B2 (en) 2011-04-19 2013-03-05 Xerox Corporation Delivery devices and methods with collimated gas stream and particle source
US8430839B2 (en) 2011-04-19 2013-04-30 Palo Alto Research Center Incorporated Drug delivery devices and methods with collimated gas stream and drug reservoir
US8486002B2 (en) 2011-04-19 2013-07-16 Palo Alto Research Center Incorporated Drug delivery devices and methods with collimated gas stream and release-activatable tape
WO2013037804A1 (en) 2011-09-12 2013-03-21 Laboratorios Del Dr. Esteve, S.A. Method for monitoring cytotoxic t lymphocyte (ctl) responses by a delayed-type hypersensitivity reaction using defined ctl viral epitopes
CA2856116A1 (en) 2011-11-17 2013-05-23 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Therapeutic rna switches compositions and methods of use
US20140058319A1 (en) * 2012-03-20 2014-02-27 Glucago Llc Compact Device For Rapidly Mixing and Delivering Substances To a Patient
US8992469B2 (en) 2012-06-26 2015-03-31 Glucago Llc Reconstitution device
US9125995B2 (en) 2012-12-05 2015-09-08 Glucago Llc Reconstitution devices
US9345487B2 (en) 2013-02-05 2016-05-24 Path Scientific, Llc Precision bone drill and method of use
EP2769732A1 (en) 2013-02-22 2014-08-27 Sanofi Serpins: methods of therapeutic beta-cell regeneration and function
EP2851086A1 (en) 2013-09-20 2015-03-25 Sanofi Serpins: methods of therapeutic ß-cell regeneration and function
EP2958585A1 (en) 2013-02-22 2015-12-30 Sanofi Serpins: methods of therapeutic beta-cell regeneration and function
CA2904703A1 (en) 2013-03-14 2014-10-02 Hallux, Inc. Method of treating infections, diseases or disorders of nail unit
US9808579B2 (en) * 2013-05-08 2017-11-07 Elwha Llc Needleless injector systems, and related methods and components
US10279113B2 (en) * 2013-05-17 2019-05-07 Socpra Sciences Et Genie S.E.C. Needleless syringe and method for delivering therapeutic particles
CN106163500A (zh) * 2014-02-26 2016-11-23 普乐药业有限公司 用于递送颗粒的装置
WO2015171964A1 (en) * 2014-05-07 2015-11-12 Sri International Needle free injection device
US9737251B2 (en) 2014-05-28 2017-08-22 Verily Life Sciences Llc Needle-free blood draw
EP2959931A1 (de) * 2014-06-24 2015-12-30 LTS LOHMANN Therapie-Systeme AG Nadellose Injektionsvorrichtung
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
EP3011988A1 (de) * 2014-10-22 2016-04-27 LTS LOHMANN Therapie-Systeme AG Nadellose Injektionsvorrichtung aufweisend ein Gel und eine Membran
WO2016077382A2 (en) 2014-11-11 2016-05-19 Massachusetts Eye & Ear Infirmary Conjunctivitis vaccines
EP3569711B1 (en) 2014-12-15 2021-02-03 Dicerna Pharmaceuticals, Inc. Ligand-modified double-stranded nucleic acids
US10078207B2 (en) 2015-03-18 2018-09-18 Endochoice, Inc. Systems and methods for image magnification using relative movement between an image sensor and a lens assembly
LT3277814T (lt) 2015-04-03 2020-10-26 University Of Massachusetts Oligonukleotidų junginiai, skirti nukreipimui į hantingtino mrnr
WO2016161378A1 (en) 2015-04-03 2016-10-06 University Of Massachusetts Oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders
EP3292206B8 (en) 2015-05-07 2022-02-09 Takeda Pharmaceutical Company Limited Glucocerebrosidase gene therapy for parkinson's disease
US10925639B2 (en) 2015-06-03 2021-02-23 Intarcia Therapeutics, Inc. Implant placement and removal systems
US20160361240A1 (en) 2015-06-11 2016-12-15 The Procter & Gamble Company Apparatus and methods for modifying keratinous surfaces
US10633653B2 (en) 2015-08-14 2020-04-28 University Of Massachusetts Bioactive conjugates for oligonucleotide delivery
US10358497B2 (en) 2015-09-29 2019-07-23 Amgen Inc. Methods of treating cardiovascular disease with an ASGR inhibitor
WO2017087708A1 (en) 2015-11-19 2017-05-26 The Brigham And Women's Hospital, Inc. Lymphocyte antigen cd5-like (cd5l)-interleukin 12b (p40) heterodimers in immunity
JP7088843B2 (ja) * 2015-12-28 2022-06-21 イノビオ ファーマシューティカルズ，インコーポレイティド 皮内ジェット注射式電気穿孔装置
JP2019503394A (ja) 2016-01-31 2019-02-07 ユニバーシティ・オブ・マサチューセッツＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍａｓｓａｃｈｕｓｅｔｔｓ 分岐オリゴヌクレオチド
KR102574993B1 (ko) 2016-05-16 2023-09-06 인타르시아 세라퓨틱스 인코포레이티드 글루카곤-수용체 선택적 폴리펩티드 및 이들의 이용 방법
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
US11753638B2 (en) 2016-08-12 2023-09-12 University Of Massachusetts Conjugated oligonucleotides
US10443055B2 (en) 2016-12-22 2019-10-15 Beth Israel Deaconess Medical Center Compounds that target MYC microRNA responsive elements for the treatment of MYC-associated cancer
KR20190104039A (ko) 2017-01-03 2019-09-05 인타르시아 세라퓨틱스 인코포레이티드 Glp-1 수용체 효능제의 연속적인 투여 및 약물의 동시-투여를 포함하는 방법
EP3642341A4 (en) 2017-06-23 2021-06-16 University Of Massachusetts TWO-DAY SELF-RELEASING SIRNA AND RELATED PROCEDURES
WO2019033114A1 (en) 2017-08-11 2019-02-14 Dana-Farber Cancer Institute, Inc. USE OF BOTULINUM TOXIN AGENT FOR THE TREATMENT OF PLASMOCYTE DISORDERS
WO2019036375A1 (en) 2017-08-14 2019-02-21 Sanford Burnham Prebys Medical Discovery Institute CARDIOGENIC MESODERMA TRAINING REGULATORS
US11413288B2 (en) 2017-11-01 2022-08-16 Dana-Farber Cancer Institute, Inc. Methods of treating cancers
JP2021522862A (ja) 2018-05-11 2021-09-02 アルファ アノマリック エスアエス ７’−５’−アルファ−アノマー二環式糖ヌクレオシドを含むオリゴヌクレオチドコンジュゲート
CN108553748A (zh) * 2018-05-11 2018-09-21 江秀秀 B超监视下体内多种细胞植入仪
USD933219S1 (en) 2018-07-13 2021-10-12 Intarcia Therapeutics, Inc. Implant removal tool and assembly
SG11202101288TA (en) 2018-08-10 2021-03-30 Univ Massachusetts Modified oligonucleotides targeting snps
WO2020047229A1 (en) 2018-08-29 2020-03-05 University Of Massachusetts Inhibition of protein kinases to treat friedreich ataxia
KR102199724B1 (ko) * 2018-10-05 2021-01-07 주식회사 피테크 무바늘 무통 주사 장치
JP7386382B2 (ja) 2018-12-12 2023-11-27 カイト ファーマ インコーポレイテッド キメラ抗原受容体及びｔ細胞受容体並びに使用方法
CN114072501A (zh) 2019-05-06 2022-02-18 马萨诸塞大学 抗c9orf72寡核苷酸及相关方法
IT201900007060A1 (it) 2019-05-21 2020-11-21 St Superiore Di Sanita Cellule tumorali ingegnerizzate e loro usi
CN110038212A (zh) * 2019-05-29 2019-07-23 徐小棠 一种呼吸内科护理给药多用装置
AU2020284136A1 (en) 2019-05-30 2022-01-20 Oregon Health & Science University Methods for detecting a mycobacterium tuberculosis infection
CN110180051B (zh) * 2019-07-13 2021-04-02 河南省中医院（河南中医药大学第二附属医院） 产科护理用清洗装置
IT201900012540A1 (it) 2019-07-22 2021-01-22 Humanitas Mirasole Spa Inibitori di CHI3L1 e loro usi
AU2020329155A1 (en) 2019-08-09 2022-03-10 University Of Massachusetts Chemically modified oligonucleotides targeting SNPs
US12037585B2 (en) 2019-12-23 2024-07-16 University Of Massachusetts Oligonucleotides for tissue specific gene expression modulation
GB202105455D0 (en) 2021-04-16 2021-06-02 Ucl Business Ltd Composition
CN117677699A (zh) 2021-06-23 2024-03-08 马萨诸塞大学 用于治疗先兆子痫和其他血管生成病症的优化抗flt1寡核苷酸化合物
CN118139663A (zh) * 2021-06-24 2024-06-04 阿维塔斯有限公司 喷雾喷嘴
GB202112471D0 (en) 2021-09-01 2021-10-13 King S College London Microna systems
US20240075265A1 (en) * 2022-09-07 2024-03-07 Particle Vaccine Canada Ltd. Method and apparatus for epidermal delivery of powdered medicaments
WO2024200831A1 (en) 2023-03-30 2024-10-03 Vivadju Pvax14 nucleic acid in combination with all-trans retinoic acid (atra) and a checkpoint inhibitor for the treatment of cancer

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE170094C (ja)
US1300654A (en) 1919-01-30 1919-04-15 William H Rose Dry-spraying machine.
US2151418A (en) 1937-05-12 1939-03-21 Scott & Bowne Powder applicator
US2147158A (en) 1937-09-28 1939-02-14 Goldenthal Philip Powder insufflator
US2307986A (en) 1940-02-15 1943-01-12 Bolte Insufflator
US2605763A (en) * 1948-01-31 1952-08-05 Becton Dickinson Co Injection device
GB677523A (en) * 1948-04-13 1952-08-20 Becton Dickinson Co Discharge structure for hypodermic injection device
US2478715A (en) 1948-07-14 1949-08-09 Vilbiss Co Powder blower
US2594093A (en) 1949-02-05 1952-04-22 Armour & Co Powder container
US2470298A (en) 1949-02-07 1949-05-17 Abbott Lab Powdered medicine dispenser
DE1047385B (de) * 1952-03-08 1958-12-24 Armour & Co Puderzerstaeuber mit einem auswechselbaren Puderbehaelter
US3216562A (en) 1963-06-13 1965-11-09 Driaire Inc Easy-open capsule
IL28680A (en) 1966-12-16 1971-12-29 American Home Prod Stabilized aqueous suspensions of benzathine penicillin
US3674028A (en) * 1969-06-04 1972-07-04 Ims Ltd Multi-mix
US3736933A (en) * 1970-12-02 1973-06-05 B Szabo Burstable seamed hypodermic applicators
US3788315A (en) * 1971-04-20 1974-01-29 S Laurens Disposable cutaneous transjector
US3914573A (en) * 1971-05-17 1975-10-21 Geotel Inc Coating heat softened particles by projection in a plasma stream of Mach 1 to Mach 3 velocity
US3853125A (en) * 1971-10-05 1974-12-10 W Clark Disposable needleless injector
US3782380A (en) * 1973-01-04 1974-01-01 Gaast H V D Medicament injecting device
US4069819A (en) * 1973-04-13 1978-01-24 Societa Farmaceutici S.P.A. Inhalation device
US3946732A (en) * 1973-08-08 1976-03-30 Ampoules, Inc. Two-chamber mixing syringe
US3967761A (en) 1974-04-08 1976-07-06 Southwest Research Institute System for injecting particulate material into the combustion chamber of a repetitive combustion coating apparatus
US3952741A (en) * 1975-01-09 1976-04-27 Bend Research Inc. Controlled release delivery system by an osmotic bursting mechanism
US3982605A (en) * 1975-05-05 1976-09-28 The Carborundum Company Nozzle noise silencer
FR2360031A1 (fr) * 1976-07-27 1978-02-24 Klein Max Dispositif distributeur silencieux d'un jet de gaz et application au diagnostic medical
JPS602489B2 (ja) * 1977-05-02 1985-01-22 株式会社豊田中央研究所 低騒音用圧力流体放出装置
US4291062A (en) * 1978-06-16 1981-09-22 Phares Pharmaceutical Research N.V. Pharmaceutical compositions containing urea
US4226236A (en) * 1979-05-07 1980-10-07 Abbott Laboratories Prefilled, vented two-compartment syringe
US4778054A (en) 1982-10-08 1988-10-18 Glaxo Group Limited Pack for administering medicaments to patients
FI79651C (fi) 1982-10-08 1990-02-12 Glaxo Group Ltd Doseringsanordning foer medicin.
US4515586A (en) 1982-11-30 1985-05-07 Abbott Laboratories Powder syringe mixing system
US4652261A (en) * 1984-06-22 1987-03-24 Regents Of The University Of Minnesota Drug-injection animal capture collar
US4945050A (en) * 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US5100792A (en) * 1984-11-13 1992-03-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues
US5036006A (en) * 1984-11-13 1991-07-30 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US4596556A (en) * 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
GR861995B (en) 1985-07-30 1986-11-04 Glaxo Group Ltd Devices for administering medicaments to patients
DK179286D0 (da) 1986-04-18 1986-04-18 Nordisk Gentofte Insulinpraeparat
USRE33801E (en) 1986-05-09 1992-01-21 Dentsply Research & Development Corp. Mixing and discharge capsule
US5120657A (en) 1986-12-05 1992-06-09 Agracetus, Inc. Apparatus for genetic transformation
IN170021B (ja) * 1987-05-26 1992-01-25 Deita Freyberg Gmbh
GB2206794A (en) * 1987-07-14 1989-01-18 Richard Kiteley Power Syringe
US4853229A (en) * 1987-10-26 1989-08-01 Alza Corporation Method for adminstering tiny pills
US5179022A (en) * 1988-02-29 1993-01-12 E. I. Du Pont De Nemours & Co. Biolistic apparatus for delivering substances into cells and tissues in a non-lethal manner
BR8801952A (pt) * 1988-04-22 1989-11-14 Sergio Landau Capsula descartavel,nao re-utilizavel,contendo dose individual de vacina a ser injetada hipodermicamente,sem agulha,com aparelho injetor a pressao
FR2638359A1 (fr) * 1988-11-03 1990-05-04 Tino Dalto Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau
JPH04504858A (ja) * 1989-04-20 1992-08-27 マウント　シナイ　スクール　オブ　メディスン　オブ　ザ　シティー　ユニバーシティー　オブ　ニューヨーク 肝臓特異性インシュリン類似体
US5239991A (en) 1989-06-21 1993-08-31 Fisons Plc Disposable powder medicament inhalation device with peel-off cover
HU200699B (en) * 1989-07-05 1990-08-28 Gyula Erdelyi Neddleless hypodermic syringe particularly for blinds and poor-sighted persons
GB8918879D0 (en) * 1989-08-18 1989-09-27 Danbiosyst Uk Pharmaceutical compositions
US5064413A (en) * 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
WO1991013595A1 (en) * 1990-03-15 1991-09-19 The United States Of America, As Represented By The Secretary Of The Army Chemotherapeutic treatment of bacterial infections with an antibiotic encapsulated within a biodegradable polymeric matrix
US5062830A (en) * 1990-04-04 1991-11-05 Derata Corporation Dry disposable nozzle assembly for medical jet injector
GB9011588D0 (en) * 1990-05-24 1990-07-11 Wellcome Found Prostaglandin analogues for use in medicine
US5204253A (en) * 1990-05-29 1993-04-20 E. I. Du Pont De Nemours And Company Method and apparatus for introducing biological substances into living cells
US5149655A (en) * 1990-06-21 1992-09-22 Agracetus, Inc. Apparatus for genetic transformation
IT1243344B (it) 1990-07-16 1994-06-10 Promo Pack Sa Inalatore plurimonodose per medicamenti in polvere
GB9016789D0 (en) * 1990-07-31 1990-09-12 Lilly Industries Ltd Medicament administering devices
WO1992004439A1 (en) * 1990-08-30 1992-03-19 Brian John Bellhouse Ballistic apparatus
US5042472A (en) 1990-10-15 1991-08-27 Merck & Co., Inc. Powder inhaler device
US5046618A (en) 1990-11-19 1991-09-10 R. P. Scherer Corporation Child-resistant blister pack
US5188615A (en) 1990-11-19 1993-02-23 Habley Medical Technology Corp. Mixing vial
DK288590D0 (da) * 1990-12-04 1990-12-04 Michael Morris Blandings/oploesnings-sproejte til cytostatika for medicinsk behandling af cancer patienter
GB9027422D0 (en) * 1990-12-18 1991-02-06 Scras Osmotically driven infusion device
GB9100950D0 (en) * 1991-01-16 1991-02-27 Dunne Miller Weston Ltd Metered dose atomising and delivery device
US5360410A (en) 1991-01-16 1994-11-01 Senetek Plc Safety syringe for mixing two-component medicaments
US5492112A (en) 1991-05-20 1996-02-20 Dura Pharmaceuticals, Inc. Dry powder inhaler
US5102388A (en) 1991-07-15 1992-04-07 Richmond John E Sequential delivery syringe
GB9118204D0 (en) * 1991-08-23 1991-10-09 Weston Terence E Needle-less injector
EP0558879B1 (en) 1992-03-04 1997-05-14 Astra Aktiebolag Disposable inhaler
ATE153299T1 (de) 1992-09-09 1997-06-15 Fisons Plc Pharmazeutisches verpacken
TW360548B (en) 1993-04-08 1999-06-11 Powderject Res Ltd Products for therapeutic use
US5349947A (en) * 1993-07-15 1994-09-27 Newhouse Michael T Dry powder inhaler and process that explosively discharges a dose of powder and gas from a soft plastic pillow
US5415162A (en) 1994-01-18 1995-05-16 Glaxo Inc. Multi-dose dry powder inhalation device
EP0690732B1 (en) 1994-01-21 2003-01-29 Powderject Vaccines, Inc. Gas driven gene delivery instrument
US5483954A (en) 1994-06-10 1996-01-16 Mecikalski; Mark B. Inhaler and medicated package
JP3320261B2 (ja) * 1995-06-01 2002-09-03 株式会社ユニシアジェックス 吸入式投薬器

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