LV10503B - Method for producing of ll-f-28249 23-(c1-c6-alkyloxime) - Google Patents
Method for producing of ll-f-28249 23-(c1-c6-alkyloxime) Download PDFInfo
- Publication number
- LV10503B LV10503B LVP-93-697A LV930697A LV10503B LV 10503 B LV10503 B LV 10503B LV 930697 A LV930697 A LV 930697A LV 10503 B LV10503 B LV 10503B
- Authority
- LV
- Latvia
- Prior art keywords
- mmojih
- dimethylsulfoxide
- nitrobenzoyl
- okco
- npn
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 6
- 238000000034 method Methods 0.000 claims abstract 8
- 230000003647 oxidation Effects 0.000 claims abstract 4
- 238000007254 oxidation reaction Methods 0.000 claims abstract 4
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 claims 11
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 8
- NUJOXMJBOLGQSY-UHFFFAOYSA-N manganese dioxide Chemical compound O=[Mn]=O NUJOXMJBOLGQSY-UHFFFAOYSA-N 0.000 claims 4
- 230000001590 oxidative effect Effects 0.000 claims 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- 125000003232 p-nitrobenzoyl group Chemical group [N+](=O)([O-])C1=CC=C(C(=O)*)C=C1 0.000 claims 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 238000001953 recrystallisation Methods 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- NKRJRPDCNYYXEZ-UHFFFAOYSA-N (2-methylpropan-2-yl)oxyalumane Chemical compound CC(C)(C)O[AlH2] NKRJRPDCNYYXEZ-UHFFFAOYSA-N 0.000 claims 1
- WOAHJDHKFWSLKE-UHFFFAOYSA-N 1,2-benzoquinone Chemical compound O=C1C=CC=CC1=O WOAHJDHKFWSLKE-UHFFFAOYSA-N 0.000 claims 1
- SKDHHIUENRGTHK-UHFFFAOYSA-N 4-nitrobenzoyl chloride Chemical compound [O-][N+](=O)C1=CC=C(C(Cl)=O)C=C1 SKDHHIUENRGTHK-UHFFFAOYSA-N 0.000 claims 1
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 claims 1
- SYNHCENRCUAUNM-UHFFFAOYSA-N Nitrogen mustard N-oxide hydrochloride Chemical compound Cl.ClCC[N+]([O-])(C)CCCl SYNHCENRCUAUNM-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- INGGGNUCWJHFKD-UHFFFAOYSA-N chromium;pyridine Chemical group [Cr].C1=CC=NC=C1 INGGGNUCWJHFKD-UHFFFAOYSA-N 0.000 claims 1
- NKRNGKIEDAVMHL-UHFFFAOYSA-L dihydroxy(dioxo)chromium;pyridine Chemical compound O[Cr](O)(=O)=O.C1=CC=NC=C1 NKRNGKIEDAVMHL-UHFFFAOYSA-L 0.000 claims 1
- YWEUIGNSBFLMFL-UHFFFAOYSA-N diphosphonate Chemical compound O=P(=O)OP(=O)=O YWEUIGNSBFLMFL-UHFFFAOYSA-N 0.000 claims 1
- DLYUQMMRRRQYAE-UHFFFAOYSA-N phosphorus pentoxide Inorganic materials O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000011780 sodium chloride Substances 0.000 description 5
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- XNXVOSBNFZWHBV-UHFFFAOYSA-N hydron;o-methylhydroxylamine;chloride Chemical compound Cl.CON XNXVOSBNFZWHBV-UHFFFAOYSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 101100397240 Arabidopsis thaliana ISPD gene Proteins 0.000 description 1
- 101000622010 Crotalus atrox Snake venom metalloproteinase atrolysin-B Proteins 0.000 description 1
- 241001669680 Dormitator maculatus Species 0.000 description 1
- 101100013145 Drosophila melanogaster Flo2 gene Proteins 0.000 description 1
- 101100168745 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) csnG gene Proteins 0.000 description 1
- WDWFRIMNWVDXGF-YQERLSOISA-N LL-F28249 beta Chemical compound C1[C@H](O)[C@H](C)[C@@H](C(/C)=C/C)O[C@]11O[C@H](C\C=C(C)\C[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 WDWFRIMNWVDXGF-YQERLSOISA-N 0.000 description 1
- 229910006561 Li—F Inorganic materials 0.000 description 1
- 102000004213 Neuropilin-2 Human genes 0.000 description 1
- 108090000770 Neuropilin-2 Proteins 0.000 description 1
- 241000187747 Streptomyces Species 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 101150078969 acoB gene Proteins 0.000 description 1
- WDWFRIMNWVDXGF-UHFFFAOYSA-N nemadectin beta Natural products C1C(O)C(C)C(C(C)=CC)OC11OC(CC=C(C)CC(C)C=CC=C2C3(C(C(=O)O4)C=C(C)C(O)C3OC2)O)CC4C1 WDWFRIMNWVDXGF-UHFFFAOYSA-N 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fats And Perfumes (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyridine Compounds (AREA)
- Photoreceptors In Electrophotography (AREA)
- Liquid Crystal Substances (AREA)
- Cosmetics (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Lubricants (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Description
LV 10503 CI10C0B nOJIREHMH 23-(Cj-C6 AJ1KMJI0KCMM0B) - Li- F 28249
OnHcaHHe
HacTOHmee Η3θ6ρβτβΗΗβ othocmtch k ycoBepmeHCTBOBaHHOMy cno-co(5y nojiy^eHHH coeflHHeHHfi 23-(Cj-C0 anKMJiOKCHMOB)-//~F 28249. 0ČO3HatieHHe LL -F 28249 HCnojib3yiOT rjir onncaHHfl pH,ū,a οοθαμηθηκη , npOflyi],HpyeMHX φΘρΜΘΗΤ3ΤΗΒΗΗΜ 6yJIb0H0M nOJĶBHfla BHfla Streptomyces cyaneogrisens,flenOHHpOBaHHOro B KOJIJieKLJHH NRRL noj; ηομθρομ 15773.
Uejibio flaHHoro Η3θ6ρβτβΗΗΗ HBJineTCH co3,n,aHHe cnocoča nojiy^e-hhh coeflHHeHHfi 23-(Cj-Cg aJiKHJioKCHM)-//- F 28249, h dojiee koh-κρβτΗο - 23 - (μθτμοκοημ) -LL - F 28249 (MOKCn,n,eKTHHa) CHJīb- HOAeficTByioinero θη,π,θκτοφϊ,π,ηογο areHTa. JļaHHoe H3o6peTeHHe othochtch k cnoco(5y ποπ^θηηη οοθαηηθηημ 23 - (Cj-Cg ajimnoKCHM) - LL - F 28249, BKHKwaromeMy 3aiiļHTy rHflpoKCHJībHOH rpynnbi b nojioHceHHH 5 coeflHHeHHK LL - F 28249 π - HHTpo6eH30HJixj!opHja,OM c o6pa30BaHHeM cooTBeTCTByiomero coe,n,H- 2 ηθηιίη 5-0-(n-HMTpo6eH3OHJi) - L L - F 28249; OKKCJieHHe yKa3aH-ΗΟΓΟ COe^HHeHMH C 06pa3OBaHHeM np0H3B0flH0r0 5-0-(n-HHTpo6eH-30mji ) - 23-okco - L. L_- F 28249 b KpucTajuiimecKOM coctohhhh; peaKUļHfo yKa3aHHoro npon3BOflCTBa c Cj-Cg ajiKOKcmiaMHHOM hjim ero cojibio c 0(5pa30BaHneM HHTepMeflHaTa 23-(Cj-Cg ajiKMJioKCHM) -5-0-(n-HHTpo6eH30MJi) - L L- F 28249 b KpHCTajuiH^ecKOM coc-tohhm; ΐΛ οηητμθ 3ainHTH c yKa3aHHoro HHTepMeflHaTa b npncyTCT-bhh ocHOBaHHH c 0(5pa30BaHneM iļeJieBoro coeflHHeHUH 23-(Cj-Cg aji-khjiokchm) - L L - F 28249. Bo3mokho οηητηθ satņuTH c KpHCTajum-HecKHx npoH3Bo,n,Hbix 5-0-( n-HHTpo6eH30HJi) - 23-okco L L - F 28249 Β npHCyTCTBHH OCHOBaHHH C 00pa30BaHHeM COOTBeTCTByK)ip[X COeAHHe- ηιλΡι 23-okco - L IrF 28249, h peaKijHH yKa3aHHbix οοθαμηθηηΚ c Cļ-Cg ajiKOKCHJiaMHHOM hjih ero cojibio c o6pa30BaHHeM qeJieBoro coe-Αηηθηηη 23-(Cj-Cg ajiKHJioKCHM) - LL - F 28249. M3BecTeH cnoco(5 nojiy^eHMH coeflHHeHHH 23-(Cj-Cg ajiKHJiOKCHMOB) - LL - F 28249 CM.naTeHT UļB 2192630.0Π 1988 r., hx ncnoJib30BaHHe b Ka^ecTBe npOTHBOrejrbMHHTHHX , HHCeKTHLļHflHbIX, Πρ0ΤΗΒ0ΗβΜ3Τ0^ΗΗΧ, ΙφΟΤΗΒΟ-3KTonapa3HTapHbix κ aKapHmmHbix areHTOB onHcaHbi b naTeHTe CU1A # 4916154. .JļaHHoe n30(5peTeHHe othochtch k ynpomeHHOMy 3a c^eT 6ojiee npOCTOft O^MCTKH M BblfleJieHHH npOMe*yTOqHOro ΟΟΘ,Π,ΗΗΘΗΗΗ, cnoco- 6y nojiy^eHHH 23-(Cj-Cg ajiKOKCHMHbnc) προΜ3Βθ,ηΗΗΧ coe^HHeHHii L L - F 28249. CoejļHHeHHfl LL - F 28249 n3o6pa«aiOTCH Humecjie-jnyiomeH oČiņeM cTpyκTypHοVi $opMyjioft: LV 10503
OH
Κ0ΜΠ0Η6ΗΤ RI % R3 R, L L- F 28249 CH(CH3)2 H ch3 CHg LL - F 28249 ch3 H ch3 CHg L L - F 28249 C ch3 ch3 ch3 ch3 L L- F 28249 CH(CH3)2 H H CHg LL- F 28249 CHgCHg H ch3 CHg LL- F 28249 CM(CH3)2 H CHg CHgCHg L L- F 28249 CH(CH3)2 H ch2ch3 CHg LL- F 28249 CH(CH3)2 ch3 CHg CHg ļanee, npeflJiaraeTCH cnocoCi nojiyweHHH coeflHHeHHft 23-(Cj-Cg ajiKHJiOKCHM) - L L - F 28249, b κοτοροΜ c KpHCTajunwecKHX npo-H3B0flHHX 5-0-( n-HHTpo(5eH30HJi) - 23-okco- L L - F 28249 b πρκ-cjttctbhh ocHOBaHHH CHHMaiOT 3amttTy, noji^aa cooTBeTCTBjrmpīe coe-Αηηθηηη 23-okco - L L - F 28249, h npHBOflflT peaKiļHio yKa3aHHHx 4 coejļmemPi c Cj-Cg ajiKOKcmamHou hjih ero cojibm c πολ^θηηθμ qejieBoro οοθαμηθηηη 23-(Cj-Cg ajiKHJiOKCHM) LL - F 28249.
ΠρΗ HCn0JIb30B&HHH B Ka^ieCTBe ΜΟΧΟβΗΟΓΟ COeflHHeHHH L L - F 28249 m cojiHHOKHCJioro MeTOKCHJiaMHHa b Ka^ecTBe Cj-Cg aJIKOKCHJiaMHHa 3aflBJIHeMhlfi CnOCO(5 MO)KHO npOHJIJIIOCTpMpOBaTb HH*e-cjiefl^Too^efi flHarpaMMoft I, b κοτοροΑ ΠΗΒ o(5o3HayaeT $yHKu;HOHa^bHyio rpynny - Π-ΗΗΤρθ6θΗ30Μ.Π. LV 10503
I
I
ΟΡΝΒ 6 3amwTa γηαροκοηλβηομ rpynnu b noJiomeHHH 5 οοθαηηθηηη L L - F 28249oC ocymecTBJiHeTCn peaKijHeM Me«Ay L L - F 28249 H n-HHTpo6eH30HJIXJIOpHAOM B npHCyTCTBHH OpraHM^eCKOTO paCTBOpM-τβΛΗ , TaKoro KaK, HanpHMep, TOJiyoji, xjiopHCTbift μθτμλθη, 3THJiaiļe-TaT, aiļeTOHHTpuJi h hm noAOČHbie, npeflno^TMTeJibHO b npHcyTCTBHH TOjryoJia, h opraHH^ecKoro ocHosaHHH, Tanoro KaK, HanpHMep, nnpn-AHH, TpK3THJiaMMH, N - MeTHJinHppOJIHAOH , H HM ΠΟΑ00ΗΗβ, ΠρθΑΠΟ^-THTeJIbHO Β npMCyTCTBHH TpH3THJiaMHHa.
HeoKHAaHHO dbiJio HaMfleHo, ^το OKHCJieHne οοθαμηθηηη 5-0-(n-HHTpo6eH30HJi) LL- F 28249 jļaeT KpncTajiJiH*iecKnft npoflyKT - coot-BeTCTByiomee coeAHHeHHe 5-0-( n-HHTpodeH30HJi) - 23-okco -LL- F 28249. KpHCTajiJiH^ecKoe coctohhh6 HHTepMeAnaTa πο3βοληθτ ocjniļecTBJiHTb ero npoCTyio h 3$$eKTHBHyio oyncTKy nyTeM nepeKpnc-TajurH3aij;nH hx noAXOAflmero opraHHuecKoro pacTBopHTeAH h ycTpaHHTb cjiojKHyio, A^HTeJibHyio npoiļeAypy o^hctkh c noMonļbio τβκμχ μθτοαοβ,
KaK KOJiOHcmHaH xpoMaTorpa$nn. Οκηολθηηθ οοθαπηθηhh 5-0-(π-ΗΗτρο-6eH30HJi) - L L - F 28249 ycnemHo ocyiqecTBJiHeTCH c ncnojib30BaHneM OKHCJIHIOmeft CHCTeMH, BbldpaHHO^ H3 rpymiH, ΟΟΟΤΟΗΐηβίί H3 ΠΗρΗΑΗΗΑΗ-xpoMaTa η yKcycHoro aHrnApHAa; nnpnflHHflHxpoMaTa h AHMeTHJi$opMa-MHAa; TpeT-(5yTOKCHajnoMHHHH h opTo6eH3oxnHOHa; πητηοκηοη $oc$opa h A™eTHJicyjib$oKCHAa; AHU,HKJioreKCHJiKap0oAHHMHAa h AHMeTHJicyjib$o-KCHAa; AByoKHCH MapraHLļa; h yKcycHoro aHmjļpiijļS. h AHMeTHJicyjib$o-KCHAa. IIpeAno^THTejibHofi OKMCJiaromen οηοτθμοΜ κάε οκηολθηηη οοθαηηθ-ΗΗΜ 5-0-( Π-ΗΗΤρθ6θΗ30ΗΑ) - LL - F 28249 HBJIfleTCfl AayOKHCb Map-ramja b npncyTCTBnn pacTBopHTeJin, TaKoro KaK, HanpHMep, xjiopHC-thh μθτηλθη, aqeTOHHTpHJi, 3THJiaqeTaT hjih hm ποαο6ηηθ, πρθΑποπ-THTeJībHO - B npHCyTCTBHH 3THJiaij[eTaTa. Βοαθθ npeAno^THTeJibHOH οκκοΑπιοηβΗ cHCTeMoii AJia οκηο-τιθηηη οοβΑΗΗβΗΗίί 5-0-(n-HHTpo6eH3OHJi) - L L - F 28249 ηβληθτοη yKcyc-HHft aHPHApHA H AMMeTHJICyJlb$OKCHA B npHCyTCTBHH nHpHAHHa H KHC— jiotu, TaKOH KaK, HanpHMep, yKcycHaH KHCJiOTa, TpH$TopyKcycHaH KHCJioTa, AHXJiopyKcycHaH KHCJiOTa, MOHOXJiopyKcycHafl KHCJiOTa h hm ποαο6ηηθ, npeAno^THTeJibHO - MOHOxjiopyKcycHafl KHCJioTa. HeojKHAaH-ho 6hjio HaftAeHO, mto Hcnojib30BaHHe yKcycHoro aHTHApHAa η αημθτηλ-cyjib$oKCHAa b npHcyTCTBHH nnpHAHHa h khcjioth CHJībHO yBejrHnHBaeT ββτχοα npoH3BOAHbix 5-0-(n-HHTpo(5eH30Hjr)-23-okco L L - F 28249 no LV 10503
CpaBHeHMK) C HCn0Jlb30BaHHeM TOJIbKO yKCyCHOrO aHrHflpMfla H £ΗΜΘ-TMJicyjrb$oKCHfla. HanpuMep, ecm οκηοπθηηθ yKcycHbTM aHrHApHAOM H AHMeTHJICyJIb$OKCHAOM ΠρΟΒΟβΗΤ B npHCyTCTBHH nHpMflMHa H MOHO-xjiopyKcycHOii khcjiotm, to βηχο^ 5-0-(n-HHTpo6eH30HJi)-23-OKCo-LL - F 28249 cC cocTaBJineT 76%; ecjin to xe οκηοιεθηηθ ripoBO-£HT B OTCyTCTBHe nupHAHHa H MOHOXJIOpyKCyCHOii KHCJIOTbl, BbTX0fl cocTaBJineT 2-4%.
KpHCTajiJiH^ecKoe npoH3BOAHoe 5-0-(n-HHTpo(5eH3OHJi)-23-OKCo-L L - F 28249 mojkho ο^ηοτητβ nepeKpncTaJuiH3aij;KeM H3 ποαχοαη-qero pacTBOpHTejifl (npeAnoHTHTeJifeHO h3 H-nponaHOJia) nepefl chh-τηθμ 3amHTH (yAajieHHeM n-HHTpo<5eH30HJibHoft rpynnbi) hjih peaKiļHefi C COJIHHOKHCJIblM Cj-Cg aJIKOKCHJiaMHHOM. ripeflno^THTejibHO προΒο,π,Ητ peaKiļnio pacTBopa HeomimeHHoro npo-AyKTa peaKu;HH 5-0-( n-HHTpo(5eH30HJi)-23-OKCo- LL- F 28249 b op-raroraecKOM pacTBopHTeJie, TaKOM, KaK TOJiyoji, c βο,π,ηημ pacTBopoM coJiHHOKHCJioro Cj-Cg ajīKOKCHJiaMHHa h ai^eTaTa HaTpHH πρκ nepeMe-DIHBaHHH flO ΤΘΧ ΠΟρ, ĪIOKa ΗΘ 3aBepfflHTCfl 06pa30BaHHe OKCHMa. Πο— jiyyeHHHft TaKHM o6pa30M HHTepMeflHaT 23-(Cj-Cg ajimnoKCKM )-5-0-(n—HHTpodeH30HJi) - 28249 BUfleJinioT h o*iHmaioT nepeKpHCTajuiH3au;HeH H3 ποΑΧΟΑΗΐηθΓο pacTBopHTeJiH, npeflnoxiTHTejibHO H3 H-(5yTaH0Jia.
B nepeKpncTajuin30BaHH0M οοθαηηθηηη 23-(Cj-Cg ajimnoKCHM) -5-0-(n-HHTpo6eH30HJi)- LL - F 28249 CHHMaiDT 3amHTHyro rpynny peaKiļneft c rHApooKHCbK) HaTpHH npn 0°C-25°C, nojiytian ijejieBofi npo,nyKT - 23-(Cj-Cg ajimnoKcnM)- L L - F 28249. Οηητηθ 3aiiļHTH ocymecTBJiHK)T peaKqnefi Me*fly pacTBopoM οοθ,π,ηηθηηη 23-(Cj-Cg aji-khjiokchm) - 5-0-( n-HHTpo6eH30HJi)- L L - F 28249 b opraHHViecKOM pacTBopHTeJie, TaKOM KaK TOJiyoji, AHOKca, H-6yTaH0Ji η τ.π., πρββ-nO^THTeJIbHO B AMOKCaHe, C BOflHHM paCTBOpOM ΓΗ,ΠρΟΟΚΗΟΗ HaTpHH npn 0°C-25°C h BbmeJieHHeM noJiy^eHHoro οοββΗΗβΗΗΗ 23-(Cj-Cg an-khjiokchm)- L L - F 28249 H3 opraHH^ecKoii $a3bi c ηοποηβ30βηηηθμ 0(5bBJHbIX ΜΘΤΟΑΗΚ, ΤΗΚΗΧ KaK KOHlļeHTpnpOBaHHe Η (JlHJIbTpOBaHH0 HJIH yAajieHHe pacTBopHTeJin.
TaKHM odpa30M, npHHiļHnnajībHoe οτηη^ηθ HacTOHDļero H3o6peTe-hhh 3aoiowaeTCH b cjieflyroiqeM: a) Hcnojib30BaHHe ηοβοη π-ΗΗτροόβΗ-30HJIbH0ft rpynribl flJIH nOJiytieHHH KpHCTaJIHH^eCKOrO Πρ0Η3Β0ΑΗ0Γ0 5-(n-HHTpo6eH30HJi) - 23-KeTOHa hjih 5-(π-ηητρο6θη30ηλ) - 23- 8
MeTOKcrnvia, Ka^biM H3 κοτορΗχ MOsceT 6biTb nepeKpHCTajum30BaH, h b) OKHCJieHHe 5-3aMemeHHoro npon3BO,n,Horo LL - F 28249od yK-CyCHbIM aHrHflpHflOM, j]MC0, ΠΗρΗ,Π,ΗΗΟΜ h kmcjiotoK c 0Čpa30BaHHeM 5-3aMemeHHoro 23-KeTOHa; n-HHTpo(5eH30HJibHafi rpynna ηβληθτοη ηθ TOJibKO xopoineft 3amHTH0fi rpynnoM, ho TaK»e no3BOJifleT npoBec-th npocTyio o^HCTKy npoMemyT01tiHbix coeflHHeHHfi KpHCTajuiH3aL(HeM, a Ηθ ,Π,ΟρΟΓΟΟΤΟΒΙΙ^ΪΟ OqHCTKy KOJlOHO^HOf! XpOMaTOrpa$Hei;t. H0BH3Ha OKHCJieHHH yKcycHbiM aHrHApH^OM - JļMCO 3aKJiioyaeTCH b τβχ cneiļH-<|)H*ieCKHX yCJIOBHHX peaKIļHH, KOTOpbie ΗβοβΧΟ,Π,ΗΜΗ B AaHHOM CJiyyae flJIH ΤΟΓΟ, UTO(5bI np0H30DIJI0 OKHCJieHHe. SKCnepHMeHTaJIbHHe yCJIOBHH, npHBO^HMHe paHee b ΧΗΜΗ^βοκοΑ JiHTepaType ajih yKcycHoro anrHflpH-,ņa - JJŅiCO, He ^aioT npoflyKTa. ΥHHKaJIbHOCTb 5-(n-HHTp0ČeH30HJI) Πρ0Η3Β0,Π,Η0Γ0 o(5HapymHBaeT-CH ΠρΗ paCCMOTpeHHH pa60TbI Sutherland H AP· (na- τθητ GULA 4900753; BpnTaHCKHH naTeHT N° 2192630, M.KJI.C07 β 493/22, ony6jiHKOBaH b 1988 r.). B npHMepe I (a) OKHCJieHHe 5-ΚΘΤΟ- ΠΡ0Η3Β0ΑΗ0Γ0 ,H,HXpOMaTOM HaTpHH IipHBOflHT K 5,23-ΑΗΚΘΤΟ-$aKTopy A - npoMe«yTOtJHOMy coeflHHeHHio, oxapaKTepH30BaHHOMy b ΒΗ,ηβ cmojih. ]ββχ.β nocjie ohhctkh cmojih kojioho^ihom xpoMaTorpa$Heii iļejieBofi npo,nyKT BbmejieH b ΒΠββ πθηη. KpoMe τογο, Heo0xo,n,HMOCTb xpoMaTorpa$H^ecKofi o^hctkh hcho noKa3aHa TaKHte κ nocjie,n,yK)mero COeflHHeHHH B 3T0H riOCJieflOBaTeJībHOCTH - 5-KeTO-23-MeTOKCHHMHHO-$aKTopa A, nojiy^eHHoro ΜβτοκρΗΗΜΗΗκροΒΒΗΗβΜ 5,23-AHKeTO-$aKTO-pa A (npHMep I (b)).
HecMOTpfl Ha npHMeHeHHe xpoMaTorpa$HtiecKOH o^hctkh npoMesy-TOtiHoe 5-KeTO-23-MeTOKCHHMHHonpoH3BOAHoe BbmeJieHO b βη,π,θ TBep-floft πθηη. itpyrne npHMepH npoK3BO,n,Hbix $aKTopa A, Tpe<5yiomHx owhct-kk xpoMaTorpa$HpoBaHHeM, πρηβο,ιι,ητοη b naTeHTe BeJiHKO(5pHTaHHH 2I76I82 b npHMepax 2-4, 6, 8, II, 14, 18, 21, 22, 28, 30, 40, 41, 44, 45-52, 56, 57, 60, 69, 70, 76, 88, 103, 105, 109, III, 112 η 123-127. To, uto 5-(π-ΗΗτρο<5βΗ3θΗϋ)-23-κβτοΗ hjih 5-(n-HHTpo6eH30HJi)-23-MeTOKCHM, a ηθ 5, 23-αηκθτο- η 5-κβτο-23 (E)-MeT0KCHM0np0H3B0AH0e MOryT ČHTb Ο^ΗίςβΗΗ npOCTOH KpKCTajIJIHaaiļHeii c noJiy^eHneM mhcthx KpHCTajuiHyecKHx npo,nyKTOB, HBJineTCH īiojio&h-TejibHHM npeHMymecTBOM 3aHBJieHHoro cnocoča nepeA ciioco6om naTeH-Ta BeJiHKOČpHTaHHH N» 2192630. 0—aiļHJinpoBaHHe n-HHTpočeH30HJixjio-Phaom cymecTBeHHO OTJiHdaeTCfl ot npHMepa, β κοτοροΜ π-ΗΗτρο6βΗ- LV 10503 30HHyiC> KKCJIOTy HCnOJIb3yK)T BMeCTe C ΤρΗφβΗΗΛφΟΟφΗΗΟΜ- flH3THJia30-flHKapdoKcmiaTOM. B ΕβροπθΜοκομ naTeHTe 307224 O-ajiKHJiHpoBaHHe 5-TpeT-6yTHJiflHMeTH^CHJiHJioKCM- φaκτopa A π-ημτρο6θη30κηομ khcjio-TOH Η ΤρΗφθΗΗΛφΟΟφΗΗΟΜ npOHCXOflHT C OČpameHHeM KOHφHΓypa^HH 23-rnflpoKCHJia, hto He ημθθτ MecTa b cjiynae ncnojib30BaHHH b Ka-^ecTBe aiļHJiHpyiomero cpeflCTBa n-HHTpodeH30HJixjiopHAa. Ba>KHbiH bh-boa npn 3tom saKjno^aeTCH b tom, hto npoMemyTO<iHoe οοθαηηθηηθ ημθθτ n-HHTpo6eH3oaTHyw rpynny b 23-πολοκθηηΚ c očpanjeHHOH koh-$HrypaqHefi η προ^κτ oxapaKTepH30BaH b βη,π,θ πθηη Aa*e nocjie Abomhoh xpoMaτoΓpaφH¾ecκofi ohhctkh. HanpoTHB 5-(n-HHTpo6eH30HJi)-23-ΚΘΤΟΗ H 5-(n-HHTp0(5eH30HJl)- 23-ΜΘΤΟΚΟΗΜ, OTHOCflmHeCH K Hac-τοπιςθΗ 3anBKe, ηθ ημθιοτ očpameHHOfi κΟΗφΗrypaqHη b πολοτκθηηη, co-AepjKaujeM π-ηητρο6θη30ηλ, h o(5a hbjihkjtch κρκcTaji jihheckhmh npoAyK-TaMH. Μηογηθ μ3βθοτηηθ OKHCJiHTejiH AawT HeyAOBJieTBopHTeJibHHe py-3yjibTaTBi πρκ οκηολθηηη 5-3aMemeHHoro F- 28249 aJIbφa. flame πρκ-BeAeHHan Ta<5jiHqa II noKa3HBaeT, hto HecKOJibKO OKHCJiHTeJieft, H3-ΒΘΟΤΗΗΧ CnOCOČHOCTbK) C ΧΟρΟΠΙΗΜΗ ΒΒΙΧ0Α9-ΜΜ npeBpaiņaTb ΒΤΟρΗΗΗΗΘ ΟΠΗρΤΗ B ΚΘΤΟΗΗ, ΗΘ ΠρΗΓΟΑΗΗ A^H Α^ΗΗΟίτ ΟΗΟΤΘΜΗ. ΧθΤΗ OKHCJIHTe-JIH Ha OCHOBe XpOMa AO ΗΘΚΟΤΟροΚ ΟΤΘΠΘΗΗ ycnemHO OKHCJlflIOT 23-ΓΗΑ-poKCHJi, τθμ ηθ μθηθθ , OAHaKO, nacTO KOMnjiecoo6pa30BaHHe HOHOB MeTajiJiHtiecKoro xpoMa c κοηθηηημ npoAyKTOM MemaeT ero οηηοτκθ m b pe3yjibTaTe πρΗΒΟΑΗΤ κ οηη*θηηιο βηχοαοβ η ηηοτοτη. iķixpoMaT HaTpuH η cepHafl KHCJiOTa, onHCaHHbie α-πη οκηολθηηη 23-rHApoKCHJia 5-κeτo-φaκτopa A b EBponeficKOM naTeHTe # 307222, BpHA JiH πρπθΜ-jihmh ajih aHanorHMHoro npeBpameHHH 5-0-ajiKHJiHpoBaHHoro npoH3BOA-ηογο. B npeAJioateHHOM cnocoče noKa3aHO, hto 0-3aMemeHHe b 5-nojio-κθηηη AeJiaeT TaKoe npoH3BOAHoe yfl3BHMHM κ a6^ctbhki khcjiot. Jļjin-TejibHoe αθΑοτβηθ κηολοτη Ha 5-0-3aMemeHHoe npou3B0AHoe πρηβοαητ κ apoMaTH3aiļHH HHsmero inecTHHJieHHoro iņiKJia b pe3yjibTaTe AernApa-TaqHH c ynacTHeM 7-rHApoKCHJia η 1,2-3JiHMHHHpoBaHHH npH yHaeTHM 5- n-HHTpo6eH3oaTHoii rpynnu. yCJIOBHH OKHCJieHHH B npHCyTCTBHM yKCyCHOrO aHrHApHAa - JĪMCO, ΠρΗΒΘΑβΗΗΗΘ B HaCTOHmeM Η30(5ρθΤΘΗΗΗ, TaKJKe HBJIHKJTCH yHHKaJIbHbIMH. Xopomo H3BecTHaH aKcnepHMeHTajībHan cncTeMa yKcycHbii! aHrnApHA -JļMCO (cm. J.D. Mbright u L. Goldman, J. Am. Chem. Soc., 89, 2416 (1967) ) AaeT μθηθθ Z% 23-KeTOHa H3 5 ΙΟ -(n-HMTpodeH30HJi)- F - 28249 ajībi^a. Μ3ο6ρθτθηηθ nJiJiiocTpHpyeTCH npHMepaMH:
ΠΡΜΜΕΡ I
Πολυ^θηηθ 5-0-(n-HHTpo(5eH3OHJi) - L L- F 28249 OC
IlepeMeiiiHBaeMbifi pacTBop LL- F 28249 (X (6,36 r, 10,4 mmo-JIh) B XJIOpHCTOM ΜΘΤΗΛΘΗΘ OČpaČaTHBaiOT ΠΗρΗ,Π,ΗΗΟΜ (1,98 Γ, 25,0 MMOJIH) H n-HHTpo6eH30HJIXJIOpHAOM (2,45 r, 13,2 mmojih) ΓφΗ 20°-25°C. Hepee 4 ^aca p6aKiļHOHHyio CMecb npH 20°-25°C o6pa6aTHBaioT
HaCtnqeHHbIM paCTBOpOM 6MKap60HaTa HaTpHH H XJIOpHCTfeIM ΜΘΤΗΛΘΗΟΜ h nepeMeuiHBaioT ,π,ο ποληογο pacTBopeHHH. Φa3L·I pa3,n,ejiHK>T, opraHH-uecKyio $a3y npoMHBaioT nocjieflOBaTejibHO HacumeHHbiM pacTBopoM 6h-Ka6oHaTa HaTpHH, 5%-Hoii cojihhoK khcjiotom h HacbniļeHHHM pacTBopoM xjiopMCToro HaTpHH, h KomjeHTpHpyioT b BaKyyMe, nojiy*iaH ijejieBoe ΟΟΘ,ϋ,ΗΗβΗΗΘ B BHfle ΤΒΘρ,Π,ΟΜ ΠΘΗΗ B KOJIHtieCTBe 7,9 Γ (ΚΟΛΗ^βΟΤΒΘΗ-hhm ΒΗχο,η); H,iļeHTH$HiļHpyiOT khakocthoM xpoMaTorpa$Hei;i, MHMP-aHa-J1H30M K MaCC-CneKTpOCKOnH^eCKHM aHajIH30M. ΠΡΗΜΕΡ 2
IlojiyxieHHe 5-0-(n-HHTpo6eH3OHJi) - L L- F 28249oc riepeMeiiiHBaeMHH pacTBop LL - 28249cC (6,13 r, 10,0 mmo-jieii) b TOJiyojie očpačaTHBaioT TpH3THJiaMHH0M (2,53 r, 25 MMOJieM), oxjiajKflaioT jļo I5°C, otfpadaTHBaioT ηθοκοηβκημη πορρΗΗΜΗ π-Ηπτρο-6eH30HJixjiopH,n,a (2,60 r, 14 MOJieft) npn TeMnepaType ot 15° So 22°C, h nepeMeuiHBaioT B Tenemie 6 nācos npn 20°-24°C. PeaKLļHOH-Hyio CMecb očpatfaTbiBaiOT βο,π,ομ, nepeMeniHBaioT b τθ^θηηθ 10 MHHyT, h $HJibTpyioT. $HJibTpaT οτ,π,θηηιοτ , opraHH^ecKyio $a3y npoMHBaioT nocjieflOBaTeJibHO HactnqeHHb!M pacTBopoM 0HKap6oHaTa HaTpHH, 3 co-JIHHOtt KHCJIOTOM Η ΒΟ,Π,Οίί, H KOHIļeHTpHpyiOT B BaKyyMe, I10Jiy^aH ije-JieBoft npo,nyKT b βη^θ τβθρ,π,ομ πθηη b KOJiHnecTBe 7,55 r. LV 10503 ΠΡΙ4ΜΕΡ 3
Ilojiy^eHHe 5-0-( π-ΗΗτρο<5θΗ3οιυι)-23-οκοο LL - F 28249c* C HCn0JIb30Ba.HHeM nnpHflMHflHXpOMaTa H flMMeTH^|)OpMaMHfla riepeMeiiiMBaeMHH pacTBop 5-0-(n-HHTpo6eH30HJi) LL - P 28249<X (3,12 r, 4,10 mmojīh) b £HMeTHJi$opMaMHfle o6pa6aTtiBaroT nupn^MH-flHxpoMaTOM (18,8 r, 50 MMOJieft), BSHTbiM b BHfle OflHofi nopiļMH, ne-peMeinHBaioT ripu 20°-25°C b τβ^βΗΗβ 6 tiacoB κ BbuiHBaioT b BOAy. PeaKiļMOHHyio CMecb nepeMemuBaioT β τθ^θηηθ 15 MHHyT h $HJibTpyioT. 0T$MJibTpoBaHHbift oca^oK npoMUBaioT BOAOft, cyinaT Ha B03,nyxe h ne-Ρθηοοητ b 9THJiaLļeTaT. nojiyyeHHyio CMecb κηπητητ c oČpaTHHM xojio-AHJIbHHKOM Β Τθ^βΗΗΘ 15 MHHyT, O<5pa(5aTbrBai0T ^HaTOMHTOM H $HJIb-TpyioT. ^HJībTpaT κ0Hiļ6HTpnpyK)T b BaKyyMe c očpasoBaHueM Kpacno-KopHtiHeBoro TBep^oro BemecTBa, κοτοροβ nepeKpncTajuiH30BbiBaroT H3 H-nponaHOJia, nojiytiaH qeJieBoft προ,π^κτ b βηαθ KpHCTajuioB 6e-jioro iļBeTa β KOJinnecTBe 3,33 r (βηχοα - 52$ b pacneTe Ha LL - F 28249o< ); τβΜΠ.Γυι.2Ι7-22Ι°0, HAeHTJKfmļHpoBaH HflMP-aHajin30M h Macc-cneKTpocKonH^ecKHM aHajiH30M. ΠΡΜΜΕΡ 4 IIoJiļnieHHe 5-0-(n-HWTpo<5eH3OKJi)-23-oKCo- L L - F 28249c* C HCn0JIb30BaHHeM nHpH,IļHH1ĪI,HXpOMaTa H yKCyCHOTO aHrHflpHAa
PacTBop 5-0-(n-HHTpodeH30HJi) LL - F 28249c* (0,38 r, 0,5 mmojīh) b xjiophctom MeTHJieHe ,n,o(5aBJiflK)T κ CBemenpHroTOBJieHHoft CMecH nHpHl]ļHH1iļHxpoMaTa (0,19 r, 0,5 mmojib) h yKcycHoro aHrHApn-fla (0,3 r, 3,0 mmojīh) πρκ ηητθηοηβηομ nepeMeniHBaHMH. PeaKiļHOH-Hyio CMecb nepeMeiiiHBaioT ripu κομηητηοη TeMnepaType β τθ^θηηθ 15 MHHyT, ΚΜΠΗΤΗΤ C OČpaTHbIM XOJIOflMJIbHHKOM Β ΤΘ^ΘΗΗΘ 6-8 HaCOB, oxjiasAaiOT ,π,ο κομηητηομ TeMnepaTypH m o(5pa6aTbiBaioT bo£OM. riocjie μητθηοηβηογο nepeMeniHBaHHH $a3bi pa3£eJinioT h opraHHciecKyio $a3y npOMHBaiOT HaCblIIļeHHblM paCTBOpOM 6HKap60HaTa HaTpHH Η ΚΟΗ£ΘΗΤρΜ-pyiOT b BaKyyMe, nojiy^an οοτητοκ . 3τοτ οοτητοκ πβρβκοοΗτ b 3thji-aneTaT η xpoMaTorpa$HpyioT, Hcnojib3yfl CHJiHKareJib h 3THJiai^eTaT b Ka^iecTBe oJiioeHTa, nojiyHan 6jie£Hoe «eJiTo-cepoe BemecTBO. 3to 12 τβθραοθ BemecTBO nepeMemuBaioT co CMecbio 3THJiaqeTaT : reKcaH (odteMH. οτηοπιθημθ 55:45), $MJibTpyioT, h φϊυΐΒτρβτ κοΗΐίβΗτρκργιοτ b BaKyyMe, nojijrvan qeJieBoe οοθαμηθηηθ μ b βμαθ ČJieAHO-meJiToro τβθραογο Be^ecTBa b KOJitreecTBe 0,26 r, κοτοροθ HAeHTH$HqnpyioT H^flMP - h ΚΧΒβ - aHajin3aMM. ĪIPMMEP 5 ilojiy^eHne 5-0-(n-HHTpodeH3OKJi)-23-OKCO- LL- F 28249c< C HCn0JIb30BaHMeM TpeT-6yTOKCMaJIIOMMHHH H 0pT0-6eH30XHH0Ha nepeMemnBaeMyio CMecb 5-0-(π-ηητρο6θη3Οκα) LL - F 28249^ (0,38 r, 0,50 mmojih) , TpeT-6yT0KCHajiKMHHHH (0,184 r, 0,75 mmojih) h 0pT00eH30XHH0Ha (0,216 r, 2,0 mmojih) b TOJiyojie κηπητητ c O^paTHblM XOJIOAHJIbHMKOM B ΤΘ^ΘΗΗΘ 2 ^aCOB, OXAaKAaiOT AO KOMHaTHOM TeMnepaTypbi, o<5pa6aTHBaioT TOJiyo;ioM κ pa30aBJieHH0ft cepHoii khcjio-TOM (16%), nepeMeniHBaiOT 5 MHHyT H (|)HJIbTpyK)T. ΦΗΛΒΤρΑΤ OTAeJIflIOT h npoMHBaioT opraHM<JecKyKi $a3y βοαομ h KOHqeHTpnpyioT b BaKyyMe, nojiytiaH CTeKJiOBHAHbiK TBepAHfi ocTaTOK. OcTaTOK nepeHOCHT b othji-aqeTaT h (f)ObTpyiOT nepe3 HeMTpajibHyio oKHCb aAioMMHHfl. ΦοπτρΗτ KOHqeHTpnpyiOT b BaKyyMe, nojijn-iaH ueJieBOM npoAyKT b βηαθ TBepAO-ro 6θαογο BeujecTBa β KOJiimecTBe 0,324 r (βηχοα 71%, corjiacHO AaHHbiM )KXB^-aHajiH3a. ΠΡΜΜΕΡ 6 noAytjeHMe 5-0-(n-HHTpo6eH3onJi)-23-oKco- LL- F 28249/)( C HCn0JIb30BaHHeM ΠΗΤΜΟΚΜΟΜ $OC$Opa H AHMeTMJICyJIb$OKCHAa
PacTBop 5-0-(n-HHTpo6eH30MA) — LL - F 28249<X(0,38 r, 0,50 mmojih) k A^MeTMJicyjib$OKCHAa (0,75 r, 9,6 MMOAefi) b xjiopmctom M6THJieHe o6pa6aTbmaiOT nopoiHKOo0pa3HOMnHTKOKncbio $oc$opa (0,107 r, 0,75 mmojih), B3HT0H b bmag OAHOft nopilu, nepeMeinMBaioT npn 20°-25°C b Te^eHMe 19 ^acoB, odpačaraBaioT α°6αβαηθμημ no KanjiHM τρκ-OTHJiaMHHOM (0,30 r, 3,0 mmojih), nepeMeniHBaiOT β τθ^θηηθ 30 MHHyT, 3aTeM o6pa6aTbiBaioT xjiopHCTbiM MeTMJieHOM κ boaoM m nepeMeniHBaiOT β τθ^θηηθ 5 MHHyT. (&a3bi pa3AeAHiOT, h opraHireecKyD $a3y npoMH- LV 10503
BaiOT pa3(5aBJieHHOfi COJIHHOfi KMCJIOTOft (7%) M KOHIļeHTpHpyiOT B Ba-KyyMe, nojiy^aH iļejreBOtf npo,nyKT b ΒΗ,ιι,β 6ejioro τβθρ,π,ογο BemecTBa b KOJiimeCTBe 0,28 r (ĪiMCTOTa 47%, no flaHHbiM )KXB(iI,-aHajiH3a). ΠΡΜΜΕΡ 7
IlojiytieHMe 5-0-(π-ΗΗτρο6βΗ3θκ;ι)-23-οκοο- L L·- F 28249 <x c Hcnojib30BaHneM flByoKHCH MapraHiļa κ χπορηοτογο MeTHJieHa b KatiecTBe pacτbopnτ e jih
PacTBop 5-0-(n-HHTpo6eH30HJi)- L L- F 28249(0,19 r, 0,25 MMOJIh) B XJIOpHCTOM ΜΘΤΗ-ΠβΗΘ 06pa6aTHBaiOT ABJTOKHCbK) Map-raHiļa (8,0 r, 92 mmojih), nepeMeniH BaiOT npn 20°-25°C b τθ^θηηθ 2 nacoB, o(5pa6aTHBaK)T 3aTeM xjiophcthm μθτηπθηομ, πβρβΜΘίπκBaiOT b TetieHne 5 μηηυτ m $HJibTpyioT. ®mibTpaT κοΗΐ^βΗτρηργιοτ b BaKy-yMe, nojijrtian iļejieBoe οοθ,π,ηηθηηθ b βη,π,θ tfenoro TBepfloro BemecT-Ba b KOJin^ecTBe 0,08 r, miCTOTa 51% no ftaHHbiM MB.lļ-aHajiHsa. ΠΡΗΜΕΡ 8 ĪIojiytīeHHe 5-0-(π-ημτρο6θη3οηπ)-23-οκοο- LL- F 28249<x c Hcnojib30BaHHeM ,n,ByoKHCn MapraHiļa n aiļeTOHHTpnjia b
Ka^eCTBe pacTBopHTeJin
PacTBop 5-0-(n-HHTpo(SeH30M^)- LL- F 28249oč (0,19 r, 0,25 mmojih) b aijeTOHHTpHJie o^paCiaTbiBaioT flByoKncbio MapraHiļa (8,0 r, 92 mmojih), nepeMemHBaioT b Tenei-me 3 tiacoB npn κομηητ-HOft TeMnepaType, 3aTeM otSpaCaraBanT aiļeTOHHTpmiOM, nepeMeniHBa-K)T b τθ^θηηθ 5 MHHyT h $HJibTpyiOT. 0T$njibTpoBaHHbifi oca^oK cyc-neH,n,HpyK)T B XJIOpWCTOM ΜβΤΗΛβΗβ H $HJIbTpyK)T. AljeTOHHTpHJIbHHft H ΜΘΤΜΠΘΗΧΠΟρΗ,Π,ΗΗίί $HJIbTpaTbI COBMeUļaiOT, npOMHBaiOT BOflOft Η ΚΟΗΙ1ΘΗ-TpnpyioT b BaxyyMe, nojiyyan iļejieBoe οοθ,π,ηηθημθ b βμ^θ dejioro τβθρ,π,ογο BeiņecTBa b KOJinnecTBe 0,14 r, tiHCTOTa 69%, no ,n,aHHbiM SiXBfl-aHajiH3a. 14 ΠΡΜΜΕΡ 9 ĪIojiyweHne 5-0-(n-HHTpo6eH3OHJi)-23-OKCo- L L - F 26249c< c Mcnojib30BaHHeM ,n,ByoKncn Mapramja h 3THJiaijeTaTa b Ka-
MecTBe pacTBopuTeJiH
PacTBop 5-0-(n-HHTpo6eH3OMJi)- LL- F 26249o( (1,0 r, 1,3 mmojih) b 3mnaqeTaTe očpadaTHBaioT flByoKHCbio MapraHu;a (20,0 r, 230 MMOJiefi), nepeMemHBaioT ripu 20°-25°C b Te^eHHe 3 yaCOB H $H^bTpyiOT. 0T$HJIbTpOBaHHHfl OC^IļOK npOMHBaiOT 3TMJiaiļe-TaTOM. $HJibTpaTH co6nparoT βμθοτθ, o(5pa(5aTHBaioT ,n,ByoKncbK) Map-ramja (8,0 r, 92 mmojih), nepeMemHBaioT ripu 20°-25°C b τθ^θηηθ 3 tiaCOB K $HJIbTpyi0T. 0τφΗ Jlb TpOBaHHbIM OCcl^OK npOMblBaiOT 3THJI-ai^eTaTOM; $mibTpaTbi cočupaioT ΒΜβοτβ n KOHiļeHTpnpyioT b BaKyyMe, nojiynaH iļejieBoii npoflyKT β βμ,π,θ dejioro TBep^oro BeiņecTBa b kojih-necTBe 0,6 r (miCTOTa 70% no flaHHHM HXB,Il1~aHajiH3a). TBepAbifi npo-flyKT nepeKpHCTajiJiH30BHBaioT H3 H-nponaHOJia, noJiy^aH čejine κρηο-Tajuiti c TeMnepaTypon njlaBJieHKH 2I8-222°C. ΠΡΜΜΕΡ 10 nojiy^eHne 5-0-(π-ΗΜτρο6θΗ3θΐυι)-23-οκοο- LL- F 28249<X C HCnOJIb30BaHIieM flHHHKJIOreKCHJIKapdojļHHMHfla H flHMeTHJI- cyjib$OKCHAa
PacTBop 5-0-(n-HHTpo6eH30HJi)- L L - F 28249<* (0,33 r, 0,50 mmojih) b 6eH30Jie o6pa0aTHBaiOT nocjieflOBaTejibHO ,π,ΗΜΘτιυι-cyjib$OKCH^OM (0,78 r, 10 MMOJieft), πηρη,π,ηηομ (0,04 r, 0,5 mmojih), TpM$TopyKcycHOfi KHCJioTOft (0,03 r, 0,25 mmojih) h AniļHKJio-reKCHJiKapeoAHHMHflOM (0,31 r, 1,5 mmojih), nepeMemHBaioT npn 20°-25°C b TeneHne 21 naca, 3aTeM očpačaTbiBaioT 6eH30JiOM h (ļ)MJIbTpyK)T. 0T$HJIbTpOBaHHHM ΟΟΘ,Π,ΟΚ npOMblBaiOT 6eH30JIOM. Co6paH-Hue βμθοτθ $HJibTpaTH προκΗΒ3ΐοτ βο,π,ΟΗ η KOHiļeHTpHpyioT β BaKyy-μθ, nojiynan iļejieeoe οοθ,β,ηηθηηθ β βη,π,θ τβθρη,ογο BemecTBa οβθτ-jioro opaHmeBO-KopunHeBoro iļBeTa β KOJinnecTBe 0,34 r, ββγχο,π, 75% no flaHHHM IXB,Iļ-aHajiH3a. LV 10503
ΠΡΙ4ΜΕΡ II riojiytieHHe 5-0-(n-HHTpo(5eH3OHJī)-23-OKCO- L L - F 26249<K c McnoJib30BaHneM yKcycKoro aHrHApnAa h flHMeTMJicyjib(So-KCHfla B npHCyTCTBMH nHpHflMHTpH$TOpaiļeTaTa CMecb 5-0-(n-HHTpo6eH3OMJi)~ L L - F 28249<X (0,38r, 0,5 mmojih) , (n,nMeTHJīcyjib$OKCH(n,a (0,78 r, 10 MMOJiefi) h πκρΗ,π,ΗΗτρΗ-$TopaiļeTaTa (0,97 r, 0,5 mmojih) b orajiaijeTaTe oČpatfaTHBaiOT flodaBJineMHM no KanjiHM yKcycHbiM ηηγη,ιι,ρηαομ (0,26 r, 2,5 mmojih), nepeMenmBaiOT b TeneHne 24 qacoB npn 20°-25°C h odpadaraBaiOT 3THJiau,eTaT0M h βοαοΚ. $a3bi pa3,n,ejiHīOT: opraHHnecKyio $a3y npoMbi-BaioT BOflon n KOHiļeHTpnpyiOT b BanyyMe, nojiynan οοτητοκ b βη,π,θ βη3κογο Macjia. OcTaTOK nepeHOCHT b xjiopHCTbift mothjioh h KOHiļeH-TpnpyiOT b BaKyyMe, nojiywaH iļeJieBOfi npoflyKT b βη,ιι,θ sejiToro TBep-floro BemecTBa b KOJinnecTBe 0,36 r; Η^βΗΤΗφκΐίΗροBaH ΗΧΒ,Ε,-aHajin- 30M. ΠΡΜΜΕΡ 12 ĪIojiyneHne 5-0-(n-HHTpo(5eH3OHJi)-23-OKCO- LL- F 28249<X c Hcnojib30BaHneM yKcycHoro aHrnApHAa m AHMeTHJicyjib(f)o-.KCHfla B npHCyTCTBHH nupH^HHa H AHXJIOpyKCyCHOft KHCJIOTbl CMecb 5-0-(n-HHTpo6eH3OHJi)- LL- Γ 28249c< (7,26 r, 10 MMOJiei!) h nHpnflHHa (31,6 r, 400 MMOJieii) o6pa6aTHBaiOT ρμ-Memncyjib(ļ)0Kcnfl0M (15,6 r, 200 MMOjieii) h rn)nxjiopyKcycHOH khc-jioth (1,29 r, 10 MMOJieii), oxjianyi;aH3T flo 2°-3°C, o<5pa6aTbiBafOT AodaBJineMbiM no KanjiHM yKcycHHM aHrHApnflOM (5,1 r, 50 MMOJiefi) npn 3°-7°C h oČpatfaTbiBaiOT xjiopkcthm M8THJieH0M n boaoh. PeaK-u;noHHyio CMecb nepeMeniHBaioT npn TeMnepaType OKpywaiomen cpeflbi b TeneHne 15-30 MMHyT, v. pa3A,eJiHK)T $a3bi. OpraHnneCKyio $a3y npOMH-BaioT xojioahom pa30aBJieHHoft cojiHHoft kmcjiotok (5%), η 5%-ηημ pac-TBopoM xjiopMCToro HaTpHH v. KOHiļ6HTpMpyioT b BaKyyMe, nojiy^afl iļe-jieBOM npoflyKT b βηαθ τβθρ,π,ομ πθηβι aceJiToro i^BeTa b KOJin^ecTBe 7,47 r, nHCTOTa 73% no ^aimiM JKXB,iļ-aHajin3a. Mcnojib3yH no cyme-CTBy tot iKe cnocotf, ηο μθηηη ncnojib3yeMbifi KucjioTHbii! peareHT, nojiynaioT cjieAyiomne βηχοα,η npoflyKTa, πρμβθ,π,θηηηθ b TaČJiniļe I.
lo I—I OKHCJieHne 5-0-(n-HMTpo6eH3OHJi)- L L- F 28249c< b 5-0-(π-ΗΜτρο6θΗ3θκ.π)-23-οκοο L L - F 28249 o< c Mcnojib30BaHneM yKcycHoro aHrM,n,pnIii,a c ,nHMeTMJicyjib<ī)OKCHfla b
Λ E- O t=5os X
cd Xs i=C S Pv S C ss (Q Eh O E-* ν'*! Os Pvu X Eh X (D §mspx co CD X X X o o o LO o LŪ LO cv cv lO cv O —' lQ o LO 1-1 1 1 1 1 o CO 2> lO c- io LO o o LO lO LO LO LO ►5 — PQ LO cv 1—\ X 2 — ^J4 ^J4 -^4 ω x Pv — 'LT4 ž> 'C4 cv cv cv ŠT lO cv co LO co CQ LO LO LO LO LO LO LO LO LO LO cv cv cv cv cv cv cv cv cv cv O CO co co 1 1 1 1 1 1 1 1 1 1 o 1 1 o o o o o o o o o o E-I cv CV Od cv cv cv cv cv CV cv CV cv cv Eh E- E" 1 X X X X X X X X cd cd cd Ο Λ s s s x s s s s Ev E- Eh 1=5 t=5 m t; t=f d n t=L l=l <=L n f=ļ CD CD ω o o ei cd s s s s s s s s cr ΡΓ df o co O Eh Pv Pv Pv Pv Pv Pv Pv Pv cd cd cd X X cd s s s s s s s s s i=; K t=i CD CD Ph Pv c c EX tx G c txj X s s s PJ 1X1 H E-i Eh co CO CO • · t=; m o X o co o o o o co o o O o o o S co cd cd E-1 —1 o 1—! 1—l 1—f 1—t C_> o 1—I 1—! 1—1 1—t 1—1 i—1 g bd bd bd bd bd bd g bd bd O >s s δ 2 bd >s IX, >J >3 >3 t=! O s O Eh X E-* co X EK s Θ» Eh Eh Eh S tci X s t=[ s o o o o o o o o o CV Pv cv 'LJ4 •V4 ši4 ^J4 1—l )—1 CV 1—1 t—1 s C 3S ct 3 S X Pv o CC >1 S CJ Ch lO LO LO io LO LO LO LO LO co co LO X X >> Cd t=C s 1 o t=i X s s 0-1 >Q< o o o o o o o o o o o o o ω λ 2 x cv CV Od cv cv cv cv cv cv cv CV cv 'LJ4 Λ ^ <=t Ο Ε4 £ Ό c —1 Ol co 'd4 LO lO E> CO σ> o 1—1 cv CO o t-H 1—1 1—1 1—i
cd E-< ct LO LO o p; O ·—' LO CO co o X ^ CO 1 i 1 te x «fl --- o o co ω K 0Q co co X o >3 δ o X w o 2 — LO co >3 >3 CD JT CO t—1 a o Py — o CQ PS >3 X Oy x o to Ov E- lO LO LO ίο co 1 E-· >& o CO CO co co X o I I 1 1 o II a Η o o o o co Eh Osi co co co 5d et X s II I 1 ft 1 o Eh w Ο Λ >=l 1=: x p; w >3 CQ Pļ o co X 2 s o e« e~* ω o o E-ι cd Eh>& E-< Ο E-· Pi co CO <D S 0 X cd cd x o a x 2 Λ 2 i=; e Pu Py EH o o 5& 4S1 o p; • #» cd o Ei x O w t? O • · « s tļ m o o o o δ w o X ·* #S ψ> X ^—- S co I—* 1—ļ h-i o ω >3 δ • x o X X w JS sr ω >3 o N -—- Λ o & l=3 cd o X s O cd p; <D o i=C Eh « w w X Ό O o >s >, >3 >3 o X Pv p? ΘΙ ΘΙ ei ΘΙ o X II 2 c o Eh E-< E-» E-* o X x 2 W a tQ X H-l II p; cd >3 Sd • *·> X X cd <D x x Pļ t=l i=t s o O >o S L—( t—t 1—t L—t co t=; s cd Pt> o o eh x • r s X e cd s E-· CQ o e p; δ o iS l=C o ω Eh 3 X x ω >3 s & « § o X >3 S io CO co co o K E-< a O X cd >& E S X X ω >s cd o a « 2 >3 ω E-< o E-< Eh X K X ω Ct »-*3 II re 5 x ft- o cd I o O « n m P! « p; θι o x s o o o o o o X EH a co E* >& -ό* s c w <D Λ t=L • «» co 2 tJ cd 2 ω 5 & II E- o X tx 3 K pļ K X >3 o cd J3 t=3 s K ω a O Eh S 3 LO cO £> co C I—I i—i 1—) 1—1 h—f cd Ό O LV 10503 18 ΠΡΜΜΕΡ 13 riojiytieHHe 5-0-(n-HHTpočeH30HJi)-23-OKco- L L - F 28249<X c ncnojib30BaHH6M yKcycHoro aHrHAP^Aa m ji,HMeTHJīcyjib$o-KCH,n,a b npncyTCTBHn nnpn,n,MHa h MOHOxjiopyKcycHOii kmcjiotlī Ομθοβ 5-0-(n-HMTpo6eH3onji) LL - F 26249i* (1,52 r, 2,0 mmojih) h nupMAHHa (3,16 r, 40 MMOJiefi) b TOJiyojie odpačaTbraaioT rn,HMeTMJICyJIb$OKCMiniOM (3,12 Γ, 40 MMOJiefi) H MOHOXJIOpyKCyCHOK kmcjiotoM (0,19 r, 2,0 mmojih), oxjiajKflajoT AP 2°-3°C, odpačaTbi-BaroT ^,o6aBJiHeMbiM no KanjiHM yKcycHbiM aHrnflpHflOM (0,82 r, 8,0 mmojih) npn 3°-5°C, nepeMeniHBaioT npn 2°-3°C b Teneroie 7 qacoB h flajiee oČpadaTbreaioT TOJiyojiOM h Βο,π,οίί. Ilocjie nepeMemHBaHHH peaKijHOHHofi CMecn npn I5°-20°C β Tenerae 10 MnnyT $a3bi pas^e-jihkdt . OpraHHnecKyio <f»3y npoMHBaioT nocjie,n,OBaTeJibHO xojio,n,HOft 2,4 N cojihhoK KucjioTOft h boaoM npn I5-20°C h KOHLļeHTpnpyiOT b BaKyyMe, nojiynaH LjeJieBoft npojļyKT β βη,π,θ τβθραοΑ πθηη aceJiToro ijBeTa b KOJinnecTBe 1,4 r, nncTOTa 71% no flaHHbiM JKKBJI-aHajiHsa. ΠΡΜΜΕΡ 14
Oi^eHKa oKHCJieHHH 5-0-(n-HHTpo(5eH3OHJi)- LL- F 28249oC c o6pa30BaHneM 5-0-(n-HHTpo6eH3OHJi)-23-OKCo- L L- F 28249 C< C HCn0JIb30BaHHeM pa3JIH^HbIX OKHCHHTeJiefi
Bbuia npoBefleHa ou;eHKa pa3JinnHbix ομοτθμ, OKncjiHiomHx 5-0-(n—HHTpo6eH30HJi)- LL- F 28249o< b 5-0-(n-HHTpo(5eH3OMJi)-23-okco- LL- F 28249 <Λ . PeareHTbi, ycjiOBHH προΒβΑΘΗΜΗ peaK-iļHH n npoijeHT nojiyneHHoro 5-0-(n-HHTpo(5eH3onji)-23-OKCo- L L- F 28249<X onpefleJieHHoro lXBjļ-aHajiH30M, πρκΒθΑβΗΗ b Ta6jmiļe II. LV 10503 σ> \—i
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CD &H s X CD K t=5 o 32 CC X CD o l=5 Pv CD S E E1 3S 3S 3S 3E 3S E S 2 2 3 3 2 CD Pv E X E< £ E< X E 32 E X 2 *=? 1—1 O O CD t=5 O CD O CD O ω O ω o 1—1 m S t=5 O s 1=5 S t=l S s t=5 3S cd co E Pv S Pv s Pv s Pv s Pv s 2 <=c 32 cd O o E t=5 o E O Et o E o E E o ω ar cd 1=5 CD O »=5 CD 1=5 CD >=; CD «=5 CD O PQ 32 s Ph X 2 E X 2 X 2 X 2 X 2 S t=5 Pv Ό o cd <=5 &H X
ω ι 2 cd X cū 3 o LO o o o o CD LO CD 1—1 X S E LO o r> O t=5 pa x o to o LO co o co 1—1 o ν' o C\i o a ω I—I cO I—I H-i 1—1 V S p >=5 ir 1 s O o X Osi X 1 s 32 1— t=C o o 2 Λ LO o s a CD 2 (=5 co 1 1 o 1 >jcd 3 X t=5 ω • ν' X E 1=5 a X E X PvE CQ CD cd E ν' o O ω o s s s o 5 S s O 1 E* Ό S o o εΟΘΈ^ Cto t=i e a KE 1 X J3 t=5 c. KH S Λ CD X S Λ S >& Osi cd o O O c CO s PvR 2 *5 Pv^ Pv S E o -<» PvX s s s oj 32 cd S X X S X s Pvčd Osi cd s a a o PQ CQ O 03 C2 01=210 32 O n E-I X 32 CQ E2 X o o E 3 σ> O t—1 c\i co LO cO E I—k 1—1 1—1 1—1 \—i l-H i—1 O LV 10503 ΠΡΜΜΕΡ 15 ΠοΛγ^θΗΗΘ 5-0- ( Π-ΗΗΤρ00ΘΗ30ΚΛ ) -23- (MeTMJIOKCHM) L L - F 28249<*
PacTBop 5-0-(n-HHTpo6eH30MJī)-23-OKCo- LL- F 28249o< , (10,67 r, 14,0 MMOJieiO b H-6yTaHOJie o6pa6aTHBaiOT pacTBopOM COJIHHDKHCJIOrO MeTOKCHJiaMMHa (2,34 Γ, 28,1 MMOJIA ) M 6e3B0R-ηογο aueTOHa HaTpMfl (2,30 r, 28,1 mmojia) b βο,π,θ npn 20-22°C, nepeMemuBaroT b TetieHHe 2 nacoe ripu 20°-22°C μ φιυΐΒτργιοτ. Οτ-$HJibTpoBaHHHft oca^oK cymaT Ha B03,nyxe m nepeKpKCTajijiH30BHBaK)T H3 H-6yTaHOJia (ropfl^ee $HJibTpoBaHHe), nojiyHafl nejieBoe coeAMHe-ηηθ b BH^e 6eciļBeTHoro τβθρλογο BenjecTBa b KOJinnecTBe 3,6 r, miCTOTa 91% no flaHHbiM 2CXB^3,. ΠΡΜΜΕΡ 16 Ποα^θηηθ 5-0- (n-HHTpo(5eH30HJi) -23- ( μθτηλοκοημ ) LL- Γ 28249o<
PacTBop 5-0-(n-HHTpo6eH3OKJi)-23-OKCo- L L- F 28249o{ (1,5 r, 2,0 mmojih) b TOJiyojie očpatfaTHBaiOT pacTBopOM cojiahokhc-Jioro MeTOKCHJiaMMHa (0,25 r, 3,0 mmojia) η (5θ3Βοαηογο aijeTaTa HaTpHA (0,25 r, 3,0 mmojia) β βο,π,θ h nepeMemHBaioT npn 20°-25°C b τθ^θηηθ 10 *iacoB. ToJiyojibHyio $a3y οτλθααιοτ, npoMHBaioT bo^oh h KOHpeHTpHpyiOT b BaKyyMe, nojiy^afl TBepAHfi οοτατοκ. 3tot ocTa-tok nepeKpHCTajiAH30BbiBaiOT H3 H-6yTaHOJia, nojrjniafl iļejieBOH npo-flyKT, 0,65 r, HAeHTH$HLļHpoBaH IXB^-aHajiH30M. ΠΡΜΜΕΡ 17 nojijmeHHe 23-(MeTHJiOKCHM)- L L- F 28249(/,.
PacTBop 5-0-(n-HHTpo6eH30HJi)-23-(MeTMJIOKCHM) LL- F 28249o<. (1,58 r, 2,0 mmojia) b AMOKcaHe odpačaTbmaiOT ^ofiaBJifle- 22 ΜΗΜ ΠΟ KanJIHM 4%-HHM paCTBOpOM ΓΗ^ρΟΟΚΗΟΜ HaTpHH (3,0 Γ, 3,0 MMOJieii NaOH) npH 8-I2°C, nepeMeuiHBaioT b τθηθηηθ 3 nacoB πρκ 8-I2°C, o6pa6aTbiBaioT TOJiyojiOM η boaom, m nepeMemHBaroT b τθπθ-Hwe 5 MHHyT npn TeMnepaType OKpy?KaiomeM cpeflbi. $a3bi pa3flejiHK)T, h opraHHMeCKyio $a3y npoMHBaiOT 10%-hhm xjiophcthm HaTpneM h koh-u;eHTpnpyiOT b BaKyyMe, nojiywan nejieBoe οοθαηηθηκθ b bHfle TBepflon πθηη čejioro iļBeTa b KOJinnecTBe 1,15 r, nncTOTa 89%, no αθηηημ }KXB/ļ-aHajīH3a. ΠΡΜΜΕΡ 18 nojiyneHne 23-okco LL- F 28249o^ Ομθοβ 5-0-(n-HHTpo6eH3onit)-23-OKCo- LL- F 28249oc (1,52 r, 2,0 mmojih) η 4%-hoh ΓΗ^ροοκηοΜ HaTpnn (3,3 r, 3,3 mmojih NaOH) b flHOKcaHe nepeMemuBaiOT npn 23°C b τθπθηηθ 2 nacoB, odpadaTHBaiOT TOJiyo;iOM η boaoh h BCTpHXHBaiOT. $a3bi pa3jļeJiHK)T, h opraHnnecKyio $a3y npoMHBaiOT βο,π,ομ η κοΗη,βΗτρη-pyiOT b BaKyyMe, nojiynafl iļeJieBoe οοθ,π,ηηθηηθ β^ βη,π,θ τβθραοΜ ΠΘΗΗ B KOJIH^eCTBe 0,90 Γ, HAeHTH$HnHpOBaHO HHMP. ΠΡΜΜΕΡ 19
IIojryneHne 23-(μθτηλοκομμ)- LL- F 28249cL CMecb 23-okco- L L- F 28249c* (0,90 r, 1,5 mmojih), cojih- ηοκηοιιογο MeTOKCHJiaMHHa (0,42 r, 5,0 mmojih), 6θ3βοαηογο aiļeTaTa HaTpnn (0,41 r, 5,0 MMOJien), yKcycHOft khcjioth h AHOKcaHa nepeMe-uiHBaiOT npn 20°-25°C b τθηθηηθ 22 nacoB, o<5pa6aTHBaiOT TOJiyojiOM h BOflon h nepeMeniHBaiOT b τθηθηηθ 5 MHHyr. 3>a3H pa3,n,eJiHK)T, h opra-HnnecKyro $a3y npoMHBaiOT boaoh m KOHi^eHTpnpyioT b BaKyyMe, nojiynan iļejieeoe οοθαηηθηηθ b βη,π,θ TBepnoft πθηη b KOJinneCTBe 0,84 r, hhc-TOTa 71%, no flaHHHM ®XB1H1-aHajiH3a. LV 10503 23
ΦΟΡΜΜ M30EPETEHMH 1. Cnocod nojiyxieHHH 23-(Cj-Cg ajiKHJiOKCHMOB)- LL - F 28249, ο τ ji in a ioh h ii c a τθμ, *ιτο 3amnmai0T rHflpoKcmibHyio rpyn-ny b nojiOHteHHH 5 coeflHHeHHH LL - F 28249 n-HHTpo6eH30HJixjiopn-flOM, nojiyweHHoe οοθ,π,ηηθηηθ 5-0-(n-HHTpo<5eH3OHJi)- LL - F 28249 okhcjīhiot , nojiytian npoH3BOflHoe 5-0-(n-HHTpo6eH3omi)-23-OKCo- L L- F 28249 b KpMCTajuiiraecKOM coctohhhh, nocjie ^ero ocymecT-BJIHIOT B JIIOdOM ΠΟρΗβΚΘ peaKIļHIO C Cj-Cg ajīKOKCHJiaMHHOM HJIH ero cojibio, noJiy^eHHoro npoMe«yToyHoro b npHcyTCTBnn ocHOBaHMH h CHHTHe 3amHTH. 2. Cn0C06 ΠΟΠ.Ι, OTJIHtiaiOIDļHMCH ΤΘΜ, ^TO OKMC-JieHHe npOBOflHT HCFI0JIb3yH OKUCJIAKU^/TO CHCT8My, BbI(5paHHyiO H3 rpyn-πη, cocTOHmeM M3: yKcycHoro aHrHflpwfla m ftMMeTHJicyjib$OKCH,n,a; ABy-okmch MapraHUļa; nHpM,n,nHAHxpoMaTa n yKcycHoro aHTH^pH^a; τρβτ-6yT0KCHaJIK)MMHHfl H 0pT0-6eH30XHH0Ha; ΠΗΤΗΟΚΗΟΗ $oc$opa 1Λ βΗΜΘΤΗΛ-cyjib$OKCH,n;a; ^HiļMKJioreKCHJiKapdoflHHMHfla h flHMeTHJicyjrb<|)OKCima. 3. CnocoO non.2, OTJiH^aronļHMCH τθμ, ^το b Ka-yecTBe OKHCJīnmiefi οηοτθμη Hcnojib3yroT yKcycHbift aHrH^pH,!!, η αημθ-THJICyJIb$OKCHfū1, H OKHCJieHHe ΠρΟΒΟ^ΗΤ B npHCyTCTBHH nnpn1iļHHa H KHCJIOTH. 4. Cnocoč no n.2, OTJin^aiomiiHCH τθμ, ητο b Ka-iiecTBe OKHCJiHromeii οηοτθμη Hcnojib3yiOT ,n,ByoKMCb MapraHua, h okhc-jieHne npoBOflHT b npHcyTCTBHn 3THJiaijeTaTa. 5. Cnocoč non.2, OTotiaioiiļiiilCH τθμ, ^to b Ka-^iecTBe OKHCJiHiomeH οκοτθμη Hcnojib3yiOT nnpHflHHflnxpoMaT m yKcycHbin aH rumpim. 24 6. CnocoČ no n.I, oTJiHtiaiomHiiCfl τθμ, wto npon3-βο,π,ηοθ 5-0-(n-HMTpo6eH3OHJi)-23-oKCO- L L - F 28249Φ otnnuaroT c nOMOIIJbK) nepeKpMCTaJIJIH3ai4HH H3 ΠΟ,Π,ΧΟ,Π,ΗΐηθΓΟ paCTBOpHTeJIH. 7. Cnocoč ΠΟ Π.Ι, OTJĪHtiaiOmHfiCH ΤΘΜ, WTO npOMe-ΤΚγΤΟ^ΗΒΙΗ ηρΟΑΥΚΤ peaKDļHM C Cj-Cg aJlKOKCHJiaMHHOM HJIM ΘΓΟ COJIbK) o^nmaioT nepeKpncTajuin3aiļHeii H3 noflxoflHmero pacTBopuTejiH. LV 10503 25 ΡΕΦΕΡΑΤ
OnHCHBaeTCH cnocod nojiyyeHM coe^HHeHMfi 23-(Cj-Cg ajiKKJi-okcmm)- LL - F 28249 πγτβΜ οκμολθηηη KpncTajumtiecKHX coeflH-hghhh 5-0-n-HHTpo(5eH3OHJi L L - F 28249.
Claims (7)
- LV 10503 Izgudrojuma formula 1. Paņēmiens savienojuma LL-F-20249 23-(0,*8ΐΙ<ΙΙοΙ<8ϊηηυ) iegūšanai, kas atšķiras ar to, ka aizsargā savienojuma LL-F-28249 5-hidroksilgrupu ar p-nitrobenzoilhloridu, iegūstot 5-0-(p-nitrobenzoil)-LL-F-28249, kuru oksidē, iegūstot kristālisku 5-0-(p-nitrobenzoil)-23-okso-LL-F-28249, un tālāk jebkurā secībā to apstrādā ar C^lkoksiamīnu vai tā sāli un noņem aizsarggrupu.
- 2. Paņēmiens pēc 1. punkta, kas atšķiras ar to, ka oksidēšanu veic ar oksidējošo sistēmu no rindas: etiķskābes anhidrīds un dimetilsulfoksids; mangāna dioksīds; piridīna hromāts un acetanhidrids; terc-butoksialumlnijs un orto-benzohinons; fosfora pentoksīds un dimetilsulfoksids; dicikloheksilkarbodiimīds un dimetilsulfoksids.
- 3. Paņēmiens pēc z. punkta, kas atšķiras ar to, ka par oksidējošo sistēmu izmanto acetanhidrīdu un dimetilsulfoksidu, veicot oksidēšanu piridīna un skābes klātbūtnē.
- 4. Paņēmiens pēc 2. punkta, kas atšķiras ar to, ka par oksidējošo sistēmu izmanto mangāna dioksīdu, veicot oksidēšanu etilacetāta klātbūtnē..
- 5. Paņēmiens pēc 2. punkta, kas atšķiras ar to, ka par oksidējošo sistēmu izmanto piridīna hromētu un acetanhidrīdu.
- 6. Paņēmiens pēc 1. punkta, kas atšķiras ar to, ka 5-0-(p-nitrobenzoil)-23-okso-LL-F-28249 attīra pārkristalizējot no piemērota šķīdinātāja.
- 7. Paņēmiens pēc 1. punkta, kas atšķiras ar to, ka reakcija ar CMalkoksiamīnu vai tā sāli iegūto starpproduktu attīra pārkristalizējot no piemērota šķīdinātāja.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/405,793 US4988824A (en) | 1989-09-11 | 1989-09-11 | Process for the preparation of 23-(C1-C6 alkyloxime)-LL-F28249 compounds |
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Publication Number | Publication Date |
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LV10503A LV10503A (lv) | 1995-02-20 |
LV10503B true LV10503B (en) | 1996-04-20 |
Family
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LVP-93-697A LV10503B (en) | 1989-09-11 | 1993-06-28 | Method for producing of ll-f-28249 23-(c1-c6-alkyloxime) |
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Country | Link |
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US (1) | US4988824A (lv) |
EP (1) | EP0421081B1 (lv) |
JP (1) | JP2939312B2 (lv) |
KR (1) | KR0160977B1 (lv) |
CN (1) | CN1028428C (lv) |
AT (1) | ATE107650T1 (lv) |
AU (1) | AU634579B2 (lv) |
BG (1) | BG60620B1 (lv) |
BR (1) | BR9004493A (lv) |
CA (1) | CA2024919C (lv) |
DE (1) | DE69010129T2 (lv) |
DK (1) | DK0421081T3 (lv) |
ES (1) | ES2057291T3 (lv) |
GE (1) | GEP19981003B (lv) |
HK (1) | HK1000095A1 (lv) |
HU (1) | HU206721B (lv) |
IE (1) | IE66030B1 (lv) |
IL (1) | IL95303A (lv) |
LV (1) | LV10503B (lv) |
MD (1) | MD425C2 (lv) |
NZ (1) | NZ235151A (lv) |
PL (1) | PL165332B1 (lv) |
PT (1) | PT95242B (lv) |
RU (1) | RU2030416C1 (lv) |
SI (1) | SI9011711A (lv) |
UA (1) | UA26907C2 (lv) |
YU (1) | YU47520B (lv) |
ZA (1) | ZA907186B (lv) |
Families Citing this family (19)
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AU660205B2 (en) | 1991-12-23 | 1995-06-15 | Virbac, Inc | Systemic control of parasites |
US5439924A (en) * | 1991-12-23 | 1995-08-08 | Virbac, Inc. | Systemic control of parasites |
US5478951A (en) | 1994-06-22 | 1995-12-26 | American Cyanamid Company | Method for the purification of 23-E isomers of 23-imino derivatives of LL-F28249 compounds |
PT810823E (pt) * | 1995-02-24 | 2001-09-28 | Novartis Ag | Composicao para controlo de parasitas |
EP0750907B1 (en) * | 1995-06-30 | 2002-03-20 | American Cyanamid Company | Stable macrolide and macrolide vaccine compositions |
WO1999017760A2 (en) | 1997-10-02 | 1999-04-15 | Microcide Pharmaceuticals, Inc. | Fungal or mammalian cell efflux pump inhibitors for enhancing susceptibility of the cell to a drug |
US6762327B2 (en) * | 2002-04-29 | 2004-07-13 | Wyeth | Selective oxidation process with enhanced safety |
US7348417B2 (en) * | 2003-08-07 | 2008-03-25 | Wyeth | Method of purifying moxidectin through crystallization |
AU2006100658C4 (en) * | 2006-05-08 | 2009-07-23 | Wyeth | Process |
AU2006100662B4 (en) * | 2006-05-08 | 2006-10-05 | Wyeth | Intermediates and processes using them |
AU2006100660B4 (en) * | 2006-06-22 | 2006-10-05 | Wyeth | Improved oxidation process with enhanced safety and use thereof |
DK3351546T5 (da) | 2011-12-02 | 2024-08-12 | Boehringer Ingelheim Vetmedica Gmbh | Langtidsvirkende injicerbare moxidectinformuleringer |
CN104277050B (zh) * | 2013-07-04 | 2016-05-04 | 北大方正集团有限公司 | 一种制备莫西克汀的方法 |
CN104017001B (zh) * | 2014-06-18 | 2016-01-13 | 大连九信生物化工科技有限公司 | 一种化学合成莫西克汀的方法 |
CN104292239A (zh) * | 2014-09-30 | 2015-01-21 | 大连九信生物化工科技有限公司 | 一种消除莫西克汀生产过程中副产物二甲基硫醚的方法 |
CN104628740B (zh) * | 2015-02-13 | 2017-06-16 | 河北圣雪大成制药有限责任公司 | 一种化学合成及纯化莫西克汀的方法 |
CN104860961B (zh) * | 2015-04-10 | 2017-08-04 | 新宇药业股份有限公司 | 一种制备5‑氧(对‑硝基苯甲酰)‑尼莫克汀的方法 |
CN105085540B (zh) * | 2015-08-12 | 2017-07-07 | 内蒙古佳瑞米精细化工有限公司 | 一种制备高含量尼莫克汀的方法 |
CN114591347B (zh) * | 2022-03-29 | 2023-03-24 | 河北美荷药业有限公司 | 莫西菌素中间体及制备方法、莫西菌素的制备方法 |
Family Cites Families (12)
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US4201861A (en) * | 1977-10-03 | 1980-05-06 | Merck & Co., Inc. | Acyl derivatives of C-076 compounds |
ES8802229A1 (es) * | 1985-04-30 | 1988-04-16 | Glaxo Group Ltd | Un procedimiento para preparar nuevos derivados lactonicos macrociclicos. |
CA1296329C (en) * | 1986-06-06 | 1992-02-25 | Derek R. Sutherland | Macrolide compounds |
ES2058082T3 (es) * | 1986-09-12 | 1994-11-01 | American Cyanamid Co | Derivados 23-oxo (ceto) y 23-imino de compuestos ll-f28249. |
US4916154A (en) * | 1986-09-12 | 1990-04-10 | American Cyanamid Company | 23-Imino derivatives of LL-F28249 compounds |
US4855317A (en) * | 1987-03-06 | 1989-08-08 | Ciba-Geigy Corporation | Insecticides and parasiticides |
GB8721377D0 (en) * | 1987-09-11 | 1987-10-21 | Glaxo Group Ltd | Chemical compounds |
GB8721376D0 (en) * | 1987-09-11 | 1987-10-21 | Glaxo Group Ltd | Chemical compounds |
US5057536A (en) * | 1988-05-10 | 1991-10-15 | American Cyanamid Company | Macrolide compounds |
GB8813150D0 (en) * | 1988-06-03 | 1988-07-06 | American Cyanamid Co | Chemical compounds |
US4900758A (en) * | 1989-05-11 | 1990-02-13 | Ici Americas Inc. | Novel insecticides |
DE69023454T2 (de) * | 1989-09-11 | 1996-06-05 | American Cyanamid Co., Wayne, N.J. | 13-Alkyl-23-Imino und 13-Halo-23-Imino-Derivate von LL-F28249-Verbindungen und ihre Verwendung als Endo- und Ectoparasitizide, Insektizide, Akarizide und Nematozide Mittel. |
-
1989
- 1989-09-11 US US07/405,793 patent/US4988824A/en not_active Expired - Lifetime
-
1990
- 1990-08-03 DK DK90114919.5T patent/DK0421081T3/da active
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- 1990-08-03 AT AT90114919T patent/ATE107650T1/de not_active IP Right Cessation
- 1990-08-03 DE DE69010129T patent/DE69010129T2/de not_active Expired - Lifetime
- 1990-08-03 ES ES90114919T patent/ES2057291T3/es not_active Expired - Lifetime
- 1990-08-06 IL IL9530390A patent/IL95303A/en unknown
- 1990-09-03 NZ NZ235151A patent/NZ235151A/en unknown
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- 1990-09-10 IE IE327390A patent/IE66030B1/en not_active IP Right Cessation
- 1990-09-10 RU SU904831093A patent/RU2030416C1/ru active
- 1990-09-10 YU YU171190A patent/YU47520B/sh unknown
- 1990-09-10 BG BG92810A patent/BG60620B1/bg unknown
- 1990-09-10 UA UA4831093A patent/UA26907C2/uk unknown
- 1990-09-10 AU AU62362/90A patent/AU634579B2/en not_active Expired
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- 1990-09-10 ZA ZA907186A patent/ZA907186B/xx unknown
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1993
- 1993-06-28 LV LVP-93-697A patent/LV10503B/lv unknown
- 1993-07-31 GE GEAP19931302A patent/GEP19981003B/en unknown
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1994
- 1994-07-12 MD MD95-0307A patent/MD425C2/ro unknown
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1997
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