LU91589I2 - Prasugrel - Google Patents

Prasugrel

Info

Publication number
LU91589I2
LU91589I2 LU91589C LU91589C LU91589I2 LU 91589 I2 LU91589 I2 LU 91589I2 LU 91589 C LU91589 C LU 91589C LU 91589 C LU91589 C LU 91589C LU 91589 I2 LU91589 I2 LU 91589I2
Authority
LU
Luxembourg
Prior art keywords
substd
alkoxy
opt
dioxolen
alkanoyl
Prior art date
Application number
LU91589C
Other languages
English (en)
Original Assignee
Daiichi Sankyo Co Ltd
Ube Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26471534&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU91589(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Daiichi Sankyo Co Ltd, Ube Industries filed Critical Daiichi Sankyo Co Ltd
Publication of LU91589I2 publication Critical patent/LU91589I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacture Of Tobacco Products (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
LU91589C 1991-09-09 2009-08-03 Prasugrel LU91589I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP22787591 1991-09-09
JP13852992 1992-05-29

Publications (1)

Publication Number Publication Date
LU91589I2 true LU91589I2 (fr) 2009-10-05

Family

ID=26471534

Family Applications (1)

Application Number Title Priority Date Filing Date
LU91589C LU91589I2 (fr) 1991-09-09 2009-08-03 Prasugrel

Country Status (24)

Country Link
US (2) US5288726A (fr)
EP (1) EP0542411B1 (fr)
JP (1) JP2683479B2 (fr)
KR (1) KR0148023B1 (fr)
CN (2) CN1041730C (fr)
AT (1) ATE169627T1 (fr)
AU (1) AU656798B2 (fr)
CA (1) CA2077695C (fr)
CZ (1) CZ287181B6 (fr)
DE (2) DE122009000045I2 (fr)
DK (1) DK0542411T3 (fr)
ES (1) ES2122984T3 (fr)
FI (1) FI101150B (fr)
GR (1) GR3027650T3 (fr)
HK (1) HK1011017A1 (fr)
HU (2) HU218785B (fr)
IL (1) IL103098A (fr)
LU (1) LU91589I2 (fr)
MX (1) MX9205160A (fr)
NL (1) NL300397I2 (fr)
NO (2) NO303733B1 (fr)
NZ (1) NZ244260A (fr)
PH (1) PH29921A (fr)
TW (1) TW213461B (fr)

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* Cited by examiner, † Cited by third party
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CN1147490C (zh) 1999-01-19 2004-04-28 神经研究公司 呋喃并四吡啶衍生物及其药物组合物和用于治疗神经变形疾病的用途
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BRPI0719529B8 (pt) 2006-12-07 2021-05-25 Daiichi Sankyo Co Ltd método para produzir uma preparação sólida
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WO2008072532A1 (fr) 2006-12-07 2008-06-19 Daiichi Sankyo Company, Limited Composition pharmaceutique présentant une stabilité au stockage améliorée
CA2671979C (fr) * 2006-12-07 2014-02-04 Daiichi Sankyo Company, Limited Composition pharmaceutique contenant de l'hydroxypropylcellulose faiblement substituee
EP2123656B1 (fr) * 2007-03-02 2014-06-11 Daiichi Sankyo Company, Limited Procédé de production de chlorhydrate de prasugrel de grande pureté
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US8669268B2 (en) * 2007-09-12 2014-03-11 Deuterx, Llc Deuterium-enriched prasugrel
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CN101245073B (zh) * 2008-03-21 2011-03-23 上海医药工业研究院 一种医药中间体及其制备方法
CN101245072B (zh) * 2008-03-21 2011-03-30 上海医药工业研究院 制备普拉格雷的中间体及其制备方法
CN101250192B (zh) * 2008-03-24 2010-08-11 上海医药工业研究院 5-(α-环丙基羰基-2-氟苄基)-2-氧-2,4,5,6,7,7a-六氢噻吩并[3,2-c]吡啶的制备方法
CN101250193B (zh) * 2008-03-28 2010-09-08 上海医药工业研究院 2-烷氧基-5-(α-环丙基羰基-2-氟苄基)-4,5,6,7-四氢噻吩并[3,2-c]吡啶的制备方法
WO2009122440A1 (fr) * 2008-03-31 2009-10-08 Torrent Pharmaceuticals Ltd. Procédé de préparation de 2-acétoxy-5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tétrahydrothiéno[3,2-c]pyridine
WO2009129983A1 (fr) * 2008-04-21 2009-10-29 Ratiopharm Gmbh Sels d'addition avec des acides de prasugrel et compositions pharmaceutiques les comprenant
PL2112155T3 (pl) 2008-04-25 2011-03-31 Sandoz Ag Wodorosiarczan (VI) 2-acetoksy-5-(α-cyklopropylokarbonylo-2-fluorobenzylo)-4,5,6,7-tetrahydrotieno[3,2-c]pirydyny i sposób jego otrzymywania
US20090281136A1 (en) * 2008-05-08 2009-11-12 Sandeep Mhetre Prasugrel pharmaceutical formulations
WO2009140092A1 (fr) 2008-05-13 2009-11-19 The Medicines Company Conservation de l'inhibition de plaquettes durant une thérapie anti-plaquettes
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US9427448B2 (en) 2009-11-11 2016-08-30 The Medicines Company Methods of treating, reducing the incidence of, and/or preventing ischemic events
CN101591344B (zh) * 2008-05-27 2012-12-05 连云港恒邦医药科技有限公司 一种抗血栓的化合物、其制备方法和用途
CN101289454B (zh) * 2008-06-10 2011-02-16 上海医药工业研究院 2-氧-2,4,5,6,7,7α-六氢噻吩并[3,2-c]吡啶的制备方法
KR20110045034A (ko) 2008-08-02 2011-05-03 루난 파마슈티컬 그룹 코퍼레이션 프라수그렐 황산수소염 및 이의 약제학적 조성물 및 용도
CN103936756B (zh) * 2008-09-22 2017-09-19 广州赫尔氏药物开发有限公司 具有抗凝血作用的化合物
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CN102050828A (zh) * 2009-10-28 2011-05-11 北京万全阳光医学技术有限公司 普拉格雷盐及其制备方法
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CZ2009762A3 (cs) 2009-11-16 2011-05-25 Zentiva, K. S. Nové soli 5-[2-cyklopropyl-1-(2-fluorfenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetátu známého pod nechráneným názvem prasugrel a zpusob jejich výroby
CZ2009828A3 (cs) 2009-12-09 2011-06-22 Zentiva, K.S. Zpusob prípravy hydrochloridu 5-[2-cyklopropyl-1-(2-fluorfenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetátu (prasugrelu hydrochloridu) v polymorfní forme B
HU229031B1 (en) 2009-12-21 2013-07-29 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Process for producing prasurgel and its intermediate
HU229035B1 (en) 2009-12-21 2013-07-29 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Process for producing prasurgel
CN102120744B (zh) 2010-02-02 2013-01-09 江苏威凯尔医药科技有限公司 光学活性2-羟基四氢噻吩并吡啶衍生物及其制备方法与在制药中的用途
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EP2545059A1 (fr) * 2010-03-09 2013-01-16 Synthon BV Procédé de préparation de prasugrel
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KR20120052381A (ko) 2010-04-08 2012-05-23 테바 파마슈티컬 인더스트리즈 리미티드 프라수그렐 염의 결정형
CN102212070B (zh) * 2010-04-08 2014-11-26 上海医药工业研究院 2-乙酰氧基-5-(α-环丙基羰基-2-氟苄基)-4,5,6,7-四氢噻吩并[3,2-c]吡啶的制备方法
CN101812069A (zh) * 2010-04-10 2010-08-25 山东新华制药股份有限公司 一种普拉格雷合成工艺
CN102241690B (zh) 2010-05-13 2015-08-12 天津药物研究院 一类含腈基的噻吩并吡啶酯类衍生物、其制备方法和用途
CN101845052B (zh) * 2010-06-11 2012-01-11 天津药物研究院 一类含氮杂环的噻吩并吡啶酮衍生物、其制备方法和用途
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CN101899056A (zh) * 2010-08-02 2010-12-01 江苏万全特创医药生物技术有限公司 普拉格雷氢溴酸盐多晶型物及其制备方法
JP5856177B2 (ja) 2010-10-18 2016-02-09 セレニス セラピューティクス ホールディング エスアー コレステロールモビリゼーションに有用な化合物、組成物及び方法
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PH29921A (en) 1996-09-16
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DE122009000045I2 (de) 2010-07-08
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EP0542411A2 (fr) 1993-05-19
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EP0542411A3 (en) 1993-07-21
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US5288726A (en) 1994-02-22
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HU218785B (hu) 2000-12-28
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DE69226607D1 (de) 1998-09-17
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