HUT61313A - Process for producing pyrrolo/2,3-d/pyrimidine derivatives and pharmaceutical compositions comprising same - Google Patents
Process for producing pyrrolo/2,3-d/pyrimidine derivatives and pharmaceutical compositions comprising sameInfo
- Publication number
- HUT61313A HUT61313A HU148792A HU148792A HUT61313A HU T61313 A HUT61313 A HU T61313A HU 148792 A HU148792 A HU 148792A HU 148792 A HU148792 A HU 148792A HU T61313 A HUT61313 A HU T61313A
- Authority
- HU
- Hungary
- Prior art keywords
- lower alkyl
- benzyl
- substd
- benzoyl
- opt
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
2-X-4-Y-5-Z-6-R1- Pyrimidine derivs. of formula (I) and their pharmaceutically acceptable salts are new: R1=H or lower alkyl; X=morpholino, 4-R2-piperazino, NR4R5 or a gp. of formula (a)-(e) R2=H, lower alkyl, phenyl, benzyl or alpha-(p-chlorophenyl)benzyl; x=1 or at least 2; each R3=lower alkyl, OH, phenyl opt. substd. by NO2, benzyl, benzoyloxy, benzoylamino, mono- or di-lower alkylamino, C(Ph)2OH, piperidino, lower hydroxyalkyl, PhSO2O, benzoyl opt. substd. by halo, lower alkylsulphonamido or lower alkoxycarbonyl; n=4-7; R4=H lower alkyl or benzyl; R5=lower alkyl, lower acyl, 2-fluroyl, benzyl, 4-piperidyl opt. substd. by benzoyl, phenethyl, a gp. of formula (g) or benzoyl opt. substd. by halo or NO2. Y= CH2R9, NR6R7 or a gp. of formula (g)-(j); R9=H, lower alkyl, lower alkoxy, lower alkylthio or di-lower alkylamino; R6=H, lower alkyl, phenyl, benzyl, lower alkoxy or 2-(N, N-dimethyl amino)ethyl; R7 = lower alkyl, lower acyl, cyclohexylcarbonyl, 2-fueoyl, lower alkoxycarbonyl, cinnamoyl, benzyl, benzylcarbonyl, tosyl, phenoxyacetyl, di-lower alkylcarbamoyl, 2-thienyl, COQ, CONHPh, COOPh, 4-lower alkyl piperazyl or benzoyl opt. substd. by halo, NO2, lower alkyl, lower alkoxy, NH2, benzoylamino or phenyl; provided that when R6=H, R7=benzoyl; Q=4-pyridyl, 1-piperidinyl or morpholino; R8=H, lower alkyl, phenyl or benzyl; m=4-7; Z=H halo, lower alkyl or lower alkoxycarbonyl; provided that (1) Y=CH2R9 only when Z=lower alkoxycarbonyl; (2) R4=H only when R5=lower alkyl, lower acyl, 2-furoyl, benzyl, phenethyl or benzoyl opt. substd. by halo or NO2 Y=CH2R9 and Z=lower alkoxycarbonyl or (3) Y=(g), (i) or (j) only when X=NR4R5 and R4= lower alkyl.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP33367088 | 1988-12-29 | ||
JP1041729A JPH02221275A (en) | 1989-02-23 | 1989-02-23 | Pyrimidines and their pharmacologically permissible salts |
JP4172889 | 1989-02-23 | ||
HU896762A HU206337B (en) | 1988-12-29 | 1989-12-22 | Process for producing pyrimidine derivatives and pharmaceutical compositions |
Publications (3)
Publication Number | Publication Date |
---|---|
HU9201487D0 HU9201487D0 (en) | 1992-07-28 |
HUT61313A true HUT61313A (en) | 1992-12-28 |
HU209594B HU209594B (en) | 1994-08-29 |
Family
ID=27451988
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9201485A HU210001B (en) | 1988-12-29 | 1989-12-22 | Process for producing 6-member heteroaromatic compounds comprising 1-3 nitrogen atoms and pharmaceutical compositions comprising same |
HU148792A HU209594B (en) | 1988-12-29 | 1989-12-22 | Process for producing pyrrolo/2,3-d/pyrimidine derivatives and pharmaceutical preparations containing them |
HU148892A HU209574B (en) | 1988-12-29 | 1989-12-22 | Process for producing pyrimidine derivatives and pharmaceutical preparations containing them |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9201485A HU210001B (en) | 1988-12-29 | 1989-12-22 | Process for producing 6-member heteroaromatic compounds comprising 1-3 nitrogen atoms and pharmaceutical compositions comprising same |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU148892A HU209574B (en) | 1988-12-29 | 1989-12-22 | Process for producing pyrimidine derivatives and pharmaceutical preparations containing them |
Country Status (1)
Country | Link |
---|---|
HU (3) | HU210001B (en) |
-
1989
- 1989-12-22 HU HU9201485A patent/HU210001B/en not_active IP Right Cessation
- 1989-12-22 HU HU148792A patent/HU209594B/en not_active IP Right Cessation
- 1989-12-22 HU HU148892A patent/HU209574B/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HUT61293A (en) | 1992-12-28 |
HU9201487D0 (en) | 1992-07-28 |
HUT61288A (en) | 1992-12-28 |
HU209574B (en) | 1994-08-29 |
HU210001B (en) | 1995-01-30 |
HU209594B (en) | 1994-08-29 |
HU9201488D0 (en) | 1992-07-28 |
HU9201485D0 (en) | 1992-07-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HPC4 | Succession in title of patentee |
Owner name: MITSUI CHEMICALS, INC., JP Owner name: MITSUI PHARMACEUTICALS INC., JP |
|
HMM4 | Cancellation of final prot. due to non-payment of fee |