LT3966B - Novel 8-substituted-2-aminotetralines, process for preparing thereof, pharmaceutical composition - Google Patents

Novel 8-substituted-2-aminotetralines, process for preparing thereof, pharmaceutical composition Download PDF

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Publication number
LT3966B
LT3966B LTIP1723A LTIP1723A LT3966B LT 3966 B LT3966 B LT 3966B LT IP1723 A LTIP1723 A LT IP1723A LT IP1723 A LTIP1723 A LT IP1723A LT 3966 B LT3966 B LT 3966B
Authority
LT
Lithuania
Prior art keywords
formula
alkyl
aryl
hydrogen
compounds
Prior art date
Application number
LTIP1723A
Other languages
English (en)
Lithuanian (lt)
Inventor
Berit Christina Elisabe Hoeoek
Anna Lena Maria Bjoerk
Uli Alf Hacksell
Sven-Erik Hillver
Ye Liu
Eva Charlotta Mellin
Eva Marie Persson
Karl Jerk Vallgaarda
Yu Hong
Nils-Erik Anden
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of LTIP1723A publication Critical patent/LTIP1723A/xx
Publication of LT3966B publication Critical patent/LT3966B/lt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
    • C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Nutrition Science (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Purification Treatments By Anaerobic Or Anaerobic And Aerobic Bacteria Or Animals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polyamides (AREA)
LTIP1723A 1989-05-26 1993-12-30 Novel 8-substituted-2-aminotetralines, process for preparing thereof, pharmaceutical composition LT3966B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8901889A SE8901889D0 (sv) 1989-05-26 1989-05-26 Novel 8-substituted-2-aminotetralines

Publications (2)

Publication Number Publication Date
LTIP1723A LTIP1723A (en) 1995-08-25
LT3966B true LT3966B (en) 1996-05-27

Family

ID=20376074

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP1723A LT3966B (en) 1989-05-26 1993-12-30 Novel 8-substituted-2-aminotetralines, process for preparing thereof, pharmaceutical composition

Country Status (41)

Country Link
US (1) US5635537A (xx)
EP (1) EP0399982B1 (xx)
JP (1) JP2818692B2 (xx)
KR (1) KR100193981B1 (xx)
CN (1) CN1023399C (xx)
AT (1) ATE129696T1 (xx)
AU (1) AU644081B2 (xx)
CA (1) CA2032498C (xx)
CY (1) CY1989A (xx)
CZ (1) CZ286038B6 (xx)
DD (1) DD298909A5 (xx)
DE (1) DE69023274T2 (xx)
DK (1) DK0399982T3 (xx)
DZ (1) DZ1417A1 (xx)
ES (1) ES2078962T3 (xx)
FI (1) FI114151B (xx)
GR (1) GR3018566T3 (xx)
HK (1) HK55697A (xx)
HR (1) HRP920622B1 (xx)
HU (2) HUT58685A (xx)
IE (1) IE75057B1 (xx)
IL (1) IL94428A (xx)
IS (1) IS1663B (xx)
JO (1) JO1617B1 (xx)
LT (1) LT3966B (xx)
LV (2) LV10243B (xx)
MX (1) MX20842A (xx)
NO (1) NO176603C (xx)
NZ (1) NZ233724A (xx)
PH (1) PH31110A (xx)
PL (2) PL164245B1 (xx)
PT (1) PT94163B (xx)
RU (1) RU2093507C1 (xx)
SA (1) SA90100274B1 (xx)
SE (1) SE8901889D0 (xx)
SI (1) SI9011006B (xx)
SK (1) SK280731B6 (xx)
UA (1) UA40562C2 (xx)
WO (1) WO1990014330A1 (xx)
YU (1) YU48830B (xx)
ZA (1) ZA903801B (xx)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2785879B2 (ja) 1989-05-31 1998-08-13 ジ・アップジョン・カンパニー 治療学的に有用な２―アミノテトラリン誘導体
DK0471515T3 (da) * 1990-08-15 1997-07-21 Lilly Co Eli Ringsubstituerede 2-amino-1,2,3,4-tetrahydronphtalener, 3-aminochromaner og 3-aminothiochromaner
US5643784A (en) * 1990-12-04 1997-07-01 H, Lundbeck A/S Indan derivatives
ES2153071T3 (es) * 1991-02-08 2001-02-16 Lilly Co Eli 2-amino-1,2,3,4-tetrahidronaftalenos y 3-aminocromanos sustituidos en anillo.
US5347013A (en) * 1991-03-28 1994-09-13 Eli Lilly And Company 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indoles
US5244911A (en) * 1991-03-28 1993-09-14 Eli Lilly And Company 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz(cd)indoles and pharmaceutical use thereof
US5244912A (en) * 1991-03-28 1993-09-14 Eli Lilly And Company 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz(cd)indoles and pharmaceutical use thereof
US5656653A (en) * 1991-03-28 1997-08-12 Eli Lilly And Company 6-heterocyclic-4-amino-1,2,2A,3,4,5-hexahydrobenz[cd]indoles
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
SE9103745D0 (sv) * 1991-12-18 1991-12-18 Wikstroem Haakan Aryl-triflates and related compounds
DK78692D0 (da) * 1992-06-12 1992-06-12 Lundbeck & Co As H Dimere piperidin- og piperazinderivater
SE9301732D0 (sv) * 1993-05-18 1993-05-18 Haakan Wilhelm Wikstroem New centrally acting 5-,6-,7-, and 8-substituted sulphone esters of n-monosubstituted 2-aminotetralins
AU1106195A (en) * 1994-11-09 1996-06-06 Novo Nordisk A/S Heterocyclic compounds, their preparation and use
GB9509156D0 (en) * 1995-05-05 1995-06-28 Sandoz Ltd Organic compounds
ES2566479T3 (es) * 2006-01-06 2016-04-13 Sunovion Pharmaceuticals Inc. Inhibidores de reabsorción de monoamina con base en tetralona
AU2022238849A1 (en) 2021-03-17 2023-08-31 Receptos Llc Methods of treating atopic dermatitis with anti il-13 antibodies

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0270947A2 (de) 1986-12-10 1988-06-15 Bayer Ag Substituierte basische 2-Aminotetraline
EP0272534A2 (de) 1986-12-22 1988-06-29 Bayer Ag 8-Substituierte 2-Aminotetraline

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2752659A1 (de) * 1976-12-07 1978-06-08 Sandoz Ag Neue tetralinderivate, ihre herstellung und verwendung
US4247907A (en) * 1978-11-27 1981-01-27 International Business Machines Corporation Method and apparatus for typing characters and optically readable binary representations thereof on same page
SE8004002L (sv) * 1980-05-29 1981-11-30 Arvidsson Folke Lars Erik Terapeutiskt anvendbara tetralinderivat
IL65501A (en) * 1981-05-08 1986-04-29 Astra Laekemedel Ab 1-alkyl-2-aminotetralin derivatives,process for their preparation and pharmaceutical compositions containing them
EP0168505B1 (en) * 1984-05-22 1989-08-09 Whitby Research Incorporated Substituted 2-aminotetralins and processes for synthesis
EP0209275B1 (en) * 1985-06-26 1988-10-19 Smithkline Beckman Corporation Benz-trisubstituted 2-aminotetralins
IL79323A (en) * 1985-07-10 1990-03-19 Sanofi Sa Phenylethanolaminotetralines,their preparation and pharmaceutical compositions containing them
WO1990007490A1 (en) * 1989-01-09 1990-07-12 The Upjohn Company Halo substituted aminotetralins
JP2785879B2 (ja) * 1989-05-31 1998-08-13 ジ・アップジョン・カンパニー 治療学的に有用な２―アミノテトラリン誘導体

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0270947A2 (de) 1986-12-10 1988-06-15 Bayer Ag Substituierte basische 2-Aminotetraline
EP0272534A2 (de) 1986-12-22 1988-06-29 Bayer Ag 8-Substituierte 2-Aminotetraline

Also Published As

Publication number Publication date
IL94428A0 (en) 1991-03-10
ZA903801B (en) 1991-01-30
UA40562C2 (uk) 2001-08-15
DZ1417A1 (fr) 2004-09-13
SI9011006A (en) 1997-12-31
DK0399982T3 (da) 1996-03-04
AU5818590A (en) 1990-12-18
IS1663B (is) 1997-07-04
CY1989A (en) 1997-09-05
CA2032498C (en) 2002-03-26
LV11736A (lv) 1997-04-20
HU904810D0 (en) 1991-06-28
RU2093507C1 (ru) 1997-10-20
CZ286038B6 (cs) 1999-12-15
PL285330A1 (en) 1991-11-04
KR920701121A (ko) 1992-08-11
LV10243A (lv) 1994-10-20
IE75057B1 (en) 1997-08-27
YU48830B (sh) 2002-03-18
GR3018566T3 (en) 1996-03-31
FI910381A0 (fi) 1991-01-25
JPH04500362A (ja) 1992-01-23
NO910310D0 (no) 1991-01-25
KR100193981B1 (ko) 1999-06-15
JO1617B1 (en) 1991-11-27
CZ256090A3 (cs) 1999-10-13
IL94428A (en) 1995-12-31
EP0399982B1 (en) 1995-11-02
SE8901889D0 (sv) 1989-05-26
PH31110A (en) 1998-02-23
SK256090A3 (en) 2000-07-11
WO1990014330A1 (en) 1990-11-29
LTIP1723A (en) 1995-08-25
DD298909A5 (de) 1992-03-19
HRP920622A2 (en) 1998-06-30
YU100690A (en) 1992-05-28
MX20842A (es) 1993-11-01
NZ233724A (en) 1993-01-27
SI9011006B (sl) 1998-12-31
HUT58685A (en) 1992-03-30
NO910310L (no) 1991-01-25
PT94163A (pt) 1991-01-08
PL164245B1 (pl) 1994-07-29
ATE129696T1 (de) 1995-11-15
FI114151B (fi) 2004-08-31
CN1047494A (zh) 1990-12-05
DE69023274D1 (de) 1995-12-07
EP0399982A1 (en) 1990-11-28
IE901833L (en) 1990-11-26
NO176603B (no) 1995-01-23
JP2818692B2 (ja) 1998-10-30
LV10243B (en) 1995-04-20
PT94163B (pt) 1996-12-31
LV11736B (en) 1997-10-20
CA2032498A1 (en) 1990-11-27
AU644081B2 (en) 1993-12-02
ES2078962T3 (es) 1996-01-01
PL165166B1 (pl) 1994-11-30
CN1023399C (zh) 1994-01-05
US5635537A (en) 1997-06-03
IS3580A7 (is) 1990-11-27
NO176603C (no) 1995-05-03
HU211880A9 (en) 1995-12-28
SK280731B6 (sk) 2000-07-11
SA90100274B1 (ar) 2005-06-01
DE69023274T2 (de) 1996-04-11
HRP920622B1 (en) 2000-04-30
HK55697A (en) 1997-05-09

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