DE69023274D1 - 8-Substituierte-2-Aminotetraline. - Google Patents

8-Substituierte-2-Aminotetraline.

Info

Publication number
DE69023274D1
DE69023274D1 DE69023274T DE69023274T DE69023274D1 DE 69023274 D1 DE69023274 D1 DE 69023274D1 DE 69023274 T DE69023274 T DE 69023274T DE 69023274 T DE69023274 T DE 69023274T DE 69023274 D1 DE69023274 D1 DE 69023274D1
Authority
DE
Germany
Prior art keywords
substituted
hydrogen
compounds
fused
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69023274T
Other languages
English (en)
Other versions
DE69023274T2 (de
Inventor
Nils-Erik Anden
Hoeoek Berit Christin Backlund
Anna Lena Maria Bjoerk
Uli Alf Hacksell
Sven-Erik Hillver
Ye Liu
Eva Charlotta Mellin
Eva Marie Persson
Karl Jerk Vallgarda
Hong Yu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Astra AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra AB filed Critical Astra AB
Application granted granted Critical
Publication of DE69023274D1 publication Critical patent/DE69023274D1/de
Publication of DE69023274T2 publication Critical patent/DE69023274T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
    • C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
DE69023274T 1989-05-26 1990-05-23 8-Substituierte-2-Aminotetraline. Expired - Lifetime DE69023274T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8901889A SE8901889D0 (sv) 1989-05-26 1989-05-26 Novel 8-substituted-2-aminotetralines

Publications (2)

Publication Number Publication Date
DE69023274D1 true DE69023274D1 (de) 1995-12-07
DE69023274T2 DE69023274T2 (de) 1996-04-11

Family

ID=20376074

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69023274T Expired - Lifetime DE69023274T2 (de) 1989-05-26 1990-05-23 8-Substituierte-2-Aminotetraline.

Country Status (41)

Country Link
US (1) US5635537A (de)
EP (1) EP0399982B1 (de)
JP (1) JP2818692B2 (de)
KR (1) KR100193981B1 (de)
CN (1) CN1023399C (de)
AT (1) ATE129696T1 (de)
AU (1) AU644081B2 (de)
CA (1) CA2032498C (de)
CY (1) CY1989A (de)
CZ (1) CZ286038B6 (de)
DD (1) DD298909A5 (de)
DE (1) DE69023274T2 (de)
DK (1) DK0399982T3 (de)
DZ (1) DZ1417A1 (de)
ES (1) ES2078962T3 (de)
FI (1) FI114151B (de)
GR (1) GR3018566T3 (de)
HK (1) HK55697A (de)
HR (1) HRP920622B1 (de)
HU (2) HUT58685A (de)
IE (1) IE75057B1 (de)
IL (1) IL94428A (de)
IS (1) IS1663B (de)
JO (1) JO1617B1 (de)
LT (1) LT3966B (de)
LV (2) LV10243B (de)
MX (1) MX20842A (de)
NO (1) NO176603C (de)
NZ (1) NZ233724A (de)
PH (1) PH31110A (de)
PL (2) PL164245B1 (de)
PT (1) PT94163B (de)
RU (1) RU2093507C1 (de)
SA (1) SA90100274B1 (de)
SE (1) SE8901889D0 (de)
SI (1) SI9011006B (de)
SK (1) SK280731B6 (de)
UA (1) UA40562C2 (de)
WO (1) WO1990014330A1 (de)
YU (1) YU48830B (de)
ZA (1) ZA903801B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2086535C1 (ru) * 1989-05-31 1997-08-10 Дзе Апджон Компани Производные 1,2,3,4-тетрагидро-2-нафтиламина
ATE149480T1 (de) * 1990-08-15 1997-03-15 Lilly Co Eli Ring-substituierte 2-amino-1,2,3,4-tetra- hydronaphthaline, 3-aminochromane und 3- aminothiochromane
US5643784A (en) * 1990-12-04 1997-07-01 H, Lundbeck A/S Indan derivatives
NZ241495A (en) * 1991-02-08 1994-10-26 Lilly Co Eli 2-amino-1,2,3,4-tetrahydronaphthalene and 3-aminochromane derivative, preparation and pharmaceutical compositions thereof
US5244911A (en) * 1991-03-28 1993-09-14 Eli Lilly And Company 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz(cd)indoles and pharmaceutical use thereof
US5244912A (en) * 1991-03-28 1993-09-14 Eli Lilly And Company 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz(cd)indoles and pharmaceutical use thereof
US5643934A (en) * 1991-03-28 1997-07-01 Eli Lilly And Company 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz [CD]indoles
US5347013A (en) * 1991-03-28 1994-09-13 Eli Lilly And Company 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indoles
NZ243065A (en) 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
SE9103745D0 (sv) * 1991-12-18 1991-12-18 Wikstroem Haakan Aryl-triflates and related compounds
DK78692D0 (da) * 1992-06-12 1992-06-12 Lundbeck & Co As H Dimere piperidin- og piperazinderivater
SE9301732D0 (sv) * 1993-05-18 1993-05-18 Haakan Wilhelm Wikstroem New centrally acting 5-,6-,7-, and 8-substituted sulphone esters of n-monosubstituted 2-aminotetralins
AU1106195A (en) * 1994-11-09 1996-06-06 Novo Nordisk A/S Heterocyclic compounds, their preparation and use
GB9509156D0 (en) * 1995-05-05 1995-06-28 Sandoz Ltd Organic compounds
KR101381768B1 (ko) * 2006-01-06 2014-04-07 선오비온 파마슈티컬스 인코포레이티드 테트랄론-기재 모노아민 재흡수 저해제
JP2024511078A (ja) 2021-03-17 2024-03-12 レセプトス エルエルシー 抗ｉｌ－１３抗体を用いてアトピー性皮膚炎を処置する方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2752659A1 (de) * 1976-12-07 1978-06-08 Sandoz Ag Neue tetralinderivate, ihre herstellung und verwendung
US4247907A (en) * 1978-11-27 1981-01-27 International Business Machines Corporation Method and apparatus for typing characters and optically readable binary representations thereof on same page
SE8004002L (sv) * 1980-05-29 1981-11-30 Arvidsson Folke Lars Erik Terapeutiskt anvendbara tetralinderivat
IL65501A (en) * 1981-05-08 1986-04-29 Astra Laekemedel Ab 1-alkyl-2-aminotetralin derivatives,process for their preparation and pharmaceutical compositions containing them
EP0168505B1 (de) * 1984-05-22 1989-08-09 Whitby Research Incorporated Substituierte 2-Aminotetraline und Verfahren zur Herstellung
ATE38029T1 (de) * 1985-06-26 1988-11-15 Smithkline Beckman Corp Benz-trisubstituierte 2-aminotetraline.
IL79323A (en) * 1985-07-10 1990-03-19 Sanofi Sa Phenylethanolaminotetralines,their preparation and pharmaceutical compositions containing them
DE3718317A1 (de) * 1986-12-10 1988-06-16 Bayer Ag Substituierte basische 2-aminotetraline
DE3719924A1 (de) * 1986-12-22 1988-06-30 Bayer Ag 8-substituierte 2-aminotetraline
ATE113271T1 (de) * 1989-01-09 1994-11-15 Upjohn Co Halogensubstituierte aminotetraline.
RU2086535C1 (ru) * 1989-05-31 1997-08-10 Дзе Апджон Компани Производные 1,2,3,4-тетрагидро-2-нафтиламина

Also Published As

Publication number Publication date
CY1989A (en) 1997-09-05
NZ233724A (en) 1993-01-27
PT94163A (pt) 1991-01-08
SA90100274B1 (ar) 2005-06-01
NO910310D0 (no) 1991-01-25
CN1023399C (zh) 1994-01-05
CZ286038B6 (cs) 1999-12-15
IS3580A7 (is) 1990-11-27
JO1617B1 (en) 1991-11-27
LV11736A (lv) 1997-04-20
KR920701121A (ko) 1992-08-11
HRP920622A2 (en) 1998-06-30
EP0399982A1 (de) 1990-11-28
GR3018566T3 (en) 1996-03-31
HUT58685A (en) 1992-03-30
NO176603B (no) 1995-01-23
FI910381A0 (fi) 1991-01-25
FI114151B (fi) 2004-08-31
HU904810D0 (en) 1991-06-28
YU100690A (en) 1992-05-28
DD298909A5 (de) 1992-03-19
ZA903801B (en) 1991-01-30
AU644081B2 (en) 1993-12-02
SK256090A3 (en) 2000-07-11
ATE129696T1 (de) 1995-11-15
RU2093507C1 (ru) 1997-10-20
JPH04500362A (ja) 1992-01-23
LTIP1723A (en) 1995-08-25
NO910310L (no) 1991-01-25
SK280731B6 (sk) 2000-07-11
CN1047494A (zh) 1990-12-05
HK55697A (en) 1997-05-09
SI9011006A (en) 1997-12-31
NO176603C (no) 1995-05-03
HRP920622B1 (en) 2000-04-30
JP2818692B2 (ja) 1998-10-30
DZ1417A1 (fr) 2004-09-13
KR100193981B1 (ko) 1999-06-15
US5635537A (en) 1997-06-03
PH31110A (en) 1998-02-23
AU5818590A (en) 1990-12-18
CA2032498C (en) 2002-03-26
MX20842A (es) 1993-11-01
LT3966B (en) 1996-05-27
WO1990014330A1 (en) 1990-11-29
SI9011006B (sl) 1998-12-31
LV10243A (lv) 1994-10-20
SE8901889D0 (sv) 1989-05-26
PT94163B (pt) 1996-12-31
EP0399982B1 (de) 1995-11-02
YU48830B (sh) 2002-03-18
IE75057B1 (en) 1997-08-27
CA2032498A1 (en) 1990-11-27
IE901833L (en) 1990-11-26
IS1663B (is) 1997-07-04
UA40562C2 (uk) 2001-08-15
PL165166B1 (pl) 1994-11-30
CZ256090A3 (cs) 1999-10-13
PL285330A1 (en) 1991-11-04
HU211880A9 (en) 1995-12-28
DE69023274T2 (de) 1996-04-11
IL94428A (en) 1995-12-31
PL164245B1 (pl) 1994-07-29
LV11736B (en) 1997-10-20
ES2078962T3 (es) 1996-01-01
IL94428A0 (en) 1991-03-10
LV10243B (en) 1995-04-20
DK0399982T3 (da) 1996-03-04

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Legal Events

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