KR930002378A - 플루로머틸린 착체 - Google Patents

플루로머틸린 착체 Download PDF

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Publication number
KR930002378A
KR930002378A KR1019920013120A KR920013120A KR930002378A KR 930002378 A KR930002378 A KR 930002378A KR 1019920013120 A KR1019920013120 A KR 1019920013120A KR 920013120 A KR920013120 A KR 920013120A KR 930002378 A KR930002378 A KR 930002378A
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KR
South Korea
Prior art keywords
cyclodextrin
derivative
formula
complex
acid addition
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KR1019920013120A
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English (en)
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KR100237719B1 (ko
Inventor
프란쯔 마토우스 하인리히
짜이즐 에리히
Original Assignee
얀 크래머, 게오르게스 그렐리니
바이오케미 게젤샤프트 엠.베.하.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 얀 크래머, 게오르게스 그렐리니, 바이오케미 게젤샤프트 엠.베.하. filed Critical 얀 크래머, 게오르게스 그렐리니
Publication of KR930002378A publication Critical patent/KR930002378A/ko
Application granted granted Critical
Publication of KR100237719B1 publication Critical patent/KR100237719B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/76—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members
    • C07C2603/80—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing eight-membered rings
    • C07C2603/82—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing eight-membered rings having three condensed rings with in total fourteen carbon atoms and having a having a [5.4.3.0(1,8)] ring structure, e.g. pleuromutiline

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

내용 없음.

Description

플루로머틸린 착체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 유리 염기, 산 부가염 또는 4급염 형태의 하기 구조식(I)의 플루로머틸렌 유도체와 사이클로덱스트린과의 착체.
  2. 제1항에 정의한 바와 같은 유리 염기, 약제학적으로 허용되는 산 부가염 또는 4급염 형태의 구조식(I)의 플루로머틸린 유도체와 사이클로덱스트린과의 착체를 약제학적으로 허용되는 하나 이상의 담체 또는 희석제와 함께 포함하는 약제학적 제제.
  3. 제1항에 있어서, 구조식(I)의 플루로머틸린 유도체가 하이드로클로라이드 형태이고 사이클로덱스트린이 β- 또는 γ-사이클로덱스트린인 착체.
  4. 제2항에 있어서, 구조식(I)의 플루로머틸린 유도체가 하이드로클로라이드 형태이고 사이클로덱스트린이 β- 또는 γ-사이클로덱스트린인 약제학적 제제.
  5. 제1항에 정의한 바와 같은 유리 염기, 산 부가염 또는 4급염 형태의 구조식(I)의 화합물을 적합한 사이클로덱스트린과 착화시킴을 포함하여, 제1항에 따른 착체를 제조하는 방법.
  6. 제1항에 정의한 바와 같은 유리 염기, 약제학적으로 허용되는 산 부가염 또는 4급염 형태의 구조식(I)의 플루로머틸린 유도체와 적합한 사이클로덱스트린과의 착제를 약제학적으로 허용되는 하나 이상의 담체 또는 희석제와 함께 혼합함을 포함하여, 제2항에 따른 약제학적 제제를 제조하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920013120A 1991-07-24 1992-07-23 플루로머틸린 착체 및 이를 함유하는 약제학적 제제 KR100237719B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0147791A AT400674B (de) 1991-07-24 1991-07-24 Pharmazeutische pleuromutilin-zubereitung
ATA1477/91 1991-07-24

Publications (2)

Publication Number Publication Date
KR930002378A true KR930002378A (ko) 1993-02-23
KR100237719B1 KR100237719B1 (ko) 2000-01-15

Family

ID=3514745

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920013120A KR100237719B1 (ko) 1991-07-24 1992-07-23 플루로머틸린 착체 및 이를 함유하는 약제학적 제제

Country Status (29)

Country Link
US (1) US5578585A (ko)
EP (1) EP0524632B1 (ko)
JP (1) JP3296847B2 (ko)
KR (1) KR100237719B1 (ko)
CN (1) CN1039319C (ko)
AT (2) AT400674B (ko)
AU (1) AU656987B2 (ko)
BG (1) BG61864B1 (ko)
BR (1) BR9202804A (ko)
CA (1) CA2074385C (ko)
CZ (1) CZ281620B6 (ko)
DE (1) DE69221793T2 (ko)
DK (1) DK0524632T3 (ko)
ES (1) ES2104775T3 (ko)
FI (1) FI104788B (ko)
GR (1) GR3025497T3 (ko)
HU (2) HU214589B (ko)
IE (1) IE80625B1 (ko)
IL (1) IL102597A (ko)
MX (1) MX9204318A (ko)
NO (1) NO300445B1 (ko)
NZ (1) NZ243662A (ko)
RO (1) RO111680B1 (ko)
RU (1) RU2099324C1 (ko)
SA (1) SA92130137B1 (ko)
SG (1) SG44633A1 (ko)
SK (1) SK280773B6 (ko)
TW (1) TW307770B (ko)
ZA (1) ZA925600B (ko)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9614017D0 (en) * 1996-07-04 1996-09-04 Biochemie Gmbh Organic compounds
UY25225A1 (es) 1997-10-29 2000-12-29 Smithkline Beecham Plc Derivados de pleuromutilina utiles como agentes antimicrobianos
TWI260220B (en) * 1999-11-22 2006-08-21 Novartis Ag A pharmaceutical composition for the transdermal treatment of bacterial infections in animals
US6716448B2 (en) 2001-10-05 2004-04-06 Rubicon Scientific Llc Domesticated household pet food including maintenance amounts of ivermectin
US6866862B2 (en) * 2001-10-05 2005-03-15 Rubicon Scientific Animal feeds including heartworm-prevention drugs
US7052712B2 (en) * 2001-10-05 2006-05-30 Rubicon Scientific Llc Animal feeds including actives and methods of preparing same
CO5390081A1 (es) * 2001-11-28 2004-04-30 Novartis Ag Compuestos organicos
GB0207495D0 (en) * 2002-03-28 2002-05-08 Biochemie Gmbh Organic compounds
GB0218578D0 (en) * 2002-08-09 2002-09-18 Glaxo Group Ltd Novel method
KR20040027191A (ko) * 2002-09-27 2004-04-01 대한민국 (강원대학교) 콜레스테롤이 감소된 알(卵)의 생산방법
GB0308114D0 (en) * 2003-04-08 2003-05-14 Glaxo Group Ltd Novel compounds
JP5091661B2 (ja) 2004-04-01 2012-12-05 ピエール ファーブル メディカモン 超臨界ｃｏ２と錯体相互作用剤を用いる方法によって得られる包接錯体
EP1686115A1 (de) * 2005-01-26 2006-08-02 Novartis AG Organische Säureadditionssalze von Valnemulin
US7750111B2 (en) * 2005-09-22 2010-07-06 Toray Industries, Inc. Polyarylene sulfide and its production method
EP2159220A1 (en) * 2008-09-02 2010-03-03 Nabriva Therapeutics AG Organic compounds
CN102266319B (zh) * 2011-07-25 2012-11-28 武汉回盛生物科技有限公司 一种兽用盐酸沃尼妙林预混剂及其制备方法
CN102764252A (zh) * 2012-08-07 2012-11-07 湖北龙翔药业有限公司 一种盐酸沃尼妙林的用途
US10532102B2 (en) 2016-08-19 2020-01-14 Foresee Pharmaceuticals Co., Ltd. Pharmaceutical composition and methods of uses

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4092424A (en) * 1964-04-17 1978-05-30 Biochemie Ges.M.B.H. Antibiotic derivatives
US4041175A (en) * 1974-05-13 1977-08-09 E. R. Squibb & Sons, Inc. Use of pleuromutilin for the treatment of swine dysentery
US3987194A (en) * 1975-05-12 1976-10-19 E. R. Squibb & Sons, Inc. Use of pleuromutilin derivatives for the treatment of swine dysentery
US4086359A (en) * 1975-09-30 1978-04-25 E. R. Squibb & Sons, Inc. Derivatives of pleuromutilin and compositions
CH627940A5 (de) * 1976-12-23 1982-02-15 Sandoz Ag Kokzidiostatisches kombinationspraeparat.
US4130709A (en) * 1977-12-08 1978-12-19 Eli Lilly And Company Pleuromutilin glycoside derivatives
US4129721A (en) * 1977-12-08 1978-12-12 Eli Lilly And Company A-40104 antibiotics and process for production thereof
CY1353A (en) * 1979-01-12 1987-04-24 Sandoz Ag New pleuromutilin derivatives, their production and use
GB2072012B (en) * 1980-03-14 1984-07-25 Squibb & Sons Inc Veterinary compositions containing pleuromutilin derivatives
JPS58148816A (ja) * 1982-02-27 1983-09-05 Nippon Zenyaku Kogyo Kk 低刺激性チアムリン注射剤
JPS58177949A (ja) * 1982-04-12 1983-10-18 Takeda Chem Ind Ltd ランカシジン群抗生物質包接化合物
JPS5910510A (ja) * 1982-07-08 1984-01-20 Nippon Zenyaku Kogyo Kk 低刺激性チアムリン注射剤
EP0153277B1 (de) * 1984-02-17 1987-08-26 Sandoz Ag Neue Pleuromutilinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung
JPS6191125A (ja) * 1984-10-11 1986-05-09 Nippon Zeon Co Ltd Ｓ−アデノシル−ｌ−メチオニン含有組成物及びその製造法
JPS62120344A (ja) * 1985-11-20 1987-06-01 Nippon Redarii Kk ４−ビフエニリル酢酸エステル−シクロデキストリン包接化合物
JPS62123196A (ja) * 1985-11-22 1987-06-04 Nisshin Flour Milling Co Ltd プレドニゾロン包接化合物
GB8613688D0 (en) * 1986-06-05 1986-07-09 Euro Celtique Sa Pharmaceutical composition
JPS63139130A (ja) * 1986-11-29 1988-06-10 Nippon Funmatsu Yakuhin Kk 長期安定型の漢方薬軟エキスの製造法
JPH0819004B2 (ja) * 1986-12-26 1996-02-28 日清製粉株式会社 徐放性医薬製剤
JPS6463552A (en) * 1987-09-04 1989-03-09 Lederle Japan Ltd 4-biphenylylacetic acid ester-cyclodextrin inclusion compound
CA1321192C (en) * 1988-04-20 1993-08-10 Abdul Majid Inclusion complexes of cyclodextrins by agglomeration
US5007966A (en) * 1988-09-21 1991-04-16 American Maize-Products Company Cyclodextrin complexing method

Also Published As

Publication number Publication date
IE922392A1 (en) 1993-01-27
RU2099324C1 (ru) 1997-12-20
RO111680B1 (ro) 1996-12-30
AT400674B (de) 1996-02-26
US5578585A (en) 1996-11-26
DK0524632T3 (da) 1997-09-29
CZ281620B6 (cs) 1996-11-13
HU214589B (hu) 1998-04-28
HUT63828A (en) 1993-10-28
BR9202804A (pt) 1994-01-25
MX9204318A (es) 1994-07-29
GR3025497T3 (en) 1998-02-27
KR100237719B1 (ko) 2000-01-15
BG61864B1 (bg) 1998-08-31
AU656987B2 (en) 1995-02-23
NZ243662A (en) 1994-10-26
IL102597A0 (en) 1993-01-14
ATA147791A (de) 1995-07-15
TW307770B (ko) 1997-06-11
IE80625B1 (en) 1998-10-21
FI923342A0 (fi) 1992-07-22
JP3296847B2 (ja) 2002-07-02
FI923342A (fi) 1993-01-25
NO922901D0 (no) 1992-07-22
EP0524632A1 (en) 1993-01-27
DE69221793T2 (de) 1998-03-12
IL102597A (en) 1996-06-18
ES2104775T3 (es) 1997-10-16
EP0524632B1 (en) 1997-08-27
SG44633A1 (en) 1997-12-19
CA2074385C (en) 2003-09-23
BG96678A (bg) 1994-03-24
NO922901L (no) 1993-01-25
ATE157260T1 (de) 1997-09-15
AU2053692A (en) 1993-01-28
ZA925600B (en) 1994-01-24
DE69221793D1 (de) 1997-10-02
CN1039319C (zh) 1998-07-29
SK280773B6 (sk) 2000-07-11
JPH05201962A (ja) 1993-08-10
CN1068813A (zh) 1993-02-10
HU9202307D0 (en) 1992-10-28
CZ231192A3 (en) 1993-02-17
SA92130137B1 (ar) 2005-06-08
FI104788B (fi) 2000-04-14
NO300445B1 (no) 1997-06-02
CA2074385A1 (en) 1993-01-25
SK231192A3 (en) 1995-03-08
HU211650A9 (en) 1995-12-28

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