JPS6463552A - 4-biphenylylacetic acid ester-cyclodextrin inclusion compound - Google Patents

4-biphenylylacetic acid ester-cyclodextrin inclusion compound

Info

Publication number
JPS6463552A
JPS6463552A JP62220492A JP22049287A JPS6463552A JP S6463552 A JPS6463552 A JP S6463552A JP 62220492 A JP62220492 A JP 62220492A JP 22049287 A JP22049287 A JP 22049287A JP S6463552 A JPS6463552 A JP S6463552A
Authority
JP
Japan
Prior art keywords
biphenylylacetic acid
cyclodextrin
beta
compound
inclusion compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP62220492A
Other languages
Japanese (ja)
Inventor
Kanehito Kamikama
Fumitoshi Hirayama
Tetsumi Irie
Hidetoshi Arima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Japan Inc
Original Assignee
Lederle Japan Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lederle Japan Ltd filed Critical Lederle Japan Ltd
Priority to JP62220492A priority Critical patent/JPS6463552A/en
Publication of JPS6463552A publication Critical patent/JPS6463552A/en
Pending legal-status Critical Current

Links

Landscapes

  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:The 4-biphenylylacetic acid ester-cyclodextrin inclusion compound. EXAMPLE:4-Biphenylylacetic acid ethyl ester-dimethyl-beta-cyclodextrin inclusion compound. USE:The inclusion improves the absorbability of 4-biphenylylacetic acid which is an active component, reduces the rate of administration owing to the increase in blood concentration and enables the application of the compound to an oral drug. 4-Biphenylylacetic acid is useful as an anti-inflammatory, analgesic and antipyretic agent. PREPARATION:A 1-6C lower alkyl ester of 4-biphenylylacetic acid is added to an aqueous solution of dimethyl-beta-cyclodextrin or hydroxypropyl-beta- cyclodextrin optionally in a state dissolved in a solvent (e.g. methanol) and the mixture is stirred at 10-90 deg.C for several house - several weeks to obtain the objective compound.
JP62220492A 1987-09-04 1987-09-04 4-biphenylylacetic acid ester-cyclodextrin inclusion compound Pending JPS6463552A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62220492A JPS6463552A (en) 1987-09-04 1987-09-04 4-biphenylylacetic acid ester-cyclodextrin inclusion compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62220492A JPS6463552A (en) 1987-09-04 1987-09-04 4-biphenylylacetic acid ester-cyclodextrin inclusion compound

Publications (1)

Publication Number Publication Date
JPS6463552A true JPS6463552A (en) 1989-03-09

Family

ID=16751909

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62220492A Pending JPS6463552A (en) 1987-09-04 1987-09-04 4-biphenylylacetic acid ester-cyclodextrin inclusion compound

Country Status (1)

Country Link
JP (1) JPS6463552A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05201962A (en) * 1991-07-24 1993-08-10 Biochem Gmbh Pluromutilin composite
US6044912A (en) * 1998-03-13 2000-04-04 Hochiki Kabushiki Kaisha Sprinkler head
JP2001089503A (en) * 1999-09-16 2001-04-03 Soc Prod Nestle Sa Cyclodextrin inclusion complex and method for producing the same

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05201962A (en) * 1991-07-24 1993-08-10 Biochem Gmbh Pluromutilin composite
US6044912A (en) * 1998-03-13 2000-04-04 Hochiki Kabushiki Kaisha Sprinkler head
JP2001089503A (en) * 1999-09-16 2001-04-03 Soc Prod Nestle Sa Cyclodextrin inclusion complex and method for producing the same

Similar Documents

Publication Publication Date Title
US4153689A (en) Stable insulin preparation for nasal administration
CA1234050A (en) Injectable solution for the treatment of inflammations
NO166448C (en) ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE TIAZOLIDE INDIANS.
EP0063870A2 (en) Cream preparation
AU624896B2 (en) Anti-inflammatory aryl derivatives
KR830002510A (en) Composition consisting of biologically active compound and hydroxyalkyl starch
ES484706A1 (en) Corticoid sulfopropionic acid esters and their salts, process for their preparation and pharmaceutical preparations containing these compounds.
JPS6463552A (en) 4-biphenylylacetic acid ester-cyclodextrin inclusion compound
KR960031442A (en) Use of phenylcyclohexylcarboxamide
KR930019212A (en) Phisostigmine derivatives and uses thereof and pharmaceutical preparations containing them
US4389414A (en) Prostaglandin compositions
KR880009943A (en) Pyridazinone derivatives
ES8307224A1 (en) Pyrazoline derivatives, processes for their preparation and pharmaceutical formulations containing them.
EP0055593B1 (en) Compositions comprising e-prostaglandins
JPS6393718A (en) Injection
KR930703251A (en) Aerosol formulations
KR880012518A (en) Analgesic and anti-inflammatory pharmaceutical compositions containing naphthal-acetic acid derivatives
FR2535205A1 (en) Stable aq. solns. of antirheumatics and cobalamin(s)
KR880006198A (en) 2,6-diamino-3-halbenzylpyridine, preparation method thereof and pharmaceutical use thereof
KR820000291B1 (en) Method for the solubilization of insoluble drugs
JPS5914005B2 (en) Stabilization method for mitomycin C
KR870010868A (en) Pharmaceutical compositions having anti-progesterogenic activity and methods for their preparation
KR920016404A (en) Novel 2- (2,6-dichloroanilino) -phenylacetate and its preparation and use of topically applied pharmaceutical preparations
EP0318560A1 (en) Antipsoriatic pharmaceutical composition and process for the preparation.
JPS5687590A (en) Diphosphoglycerine derivative