JPS6463552A - 4-biphenylylacetic acid ester-cyclodextrin inclusion compound - Google Patents
4-biphenylylacetic acid ester-cyclodextrin inclusion compoundInfo
- Publication number
- JPS6463552A JPS6463552A JP62220492A JP22049287A JPS6463552A JP S6463552 A JPS6463552 A JP S6463552A JP 62220492 A JP62220492 A JP 62220492A JP 22049287 A JP22049287 A JP 22049287A JP S6463552 A JPS6463552 A JP S6463552A
- Authority
- JP
- Japan
- Prior art keywords
- biphenylylacetic acid
- cyclodextrin
- beta
- compound
- inclusion compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:The 4-biphenylylacetic acid ester-cyclodextrin inclusion compound. EXAMPLE:4-Biphenylylacetic acid ethyl ester-dimethyl-beta-cyclodextrin inclusion compound. USE:The inclusion improves the absorbability of 4-biphenylylacetic acid which is an active component, reduces the rate of administration owing to the increase in blood concentration and enables the application of the compound to an oral drug. 4-Biphenylylacetic acid is useful as an anti-inflammatory, analgesic and antipyretic agent. PREPARATION:A 1-6C lower alkyl ester of 4-biphenylylacetic acid is added to an aqueous solution of dimethyl-beta-cyclodextrin or hydroxypropyl-beta- cyclodextrin optionally in a state dissolved in a solvent (e.g. methanol) and the mixture is stirred at 10-90 deg.C for several house - several weeks to obtain the objective compound.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62220492A JPS6463552A (en) | 1987-09-04 | 1987-09-04 | 4-biphenylylacetic acid ester-cyclodextrin inclusion compound |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62220492A JPS6463552A (en) | 1987-09-04 | 1987-09-04 | 4-biphenylylacetic acid ester-cyclodextrin inclusion compound |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS6463552A true JPS6463552A (en) | 1989-03-09 |
Family
ID=16751909
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP62220492A Pending JPS6463552A (en) | 1987-09-04 | 1987-09-04 | 4-biphenylylacetic acid ester-cyclodextrin inclusion compound |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6463552A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05201962A (en) * | 1991-07-24 | 1993-08-10 | Biochem Gmbh | Pluromutilin composite |
US6044912A (en) * | 1998-03-13 | 2000-04-04 | Hochiki Kabushiki Kaisha | Sprinkler head |
JP2001089503A (en) * | 1999-09-16 | 2001-04-03 | Soc Prod Nestle Sa | Cyclodextrin inclusion complex and method for producing the same |
-
1987
- 1987-09-04 JP JP62220492A patent/JPS6463552A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05201962A (en) * | 1991-07-24 | 1993-08-10 | Biochem Gmbh | Pluromutilin composite |
US6044912A (en) * | 1998-03-13 | 2000-04-04 | Hochiki Kabushiki Kaisha | Sprinkler head |
JP2001089503A (en) * | 1999-09-16 | 2001-04-03 | Soc Prod Nestle Sa | Cyclodextrin inclusion complex and method for producing the same |
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