KR920006879B1 - 고정제 단백질의 제조방법 - Google Patents

고정제 단백질의 제조방법 Download PDF

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Publication number
KR920006879B1
KR920006879B1 KR1019840007430A KR840007430A KR920006879B1 KR 920006879 B1 KR920006879 B1 KR 920006879B1 KR 1019840007430 A KR1019840007430 A KR 1019840007430A KR 840007430 A KR840007430 A KR 840007430A KR 920006879 B1 KR920006879 B1 KR 920006879B1
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KR
South Korea
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leu
protein
thr
human
glu
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Expired
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KR1019840007430A
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English (en)
Korean (ko)
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KR850003734A (ko
Inventor
고오이찌 가또
다까오 야마다
하루오 온다
Original Assignee
다께다야꾸힝고오교가부시끼가이샤
구라바야시 이꾸시로
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=16823684&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR920006879(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 다께다야꾸힝고오교가부시끼가이샤, 구라바야시 이꾸시로 filed Critical 다께다야꾸힝고오교가부시끼가이샤
Publication of KR850003734A publication Critical patent/KR850003734A/ko
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Publication of KR920006879B1 publication Critical patent/KR920006879B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1019840007430A 1983-11-28 1984-11-27 고정제 단백질의 제조방법 Expired KR920006879B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP225079 1983-11-28
JP58225079A JPS60115528A (ja) 1983-11-28 1983-11-28 ヒトインタ―ロイキン―２蛋白質を含有する抗腫瘍用または免疫機能低下疾患治療用組成物
JP225079/83 1983-11-28

Publications (2)

Publication Number Publication Date
KR850003734A KR850003734A (ko) 1985-06-26
KR920006879B1 true KR920006879B1 (ko) 1992-08-21

Family

ID=16823684

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840007430A Expired KR920006879B1 (ko) 1983-11-28 1984-11-27 고정제 단백질의 제조방법

Country Status (16)

Country Link
US (1) US5464939A (enExample)
EP (3) EP0442538A1 (enExample)
JP (1) JPS60115528A (enExample)
KR (1) KR920006879B1 (enExample)
DK (1) DK164174C (enExample)
ES (1) ES8606489A1 (enExample)
FI (1) FI81118C (enExample)
GR (1) GR81040B (enExample)
HU (1) HU200793B (enExample)
IL (1) IL73530A0 (enExample)
MY (1) MY103892A (enExample)
NO (1) NO169021C (enExample)
NZ (1) NZ210352A (enExample)
PT (1) PT79555B (enExample)
SG (1) SG46452A1 (enExample)
ZA (1) ZA849221B (enExample)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925919A (en) * 1984-04-25 1990-05-15 Roland Mertelsmann Purified interleukin 2
US4992271A (en) * 1982-09-23 1991-02-12 Cetus Corporation Formulation for lipophilic IL-2 proteins
US4853332A (en) * 1982-10-19 1989-08-01 Cetus Corporation Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of biologically active proteins
CA1340853C (en) * 1983-12-23 1999-12-21 Hsiang-Fu Kung Purification of recombinant interleukin-2
JPS60243021A (ja) * 1984-03-28 1985-12-03 シタス　コ−ポレイシヨン システイン含有蛋白質の制御された酸化方法
US4569790A (en) 1984-03-28 1986-02-11 Cetus Corporation Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions
EP0158487B1 (en) * 1984-04-09 1991-08-28 Takeda Chemical Industries, Ltd. Stable composition of interleukin-2
US4908434A (en) * 1984-04-25 1990-03-13 Sloan-Kettering Institute For Cancer Research Process for preparing purified interleukin-2
US4908433A (en) * 1984-04-25 1990-03-13 Sloan-Kettering Institute For Cancer Research Uses of interleukin-2
IL76360A0 (en) 1984-09-26 1986-01-31 Takeda Chemical Industries Ltd Mutual separation of proteins
WO1986002068A1 (fr) * 1984-09-26 1986-04-10 Takeda Chemical Industries, Ltd. Separation mutuelle de proteines
JPH0646957B2 (ja) * 1985-03-11 1994-06-22 武田薬品工業株式会社 インタ−ロイキン−２の製造方法
WO1986007093A1 (fr) * 1985-05-29 1986-12-04 The Green Cross Corporation Procede de preparation d'une proteine heterogene
US4748234A (en) * 1985-06-26 1988-05-31 Cetus Corporation Process for recovering refractile bodies containing heterologous proteins from microbial hosts
DE3581412D1 (de) * 1985-07-16 1991-02-21 Green Cross Corp Verfahren zur herstellung von heteroproteinen.
DE3526096A1 (de) * 1985-07-22 1987-01-22 Basf Ag Verfahren zur reinigung von htnf
CN86104525A (zh) * 1985-07-31 1987-02-25 武田药品工业株式会社 人类白细胞介素-2的分析方法和试剂
DK585886A (da) * 1985-12-24 1987-06-25 Takeda Chemical Industries Ltd Immunstimulerende middel og anvendelse deraf
US4933433A (en) * 1986-01-31 1990-06-12 E. I. Du Pont De Nemours And Company Recombinant interleukin-2 composition and process for making it
JPH0655153B2 (ja) * 1986-02-26 1994-07-27 武田薬品工業株式会社 ヒトインターロイキン―２結晶の製造法
US4929700A (en) * 1987-04-16 1990-05-29 Cetus Corporation Production of purified, biologically active, bacterially produced recombinant human CSF-1
CA1339757C (en) * 1987-04-16 1998-03-17 Robert F. Halenbeck Production of purified biologically active, bacterially produced recombinant human csf-1
US4961969A (en) * 1987-05-11 1990-10-09 Cetus Corporation Process for recovering microbially produced interferon-β
US4931543A (en) * 1987-05-11 1990-06-05 Cetus Corporation Process for recovering microbially produced interleukin-2
US5149788A (en) * 1987-05-19 1992-09-22 Hoffmann-La Roche, Inc. Purification of chimeric proteins containing an IL-2 moiety by receptor-affinity chromatography
US5162503A (en) * 1987-05-19 1992-11-10 Hoffmann-La Roche, Inc. Purification of interleukin-2 by receptor-affinity chromatography
FR2635527B1 (fr) * 1988-07-28 1992-06-12 Roussel Uclaf Il2 humaine recombinante non glycosylee sous forme reduite, son procede d'obtention et son application comme medicament
US5250296A (en) * 1990-11-29 1993-10-05 Takeda Chemical Industries, Ltd. Immunostimulant agent containing interleukin-2 and 5'-deoxy-5-fluorouridine
US5416071A (en) * 1991-03-12 1995-05-16 Takeda Chemical Industries, Ltd. Water-soluble composition for sustained-release containing epo and hyaluronic acid
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
EP2275557A1 (en) 2000-04-12 2011-01-19 Human Genome Sciences, Inc. Albumin fusion proteins
EP2990417A1 (en) 2001-12-21 2016-03-02 Human Genome Sciences, Inc. Albumin insulin fusion protein
EP1594530A4 (en) 2003-01-22 2006-10-11 Human Genome Sciences Inc HYBRID PROTEINS OF ALBUMIN
GB201000693D0 (en) 2010-01-15 2010-03-03 Isis Innovation A solar cell
KR20200070407A (ko) * 2010-11-12 2020-06-17 넥타르 테라퓨틱스 Ｉｌ-2 부분 및 중합체의 접합체
JP6941561B2 (ja) 2014-10-09 2021-09-29 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 免疫障害を処置するための複数の可変ｉｌ−２用量レジメン

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58116498A (ja) * 1981-12-28 1983-07-11 Takeda Chem Ind Ltd Ｉｌ‐２をコードする新規伝令ｒｎａの製造法
JPH0751511B2 (ja) * 1982-03-15 1995-06-05 味の素株式会社 インターロイキン２を含有してなる癌治療剤
CA1210714A (en) * 1982-03-23 1986-09-02 Alan Sloma .alpha.-INTERFERON GX-1
JPS58168492A (ja) * 1982-03-31 1983-10-04 Nippon Kokan Kk <Nkk> パイプ切断機
EP0091539B2 (en) * 1982-03-31 1996-11-27 Ajinomoto Co., Inc. Gene coding for interleukin-2 polypeptide, recombinant DNA carrying said gene, cell lines possessing the recombinant DNA,and method for producing interleukin-2 using said cells
JPS58201979A (ja) * 1982-05-18 1983-11-25 Japan Found Cancer ヒトインタ−ロイキン２遺伝子が組込まれているエシエリヒア・コリおよびその育種方法
CA1341562C (en) * 1982-03-31 2007-11-27 Tadatsugu Taniguchi Gene coded for interleukin-2 polypeptide, recombinant dna carrying the said gene, a living cell line possessing the recombinant dna, and method for producing interleukin-2 using the said cell
ATE37564T1 (de) * 1982-04-20 1988-10-15 Sloan Kettering Inst Cancer Reinigung von interleukin-2.
JPS58198293A (ja) * 1982-05-12 1983-11-18 Shionogi & Co Ltd インタ−ロイキン等免疫調節因子の製造方法
NL8203321A (nl) * 1982-08-25 1984-03-16 Philips Nv Kleurenbeeldbuis.
US4490289A (en) * 1982-09-16 1984-12-25 Hoffmann-La Roche Inc. Homogeneous human interleukin 2
AU579089B2 (en) * 1983-02-08 1988-11-17 Biogen, Inc. Human interleukin-2-like polypeptides
IL71275A0 (en) * 1983-03-21 1984-06-29 Sparamedica Ag Human interleukin-2-and its preparation
US4518584A (en) * 1983-04-15 1985-05-21 Cetus Corporation Human recombinant interleukin-2 muteins
WO1985002200A1 (en) * 1983-11-14 1985-05-23 Chiron Corporation Interleukin-2 production using cloned genes for interleukin-2 and yeast alpha-factor
CA1340853C (en) * 1983-12-23 1999-12-21 Hsiang-Fu Kung Purification of recombinant interleukin-2
US4569790A (en) * 1984-03-28 1986-02-11 Cetus Corporation Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions
US4530787A (en) * 1984-03-28 1985-07-23 Cetus Corporation Controlled oxidation of microbially produced cysteine-containing proteins
JP2608730B2 (ja) * 1987-08-10 1997-05-14 株式会社リコー 感熱記録材料

Also Published As

Publication number Publication date
JPH0542413B2 (enExample) 1993-06-28
PT79555A (en) 1984-12-01
ES8606489A1 (es) 1986-04-01
EP0442538A1 (en) 1991-08-21
FI844678L (fi) 1985-05-29
DK560784A (da) 1985-05-29
GR81040B (en) 1985-03-27
US5464939A (en) 1995-11-07
IL73530A0 (en) 1985-02-28
DK164174B (da) 1992-05-18
NO169021C (no) 1992-04-29
EP0145390A2 (en) 1985-06-19
KR850003734A (ko) 1985-06-26
HUT36186A (en) 1985-08-28
AU3575684A (en) 1985-06-06
MY103892A (en) 1993-10-30
NZ210352A (en) 1988-11-29
DK560784D0 (da) 1984-11-27
PT79555B (en) 1986-12-15
FI844678A0 (fi) 1984-11-28
SG46452A1 (en) 1998-02-20
EP0145390A3 (en) 1987-01-21
NO169021B (no) 1992-01-20
EP0751220A1 (en) 1997-01-02
NO844710L (no) 1985-05-29
ES537994A0 (es) 1986-04-01
HU200793B (en) 1990-08-28
DK164174C (da) 1992-10-05
FI81118B (fi) 1990-05-31
FI81118C (fi) 1990-09-10
JPS60115528A (ja) 1985-06-22
ZA849221B (en) 1986-07-30
AU592527B2 (en) 1990-01-18

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PN2301 Change of applicant

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