DK164174C - Et i det vaesentlige rent, ikke-glykolyseret humant interleukin-2-protein, fremgangsmaade til fremstilling af dette protein og farmaceutisk produkt indeholdende dette protein - Google Patents

Et i det vaesentlige rent, ikke-glykolyseret humant interleukin-2-protein, fremgangsmaade til fremstilling af dette protein og farmaceutisk produkt indeholdende dette protein

Info

Publication number
DK164174C
DK164174C DK560784A DK560784A DK164174C DK 164174 C DK164174 C DK 164174C DK 560784 A DK560784 A DK 560784A DK 560784 A DK560784 A DK 560784A DK 164174 C DK164174 C DK 164174C
Authority
DK
Denmark
Prior art keywords
protein
gycolycized
preparing
procedure
product containing
Prior art date
Application number
DK560784A
Other languages
Danish (da)
English (en)
Other versions
DK164174B (da
DK560784D0 (da
DK560784A (da
Inventor
Koichi Kato
Takao Yamada
Haruo Onda
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=16823684&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK164174(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of DK560784D0 publication Critical patent/DK560784D0/da
Publication of DK560784A publication Critical patent/DK560784A/da
Publication of DK164174B publication Critical patent/DK164174B/da
Application granted granted Critical
Publication of DK164174C publication Critical patent/DK164174C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK560784A 1983-11-28 1984-11-27 Et i det vaesentlige rent, ikke-glykolyseret humant interleukin-2-protein, fremgangsmaade til fremstilling af dette protein og farmaceutisk produkt indeholdende dette protein DK164174C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP58225079A JPS60115528A (ja) 1983-11-28 1983-11-28 ヒトインタ―ロイキン―２蛋白質を含有する抗腫瘍用または免疫機能低下疾患治療用組成物
JP22507983 1983-11-28

Publications (4)

Publication Number Publication Date
DK560784D0 DK560784D0 (da) 1984-11-27
DK560784A DK560784A (da) 1985-05-29
DK164174B DK164174B (da) 1992-05-18
DK164174C true DK164174C (da) 1992-10-05

Family

ID=16823684

Family Applications (1)

Application Number Title Priority Date Filing Date
DK560784A DK164174C (da) 1983-11-28 1984-11-27 Et i det vaesentlige rent, ikke-glykolyseret humant interleukin-2-protein, fremgangsmaade til fremstilling af dette protein og farmaceutisk produkt indeholdende dette protein

Country Status (16)

Country Link
US (1) US5464939A (enExample)
EP (3) EP0751220A1 (enExample)
JP (1) JPS60115528A (enExample)
KR (1) KR920006879B1 (enExample)
DK (1) DK164174C (enExample)
ES (1) ES8606489A1 (enExample)
FI (1) FI81118C (enExample)
GR (1) GR81040B (enExample)
HU (1) HU200793B (enExample)
IL (1) IL73530A0 (enExample)
MY (1) MY103892A (enExample)
NO (1) NO169021C (enExample)
NZ (1) NZ210352A (enExample)
PT (1) PT79555B (enExample)
SG (1) SG46452A1 (enExample)
ZA (1) ZA849221B (enExample)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925919A (en) * 1984-04-25 1990-05-15 Roland Mertelsmann Purified interleukin 2
US4992271A (en) * 1982-09-23 1991-02-12 Cetus Corporation Formulation for lipophilic IL-2 proteins
US4853332A (en) * 1982-10-19 1989-08-01 Cetus Corporation Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of biologically active proteins
CA1340853C (en) * 1983-12-23 1999-12-21 Hsiang-Fu Kung Purification of recombinant interleukin-2
US4569790A (en) * 1984-03-28 1986-02-11 Cetus Corporation Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions
JPS60243021A (ja) * 1984-03-28 1985-12-03 シタス　コ−ポレイシヨン システイン含有蛋白質の制御された酸化方法
DE3583880D1 (de) * 1984-04-09 1991-10-02 Takeda Chemical Industries Ltd Stabile interleukin-2-zusammensetzung.
US4908433A (en) * 1984-04-25 1990-03-13 Sloan-Kettering Institute For Cancer Research Uses of interleukin-2
US4908434A (en) * 1984-04-25 1990-03-13 Sloan-Kettering Institute For Cancer Research Process for preparing purified interleukin-2
WO1986002068A1 (fr) * 1984-09-26 1986-04-10 Takeda Chemical Industries, Ltd. Separation mutuelle de proteines
IL76360A0 (en) 1984-09-26 1986-01-31 Takeda Chemical Industries Ltd Mutual separation of proteins
JPH0646957B2 (ja) * 1985-03-11 1994-06-22 武田薬品工業株式会社 インタ−ロイキン−２の製造方法
WO1986007093A1 (fr) * 1985-05-29 1986-12-04 The Green Cross Corporation Procede de preparation d'une proteine heterogene
US4748234A (en) * 1985-06-26 1988-05-31 Cetus Corporation Process for recovering refractile bodies containing heterologous proteins from microbial hosts
EP0227833B1 (en) * 1985-07-16 1991-01-16 Green Cross Corporation Process for preparing hetero-protein
DE3526096A1 (de) * 1985-07-22 1987-01-22 Basf Ag Verfahren zur reinigung von htnf
CN86104525A (zh) * 1985-07-31 1987-02-25 武田药品工业株式会社 人类白细胞介素-2的分析方法和试剂
DK585886A (da) * 1985-12-24 1987-06-25 Takeda Chemical Industries Ltd Immunstimulerende middel og anvendelse deraf
US4933433A (en) * 1986-01-31 1990-06-12 E. I. Du Pont De Nemours And Company Recombinant interleukin-2 composition and process for making it
JPH0655153B2 (ja) * 1986-02-26 1994-07-27 武田薬品工業株式会社 ヒトインターロイキン―２結晶の製造法
CA1339757C (en) 1987-04-16 1998-03-17 Robert F. Halenbeck Production of purified biologically active, bacterially produced recombinant human csf-1
US4929700A (en) * 1987-04-16 1990-05-29 Cetus Corporation Production of purified, biologically active, bacterially produced recombinant human CSF-1
US4961969A (en) * 1987-05-11 1990-10-09 Cetus Corporation Process for recovering microbially produced interferon-β
US4931543A (en) * 1987-05-11 1990-06-05 Cetus Corporation Process for recovering microbially produced interleukin-2
US5162503A (en) * 1987-05-19 1992-11-10 Hoffmann-La Roche, Inc. Purification of interleukin-2 by receptor-affinity chromatography
US5149788A (en) * 1987-05-19 1992-09-22 Hoffmann-La Roche, Inc. Purification of chimeric proteins containing an IL-2 moiety by receptor-affinity chromatography
FR2635527B1 (fr) * 1988-07-28 1992-06-12 Roussel Uclaf Il2 humaine recombinante non glycosylee sous forme reduite, son procede d'obtention et son application comme medicament
US5250296A (en) * 1990-11-29 1993-10-05 Takeda Chemical Industries, Ltd. Immunostimulant agent containing interleukin-2 and 5'-deoxy-5-fluorouridine
US5416071A (en) * 1991-03-12 1995-05-16 Takeda Chemical Industries, Ltd. Water-soluble composition for sustained-release containing epo and hyaluronic acid
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
ES2529300T3 (es) 2000-04-12 2015-02-18 Novozymes Biopharma Dk A/S Proteínas de fusión de albúmina
WO2003060071A2 (en) 2001-12-21 2003-07-24 Human Genome Sciences, Inc. Albumin fusion proteins
WO2005003296A2 (en) 2003-01-22 2005-01-13 Human Genome Sciences, Inc. Albumin fusion proteins
GB201000693D0 (en) 2010-01-15 2010-03-03 Isis Innovation A solar cell
PT2637694T (pt) * 2010-11-12 2021-05-05 Nektar Therapeutics Conjugados de uma fração de il-2 e um polímero
JP6941561B2 (ja) 2014-10-09 2021-09-29 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 免疫障害を処置するための複数の可変ｉｌ−２用量レジメン

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58116498A (ja) * 1981-12-28 1983-07-11 Takeda Chem Ind Ltd Ｉｌ‐２をコードする新規伝令ｒｎａの製造法
JPH0751511B2 (ja) * 1982-03-15 1995-06-05 味の素株式会社 インターロイキン２を含有してなる癌治療剤
CA1210714A (en) * 1982-03-23 1986-09-02 Alan Sloma .alpha.-INTERFERON GX-1
JPS58168492A (ja) * 1982-03-31 1983-10-04 Nippon Kokan Kk <Nkk> パイプ切断機
CA1341562C (en) * 1982-03-31 2007-11-27 Tadatsugu Taniguchi Gene coded for interleukin-2 polypeptide, recombinant dna carrying the said gene, a living cell line possessing the recombinant dna, and method for producing interleukin-2 using the said cell
JPS58201979A (ja) * 1982-05-18 1983-11-25 Japan Found Cancer ヒトインタ−ロイキン２遺伝子が組込まれているエシエリヒア・コリおよびその育種方法
EP0091539B2 (en) * 1982-03-31 1996-11-27 Ajinomoto Co., Inc. Gene coding for interleukin-2 polypeptide, recombinant DNA carrying said gene, cell lines possessing the recombinant DNA,and method for producing interleukin-2 using said cells
EP0092163B1 (en) * 1982-04-20 1988-09-28 Sloan-Kettering Institute For Cancer Research Purification of interleukin 2
JPS58198293A (ja) * 1982-05-12 1983-11-18 Shionogi & Co Ltd インタ−ロイキン等免疫調節因子の製造方法
NL8203321A (nl) * 1982-08-25 1984-03-16 Philips Nv Kleurenbeeldbuis.
US4490289A (en) * 1982-09-16 1984-12-25 Hoffmann-La Roche Inc. Homogeneous human interleukin 2
AU579089B2 (en) * 1983-02-08 1988-11-17 Biogen, Inc. Human interleukin-2-like polypeptides
IL71275A0 (en) * 1983-03-21 1984-06-29 Sparamedica Ag Human interleukin-2-and its preparation
US4518584A (en) * 1983-04-15 1985-05-21 Cetus Corporation Human recombinant interleukin-2 muteins
EP0162898A4 (en) * 1983-11-14 1987-07-23 Chiron Corp INTERLEUKIN-2 GENERATION USING CLONED GENES FOR INTERLEUKIN-2 AND YEAR ALPHA FACTOR.
CA1340853C (en) * 1983-12-23 1999-12-21 Hsiang-Fu Kung Purification of recombinant interleukin-2
US4530787A (en) * 1984-03-28 1985-07-23 Cetus Corporation Controlled oxidation of microbially produced cysteine-containing proteins
US4569790A (en) * 1984-03-28 1986-02-11 Cetus Corporation Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions
JP2608730B2 (ja) * 1987-08-10 1997-05-14 株式会社リコー 感熱記録材料

Also Published As

Publication number Publication date
EP0442538A1 (en) 1991-08-21
EP0145390A2 (en) 1985-06-19
DK164174B (da) 1992-05-18
PT79555B (en) 1986-12-15
JPS60115528A (ja) 1985-06-22
PT79555A (en) 1984-12-01
KR920006879B1 (ko) 1992-08-21
SG46452A1 (en) 1998-02-20
NZ210352A (en) 1988-11-29
NO169021C (no) 1992-04-29
FI844678A0 (fi) 1984-11-28
GR81040B (en) 1985-03-27
ZA849221B (en) 1986-07-30
ES8606489A1 (es) 1986-04-01
HUT36186A (en) 1985-08-28
EP0751220A1 (en) 1997-01-02
HU200793B (en) 1990-08-28
IL73530A0 (en) 1985-02-28
MY103892A (en) 1993-10-30
AU592527B2 (en) 1990-01-18
KR850003734A (ko) 1985-06-26
NO844710L (no) 1985-05-29
EP0145390A3 (en) 1987-01-21
DK560784D0 (da) 1984-11-27
FI81118B (fi) 1990-05-31
FI81118C (fi) 1990-09-10
ES537994A0 (es) 1986-04-01
FI844678L (fi) 1985-05-29
JPH0542413B2 (enExample) 1993-06-28
NO169021B (no) 1992-01-20
US5464939A (en) 1995-11-07
AU3575684A (en) 1985-06-06
DK560784A (da) 1985-05-29

Similar Documents

Publication Publication Date Title
DK164174C (da) Et i det vaesentlige rent, ikke-glykolyseret humant interleukin-2-protein, fremgangsmaade til fremstilling af dette protein og farmaceutisk produkt indeholdende dette protein
DK165112C (da) 2,2&#39;-iminobisethanolderivater, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende disse
DK539789D0 (da) Carbostyrilderivater, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende et saadant carbostyrilderivat
DK162445C (da) Pyranopyridiner, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende pyranopyridinerne
DK211084A (da) Hurtigtoploesende laegemiddelpraeparater og fremgangsmaade til fremstilling heraf
DK446386A (da) Proteinhydrolysater, fremgangsmaader til fremstilling deraf og laegemidler, der indeholder disse hydrolysater
DK165199C (da) Aktivatorpraeparat, fremgangsmaade til kvantitativ bestemmelse af protein c under anvendelse af praeparatet, antithrombotisk laegemiddel indeholdende praeparatet og fremgangsmaade til udvinding af aktiveret protein c under anvendelse af praeparatet
DK431586D0 (da) Benzimidazolderivater, fremgangsmaade til fremstilling deraf og laegemiddel indeholdende disse
DK106989A (da) Isoindolinonderivat, fremgangsmaade til fremstilling af dette, og laegemiddel indeholdende dette
DK162221C (da) Cinnolinforbindelser, fremgangsmaade til fremstilling deraf og farmaceutiske midler indeholdende forbindelserne
DK305884D0 (da) Phenoxyderivat, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende et saadant derivat
DK183986A (da) Cyklopentylaetere, fremgangsmaade til fremstilling deraf og laegemiddelpraeparat indeholdende saadanne forbindelser
DK612788A (da) Alkoxyderivater af ginkolider, fremgangsmaade til fremstilling heraf og farmaceutiske praeparater indeholdende saadanne forbindelser
DK634788A (da) 22-deklorteicoplaniner, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende saadanne forbindelser
DK340388A (da) Aminocyklopentylaetere, fremstilling deraf og farmaceutisk praeparat indeholdende saadanne forbindelser
DK92789D0 (da) Polypeptidderivater, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende disse
DK162841C (da) N-(3-nitro-4-quinolyl)-4-karboxamidiner, fremgangsmaade til fremstilling heraf og farmaceutisk praeparat indeholdende saadanne forbindelser
DK187989D0 (da) Substituerede propanaminer, fremgangsmaade til fremstilling heraf og laegemidler indeholdende saadanne forbindelser
DK493988D0 (da) 4-oxo-3-quinolincarboxylsyrer, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende disse forbindelser
DK597184A (da) Substituerede spiro-pyridinderivater, farmaceutiske praeparater indeholdende dem og fremgangsmaade til fremstilling af saadanne forbindelser
DK300989D0 (da) Alaninderivater, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende saadanne forbindelser
DK165115C (da) Bicycliske catechol-derivater, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende saadanne derivater
DK159779C (da) Substituerede phenoxypropylthiopyrazolo(1,5-a)-pyridin- eller -benzimidazolderivater, fremgangsmaade til fremstilling deraf og laegemiddel indeholdende disse forbindelser
DK711988D0 (da) Methyltetrahydropyridyloxadiazol, farmaceutisk praeparat indeholdende en saadan forbindelse og fremgangsmaade til fremstilling af en saadan forbindelse
DK320084D0 (da) Imidazolylsubstituerede diphenylazomethiner, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse

Legal Events

Date Code Title Description
PUP Patent expired