KR870000923B1 - 2, 2'-이미노 비스 에탄올 유도체의 제조방법 - Google Patents

2, 2'-이미노 비스 에탄올 유도체의 제조방법 Download PDF

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Publication number
KR870000923B1
KR870000923B1 KR1019840007404A KR840007404A KR870000923B1 KR 870000923 B1 KR870000923 B1 KR 870000923B1 KR 1019840007404 A KR1019840007404 A KR 1019840007404A KR 840007404 A KR840007404 A KR 840007404A KR 870000923 B1 KR870000923 B1 KR 870000923B1
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KR
South Korea
Prior art keywords
parts
dihydro
benzopyran
alkyl
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019840007404A
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English (en)
Korean (ko)
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KR850004485A (ko
Inventor
반 롬멘 가이
드 브라운 마아셀
슈로벤 마아크
Original Assignee
쟈안센 파아마슈우티카 엔 · 부이
폴 아드리안, 쟌 쟈안센
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Publication of KR850004485A publication Critical patent/KR850004485A/ko
Application granted granted Critical
Publication of KR870000923B1 publication Critical patent/KR870000923B1/ko
Expired legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1019840007404A 1983-12-05 1984-11-26 2, 2'-이미노 비스 에탄올 유도체의 제조방법 Expired KR870000923B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55808183A 1983-12-05 1983-12-05
US558,081 1983-12-05

Publications (2)

Publication Number Publication Date
KR850004485A KR850004485A (ko) 1985-07-15
KR870000923B1 true KR870000923B1 (ko) 1987-05-07

Family

ID=24228139

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840007404A Expired KR870000923B1 (ko) 1983-12-05 1984-11-26 2, 2'-이미노 비스 에탄올 유도체의 제조방법

Country Status (32)

Country Link
EP (1) EP0145067B1 (https=)
JP (1) JPS60132977A (https=)
KR (1) KR870000923B1 (https=)
AR (1) AR241414A1 (https=)
AT (1) ATE40361T1 (https=)
AU (1) AU573658B2 (https=)
BG (1) BG43866A3 (https=)
CA (1) CA1337429C (https=)
CS (1) CS250242B2 (https=)
CY (1) CY1609A (https=)
DD (1) DD235453A5 (https=)
DE (1) DE3476388D1 (https=)
DK (2) DK165112C (https=)
DZ (1) DZ712A1 (https=)
ES (1) ES8603870A1 (https=)
FI (1) FI82460C (https=)
GR (1) GR81098B (https=)
HK (1) HK52791A (https=)
HU (1) HU202219B (https=)
IE (1) IE57831B1 (https=)
IL (1) IL73706A (https=)
MA (1) MA20292A1 (https=)
NO (2) NO169839C (https=)
NZ (1) NZ210388A (https=)
PH (1) PH22432A (https=)
PL (1) PL146342B1 (https=)
PT (1) PT79609B (https=)
RO (1) RO91184B (https=)
SG (1) SG47091G (https=)
SU (1) SU1428199A3 (https=)
ZA (1) ZA849445B (https=)
ZW (1) ZW19784A1 (https=)

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JPH02218675A (ja) * 1989-02-21 1990-08-31 Nippon Kayaku Co Ltd ６―フルオロクロモン―２―カルボン酸及びその製造法
TW199152B (https=) * 1990-11-01 1993-02-01 Takeda Pharm Industry Co Ltd
ES2212797T3 (es) * 1993-08-19 2004-08-01 Janssen Pharmaceutica N.V. Derivados de dihidrobenzopirano vasoconstrictores.
TW355683B (en) * 1994-02-17 1999-04-11 Janssen Pharmaceutica Nv Composition containing micronized nebivolol
ATE210657T1 (de) * 1994-10-14 2001-12-15 Merck Patent Gmbh Zns wirksames (r)-(-)-2-(5-(4-fluorophenyl)-3- pyridylmethylaminomethyl)chroman
JP3454832B2 (ja) * 1996-06-07 2003-10-06 バンダービルト ユニバーシティ 抗炎症剤として有用なジヒドロベンゾピランおよび関連化合物
JP2001526282A (ja) * 1997-12-19 2001-12-18 バイエル・コーポレーシヨン β−３アドレナリン受容体作用薬として有用なカルボキシル置換クロマン誘導体
US6541669B1 (en) 1998-06-08 2003-04-01 Theravance, Inc. β2-adrenergic receptor agonists
US6713651B1 (en) 1999-06-07 2004-03-30 Theravance, Inc. β2-adrenergic receptor agonists
US6683115B2 (en) 1999-06-02 2004-01-27 Theravance, Inc. β2-adrenergic receptor agonists
US6593497B1 (en) 1999-06-02 2003-07-15 Theravance, Inc. β2-adrenergic receptor agonists
UA73965C2 (en) 1999-12-08 2005-10-17 Theravance Inc b2 ADRENERGIC RECEPTOR ANTAGONISTS
UA73981C2 (en) 2000-03-10 2005-10-17 Merck Patent Gmbh (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit
WO2002087508A2 (en) 2001-05-02 2002-11-07 Nitromed, Inc. Nitrosated and nitrosylated nebivolol and its metabolites, compositions and methods of use
PT1408964E (pt) 2001-07-26 2007-05-31 Merck Patent Gmbh Utilização de 2-5-(4-fluorofenil) -3-piridilmetilaminometil-cromano e de seus sais fisiologicamente aceitáveis.
US6653323B2 (en) 2001-11-13 2003-11-25 Theravance, Inc. Aryl aniline β2 adrenergic receptor agonists
TWI249515B (en) 2001-11-13 2006-02-21 Theravance Inc Aryl aniline beta2 adrenergic receptor agonists
EP1741712B1 (en) 2004-07-30 2011-06-15 Torrent Pharmaceuticals Ltd amorphous form of nebivolol hydrochloride and its preparation
PL1776354T3 (pl) * 2004-08-11 2010-09-30 Hetero Drugs Ltd Nowy sposób wytwarzania związków pośrednich nebiwololu
CN100341866C (zh) * 2004-08-30 2007-10-10 中国科学院理化技术研究所 α，α’－[亚氨基二（亚甲基）]－双－（6－氟－3，4－二氢－2H－1－苯并吡喃－2－甲醇）甲烷磺酸盐的合成方法
JP2008528626A (ja) * 2005-01-31 2008-07-31 マイラン ラボラトリーズ インク． ヒドロキシル化されたネビボロールを含む薬学的組成物
KR101390563B1 (ko) * 2005-01-31 2014-04-30 밀란 인크. 글루쿠로니드화된 네비볼롤
WO2006084684A1 (de) * 2005-02-11 2006-08-17 Stada Arzneimittel Ag Pharmazeutische zusammensetzungen nebivolo und ein hydrophiles polymer
AT502220A1 (de) * 2005-07-19 2007-02-15 Pharmacon Forschung & Beratung Verfahren zur herstellung von nebivolol
RU2392277C2 (ru) * 2005-12-28 2010-06-20 Асино Фарма Аг Способ получения рацемического небиволола
EP1803716B1 (en) * 2005-12-28 2012-07-25 Acino Pharma AG A process for preparation of racemic nebivolol
US7560575B2 (en) 2005-12-28 2009-07-14 Acino Pharma Ag Process for preparation of racemic Nebivolol
WO2007083318A1 (en) 2006-01-18 2007-07-26 Hetero Drugs Limited Process for isolation of desired isomers of nebivolol intermediates
ITMI20061889A1 (it) * 2006-10-03 2008-04-04 Zambon Spa Processo di preparazione di nebivololo
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CN101463024B (zh) 2007-12-21 2011-06-08 上海现代制药股份有限公司 一种制备rrrs和sssr型的奈必洛尔中间体混合物的方法
ITMI20080547A1 (it) * 2008-03-31 2009-10-01 Zach System Spa Processo di preparazione di nebivololo
IT1392067B1 (it) * 2008-10-31 2012-02-09 Zach System Spa Processo di preparazione di nebivololo
IT1395354B1 (it) * 2009-07-23 2012-09-14 Zach System Spa Processo di preparazione di nebivololo
DE102010005953A1 (de) 2010-01-27 2011-07-28 Corden PharmaChem GmbH, 68305 Verfahren zur Herstellung von Nebivolol
IT1397962B1 (it) 2010-02-11 2013-02-04 Menarini Int Operations Lu Sa Processo per la preparazione del nebivololo.
IT1402974B1 (it) 2010-11-30 2013-09-27 Menarini Int Operations Lu Sa Processo per la preparazione del nebivololo.
ITRM20110418A1 (it) 2011-08-02 2013-02-03 Menarini Int Operations Lu Sa Processo per la preparazione di epossidi quali intermedi per la sintesi del nebivololo.
ES2700973T3 (es) 2014-02-14 2019-02-20 Corden Pharma Int Gmbh Proceso sin base para la preparación de compuestos intermedios de cetona que se pueden usar para fabricar nebivolol
EP2907810A1 (en) 2014-02-14 2015-08-19 Corden Pharma International GmbH A new method for producing nebivolol hydrochloride of high purity
DE102014107132A1 (de) 2014-05-20 2015-11-26 Corden Pharma International Gmbh Verfahren zur Herstellung von Epoxiden die in der Herstellung von Nebivolol und dessen Derivaten einsetzbar sind
EP3299364B1 (en) 2015-05-19 2021-10-20 Zhejiang Ausun Pharmaceutical Co., Ltd. Nebivolol synthesis method and intermediate compound thereof
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GB8418472D0 (en) * 1984-07-19 1984-08-22 Beecham Group Plc Compounds

Also Published As

Publication number Publication date
HU202219B (en) 1991-02-28
FI844777A0 (fi) 1984-12-04
ZA849445B (en) 1986-07-30
NO169839B (no) 1992-05-04
EP0145067A2 (en) 1985-06-19
RO91184A (ro) 1987-07-30
HK52791A (en) 1991-07-19
JPS60132977A (ja) 1985-07-16
PH22432A (en) 1988-09-12
DK165112B (da) 1992-10-12
EP0145067B1 (en) 1989-01-25
ES538256A0 (es) 1986-01-01
DK165321B (da) 1992-11-09
DK165112C (da) 1993-03-01
CY1609A (en) 1992-04-03
GR81098B (en) 1984-12-17
KR850004485A (ko) 1985-07-15
DK165321C (da) 1993-03-29
MA20292A1 (fr) 1985-07-01
CS250242B2 (en) 1987-04-16
RO91184B (ro) 1987-07-31
HUT37418A (en) 1985-12-28
SG47091G (en) 1991-07-26
IL73706A0 (en) 1985-03-31
SU1428199A3 (ru) 1988-09-30
DD235453A5 (de) 1986-05-07
NO169839C (no) 1992-08-12
JPH0250114B2 (https=) 1990-11-01
IE843103L (en) 1985-06-05
ES8603870A1 (es) 1986-01-01
FI844777L (fi) 1985-06-06
FI82460B (fi) 1990-11-30
IL73706A (en) 1988-07-31
FI82460C (fi) 1991-03-11
AU573658B2 (en) 1988-06-16
PT79609A (en) 1985-01-01
DK577084A (da) 1985-06-06
CA1337429C (en) 1995-10-24
DK11892A (da) 1992-01-31
EP0145067A3 (en) 1986-03-26
DE3476388D1 (en) 1989-03-02
NZ210388A (en) 1987-07-31
PT79609B (en) 1986-12-12
PL250524A1 (en) 1986-02-25
PL146342B1 (en) 1989-01-31
DK577084D0 (da) 1984-12-04
BG43866A3 (en) 1988-08-15
IE57831B1 (en) 1993-04-21
ATE40361T1 (de) 1989-02-15
AU3632684A (en) 1985-06-13
AR241414A1 (es) 1992-07-31
DK11892D0 (da) 1992-01-31
NO844845L (no) 1985-06-06
DZ712A1 (fr) 2004-09-13
NO2004007I2 (no) 2005-05-09
NO2004007I1 (no) 2004-12-20
ZW19784A1 (en) 1986-07-02

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