KR860003335A - A-21978c 유도체의 제조방법 - Google Patents
A-21978c 유도체의 제조방법 Download PDFInfo
- Publication number
- KR860003335A KR860003335A KR1019850007397A KR850007397A KR860003335A KR 860003335 A KR860003335 A KR 860003335A KR 1019850007397 A KR1019850007397 A KR 1019850007397A KR 850007397 A KR850007397 A KR 850007397A KR 860003335 A KR860003335 A KR 860003335A
- Authority
- KR
- South Korea
- Prior art keywords
- acid
- producing
- salt
- ester
- alkanoic acid
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Treating Waste Gases (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrane Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (11)
- A-21978C-생성 배양체에 상응하는 C2내지 C14알카노산, 그의 에스테르 또는 염을 공급함을 특징으로하여, R이 C2내지 C14-알카노일 그룹인 일반식(Ⅰ)의 A-21978C 유도체를 생산하는 방법.
- 제1항에 있어서, C2내지 C14-알카노산을 사용하는 방법.
- 제1항에 있어서, C2내지 C14-알카노산의 C1내지 C4-알킬 에스테르를 사용하는 방법.
- 제1항에 있어서, C2내지 C14-알카노산의 염을 사용하는 방법.
- 제1 내지 제4항중 어느 한 항에 있어서, 카프르산, 그의 에스테르 또는 염을 사용하는 방법.
- 제1항에 있어서, 사용하는 C2내지 C14알카노산이 카프릴산, 노나노산, 운데카노산, 라우르산 또는 그의 에스테르 또는 염인 방법.
- 제1 내지 4항중 어느 한 항에 있어서, A-21978C 생성 배양체를 스트렙토마이세스 로세오스포러스 NRRL 11379(한국기탁기관 : 한국종균협회, 기탁번호 : KFCC-10051, 기탁일 : 1983.8.17), 또는 그의 돌연변이주, 변종 또는 유전자 재조합체로 구성하는 방법.
- 제7항에 있어서, 배양체가 스트렙토마이세스 로세오스포러스 NRRL-(한국기탁기관 : 한국종균협회, 기탁번호 : KFCC-10175, 기탁일 : 1988.9.24), 또는 그의 A-21978C 생성 돌연변이주, 변종 또는 유전자 재조합체로 이루어진 방법.
- 스트렙토마이세스 로세오스포러스 NRRL-, 또는 그의 A-21978C-생성 돌연변이주, 변종 또는 유전자 재조합체를 수중 호기 발효 조건하에, 탄소, 질소 및 무기염의 동화원을 함유하는 배양 배지에서 A-21978C 항생 물질이 생성될 때까지, 경우에 따라 생성된 A-21978C 복합체를 분리하고, 경우에 따로 복합체로부터 각각의 A-21978C 인자를 분리하여 배양함을 특징으로하여 항생물질 A-21978C 복합체 또는 인자를 생산하는 방법.
- 제9항에 있어서, 배양 배지로부터 A-21978C 복합체를 분리하는 추가 단계를 포함하는 항생물질 A-21978C 복합체의 생산방법.
- 제9 또는 제10항에 있어서, A-21978C 항생물질 복합체로부터 각각의 인자를 분리하는 추가단계를 포함하는 각각의 항생물질 A-21978C 인자 C0,C1,C2,C3,C4, 또는 C5의 생산방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65897984A | 1984-10-09 | 1984-10-09 | |
US658,979 | 1984-10-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR860003335A true KR860003335A (ko) | 1986-05-23 |
KR890000800B1 KR890000800B1 (ko) | 1989-04-07 |
Family
ID=24643546
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019850007397A KR890000800B1 (ko) | 1984-10-09 | 1985-10-08 | A-21978c 유도체의 제조방법 |
Country Status (27)
Country | Link |
---|---|
EP (1) | EP0178152B1 (ko) |
JP (1) | JPH0787796B2 (ko) |
KR (1) | KR890000800B1 (ko) |
CN (2) | CN1051200A (ko) |
AT (1) | ATE67788T1 (ko) |
AU (2) | AU4837785A (ko) |
BG (1) | BG47040A3 (ko) |
CS (2) | CS276983B6 (ko) |
CY (1) | CY1633A (ko) |
DD (2) | DD238068A5 (ko) |
DE (1) | DE3584218D1 (ko) |
DK (2) | DK165416C (ko) |
EG (1) | EG17619A (ko) |
ES (2) | ES8700862A1 (ko) |
FI (1) | FI82075C (ko) |
GR (1) | GR852432B (ko) |
HK (1) | HK24292A (ko) |
HU (1) | HU196845B (ko) |
IE (1) | IE58655B1 (ko) |
IL (1) | IL76608A (ko) |
NZ (1) | NZ213731A (ko) |
PH (1) | PH21217A (ko) |
PL (1) | PL152359B1 (ko) |
PT (1) | PT81265B (ko) |
SG (1) | SG3292G (ko) |
SU (1) | SU1452484A3 (ko) |
ZA (1) | ZA857759B (ko) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0294990A3 (en) * | 1987-06-10 | 1990-05-09 | Eli Lilly And Company | Chromatographic purification process |
US4930494A (en) * | 1988-03-09 | 1990-06-05 | Olympus Optical Co., Ltd. | Apparatus for bending an insertion section of an endoscope using a shape memory alloy |
US4977083A (en) * | 1988-04-11 | 1990-12-11 | Eli Lilly And Company | Processes for preparing A54145 compounds |
DE3832362A1 (de) * | 1988-09-23 | 1990-03-29 | Sandoz Ag | Neue cyclopeptolide, verfahren zu ihrer herstellung und ihre verwendung |
CA2394350A1 (en) * | 1999-12-15 | 2001-06-21 | Cubist Pharmaceuticals, Inc. | Lipopeptides as antibacterial agents |
EP2298790A1 (en) | 1999-12-15 | 2011-03-23 | Cubist Pharmaceuticals, Inc. | Daptomycin analogs as antibacterial agents |
US6696412B1 (en) * | 2000-01-20 | 2004-02-24 | Cubist Pharmaceuticals, Inc. | High purity lipopeptides, Lipopeptide micelles and processes for preparing same |
US20060014674A1 (en) | 2000-12-18 | 2006-01-19 | Dennis Keith | Methods for preparing purified lipopeptides |
MX2011006803A (es) | 2008-12-22 | 2011-09-06 | Cubist Pharm Inc | Agentes antibacterianos novedosos para el tratamiento de infecciones gram positivas. |
RU2607526C2 (ru) | 2009-11-23 | 2017-01-10 | Кьюбист Фармасьютикалз ЭлЭлСи | Липопептидные композиции и родственные способы |
CN103857440B (zh) | 2011-06-22 | 2018-09-25 | 维奥姆生物科学有限公司 | 基于缀合物的抗真菌和抗细菌前药 |
IT201600127655A1 (it) | 2016-12-16 | 2018-06-16 | Gnosis Spa | Processo per la purificazione di antibiotici lipopolipeptidici |
CN107964557B (zh) * | 2018-01-17 | 2020-11-20 | 自然资源部第三海洋研究所 | 一种提高芽孢杆菌抗菌脂肽产量的发酵方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4208403A (en) * | 1978-10-16 | 1980-06-17 | Eli Lilly And Company | A-21978 Antibiotics and process for their production |
IL68700A0 (en) * | 1982-05-21 | 1983-09-30 | Lilly Co Eli | Improvements relating to a-21978c cyclic peptide derivatives and their production |
-
1985
- 1985-10-08 SU SU853964395A patent/SU1452484A3/ru active
- 1985-10-08 CS CS868192A patent/CS276983B6/cs not_active IP Right Cessation
- 1985-10-08 DE DE8585307185T patent/DE3584218D1/de not_active Expired - Lifetime
- 1985-10-08 CN CN90109304A patent/CN1051200A/zh active Pending
- 1985-10-08 FI FI853910A patent/FI82075C/fi not_active IP Right Cessation
- 1985-10-08 PH PH32894A patent/PH21217A/en unknown
- 1985-10-08 EG EG634/85A patent/EG17619A/xx active
- 1985-10-08 AT AT85307185T patent/ATE67788T1/de not_active IP Right Cessation
- 1985-10-08 CN CN85107552A patent/CN1013120B/zh not_active Expired
- 1985-10-08 ES ES547689A patent/ES8700862A1/es not_active Expired
- 1985-10-08 DD DD85281515A patent/DD238068A5/de not_active IP Right Cessation
- 1985-10-08 AU AU48377/85A patent/AU4837785A/en not_active Abandoned
- 1985-10-08 PL PL1985255683A patent/PL152359B1/pl unknown
- 1985-10-08 JP JP60225925A patent/JPH0787796B2/ja not_active Expired - Lifetime
- 1985-10-08 CS CS857198A patent/CS276978B6/cs not_active IP Right Cessation
- 1985-10-08 HU HU853912A patent/HU196845B/hu unknown
- 1985-10-08 DK DK457585A patent/DK165416C/da not_active IP Right Cessation
- 1985-10-08 BG BG071957A patent/BG47040A3/xx unknown
- 1985-10-08 PT PT81265A patent/PT81265B/pt unknown
- 1985-10-08 GR GR852432A patent/GR852432B/el unknown
- 1985-10-08 KR KR1019850007397A patent/KR890000800B1/ko not_active IP Right Cessation
- 1985-10-08 IL IL76608A patent/IL76608A/xx not_active IP Right Cessation
- 1985-10-08 ZA ZA857759A patent/ZA857759B/xx unknown
- 1985-10-08 EP EP85307185A patent/EP0178152B1/en not_active Expired - Lifetime
- 1985-10-08 IE IE246685A patent/IE58655B1/en not_active IP Right Cessation
- 1985-10-08 NZ NZ213731A patent/NZ213731A/en unknown
-
1986
- 1986-03-25 DD DD86288284A patent/DD247023A5/de unknown
- 1986-04-01 ES ES553603A patent/ES8800362A1/es not_active Expired
-
1990
- 1990-04-20 AU AU53752/90A patent/AU634766B2/en not_active Expired
-
1991
- 1991-08-21 DK DK148791A patent/DK165757C/da not_active IP Right Cessation
-
1992
- 1992-01-11 SG SG32/92A patent/SG3292G/en unknown
- 1992-04-02 HK HK242/92A patent/HK24292A/xx not_active IP Right Cessation
- 1992-11-06 CY CY1633A patent/CY1633A/xx unknown
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