KR860003335A - A-21978c 유도체의 제조방법 - Google Patents

A-21978c 유도체의 제조방법 Download PDF

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KR860003335A
KR860003335A KR1019850007397A KR850007397A KR860003335A KR 860003335 A KR860003335 A KR 860003335A KR 1019850007397 A KR1019850007397 A KR 1019850007397A KR 850007397 A KR850007397 A KR 850007397A KR 860003335 A KR860003335 A KR 860003335A
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acid
producing
salt
ester
alkanoic acid
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KR1019850007397A
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KR890000800B1 (ko
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밀톤 후버 플로이드 (외 7)
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메리 앤 터커
일라이 릴리 앤드 캄파니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Treating Waste Gases (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)

Abstract

내용 없음

Description

A-21978C 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. A-21978C-생성 배양체에 상응하는 C2내지 C14알카노산, 그의 에스테르 또는 염을 공급함을 특징으로하여, R이 C2내지 C14-알카노일 그룹인 일반식(Ⅰ)의 A-21978C 유도체를 생산하는 방법.
  2. 제1항에 있어서, C2내지 C14-알카노산을 사용하는 방법.
  3. 제1항에 있어서, C2내지 C14-알카노산의 C1내지 C4-알킬 에스테르를 사용하는 방법.
  4. 제1항에 있어서, C2내지 C14-알카노산의 염을 사용하는 방법.
  5. 제1 내지 제4항중 어느 한 항에 있어서, 카프르산, 그의 에스테르 또는 염을 사용하는 방법.
  6. 제1항에 있어서, 사용하는 C2내지 C14알카노산이 카프릴산, 노나노산, 운데카노산, 라우르산 또는 그의 에스테르 또는 염인 방법.
  7. 제1 내지 4항중 어느 한 항에 있어서, A-21978C 생성 배양체를 스트렙토마이세스 로세오스포러스 NRRL 11379(한국기탁기관 : 한국종균협회, 기탁번호 : KFCC-10051, 기탁일 : 1983.8.17), 또는 그의 돌연변이주, 변종 또는 유전자 재조합체로 구성하는 방법.
  8. 제7항에 있어서, 배양체가 스트렙토마이세스 로세오스포러스 NRRL-(한국기탁기관 : 한국종균협회, 기탁번호 : KFCC-10175, 기탁일 : 1988.9.24), 또는 그의 A-21978C 생성 돌연변이주, 변종 또는 유전자 재조합체로 이루어진 방법.
  9. 스트렙토마이세스 로세오스포러스 NRRL-, 또는 그의 A-21978C-생성 돌연변이주, 변종 또는 유전자 재조합체를 수중 호기 발효 조건하에, 탄소, 질소 및 무기염의 동화원을 함유하는 배양 배지에서 A-21978C 항생 물질이 생성될 때까지, 경우에 따라 생성된 A-21978C 복합체를 분리하고, 경우에 따로 복합체로부터 각각의 A-21978C 인자를 분리하여 배양함을 특징으로하여 항생물질 A-21978C 복합체 또는 인자를 생산하는 방법.
  10. 제9항에 있어서, 배양 배지로부터 A-21978C 복합체를 분리하는 추가 단계를 포함하는 항생물질 A-21978C 복합체의 생산방법.
  11. 제9 또는 제10항에 있어서, A-21978C 항생물질 복합체로부터 각각의 인자를 분리하는 추가단계를 포함하는 각각의 항생물질 A-21978C 인자 C0,C1,C2,C3,C4, 또는 C5의 생산방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850007397A 1984-10-09 1985-10-08 A-21978c 유도체의 제조방법 KR890000800B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65897984A 1984-10-09 1984-10-09
US658,979 1985-10-09

Publications (2)

Publication Number Publication Date
KR860003335A true KR860003335A (ko) 1986-05-23
KR890000800B1 KR890000800B1 (ko) 1989-04-07

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Country Link
EP (1) EP0178152B1 (ko)
JP (1) JPH0787796B2 (ko)
KR (1) KR890000800B1 (ko)
CN (2) CN1013120B (ko)
AT (1) ATE67788T1 (ko)
AU (2) AU4837785A (ko)
BG (1) BG47040A3 (ko)
CS (2) CS276983B6 (ko)
CY (1) CY1633A (ko)
DD (2) DD238068A5 (ko)
DE (1) DE3584218D1 (ko)
DK (2) DK165416C (ko)
EG (1) EG17619A (ko)
ES (2) ES8700862A1 (ko)
FI (1) FI82075C (ko)
GR (1) GR852432B (ko)
HK (1) HK24292A (ko)
HU (1) HU196845B (ko)
IE (1) IE58655B1 (ko)
IL (1) IL76608A (ko)
NZ (1) NZ213731A (ko)
PH (1) PH21217A (ko)
PL (1) PL152359B1 (ko)
PT (1) PT81265B (ko)
SG (1) SG3292G (ko)
SU (1) SU1452484A3 (ko)
ZA (1) ZA857759B (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0294990A3 (en) * 1987-06-10 1990-05-09 Eli Lilly And Company Chromatographic purification process
US4930494A (en) * 1988-03-09 1990-06-05 Olympus Optical Co., Ltd. Apparatus for bending an insertion section of an endoscope using a shape memory alloy
US4977083A (en) * 1988-04-11 1990-12-11 Eli Lilly And Company Processes for preparing A54145 compounds
DE3832362A1 (de) * 1988-09-23 1990-03-29 Sandoz Ag Neue cyclopeptolide, verfahren zu ihrer herstellung und ihre verwendung
MXPA02006030A (es) * 1999-12-15 2004-08-23 Cubist Pharm Inc Lipopeptidos como agentes antibacterianos.
AU784755B2 (en) 1999-12-15 2006-06-08 Merck Sharp & Dohme Corp. Daptomycin Analogs as antibacterial agents
US6696412B1 (en) 2000-01-20 2004-02-24 Cubist Pharmaceuticals, Inc. High purity lipopeptides, Lipopeptide micelles and processes for preparing same
US20060014674A1 (en) 2000-12-18 2006-01-19 Dennis Keith Methods for preparing purified lipopeptides
RU2512396C2 (ru) 2008-12-22 2014-04-10 Кьюбист Фармасьютикалз, Инк. Новые противобактериальные средства для лечения грамположительных инфекций
PE20151717A1 (es) 2009-11-23 2015-11-19 Cubist Pharm Inc Compuestos lipopeptidos y metodos relacionados
MX2013015434A (es) 2011-06-22 2014-10-14 Vyome Biosciences Pvt Ltd Profarmacos antifungicos y antibacterianos a base de conjugado.
IT201600127655A1 (it) 2016-12-16 2018-06-16 Gnosis Spa Processo per la purificazione di antibiotici lipopolipeptidici
CN107964557B (zh) * 2018-01-17 2020-11-20 自然资源部第三海洋研究所 一种提高芽孢杆菌抗菌脂肽产量的发酵方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4208403A (en) * 1978-10-16 1980-06-17 Eli Lilly And Company A-21978 Antibiotics and process for their production
IL68700A0 (en) * 1982-05-21 1983-09-30 Lilly Co Eli Improvements relating to a-21978c cyclic peptide derivatives and their production

Also Published As

Publication number Publication date
CS819286A3 (en) 1992-03-18
PT81265A (en) 1985-11-01
ES8700862A1 (es) 1986-11-16
CN85107552A (zh) 1987-05-20
CS719885A3 (en) 1992-03-18
FI853910A0 (fi) 1985-10-08
DK457585A (da) 1986-04-10
DK165757B (da) 1993-01-11
PH21217A (en) 1987-08-21
GR852432B (ko) 1986-02-10
IL76608A0 (en) 1986-02-28
AU5375290A (en) 1990-11-01
SG3292G (en) 1992-03-20
EP0178152B1 (en) 1991-09-25
PL152359B1 (en) 1990-12-31
CS276978B6 (en) 1992-11-18
JPS6192588A (ja) 1986-05-10
AU634766B2 (en) 1993-03-04
EP0178152A2 (en) 1986-04-16
BG47040A3 (en) 1990-04-16
ES8800362A1 (es) 1987-11-01
HUT39782A (en) 1986-10-29
PT81265B (pt) 1988-02-17
DK165416C (da) 1993-04-05
FI82075B (fi) 1990-09-28
ES553603A0 (es) 1987-11-01
FI82075C (fi) 1991-01-10
FI853910L (fi) 1986-04-10
ES547689A0 (es) 1986-11-16
DE3584218D1 (de) 1991-10-31
DK165416B (da) 1992-11-23
HU196845B (en) 1989-01-30
AU4837785A (en) 1986-04-17
EG17619A (en) 1991-03-30
HK24292A (en) 1992-04-10
CN1051200A (zh) 1991-05-08
IE58655B1 (en) 1993-11-03
IE852466L (en) 1986-04-09
JPH0787796B2 (ja) 1995-09-27
DK457585D0 (da) 1985-10-08
DK148791D0 (da) 1991-08-21
KR890000800B1 (ko) 1989-04-07
ATE67788T1 (de) 1991-10-15
IL76608A (en) 1991-03-10
NZ213731A (en) 1988-04-29
EP0178152A3 (en) 1988-11-02
DD247023A5 (de) 1987-06-24
DD238068A5 (de) 1986-08-06
CS276983B6 (en) 1992-11-18
SU1452484A3 (ru) 1989-01-15
CY1633A (en) 1992-11-06
DK165757C (da) 1993-06-07
PL255683A1 (en) 1986-07-29
ZA857759B (en) 1987-05-27
CN1013120B (zh) 1991-07-10
DK148791A (da) 1991-08-21

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