KR930006041A - 화합물 ll-e19020 알파₁, 그의 생산방법, 및 그를 포함하는 제약학적 항생물질 조성물 - Google Patents
화합물 ll-e19020 알파₁, 그의 생산방법, 및 그를 포함하는 제약학적 항생물질 조성물 Download PDFInfo
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- KR930006041A KR930006041A KR1019920016400A KR920016400A KR930006041A KR 930006041 A KR930006041 A KR 930006041A KR 1019920016400 A KR1019920016400 A KR 1019920016400A KR 920016400 A KR920016400 A KR 920016400A KR 930006041 A KR930006041 A KR 930006041A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
- C07H15/232—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with at least three saccharide radicals in the molecule, e.g. lividomycin, neomycin, paromomycin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
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- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Biotechnology (AREA)
- Genetics & Genomics (AREA)
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- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
본 발명은 미생물 스트랩토마이세스 리디쿠스 탄자니우스 NRRL 18036로부터 유래된, LL-E19020 알파로 표시되는 항생물질을 제공한다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제I도는 LL-E19020알파1의 자외선 흡수 스펙트럼을 나타낸다.
제II도는 LL-E19020알파1의 적외선 흡수 스펙트럼을 나타낸다.
제III도는 LL-E19020알파1의 양성자 핵 자기 공명 스펙트럼을 나타낸다.
제IV도는 LL-E19020알파1의 탄소-13핵 자기 공명 스펙트럼을 나타낸다.
Claims (5)
- 하기 (a)-(h)로 구성되는 화합물 LL-E19020 알파1: (a)구조(b) 분자량 1225(FABMS=[M+Na]+에 상응하는 M/Z 1248) ; (c) 분자식: C65H95NO21(d) 첨부된 도면의 제1도에 제시된 바와 같은 특성적 자외선 흡수 스팩트럼 ; (e) 첨부된 도면의 제Ⅲ도에 제시된 바와 같은 특성적인 적외선 흡수 스팩트럼 ; (f) 첨부된 도면의 제Ⅲ도의 제시된 바와 같은 특성적 양성자 핵자기 공명 스팩트럼 ; (g) 첨부된 도면의 제Ⅳ도에 제시된 바와 같은 특성적 탄소-13핵자기 공명 스팩트럼 ; (h) 수성 아세트 산내 디옥산의 구배를 사용하는 특성적인 HPLC체류시간 23.1분.
- 탄소, 질소 및 무기염 동화원을 함유하는 액체 배지에서, 실질적인 항생물질 활성이 상기 배지에 부여될때까지, 생물 스트렙토마이세스 리디쿠스아종 탄자 니우스 NRRL 18036 또는 그의 돌연변이체를 호기적으로 발효시킨 다음 항생물LL-E19020 감마를 그로부터 회수함으로 구성되는, 제1항에서 정의한 바의 항생물질LL-E19020 알파1의 생산방법.
- 탄소, 질소 및 무기염 동화원을 함유하는 액체 배지를 호기적으로 발호시키되,배지는 생물 스트렙토마이세스 리디쿠스아종 탄자 니우스 NRRL 18036 또는 이의 돌연변이체를 생존성 배양물로 접종되어 있고, 상기 발효배양물을 25-32℃ 온도에서 약80-200시간 동안 유지하고, 담금액을 수확하고 항생물질을 추출함으로 구성되는, 제1항에서 정의한 바의 항생물질 LL-E19020 알파1의 생산방법.
- 제1항에서 정의한 바의 항생물질 LL-E19020 알파1의 항균적 유효량을 온혈 동물에 투여함으로 구성되는, 온혈 동물에 있어서 세균 감염 치료 방법.
- 제1항에서 정의한 바의 LL-E19020 알파1의 항생물질양을 제약학적으로 허용가능한 운반체와 함께 포함하는, 제약학적 항생물질 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7/756646 | 1991-09-09 | ||
US07/756,646 US5814615A (en) | 1991-09-09 | 1991-09-09 | Antibiotic LL-E19020 Alpha1 |
US07/756646 | 1991-09-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR930006041A true KR930006041A (ko) | 1993-04-20 |
KR100272197B1 KR100272197B1 (ko) | 2000-11-15 |
Family
ID=25044427
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019920016400A KR100272197B1 (ko) | 1991-09-09 | 1992-09-08 | 화합물 ll-e19020 알파1 및 이의 생산방법 |
Country Status (16)
Country | Link |
---|---|
US (1) | US5814615A (ko) |
EP (1) | EP0531638B1 (ko) |
JP (1) | JPH05202089A (ko) |
KR (1) | KR100272197B1 (ko) |
AT (1) | ATE161847T1 (ko) |
AU (1) | AU652280B2 (ko) |
CA (1) | CA2077597A1 (ko) |
DE (1) | DE69223883T2 (ko) |
DK (1) | DK0531638T3 (ko) |
ES (1) | ES2112875T3 (ko) |
GR (1) | GR3026156T3 (ko) |
IE (1) | IE922644A1 (ko) |
IL (1) | IL103087A (ko) |
NZ (1) | NZ244198A (ko) |
TW (1) | TW222002B (ko) |
ZA (1) | ZA926831B (ko) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7799751B2 (en) * | 2000-12-14 | 2010-09-21 | The Clorox Company | Cleaning composition |
US20030100465A1 (en) * | 2000-12-14 | 2003-05-29 | The Clorox Company, A Delaware Corporation | Cleaning composition |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4968493A (en) * | 1986-06-30 | 1990-11-06 | American Cyanamid Company | Method for controlling chronic respiratory disease, fowl cholera and necrotic enteritis in avian species |
US4704276A (en) * | 1986-06-30 | 1987-11-03 | American Cyanamid Company | Compositions and methods for increasing the growth rate of meat producing animals, improving the efficiency of feed utilization thereby and enhancing lactation in lactating ruminants |
DE3778225D1 (de) * | 1986-06-30 | 1992-05-21 | American Cyanamid Co | Antibiotikum ll-e19020 alpha und beta. |
US4705688A (en) * | 1986-06-30 | 1987-11-10 | American Cyanamid Company | Antibiotic LL-E19020 α and β |
FR2657873B1 (fr) * | 1990-02-08 | 1992-04-17 | Rhone Poulenc Sante | Nouvelle elfamycine, son procede de preparation et son utilisation. |
-
1991
- 1991-09-09 US US07/756,646 patent/US5814615A/en not_active Expired - Fee Related
-
1992
- 1992-06-24 DE DE69223883T patent/DE69223883T2/de not_active Expired - Fee Related
- 1992-06-24 DK DK92110626.6T patent/DK0531638T3/da active
- 1992-06-24 EP EP92110626A patent/EP0531638B1/en not_active Expired - Lifetime
- 1992-06-24 ES ES92110626T patent/ES2112875T3/es not_active Expired - Lifetime
- 1992-06-24 AT AT92110626T patent/ATE161847T1/de not_active IP Right Cessation
- 1992-06-30 TW TW081105152A patent/TW222002B/zh active
- 1992-09-03 NZ NZ244198A patent/NZ244198A/xx unknown
- 1992-09-04 CA CA002077597A patent/CA2077597A1/en not_active Abandoned
- 1992-09-07 IL IL103087A patent/IL103087A/xx not_active IP Right Cessation
- 1992-09-08 IE IE264492A patent/IE922644A1/en unknown
- 1992-09-08 ZA ZA926831A patent/ZA926831B/xx unknown
- 1992-09-08 JP JP4264106A patent/JPH05202089A/ja active Pending
- 1992-09-08 AU AU22834/92A patent/AU652280B2/en not_active Ceased
- 1992-09-08 KR KR1019920016400A patent/KR100272197B1/ko not_active IP Right Cessation
-
1998
- 1998-02-17 GR GR980400331T patent/GR3026156T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
US5814615A (en) | 1998-09-29 |
IE922644A1 (en) | 1993-03-10 |
EP0531638A1 (en) | 1993-03-17 |
JPH05202089A (ja) | 1993-08-10 |
AU652280B2 (en) | 1994-08-18 |
IL103087A0 (en) | 1993-02-21 |
ATE161847T1 (de) | 1998-01-15 |
DK0531638T3 (da) | 1998-05-04 |
CA2077597A1 (en) | 1993-03-10 |
ES2112875T3 (es) | 1998-04-16 |
AU2283492A (en) | 1993-03-11 |
DE69223883D1 (de) | 1998-02-12 |
NZ244198A (en) | 1993-11-25 |
TW222002B (ko) | 1994-04-01 |
IL103087A (en) | 1997-04-15 |
DE69223883T2 (de) | 1998-06-10 |
GR3026156T3 (en) | 1998-05-29 |
KR100272197B1 (ko) | 2000-11-15 |
EP0531638B1 (en) | 1998-01-07 |
ZA926831B (en) | 1993-03-15 |
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