GB2296716A - New antifungal antibiotic,and new bacillus SP microorganism which can produce the above antibiotic and its manufacturing method - Google Patents

New antifungal antibiotic,and new bacillus SP microorganism which can produce the above antibiotic and its manufacturing method

Info

Publication number
GB2296716A
GB2296716A GB9605096A GB9605096A GB2296716A GB 2296716 A GB2296716 A GB 2296716A GB 9605096 A GB9605096 A GB 9605096A GB 9605096 A GB9605096 A GB 9605096A GB 2296716 A GB2296716 A GB 2296716A
Authority
GB
United Kingdom
Prior art keywords
antibiotic
new
trihexocin
dissolved
bacillus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB9605096A
Other versions
GB9605096D0 (en
Inventor
Won Cheol Shin
Jae-Hong Yoo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of GB9605096D0 publication Critical patent/GB9605096D0/en
Publication of GB2296716A publication Critical patent/GB2296716A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/162—Heterorings having oxygen atoms as the only ring heteroatoms, e.g. Lasalocid
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01S—DEVICES USING THE PROCESS OF LIGHT AMPLIFICATION BY STIMULATED EMISSION OF RADIATION [LASER] TO AMPLIFY OR GENERATE LIGHT; DEVICES USING STIMULATED EMISSION OF ELECTROMAGNETIC RADIATION IN WAVE RANGES OTHER THAN OPTICAL
    • H01S5/00—Semiconductor lasers
    • H01S5/30—Structure or shape of the active region; Materials used for the active region
    • H01S5/34—Structure or shape of the active region; Materials used for the active region comprising quantum well or superlattice structures, e.g. single quantum well [SQW] lasers, multiple quantum well [MQW] lasers or graded index separate confinement heterostructure [GRINSCH] lasers

Abstract

The present invention relates to new Bacillus sp. SY-414 that produced antifungal antibiotic, trihexocin, which was produced by the above Bacillus sp. SY-414 and its manufacturing method. New antifungal antibiotic represented by general formula (1), wherein each R denotes -H, -OH, -NH2, alkyl group of C1-C6, allyl group of C5-C20, or alkylene group of C2-C6, and subscript 1, m, or n is an integer less than 3. The manufacturing method for the above antifungal antibiotic is as follows: new Bacillus sp. microorganism showing a high activity against plant fungi, especially Pyricularia oryzae and Pellicularia filamentosa, was isolated from soil and identified; the culture broth was centrifuged and the supernatant was extracted with ethyl acetate, and the organic layer was collected. The active fraction was evaporated and dissolved in methanol, and then silica gel column chromatography was carried out; the active fraction was evaporated and dissolved in dichloromethane: methaol (1:5) mixture and Sephadex LH-20 column chromatography was carried out. The active fraction was evaporated and dissolved in water and lyophilized. The powdery antibiotic obtained in the above was dissolved in methanol and stored at 4 DEG C, and the crystalline antibiotic, trihexocin, was prepared; trihexocin had an antifungal activity against the plants infected with fungi at the concentration of 50-100 mu g/ml. Trihexocin consisted of three fructose units and showed a non-toxicity. <IMAGE>
GB9605096A 1993-09-17 1994-09-15 New antifungal antibiotic,and new bacillus SP microorganism which can produce the above antibiotic and its manufacturing method Withdrawn GB2296716A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR930018746 1993-09-17
KR1019940019211A KR970010603B1 (en) 1993-09-17 1994-08-03 New antifungal antibiotic and new bacillus sp. microorganism which can produce the above antibiotic and its preparing method
PCT/KR1994/000123 WO1995007997A1 (en) 1993-09-17 1994-09-15 New antifungal antibiotic, and new bacillus sp. microorganism which can produce the above antibiotic and its manufacturing method

Publications (2)

Publication Number Publication Date
GB9605096D0 GB9605096D0 (en) 1996-05-08
GB2296716A true GB2296716A (en) 1996-07-10

Family

ID=26629896

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9605096A Withdrawn GB2296716A (en) 1993-09-17 1994-09-15 New antifungal antibiotic,and new bacillus SP microorganism which can produce the above antibiotic and its manufacturing method

Country Status (7)

Country Link
JP (1) JPH09510862A (en)
KR (1) KR970010603B1 (en)
CN (1) CN1135238A (en)
AU (1) AU7709094A (en)
CA (1) CA2171947A1 (en)
GB (1) GB2296716A (en)
WO (1) WO1995007997A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1055310C (en) * 1995-06-22 2000-08-09 华中农业大学 Supper toxic strain YBT-1520 of thuricin brood cell and its zymosis process and products
KR100385152B1 (en) * 2001-03-14 2003-05-23 씨제이 주식회사 Process for the purification of capreomycin
KR100514430B1 (en) * 2002-12-12 2005-09-14 대한민국 Isolation method of secondary product having weeding efficacy against white clover released from culture floid of sclerotinia trifoliorum bwc98-105
WO2007016680A2 (en) * 2005-08-02 2007-02-08 University Of Missouri Board Of Curators Phage-display plant defense peptides directed against phakopsora pachyrhizi and uromyces appendiculatus
EP2098536A1 (en) 2008-03-05 2009-09-09 4-Antibody AG Isolation and identification of antigen- or ligand-specific binding proteins
CN110954625A (en) * 2019-12-21 2020-04-03 潍坊科技学院 Method for detecting antibiotic residues in soil
JP2022094481A (en) * 2020-12-15 2022-06-27 大阪瓦斯株式会社 Method for producing hydroxyalkanoic acid crystal and crystalline polymorph of hydroxyalkanoic acid

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0293787A1 (en) * 1987-05-30 1988-12-07 Kaken Pharmaceutical Co., Ltd. Antibiotic 6270B, processes for its production, and its use as an anticoccidiosis agent and a feed additive
DD270542A1 (en) * 1988-04-12 1989-08-02 Adw Ddr PROCESS FOR THE PREPARATION OF 26-DESOXYLAID LOMYCIN
EP0328303A2 (en) * 1988-02-08 1989-08-16 Pfizer Inc. Acidic polycyclic ether antibiotic having anticoccidial and growth promotant activity
EP0537897A1 (en) * 1991-09-16 1993-04-21 Eli Lilly And Company Method of producing antibiotic A82810 from Actinomadura fibrosa sp. nov. NRRL 18348 and Actinomadura sp. NRRL 18880

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0293787A1 (en) * 1987-05-30 1988-12-07 Kaken Pharmaceutical Co., Ltd. Antibiotic 6270B, processes for its production, and its use as an anticoccidiosis agent and a feed additive
EP0328303A2 (en) * 1988-02-08 1989-08-16 Pfizer Inc. Acidic polycyclic ether antibiotic having anticoccidial and growth promotant activity
DD270542A1 (en) * 1988-04-12 1989-08-02 Adw Ddr PROCESS FOR THE PREPARATION OF 26-DESOXYLAID LOMYCIN
EP0537897A1 (en) * 1991-09-16 1993-04-21 Eli Lilly And Company Method of producing antibiotic A82810 from Actinomadura fibrosa sp. nov. NRRL 18348 and Actinomadura sp. NRRL 18880

Also Published As

Publication number Publication date
KR970010603B1 (en) 1997-06-28
GB9605096D0 (en) 1996-05-08
JPH09510862A (en) 1997-11-04
KR950008689A (en) 1995-04-19
AU7709094A (en) 1995-04-03
CA2171947A1 (en) 1995-03-23
WO1995007997A1 (en) 1995-03-23
CN1135238A (en) 1996-11-06

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)