KR880701727A - 항생제 10381b의 제조방법 - Google Patents

항생제 10381b의 제조방법

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Publication number
KR880701727A
KR880701727A KR1019880700236A KR880700236A KR880701727A KR 880701727 A KR880701727 A KR 880701727A KR 1019880700236 A KR1019880700236 A KR 1019880700236A KR 880700236 A KR880700236 A KR 880700236A KR 880701727 A KR880701727 A KR 880701727A
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KR
South Korea
Prior art keywords
antibiotic
animal
alginensis
nrrl
concentration
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Application number
KR1019880700236A
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English (en)
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KR950001704B1 (ko
Inventor
디이 아르고우델리스 알렉잰더
비이 쉴리데이 프랭클린
엘 라보오드 엘리스
이이 투루에스델 스콧트
Original Assignee
로버어트 에이 아미테이즈
디 엎죤 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 로버어트 에이 아미테이즈, 디 엎죤 캄파니 filed Critical 로버어트 에이 아미테이즈
Publication of KR880701727A publication Critical patent/KR880701727A/ko
Application granted granted Critical
Publication of KR950001704B1 publication Critical patent/KR950001704B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
    • C07G11/00—Antibiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/195—Antibiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Mycology (AREA)
  • Food Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Birds (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

내용 없음

Description

항생제 10381b의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (16)

  1. 호기성 조건하에서 동화가능한 탄소원과 동화가능한 질소원을 함유하는 수성 영양 배지를 균주 스트렙토마이세스 알기넨시스 NRRL 15491 및 그 변종으로 발효시키는 것으로 구성된 항생제 10381b의 제조방법.
  2. 제1항에 있어서,
    발효를 약 15-50℃의 온도와 약 6.0-9.0의 pH에서 수행하는 방법.
  3. 제2항에 있어서,
    온도가 약 20-35℃이고 pH가 약 7.2인 방법.
  4. 제3항에 있어서,
    온도가 약 24-32℃인 방법.
  5. 제1항에 있어서,
    영양배지가 탄소원 2-3중량%와 질소원 2-3중량%를 포함하는 방법.
  6. 제1항에 있어서,
    발효가 약 2-10일에 완료되는 방법.
  7. 제1항에 있어서,
    항생제 1038b를 분리하는 방법.
  8. 제1항에 있어서,
    균주가 스트렙토마이세스 알기넨시스 NRRL 15941인 방법.
  9. 성장을 촉진시키기에 유효한 양의 항생제 1038b를 동물에게 투여하는 것으로 구성된 비육 동물의 성장을 촉진시키는 방법.
  10. 제9항에 있어서,
    항생제를 동물 사료에 첨가함으로 항생제 10381b가 투여되는 방법.
  11. 제10항에 있어서,
    항생제 10381b의 농도가 동물 사료 kg당 약 0.5- 약 55mg인 방법.
  12. 제11항에 있어서,
    비육동물이 브로일러 닭인 방법.
  13. 제12항에 있어서,
    항생제 10381b의 농도가 닭의 사료 kg당 약 0.5 약 11mg인 방법.
  14. 제11항에 있어서,
    비육동물이 돼지인 방법.
  15. 제14항에 있어서,
    항생제 10381b의 농도가 돼지의 사료 kg당 약 10- 약 55mg인 방법.
  16. 본질적으로 NRRL-15941로 동정된 균주임을 특징으로 하는 미생물 스트렙토마이세스 알기넨시스의 생물학적으로 순수한 배양물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880700236A 1986-07-03 1987-06-25 항생제 10381b의 제조방법 KR950001704B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US88207586A 1986-07-03 1986-07-03
US882075 1986-07-03
US882,075 1986-07-03
PCT/US1987/001450 WO1988000200A2 (en) 1986-07-03 1987-06-25 Process for the preparation of antibiotics 10381b

Publications (2)

Publication Number Publication Date
KR880701727A true KR880701727A (ko) 1988-11-04
KR950001704B1 KR950001704B1 (ko) 1995-02-28

Family

ID=25379842

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880700236A KR950001704B1 (ko) 1986-07-03 1987-06-25 항생제 10381b의 제조방법

Country Status (9)

Country Link
EP (1) EP0316313B1 (ko)
JP (3) JPH0746996B2 (ko)
KR (1) KR950001704B1 (ko)
AT (1) ATE81341T1 (ko)
AU (1) AU605495B2 (ko)
DE (1) DE3782169T2 (ko)
FI (1) FI100337B (ko)
HK (1) HK165995A (ko)
WO (1) WO1988000200A2 (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985274A (en) * 1985-04-02 1999-11-16 Pharmacia & Upjohn Company Antibiotic 10381A1 and process for the preparation of antibiotics 10381B
US5616320A (en) * 1985-04-02 1997-04-01 The Upjohn Company Use of antibiotics 10381b to promote growth
US6224864B1 (en) 1986-12-03 2001-05-01 Pharmacia & Upjohn Company Antibiotic 10381A, and process for the preparation of anitbiotics 10381B
US5616690A (en) * 1992-06-09 1997-04-01 Neorx Corporation Hexose derivatized human serum albumin clearing agents
US5911969A (en) 1992-06-09 1999-06-15 Neorx Corporation Pretargeting protocols for enhanced localization of active agents to target sites
ATE210464T1 (de) * 1992-06-09 2001-12-15 Neorx Corp BIOTIN-DOTA KONJUGATE UND DEREN VERWENDUNG IN ßPRETARGETINGß VERFAHREN
TW380140B (en) * 1993-09-10 2000-01-21 Upjohn Co Antibiotics 10381v, w, x, y, z1, z2, pre-b and t

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0217923A1 (en) * 1985-04-02 1987-04-15 The Upjohn Company Antibiotic 10381a 1?

Also Published As

Publication number Publication date
JPH0775587A (ja) 1995-03-20
HK165995A (en) 1995-11-03
ATE81341T1 (de) 1992-10-15
EP0316313A1 (en) 1989-05-24
JPH0746996B2 (ja) 1995-05-24
AU7641787A (en) 1988-01-29
WO1988000200A2 (en) 1988-01-14
FI890009A0 (fi) 1989-01-02
JP2506568B2 (ja) 1996-06-12
JPH01503115A (ja) 1989-10-26
FI890009A (fi) 1989-01-02
AU605495B2 (en) 1991-01-17
KR950001704B1 (ko) 1995-02-28
JPH06233674A (ja) 1994-08-23
FI100337B (fi) 1997-11-14
DE3782169D1 (de) 1992-11-12
DE3782169T2 (de) 1993-02-25
WO1988000200A3 (en) 1988-04-21
JPH07110226B2 (ja) 1995-11-29
EP0316313B1 (en) 1992-10-07

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