KR900018384A - 항생제 아라노로신, 이의 미생물학적 제조방법 및 이의 약제로서의 용도 - Google Patents

항생제 아라노로신, 이의 미생물학적 제조방법 및 이의 약제로서의 용도 Download PDF

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KR900018384A
KR900018384A KR1019890006307A KR890006307A KR900018384A KR 900018384 A KR900018384 A KR 900018384A KR 1019890006307 A KR1019890006307 A KR 1019890006307A KR 890006307 A KR890006307 A KR 890006307A KR 900018384 A KR900018384 A KR 900018384A
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South Korea
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compound
medicament
aranosine
antibiotic
dsm
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KR1019890006307A
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로이 키리티
무코패드하이야이 트립티쿠마르
챤드라 셰카라 레디 고우카나팔리
코테스와라 사트야 비자야쿠마르 엘라
나레쉬 강굴리 비말
헬무트 루프 리카르트
펠하버 한스-볼프람
코글러 헤르베르트
Original Assignee
하인리히 벡커, 베른하르트 벡크
훽스트 아크티엔게젤샤프트
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Application filed by 하인리히 벡커, 베른하르트 벡크, 훽스트 아크티엔게젤샤프트 filed Critical 하인리히 벡커, 베른하르트 벡크
Publication of KR900018384A publication Critical patent/KR900018384A/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
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  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

내용 없음

Description

항생제 아라노로신, 이의 미생물학적 제조방법 및 이의 약제로서의 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 하기 구조식의 화합물.
  2. 진균 균주 Y-30499 (DSM 4151)를 탄소원, 질소원, 무기영양염류 및 미량원소를 함유하는 영양배지중에서, 24내지 30℃의 온도, 6.0 내지 8.0의 pH 및 호기조건하에서 66내지 90시간 동안 배양시키고, 통상의 방법으로 배양액에서 화합물을 분리 및 정제시키는 단계를 포함하는 제1항의 화합물의 제조방법.
  3. 제2항에 있어서, 26℃(±1℃) 및 pH6.5에서 배양시키는 방법.
  4. 제1항 또는 3항에 있어서, 72시간 동안 배양시키는 방법.
  5. 제2항 내지 4항중 어느 한 항에 있어서, 침지 발효법으로 발효시키는 방법.
  6. 통상의 보조제 및/또는 부형제와 함께 제1항의 화합물을 함유하는 약제.
  7. 항생활성을 지니는 약제제조를 위한 제1항의 화합물의 용도.
  8. 악성종양제어 활성을 지니는 약제조를 위한 제1항의 화합물의 용도.
  9. 수도아라크니오투스 로제우스Y-30499 (DSM 451).
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890006307A 1988-05-13 1989-05-11 항생제 아라노로신, 이의 미생물학적 제조방법 및 이의 약제로서의 용도 KR900018384A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3816411.6 1988-05-13
DE3816411 1988-05-13

Publications (1)

Publication Number Publication Date
KR900018384A true KR900018384A (ko) 1990-12-21

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ID=6354342

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890006307A KR900018384A (ko) 1988-05-13 1989-05-11 항생제 아라노로신, 이의 미생물학적 제조방법 및 이의 약제로서의 용도

Country Status (10)

Country Link
US (1) US5112858A (ko)
EP (1) EP0341649A1 (ko)
JP (1) JPH0236185A (ko)
KR (1) KR900018384A (ko)
AU (1) AU615546B2 (ko)
DK (1) DK234989A (ko)
HU (1) HU202286B (ko)
IL (1) IL90250A0 (ko)
PT (1) PT90544A (ko)
ZA (1) ZA893556B (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0366189A3 (en) * 1988-10-24 1992-01-02 Norwich Eaton Pharmaceuticals, Inc. Novel antimicrobial lactam-quinolones
TW209866B (ko) * 1991-03-20 1993-07-21 Hoechst Ag

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4174327A (en) * 1974-02-04 1979-11-13 Firmenich Sa Spirane derivatives
US4190591A (en) * 1977-01-21 1980-02-26 Givaudan Corporation Odorant and flavorant
US4588591A (en) * 1984-05-25 1986-05-13 The Upjohn Company Analgesic 2-oxa-spirocyclic compounds

Also Published As

Publication number Publication date
JPH0236185A (ja) 1990-02-06
US5112858A (en) 1992-05-12
ZA893556B (en) 1989-12-27
DK234989D0 (da) 1989-05-12
DK234989A (da) 1989-11-14
HUT50217A (en) 1989-12-28
HU202286B (en) 1991-02-28
EP0341649A1 (de) 1989-11-15
IL90250A0 (en) 1989-12-15
AU615546B2 (en) 1991-10-03
AU3471689A (en) 1989-11-16
PT90544A (pt) 1989-11-30

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