KR930019833A - 프라디미신 항생제의 제조방법 - Google Patents

프라디미신 항생제의 제조방법 Download PDF

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Publication number
KR930019833A
KR930019833A KR1019920012991A KR920012991A KR930019833A KR 930019833 A KR930019833 A KR 930019833A KR 1019920012991 A KR1019920012991 A KR 1019920012991A KR 920012991 A KR920012991 A KR 920012991A KR 930019833 A KR930019833 A KR 930019833A
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South Korea
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antibiotic
further contains
medium further
actinoids
norma
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KR1019920012991A
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English (en)
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후루마이 다모쓰
하또리 마사미
가꾸시마 마사또시
이께다 찌하루
사이또 교이찌로
고바루 세이끼찌
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도미닉 엠. 메짜펠
브리스톨-마이어즈 스퀴브 컴페니
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Application filed by 도미닉 엠. 메짜펠, 브리스톨-마이어즈 스퀴브 컴페니 filed Critical 도미닉 엠. 메짜펠
Publication of KR930019833A publication Critical patent/KR930019833A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/244—Anthraquinone radicals, e.g. sennosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/03—Actinomadura
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/825—Actinomadura

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 BMY-28960 및 데스크실로실 BMY-28960의 제조를 위한 발효방법, 및 악티노마두라속에 속하며, AB 1236 스트레인 (ATCC 55208)이라 명명된 신규의 BMY-28960-생산 미생물에 관한다.

Description

프라디미신 항생제의 제조방법.
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 BMY-28960의 IR 스펙트럼(KBr)임.
제2도는 BMY-28960의1H NMR 스펙트럼(DMS0-d6, 400 MHz) 임.
제3도는 BMY-28960의13H NMR 스펙트럼(DMSO-d6, 100 MHz) 임.

Claims (7)

  1. 다음식의 항생제를 생산할 수 있는악티노마두라 (Actinomadura)스트레인을 탄소, 질소 및 D-세린의 자화원을 함유하는 수성배지에서 호기적 조건하에 배양한 다음 상기 항생제를 배양 브로쓰로부터 회수하는 단계로 됨을 특징으로 하는 다음 일반식을 갖는 항생제의 제조방법.
    (식중, R은 수소 또는 β-D-크실로실임).
  2. 제1항에 있어서, 상기악티노마두라스트레이 AB 1236으로 표시되고, 아메리칸 타잎 컬춰 콜렉션(American Type Culture Collection)에 기탁번호 ATCC 55208로 기탁된 스트레인인 것이 특징인 방법.
  3. 제1항에 있어서, 상기 배지가 D-시클로세린을 추가로 함유하는 것이 특징인 방법.
  4. 제2항에 있어서, 상기 배지가 D-시클로세린을 추가로 함유하는 것이 특징인 방법.
  5. 제3항에 있어서, 상기 배지가 쓰레오닌을 추가로 함유하는 것이 특징인 방법.
  6. 제4항에 있어서, 상기 배지가 쓰레오닌을 추가로 함유하는 것이 특징인 방법.
  7. ATCC 55208의 동정 특성을 가지며, 탄소, 질소 및 D-세린의 자화원을 함유하는 수성배지에서 배양될 때 제1항의 항생제를 생산할 수 있음을 특징으로 하는 미생물악티노마두라sp. AB 1236의 생물학적 순수 배양체.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920012991A 1991-07-31 1992-07-21 프라디미신 항생제의 제조방법 KR930019833A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US739,019 1991-07-31
US07/739,019 US5194371A (en) 1991-07-31 1991-07-31 Production of pradimicin antibiotics

Publications (1)

Publication Number Publication Date
KR930019833A true KR930019833A (ko) 1993-10-19

Family

ID=24970472

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920012991A KR930019833A (ko) 1991-07-31 1992-07-21 프라디미신 항생제의 제조방법

Country Status (19)

Country Link
US (2) US5194371A (ko)
EP (1) EP0525588A2 (ko)
JP (1) JPH05227985A (ko)
KR (1) KR930019833A (ko)
CN (1) CN1033591C (ko)
AR (1) AR247247A1 (ko)
AU (1) AU652268B2 (ko)
CA (1) CA2071140A1 (ko)
CZ (1) CZ281277B6 (ko)
FI (1) FI923310A (ko)
HU (1) HUT66834A (ko)
IE (1) IE922354A1 (ko)
IL (1) IL102587A (ko)
NO (1) NO922864L (ko)
NZ (1) NZ243601A (ko)
PL (2) PL169264B1 (ko)
RU (1) RU2057181C1 (ko)
TW (1) TW215929B (ko)
ZA (1) ZA924167B (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5326867A (en) * 1992-07-16 1994-07-05 Bristol-Myers Squibb Company Pradimic acids, amides, and pradimicin derivatives
ATE519485T1 (de) 2001-03-29 2011-08-15 Michael Davis Akute pharmakologische verstärkung einer psychotherapie mit d-cycloserine
JP4046708B2 (ja) * 2004-06-04 2008-02-13 明治製菓株式会社 ３−アルケニルセフェム化合物の製造方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4870165A (en) * 1987-02-02 1989-09-26 Bristol-Myers Company Antifungal antibiotics
US4990497A (en) * 1987-02-02 1991-02-05 Toshikazu Oki Antifungal antibiotics
US4992425A (en) * 1988-06-07 1991-02-12 Bristol-Myers Company Antibiotics BU-3608D and BU-3608E
US5096817A (en) * 1988-06-07 1992-03-17 Bristol-Myers Company Process for producing antibiotics BU-3608 D and BU-3608 E
US5114857A (en) * 1988-11-10 1992-05-19 Bristol-Myers Company Actinomadura hibisca microorganism useful for preparing serine analogs of BU-3608 antibiotics
US5061624A (en) * 1988-11-10 1991-10-29 Bristol-Myers Company Serine analogs of BU-3608 antibiotics
US4973673A (en) * 1988-11-10 1990-11-27 Bristol-Myers Company Serine analogs of BU-3608 antibiotics
US5053395A (en) * 1989-03-24 1991-10-01 Bristol-Myers Company Pradimicin amide derivatives
CA2030166C (en) * 1989-11-22 1997-10-07 Shimpei Aburaki Pradimicin derivatives
US5091418A (en) * 1990-09-28 1992-02-25 Bristol-Myers Squibb Company Novel alpha-glucosidase inhibitor, pradimicin Q

Also Published As

Publication number Publication date
FI923310A (fi) 1993-02-01
EP0525588A3 (ko) 1994-03-30
PL169264B1 (pl) 1996-06-28
IE922354A1 (en) 1993-02-10
AU652268B2 (en) 1994-08-18
HUT66834A (en) 1995-01-30
TW215929B (ko) 1993-11-11
FI923310A0 (fi) 1992-07-20
CZ281277B6 (cs) 1996-08-14
IL102587A0 (en) 1993-01-14
AU2063992A (en) 1993-02-04
JPH05227985A (ja) 1993-09-07
CZ227492A3 (en) 1993-02-17
EP0525588A2 (en) 1993-02-03
CN1033591C (zh) 1996-12-18
US5374552A (en) 1994-12-20
PL169657B1 (pl) 1996-08-30
NO922864L (no) 1993-02-01
NZ243601A (en) 1993-11-25
IL102587A (en) 1996-05-14
PL295353A1 (ko) 1993-02-08
AR247247A1 (es) 1994-11-30
CA2071140A1 (en) 1993-02-01
RU2057181C1 (ru) 1996-03-27
ZA924167B (en) 1993-02-26
NO922864D0 (no) 1992-07-20
US5194371A (en) 1993-03-16
CN1069286A (zh) 1993-02-24
HU9202387D0 (en) 1992-12-28

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