ES8800362A1 - Un procedimiento para la preparacion del complejo antibiotico a-21978 c o sus factores c0,c1,c2,c3,c4, 0 c5. - Google Patents

Un procedimiento para la preparacion del complejo antibiotico a-21978 c o sus factores c0,c1,c2,c3,c4, 0 c5.

Info

Publication number
ES8800362A1
ES8800362A1 ES553603A ES553603A ES8800362A1 ES 8800362 A1 ES8800362 A1 ES 8800362A1 ES 553603 A ES553603 A ES 553603A ES 553603 A ES553603 A ES 553603A ES 8800362 A1 ES8800362 A1 ES 8800362A1
Authority
ES
Spain
Prior art keywords
producing
derivatives
production
new
alkonoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES553603A
Other languages
English (en)
Other versions
ES553603A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES8800362A1 publication Critical patent/ES8800362A1/es
Publication of ES553603A0 publication Critical patent/ES553603A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Treating Waste Gases (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR EL COMPLEJO ANTIBIOTICO A-21978C O SUS FACTORES. COMPRENDE: A) CULTIVAR STREPTOMYCES ROSEOSPORUS NRRL 15998 O UN MUTANTE PRODUCTOR DE A-21978C, EN UN MEDIO DE CULTIVO, EN CONDICIONES DE FERMENTACION AEROBIA SUMERGIDA, CON UN PORCENAJE DE SATURACION DE AIRE DE 20 POR CIEN Y ENTRE 20G Y 40GC, PARA PRODUCIR LOS ANTIBIOTICOS A-21798C; Y B) SEPARAR EL COMPLEJO A-21978C DEL MEDIO DEL CULTIVO. EL MEDIO DE CULTIVO CONTIENE FUENTES DE CARBONO COMO FRUCTOSA, MANOSA Y OLEATO DE METILO, FUENTES DE NITROGENO COMO PEPTONA DE CARNE SOLUBLE, SEMOLA DE SOJA Y LEVADURA Y SALES INORGANICAS NUTRIENTES COMO SULFATO POTASICO Y CENIZA DE MELAZA.
ES553603A 1984-10-09 1986-04-01 Un procedimiento para la preparacion del complejo antibiotico a-21978 c o sus factores c0,c1,c2,c3,c4, 0 c5. Expired ES8800362A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65897984A 1984-10-09 1984-10-09

Publications (2)

Publication Number Publication Date
ES8800362A1 true ES8800362A1 (es) 1987-11-01
ES553603A0 ES553603A0 (es) 1987-11-01

Family

ID=24643546

Family Applications (2)

Application Number Title Priority Date Filing Date
ES547689A Expired ES8700862A1 (es) 1984-10-09 1985-10-08 Un procedimiento para la preparacion de un derivado de a-21978c
ES553603A Expired ES8800362A1 (es) 1984-10-09 1986-04-01 Un procedimiento para la preparacion del complejo antibiotico a-21978 c o sus factores c0,c1,c2,c3,c4, 0 c5.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES547689A Expired ES8700862A1 (es) 1984-10-09 1985-10-08 Un procedimiento para la preparacion de un derivado de a-21978c

Country Status (27)

Country Link
EP (1) EP0178152B1 (es)
JP (1) JPH0787796B2 (es)
KR (1) KR890000800B1 (es)
CN (2) CN1013120B (es)
AT (1) ATE67788T1 (es)
AU (2) AU4837785A (es)
BG (1) BG47040A3 (es)
CS (2) CS276983B6 (es)
CY (1) CY1633A (es)
DD (2) DD238068A5 (es)
DE (1) DE3584218D1 (es)
DK (2) DK165416C (es)
EG (1) EG17619A (es)
ES (2) ES8700862A1 (es)
FI (1) FI82075C (es)
GR (1) GR852432B (es)
HK (1) HK24292A (es)
HU (1) HU196845B (es)
IE (1) IE58655B1 (es)
IL (1) IL76608A (es)
NZ (1) NZ213731A (es)
PH (1) PH21217A (es)
PL (1) PL152359B1 (es)
PT (1) PT81265B (es)
SG (1) SG3292G (es)
SU (1) SU1452484A3 (es)
ZA (1) ZA857759B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0294990A3 (en) * 1987-06-10 1990-05-09 Eli Lilly And Company Chromatographic purification process
US4930494A (en) * 1988-03-09 1990-06-05 Olympus Optical Co., Ltd. Apparatus for bending an insertion section of an endoscope using a shape memory alloy
US4977083A (en) * 1988-04-11 1990-12-11 Eli Lilly And Company Processes for preparing A54145 compounds
DE3832362A1 (de) * 1988-09-23 1990-03-29 Sandoz Ag Neue cyclopeptolide, verfahren zu ihrer herstellung und ihre verwendung
MXPA02006030A (es) * 1999-12-15 2004-08-23 Cubist Pharm Inc Lipopeptidos como agentes antibacterianos.
AU784755B2 (en) 1999-12-15 2006-06-08 Merck Sharp & Dohme Corp. Daptomycin Analogs as antibacterial agents
US6696412B1 (en) 2000-01-20 2004-02-24 Cubist Pharmaceuticals, Inc. High purity lipopeptides, Lipopeptide micelles and processes for preparing same
US20060014674A1 (en) 2000-12-18 2006-01-19 Dennis Keith Methods for preparing purified lipopeptides
RU2512396C2 (ru) 2008-12-22 2014-04-10 Кьюбист Фармасьютикалз, Инк. Новые противобактериальные средства для лечения грамположительных инфекций
PE20151717A1 (es) 2009-11-23 2015-11-19 Cubist Pharm Inc Compuestos lipopeptidos y metodos relacionados
MX2013015434A (es) 2011-06-22 2014-10-14 Vyome Biosciences Pvt Ltd Profarmacos antifungicos y antibacterianos a base de conjugado.
IT201600127655A1 (it) 2016-12-16 2018-06-16 Gnosis Spa Processo per la purificazione di antibiotici lipopolipeptidici
CN107964557B (zh) * 2018-01-17 2020-11-20 自然资源部第三海洋研究所 一种提高芽孢杆菌抗菌脂肽产量的发酵方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4208403A (en) * 1978-10-16 1980-06-17 Eli Lilly And Company A-21978 Antibiotics and process for their production
IL68700A0 (en) * 1982-05-21 1983-09-30 Lilly Co Eli Improvements relating to a-21978c cyclic peptide derivatives and their production

Also Published As

Publication number Publication date
CS819286A3 (en) 1992-03-18
PT81265A (en) 1985-11-01
ES8700862A1 (es) 1986-11-16
CN85107552A (zh) 1987-05-20
CS719885A3 (en) 1992-03-18
FI853910A0 (fi) 1985-10-08
DK457585A (da) 1986-04-10
DK165757B (da) 1993-01-11
PH21217A (en) 1987-08-21
GR852432B (es) 1986-02-10
IL76608A0 (en) 1986-02-28
AU5375290A (en) 1990-11-01
SG3292G (en) 1992-03-20
EP0178152B1 (en) 1991-09-25
PL152359B1 (en) 1990-12-31
CS276978B6 (en) 1992-11-18
JPS6192588A (ja) 1986-05-10
AU634766B2 (en) 1993-03-04
EP0178152A2 (en) 1986-04-16
BG47040A3 (en) 1990-04-16
HUT39782A (en) 1986-10-29
PT81265B (pt) 1988-02-17
DK165416C (da) 1993-04-05
FI82075B (fi) 1990-09-28
ES553603A0 (es) 1987-11-01
FI82075C (fi) 1991-01-10
FI853910L (fi) 1986-04-10
ES547689A0 (es) 1986-11-16
DE3584218D1 (de) 1991-10-31
DK165416B (da) 1992-11-23
HU196845B (en) 1989-01-30
AU4837785A (en) 1986-04-17
EG17619A (en) 1991-03-30
HK24292A (en) 1992-04-10
CN1051200A (zh) 1991-05-08
IE58655B1 (en) 1993-11-03
IE852466L (en) 1986-04-09
JPH0787796B2 (ja) 1995-09-27
DK457585D0 (da) 1985-10-08
DK148791D0 (da) 1991-08-21
KR890000800B1 (ko) 1989-04-07
ATE67788T1 (de) 1991-10-15
IL76608A (en) 1991-03-10
KR860003335A (ko) 1986-05-23
NZ213731A (en) 1988-04-29
EP0178152A3 (en) 1988-11-02
DD247023A5 (de) 1987-06-24
DD238068A5 (de) 1986-08-06
CS276983B6 (en) 1992-11-18
SU1452484A3 (ru) 1989-01-15
CY1633A (en) 1992-11-06
DK165757C (da) 1993-06-07
PL255683A1 (en) 1986-07-29
ZA857759B (en) 1987-05-27
CN1013120B (zh) 1991-07-10
DK148791A (da) 1991-08-21

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20060811