KR840002354A - 시스, 엔도-2-아자비사이클로-[3.3.0]-옥탄-3-카복실산 유도체의 제조방법 - Google Patents

시스, 엔도-2-아자비사이클로-[3.3.0]-옥탄-3-카복실산 유도체의 제조방법 Download PDF

Info

Publication number
KR840002354A
KR840002354A KR1019820004953A KR820004953A KR840002354A KR 840002354 A KR840002354 A KR 840002354A KR 1019820004953 A KR1019820004953 A KR 1019820004953A KR 820004953 A KR820004953 A KR 820004953A KR 840002354 A KR840002354 A KR 840002354A
Authority
KR
South Korea
Prior art keywords
hydrogen
compound
carbon atoms
formula
general formula
Prior art date
Application number
KR1019820004953A
Other languages
English (en)
Other versions
KR890000007B1 (ko
Inventor
데츠 볼커
Original Assignee
하인리히 벡커, 베른하르트 벡크
휙스트 아크티엔 게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25797115&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR840002354(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 하인리히 벡커, 베른하르트 벡크, 휙스트 아크티엔 게젤샤프트 filed Critical 하인리히 벡커, 베른하르트 벡크
Publication of KR840002354A publication Critical patent/KR840002354A/ko
Application granted granted Critical
Publication of KR890000007B1 publication Critical patent/KR890000007B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음.

Description

시스, 엔도－2－아자비사이클로－[3,3,0]－옥탄－3－카복실산 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 다음 일반식(Ⅱ)의 화합물을 다음 일반식(Ⅲa) 또는 (Ⅲb)의 화합물과 반응시킨후 생성물을 수소첨가시키거나 또는 산 또는 염기로 처리함을 특징으로 하는, 다음 일반식(Ⅰ)의 화합물 및 이의 생리적으로 허용되는 염의 제조방법.
    상기식에서, 1 및 5번 브리지－헤드 탄소원자상의 수소원자는 서로에 대해 시스－배위이며 3번 탄소 원자상의 카복실그룹은 2환성 환계에 대해 엔도－위치로 배향하고, R1은 수소, 알릴, 비닐 또는 보호된 천연 α－아미노산 R1－CH(NH2)－COOH의 측쇄이며, R2는 수소, (탄소수 1내지 6의)－알킬, (탄소수 2내지 6의)알케일 또는 아릴－(탄소수 1내지 4의)－알킬이고(단 일반식(Ⅱ)에서는 수소를 제외한다).
    Y는 수소 또는 하이드록실이며, Z는 수소이거나, 또는 Y 및 Z는 함께 산소이고, X는(탄소수 1내지 6의)－알킬, (탄소수 2내지 6의)－알케닐 또는(탄소수 5내지 9의)－사이클로알킬, 또는(탄소수 1내지 4의)－알킬, (탄소수 1내지 4의)－알콕시, 하이드록실, 할로겐, 니트로, 아미노, (탄소수 1내지 4의)－알킬아미노, 디－(탄소수 1내지 4의(－알킬아미노 또는 메틸렌디옥시로 모노－, 디－또는 트리－치환된(탄소수 6내지 12)의－아릴 또는 인돌－3－일이며, W는 카복실－에스네르화그룹이다.
  2. 다음 일반식(Ⅵ)의 엔아민 또는 다음 일반식(Ⅶ)의 기를 다음 일반식(Ⅷ)의 N－아실화된 β－할로게노－α－아미노－카복실산 에스테르 또는 다음 일반식(Ⅸ)의 아크릴산 에스테르와 반응시켜 다음 일반식(Ⅹ)의 화합물을 생성시킨후, 이 화합물을 강산의 첨가, 아실 아미드 및 에스테르 분비로써 폐환하여 다음 일반식(XIa) 또는 (IXb)의 화합물을 생성시키고, 이화합물을 전이 금속 촉매 존재하에 촉매적 수소첨가로써 또는 저급 알콜중 보란－아민 착화합물 또는 착붕소 수소화물로 환원시킴으로써 W가 수소인 다음 일반식(Ⅲa) 또는 (Ⅲb)의 화합물로 전환시키며, 임의로 이생성물을 에스테르화하여 W가 탄소수 1내지 6의 알킬 또는 탄소수 7내지 8의 아르알킬인 다음 일반식(Ⅲa) 또는(Ⅲb)의 화합물을 생성시킴을 특징으로 하는, 다음 일반식(Ⅲa) 또는 (Ⅲb)의 화합물 및 이의 산(W가 수소인 경우) 또는 염기와의 염의 제조방법.
    상기 일반식(Ⅲa) 도는 (Ⅲb)에서 W는 수소, 탄소수 1내지 6의 알킬 또는 탄소수 7내지 8의 아르알킬이며, 상기 일반식(Ⅵ)에서, X1은 탄소수 2내지 10의 디알킬아미노이고, 상기 일반식(Ⅶ)에서 m 및 0은 1내지 3의 정수이며, m 및 0의 총합은 3이상이고, A는 CH2, NH, O 또는 S이며,상기 일반식(Ⅷ)에서, X2는 뉴클레오퓨직 그룹이고, Y1은 탄소수 1내지 5의 알카노일, 탄소수 7내지 9의 아르오일 또는 펩타이드 화학에서 통상적이고 산조건하에서 분리되는 기타 보호그룹이며, R2는 탄소수 1내지 5의 알킬 또는 탄소수 7내지 9의 아르알킬이고, 상기 일반식(Ⅸ)에서 Y1및 R2는 전술한 바와 같으며, 상기 일반식(Ⅹ)에서 R2및 Y1은 전술한 바와 같다.
  3. a) X가 아릴이면, 아릴메틸 케톤 X－CO－CH3을 글리옥실산 에스테르 CHO－CO2R2및 α－아미노산 에스데르 H2N－CHR1－CO2W(여기서 W′는 염기성 또는 산성 가수분해로써 분리되는 기이고, 만일 W′가 벤질이면 R2는 벤질 또는 니트로벤질이 아니다)와 반응시켜 다음 일반식(Ⅳ)의 화합물을 생성시키거나, 또는 b) 케토－아크릴산 에스테르 X－CO_CH=CH=CO2R2를 α－아미노산 에스테르 H2N－CHCR1)－CO2W′와 반응시켜 다음 일반식(Ⅳ)의 화합물을 생성시키고, 적절하다면 a) 또는 b)에 따라 수득한 이화합물을, W′가 산성 또는 염기성 조건하에서 제거될수 있는 기이면, 산성 또는 염기성 에스테르 분리시키거나, 또는 W′가 벤질 또는 니트로벤질이면(R2=벤질 또는 니트로벤질)이화합물을 가수소분해로써 카복실산으로 전환시키고 이 생성물을 수소첨가시켜 X,R1및 R2가 전술한 바와같고 Y가 수소 또는 하이드록실이며 Z가 수소인, 다음 일반식(Ⅱ)의 화합물 또는 적절하다면 산－촉매적으로 에스테르 분리시키는 이의 저급알킬 에스테르를 생성시킴을 특징으로 하는, 다음 일반식(Ⅱ)의 화합물의 제조방법.
    상기식에서, x,R1,R2및 W′는 전술한 바와같고, Y는 수소 또는 하이드록실이며, Z는 수소이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR8204953A 1981-11-05 1982-11-03 시스, 엔도-2-아자비사이클로-[3.3.0]-옥탄-3-카복실산 유도체의 제조방법 KR890000007B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DEP3143946.2 1981-11-05
DE3143946 1981-11-05
DE3143946.2 1981-11-05
DE19823226768 DE3226768A1 (de) 1981-11-05 1982-07-17 Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
DEP3226768.1 1982-07-17

Publications (2)

Publication Number Publication Date
KR840002354A true KR840002354A (ko) 1984-06-25
KR890000007B1 KR890000007B1 (ko) 1989-03-02

Family

ID=25797115

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8204953A KR890000007B1 (ko) 1981-11-05 1982-11-03 시스, 엔도-2-아자비사이클로-[3.3.0]-옥탄-3-카복실산 유도체의 제조방법

Country Status (31)

Country Link
US (4) US4727160A (ko)
EP (2) EP0079022B1 (ko)
JP (3) JPH02104526A (ko)
KR (1) KR890000007B1 (ko)
AR (1) AR240675A1 (ko)
AU (3) AU565200B2 (ko)
BG (1) BG60532B2 (ko)
CA (1) CA1187087A (ko)
CS (1) CS247159B2 (ko)
CZ (1) CZ416291A3 (ko)
DD (2) DD219480A5 (ko)
DE (3) DE3226768A1 (ko)
DK (2) DK166624C (ko)
DZ (1) DZ473A1 (ko)
ES (3) ES8307746A1 (ko)
FI (1) FI81087C (ko)
GR (1) GR77381B (ko)
HK (1) HK74889A (ko)
HU (2) HU186339B (ko)
IE (1) IE56476B1 (ko)
IL (1) IL67172A (ko)
JO (1) JO1224B1 (ko)
LU (1) LU88260I2 (ko)
MA (1) MA19639A1 (ko)
NL (1) NL930039I2 (ko)
NO (2) NO156940C (ko)
NZ (1) NZ202378A (ko)
PH (2) PH22417A (ko)
PT (1) PT75792A (ko)
SG (1) SG1189G (ko)
SU (1) SU1277895A3 (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11289233B2 (en) 2016-04-28 2022-03-29 Kepco Nuclear Fuel Co., Ltd. Method for collecting uranium by treatment process of washing waste liquid generated in uranium hexafluoride cylinder washing process

Families Citing this family (126)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19575012I2 (de) * 1980-10-23 2002-01-24 Schering Corp Carboxyalkyl-Dipeptide Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE3226768A1 (de) * 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
GR78413B (ko) * 1981-12-29 1984-09-27 Hoechst Ag
DE3246503A1 (de) * 1982-12-16 1984-06-20 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(5.3.0)-decan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
DE3303112A1 (de) * 1983-01-31 1984-08-09 Hoechst Ag, 6230 Frankfurt Verfahren zur racemattrennung optisch aktiver bicyclischer imino-(alpha)-carbonsaeuren
US5175306A (en) * 1983-01-31 1992-12-29 Hoechst Aktiengesellschaft Process for the resolution of racemates of optically active bicyclic imino-α-carboxylic esters
DE3303344A1 (de) 1983-02-02 1984-08-02 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten aminosaeuren und deren estern
DE3324263A1 (de) * 1983-07-06 1985-01-17 Hoechst Ag, 6230 Frankfurt Derivate der 2-azabicyclo(3.1.0)hexan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie 2-azabicyclo(3.1.0)hexan-derivate als zwischenprodukte und verfahren zu deren herstellung
DE3333455A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung n-alkylierter dipeptide und deren estern
DE3333454A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
DE3410732A1 (de) * 1984-03-23 1985-09-26 Hoechst Ag, 6230 Frankfurt Methode zur behandlung des glaukoms
DE3413710A1 (de) * 1984-04-12 1985-10-24 Hoechst Ag, 6230 Frankfurt Verfahren zur behandlung der herzinsuffizienz
US5684016A (en) * 1984-04-12 1997-11-04 Hoechst Aktiengesellschaft Method of treating cardiac insufficiency
AU581919B2 (en) * 1984-07-30 1989-03-09 Schering Corporation Process for the preparation of cis, endooctahydrocyclopenta (b) pyrrole-2-carboxylate
DE3431541A1 (de) * 1984-08-28 1986-03-06 Hoechst Ag, 6230 Frankfurt Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung
EP0190687B1 (en) * 1985-02-04 1988-10-05 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Process for preparing ethyl-alpha-(1-carboxyethyl)-amino-gamma-oxo-gamma-phenylbutyrate
US4925969A (en) * 1985-02-04 1990-05-15 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Process for preparing ethyl-alpha-amino-gamma-oxo-gamma-phenybutyrate derivatives
US4762821A (en) * 1985-03-22 1988-08-09 Syntex (U.S.A.) Inc. N',N"-dialkylguanidino dipeptides
DE3518514A1 (de) * 1985-05-23 1986-11-27 Hoechst Ag, 6230 Frankfurt Neue derivate bicyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
US5231080A (en) * 1985-10-15 1993-07-27 Hoechst Aktiengesellschaft Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease
ES2028812T3 (es) * 1986-03-27 1992-07-16 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Un procedimiento para la preparacion de un derivado de n2-(1-carboxi-3-oxo-3-fenilpropil)-l-lisina.
US5231084A (en) * 1986-03-27 1993-07-27 Hoechst Aktiengesellschaft Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons
EP0566157A1 (en) 1986-06-20 1993-10-20 Schering Corporation Neutral metalloendopeptidase inhibitors in the treatment of hypertension
EP0254032A3 (en) * 1986-06-20 1990-09-05 Schering Corporation Neutral metalloendopeptidase inhibitors in the treatment of hypertension
US4749688A (en) * 1986-06-20 1988-06-07 Schering Corporation Use of neutral metalloendopeptidase inhibitors in the treatment of hypertension
DE3633496A1 (de) * 1986-10-02 1988-04-14 Hoechst Ag Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln
DE3639879A1 (de) * 1986-11-21 1988-06-01 Hoechst Ag Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren, zwischenprodukte dieses verfahrens sowie ein verfahren zu deren herstellung
DE3641451A1 (de) * 1986-12-04 1988-06-16 Hoechst Ag Derivate bicyclischer aminocarbonsaeuren, verfahren und zwischenprodukte zu deren herstellung sowie deren verwendung
US5262436A (en) * 1987-03-27 1993-11-16 Schering Corporation Acylamino acid antihypertensives in the treatment of congestive heart failure
DE3722007A1 (de) * 1987-07-03 1989-01-12 Hoechst Ag Verfahren zur herstellung bicyclischer aminocarbonsaeuren, zwischenprodukte dieses verfahrens und deren verwendung
DE3731085A1 (de) * 1987-09-16 1989-04-06 Hoechst Ag Neue aminosaeureester, verfahren zu ihrer herstellung, sie enthaltende arzneimittel und deren verwendung
FR2620703B1 (fr) * 1987-09-17 1991-10-04 Adir Procede de synthese industrielle de l'acide perhydroindole carboxylique - 2(2s, 3as, 7as). application a la synthese de carboxyalkyl dipeptides
DE3739690A1 (de) * 1987-11-24 1989-06-08 Hoechst Ag Stabilisierte arzneistoffe, verfahren zu ihrer herstellung sowie stabile arzneizubereitungen
HU904967D0 (en) * 1988-04-22 1991-01-28 Hoechst Ag Process for producing new azabicyclo(3.3.o)octane-3-carboxylic acid-octylesther derivatives
DE3839127A1 (de) * 1988-11-19 1990-05-23 Hoechst Ag Pyrrolidon-2-carbonsaeure-derivate mit psychotroper wirkung
DD284030A5 (de) 1988-11-24 1990-10-31 Hoechst Ag,De Verfahren zur herstellung von peptiden mit bradykinin-antagonistischer wirkung
ZA902661B (en) * 1989-04-10 1991-01-30 Schering Corp Mercapto-acyl amino acids
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
JPH075530B2 (ja) * 1989-11-21 1995-01-25 シェリング・コーポレーション カルボキシアルキルカルボニルアミノ酸エンドペプチダーゼ阻害剤
US5075302A (en) * 1990-03-09 1991-12-24 Schering Corporation Mercaptoacyl aminolactam endopeptidase inhibitors
US5173506A (en) * 1990-08-16 1992-12-22 Schering Corporation N-(mercaptoalkyl)ureas and carbamates
TW197945B (ko) * 1990-11-27 1993-01-11 Hoechst Ag
CN1047384C (zh) * 1994-07-28 1999-12-15 北京大学 雷米普利的合成方法
PT796855E (pt) 1996-03-20 2002-07-31 Hoechst Ag Inibicao da reabsorcao nos ossos e antagonistas de vitronectina
FR2746394B1 (fr) 1996-03-20 1998-05-29 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
EP2409985A3 (en) 1996-10-18 2013-05-01 Vertex Pharmaceuticals Incorporated Inhibitors de serine proteases, especially of the NS3 protease of the hepatitis C virus
DE19653647A1 (de) 1996-12-20 1998-06-25 Hoechst Ag Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
JP3847934B2 (ja) * 1997-02-14 2006-11-22 株式会社カネカ γ−オキソ−ホモフェニルアラニン誘導体及びそれを還元してなるホモフェニルアラニン誘導体の製造方法
DE19741235A1 (de) 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19741873A1 (de) * 1997-09-23 1999-03-25 Hoechst Marion Roussel De Gmbh Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19751251A1 (de) 1997-11-19 1999-05-20 Hoechst Marion Roussel De Gmbh Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
DE19821483A1 (de) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
SE9903028D0 (sv) 1999-08-27 1999-08-27 Astra Ab New use
EP1611886A3 (en) * 1999-08-30 2008-06-04 Sanofi-Aventis Deutschland GmbH Inhibitors of the renin-angiotensin system for the prevention of cardiovascular disorders
CA2382549C (en) 1999-08-30 2005-03-15 Aventis Pharma Deutschland Gmbh Use of inhibitors of the renin-angiotensin system in the prevention of cardiovascular events
US8088060B2 (en) 2000-03-15 2012-01-03 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US9522217B2 (en) 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
SV2003000617A (es) 2000-08-31 2003-01-13 Lilly Co Eli Inhibidores de la proteasa peptidomimetica ref. x-14912m
BR0207297A (pt) 2001-02-15 2005-04-19 King Pharmaceuticals Inc Composição farmacêutica em forma sólida e método de preparar uma forma de dosagem sólida de um ingrediente farmaceuticamente ativo
US6555581B1 (en) 2001-02-15 2003-04-29 Jones Pharma, Inc. Levothyroxine compositions and methods
US20030198671A1 (en) * 2001-08-10 2003-10-23 Franz G. Andrew Levothyroxine compositions having unique plasma AUC properties
US7101569B2 (en) * 2001-08-14 2006-09-05 Franz G Andrew Methods of administering levothyroxine pharmaceutical compositions
US20030180356A1 (en) * 2001-10-29 2003-09-25 Franz G. Andrew Levothyroxine compositions having unique triiodothyronine Tmax properties
AU2002348276A1 (en) 2001-11-16 2003-06-10 Bristol-Myers Squibb Company Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein
US6407262B1 (en) 2001-11-21 2002-06-18 Brantford Chemicals Inc. Process for the preparation of Ramipril
US6812355B2 (en) 2002-10-22 2004-11-02 Sekhsaria Chemicals Limited Process for the manufacture of citalopram hydrobromide from 5-bromophthalide
BRPI0409428A (pt) * 2003-04-15 2006-04-18 Warner Lambert Co derivados de prolina bicìclicos [c]-fundidos e a sua utilização para tratar estados artrìticos
MXPA05011168A (es) * 2003-04-15 2005-12-14 Warner Lambert Co Derivados de prolina biciclicos [b]-condensados y sus usos para tratar afecciones artriticas.
US7459474B2 (en) 2003-06-11 2008-12-02 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor and method
DK1635792T3 (da) * 2003-06-26 2009-06-15 Teva Pharma Stabile farmaceutiske sammensætninger af 2-aza-bicyklo-3.3.0-oktan-3-carboxylsyrederivater
MY148123A (en) 2003-09-05 2013-02-28 Vertex Pharma Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
DE10347873B4 (de) * 2003-10-10 2005-08-04 Wirtgen Gmbh Straßenfräsmaschine mit Lenkeinrichtung
WO2005049568A1 (en) * 2003-11-24 2005-06-02 Potluri Ramesh Babu A process for industrially viable preparation of (s,s,s) phenylmethyl-2-azabicyclo-[3.3.0]-octane-3-carboxylate tosylate
JP2007518794A (ja) * 2004-01-19 2007-07-12 ルピン・リミテッド ラミプリルの結晶化方法およびその水和された形態の調製方法
WO2005067887A2 (en) * 2004-03-24 2005-07-28 Actavis Group Formulations of ramipril
PL367931A1 (en) * 2004-05-12 2005-11-14 Instytut Farmaceutyczny Method for manufacture of 2-[n-[(s)-1- etoxycarbonyl-3-phenyl propyl]-(s)-alanyl] -(1s,3s,5s)-2-azabicyclo [3.3.0] octane-3-carboxylic acid
CZ296860B6 (cs) * 2004-06-08 2006-07-12 Zentiva, A. S. Zpusob výroby ramiprilu
CA2586547A1 (en) * 2004-11-05 2006-05-11 King Pharmaceuticals Research & Development, Inc. Stabilized individually coated ramipril particles, compositions and methods
DE102005012771A1 (de) * 2005-03-19 2006-09-21 Degussa Ag Verfahren zur Herstellung von 2-Azabicyclo(3.3.0)octan-3-carbonsäurederivaten
US8399615B2 (en) * 2005-08-19 2013-03-19 Vertex Pharmaceuticals Incorporated Processes and intermediates
US7964624B1 (en) 2005-08-26 2011-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
AR055395A1 (es) 2005-08-26 2007-08-22 Vertex Pharma Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
GB0518129D0 (en) * 2005-09-06 2005-10-12 Arrow Int Ltd Ramipril formulation
US8080579B2 (en) 2005-10-03 2011-12-20 The Regents Of The University Of Michigan Compositions and methods for treatment of inflammatory bowel disease
CN100376556C (zh) * 2005-10-14 2008-03-26 浙江工业大学 2-氮杂双环[3,3,0]辛烷-3-羧酸盐酸盐的制备方法
GB2431579A (en) * 2005-10-28 2007-05-02 Arrow Int Ltd Ramipril formulations
US20070098782A1 (en) * 2005-10-28 2007-05-03 Selamine Limited Ramipril Formulation
US7592461B2 (en) 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
DE102005061756B4 (de) * 2005-12-21 2008-01-03 Sanofi-Aventis Deutschland Gmbh Verbessertes Verfahren zur Herstellung von Ramipril
CN102614490A (zh) 2006-02-27 2012-08-01 弗特克斯药品有限公司 包含vx-950的共晶体和包含所述共晶体的药物组合物
WO2007109080A2 (en) * 2006-03-16 2007-09-27 Vertex Pharmaceuticals Incorporated Deuterated hepatitis c protease inhibitors
US20070232680A1 (en) * 2006-04-04 2007-10-04 Vijayabhaskar Bolugoddu Preparation of ramipril and stable pharmaceutical compositions
RU2008145115A (ru) * 2006-04-19 2010-05-27 Тева Фармасьютикл Индастриес Лтд. (Il) Стабильные фармацевтические композиции производственных соединений 2-аза-бицикло[3.3.0]-октан-3-карбоновой кислоты
CA2661598A1 (en) * 2006-08-28 2008-03-06 Sanofi-Aventis Deutschland Gmbh Methods of lowering glucose levels
US20080096863A1 (en) * 2006-10-19 2008-04-24 Torrent Pharmaceuticals Limited Stable pharmaceutical compositions of calcium channel blocker and an ACE inhibitor
EP2099767A1 (en) 2006-11-01 2009-09-16 Brystol-Myers Squibb Company Modulators of glucocorticoid receptor, ap-1, and/or nf- b activity and use thereof
WO2008057862A2 (en) 2006-11-01 2008-05-15 Bristol-Myers Squibb Company MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-ϰB ACTIVITY AND USE THEREOF
GB0624090D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amine salts
GB0624087D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril combination salt
GB0624084D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amino acid salts
EP2102353A2 (en) * 2006-12-04 2009-09-23 DSM IP Assets B.V. Whole-cell catalytic system comprising a hydantoinase, a racemase and a carbamoylase
CA2679426A1 (en) 2007-02-27 2008-09-04 Luc Farmer Inhibitors of serine proteases
ATE542815T1 (de) 2007-02-27 2012-02-15 Vertex Pharma Kokristalle und pharmazeutische zusammensetzungen damit
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
WO2008157308A2 (en) 2007-06-13 2008-12-24 Wayne State University Board Of Governors A zwitterion solution for low-volume therapeutic delivery
WO2008157288A2 (en) 2007-06-13 2008-12-24 Wayne State University Board Of Governors A baclofen solution for low-volume therapeutic delivery
JP5443360B2 (ja) 2007-08-30 2014-03-19 バーテックス ファーマシューティカルズ インコーポレイテッド 共結晶体およびそれを含む医薬組成物
US20090076119A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched ramipril
EP2211906A2 (en) * 2007-11-07 2010-08-04 Janssen Pharmaceutica, N.V. Combination therapy comprising angiotensin converting enzyme inhibitors and vasopressin receptor antagonists
WO2009122433A2 (en) * 2008-03-13 2009-10-08 Ipca Laboratories Limited A process for preparation of ramipril
CA2726917C (en) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2009157018A2 (en) * 2008-06-24 2009-12-30 Matrix Laboratories Ltd Novel polymorphic forms of perindopril (l)-arginine and process for the preparation thereof
CN102149710A (zh) 2008-06-24 2011-08-10 百时美施贵宝公司 糖皮质激素受体、AP-1和/或NF-κB 活性的环戊噻吩调节剂及其用途
WO2010009319A2 (en) 2008-07-16 2010-01-21 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US8263784B2 (en) 2008-10-30 2012-09-11 Dsm Sinochem Pharmaceuticals Netherlands B.V. Method for the synthesis of a ramipril intermediate
TR200906322A2 (tr) 2009-08-17 2011-07-21 Bi̇lgi̇ç Mahmut Çözünürlük ve stabilite özellikleri geliştirilmiş granüller.
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US20150094345A1 (en) 2012-02-17 2015-04-02 Egis Gyogyszergyar Zrt. Pharmaceutical formulation having improved stability
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
HUP1300496A2 (hu) 2013-08-16 2015-03-02 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Stabil kombinációs gyógyszerkészítmény
WO2015027021A1 (en) 2013-08-22 2015-02-26 Bristol-Myers Squibb Company Imide and acylurea derivatives as modulators of the glucocorticoid receptor
WO2015189108A1 (en) 2014-06-11 2015-12-17 Sanofi-Aventis Deutschland Gmbh Process for the preparation of ramipril
EP3501502A1 (en) 2017-12-20 2019-06-26 Midas Pharma GmbH Fixed dosed pharmaceutical compositions comprising amlodipine, ramipril and atorvastatin

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR31741E (fr) * 1926-03-29 1927-06-10 Essuie-glace
JPS5239020B1 (ko) * 1968-10-28 1977-10-03
BE758462A (fr) * 1969-11-04 1971-05-04 Basf Ag Procede pour l'obtention de composes carbonyles beta-hydroxy etalpha-non satures
AT343125B (de) * 1976-03-24 1978-05-10 Chemie Linz Ag Verfahren zur herstellung von 3-phenylpyridazon- (6)
SU761462A1 (en) * 1978-07-31 1980-09-07 Inst Orch Khim An Armyanskoj S Method of preparing trans-cyclopentano-2,3-pyrrolidine
JPS5572169A (en) * 1978-11-27 1980-05-30 Tanabe Seiyaku Co Ltd Isoquinoline derivative and its preparation
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4294832A (en) * 1979-04-28 1981-10-13 Tanabe Seiyaku Co., Ltd. Tetrahydroisoquinoline compounds and a pharmaceutical composition thereof
FR2487829A2 (fr) * 1979-12-07 1982-02-05 Science Union & Cie Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
US4508729A (en) * 1979-12-07 1985-04-02 Adir Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
FR2491469A1 (fr) * 1980-10-02 1982-04-09 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
JPS56112359A (en) * 1980-02-08 1981-09-04 Fuji Electric Co Ltd Centralized cooling device for car electric apparatus
US4350704A (en) * 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
IE52663B1 (en) * 1980-04-02 1988-01-20 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
DE3032709A1 (de) * 1980-08-30 1982-04-29 Hoechst Ag, 6000 Frankfurt Aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
DE3177311D1 (de) * 1980-08-30 1994-06-09 Hoechst Ag Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung.
IL63813A0 (en) * 1980-09-17 1981-12-31 Univ Miami Carboxyalkyl peptides and thioethers and ethers of peptides,antihypertensive compositions and methods for their use
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
ZA817261B (en) * 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
DE19575012I2 (de) * 1980-10-23 2002-01-24 Schering Corp Carboxyalkyl-Dipeptide Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US4470972A (en) * 1981-04-28 1984-09-11 Schering Corporation 7-Carboxyalkylaminoacyl-1,4-dithia-7-azaspiro[4.4]-nonane-8-carboxylic acids
GB2086390B (en) * 1980-11-03 1984-06-06 Ciba Geigy Ag 1-carboxy-azaalkanoylindoline-2-carboxylic acids process for their manufacture pharmaceutical preparations containing these compounds and their therapeutic application
US4820729A (en) * 1981-03-30 1989-04-11 Rorer Pharmaceutical Corporation N-substituted-amido-amino acids
DE3226768A1 (de) * 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
DE3210496A1 (de) * 1982-03-23 1983-10-06 Hoechst Ag Neue derivate bicyclischer aminsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung
DE3211397A1 (de) * 1982-03-27 1983-11-10 Hoechst Ag, 6230 Frankfurt Spiro (4.(3+n))-2-aza-3-carbonsaeure-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
DE3211676A1 (de) * 1982-03-30 1983-10-06 Hoechst Ag Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung
US4490386A (en) * 1982-09-23 1984-12-25 Warner-Lambert Company Phosphate salts of 1-[2-[(1-alkoxycarbonyl-3-aralkyl)-amino]-1-oxoalkyl]octahydro-1H-indole-2-carboxylic acids, preparation of, and medical compositions thereof
DE3242151A1 (de) * 1982-11-13 1984-05-17 Hoechst Ag, 6230 Frankfurt Neue derivate tricyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung, sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung
DE3246503A1 (de) * 1982-12-16 1984-06-20 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(5.3.0)-decan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
US4468396A (en) * 1982-12-20 1984-08-28 Schering Corporation Antihypertensive benzothiadiazines
DE3300316A1 (de) * 1983-01-07 1984-07-12 Hoechst Ag, 6230 Frankfurt Disubstituierte prolinderivate, verfahren zu ihrer herstellung und ihre verwendung
DE3300774A1 (de) * 1983-01-12 1984-07-12 Hoechst Ag, 6230 Frankfurt Neue spirocyclische aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue spirocyclische aminosaeuren als zwischenprodukte und verfahren zu deren herstellung
DE3303112A1 (de) * 1983-01-31 1984-08-09 Hoechst Ag, 6230 Frankfurt Verfahren zur racemattrennung optisch aktiver bicyclischer imino-(alpha)-carbonsaeuren
DE3315464A1 (de) * 1983-04-28 1984-10-31 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
DE3322530A1 (de) * 1983-06-23 1985-01-10 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren
DE3324263A1 (de) * 1983-07-06 1985-01-17 Hoechst Ag, 6230 Frankfurt Derivate der 2-azabicyclo(3.1.0)hexan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie 2-azabicyclo(3.1.0)hexan-derivate als zwischenprodukte und verfahren zu deren herstellung
US4542234A (en) * 1983-10-06 1985-09-17 Usv Pharmaceutical Corp. Process for the separation of (S,S) diastereoisomers
US4535177A (en) * 1983-11-14 1985-08-13 Usv Pharmaceutical Corp. N-substituted amino acid derivatives
US4559340A (en) * 1983-11-25 1985-12-17 Schering Corporation Antihypertensive agents
DE3345355A1 (de) * 1983-12-15 1985-06-27 Hoechst Ag, 6230 Frankfurt Verfahren zur racematspaltung bicyclischer imino-(alpha)-carbonsaeureester
AU581919B2 (en) * 1984-07-30 1989-03-09 Schering Corporation Process for the preparation of cis, endooctahydrocyclopenta (b) pyrrole-2-carboxylate
JPH074338B2 (ja) * 1987-02-27 1995-01-25 オリンパス光学工業株式会社 内視鏡

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11289233B2 (en) 2016-04-28 2022-03-29 Kepco Nuclear Fuel Co., Ltd. Method for collecting uranium by treatment process of washing waste liquid generated in uranium hexafluoride cylinder washing process

Also Published As

Publication number Publication date
NO823674L (no) 1983-05-06
PT75792A (de) 1982-12-01
EP0079022A2 (de) 1983-05-18
DK114492A (da) 1992-09-17
DK172751B1 (da) 1999-06-28
JPH0355449B2 (ko) 1991-08-23
FI81087C (fi) 1990-09-10
JPH02104573A (ja) 1990-04-17
AU6851087A (en) 1987-05-07
HU186339B (en) 1985-07-29
CS247159B2 (en) 1986-12-18
FI81087B (fi) 1990-05-31
HU186594B (en) 1985-08-28
DE3269875D1 (en) 1986-04-17
US4879403A (en) 1989-11-07
DK166624B (da) 1993-06-21
HK74889A (en) 1989-09-22
AU585429B2 (en) 1989-06-15
JPH0694443B2 (ja) 1994-11-24
EP0079022A3 (en) 1983-10-05
IE56476B1 (en) 1991-08-14
JPH04217949A (ja) 1992-08-07
ES8308542A1 (es) 1983-09-01
ES8308541A1 (es) 1983-09-01
US4727160A (en) 1988-02-23
ES518133A0 (es) 1983-09-01
ES518132A0 (es) 1983-09-01
US5053519A (en) 1991-10-01
KR890000007B1 (ko) 1989-03-02
NL930039I1 (nl) 1993-08-02
NO156940C (no) 1987-12-23
SG1189G (en) 1993-02-19
AU6850987A (en) 1987-05-07
EP0150263A1 (de) 1985-08-07
AU9014582A (en) 1983-05-12
EP0150263B1 (de) 1990-06-20
GR77381B (ko) 1984-09-11
LU88260I2 (ko) 1994-02-03
BG60532B2 (bg) 1995-07-28
DE3226768A1 (de) 1983-05-26
DZ473A1 (fr) 2004-09-13
MA19639A1 (fr) 1983-07-01
ES517066A0 (es) 1983-08-01
AU565200B2 (en) 1987-09-10
AR240675A1 (es) 1990-08-31
JPH02104526A (ja) 1990-04-17
DD203047A5 (de) 1983-10-12
NO1995001I1 (no) 1995-03-03
FI823757A0 (fi) 1982-11-03
IL67172A (en) 1991-06-30
JPH0565508B2 (ko) 1993-09-17
CZ416291A3 (en) 1993-09-15
NL930039I2 (nl) 1993-09-16
FI823757L (fi) 1983-05-06
DK166624C (da) 1993-11-08
DK490482A (da) 1983-05-06
EP0079022B1 (de) 1986-03-12
DE3280196D1 (de) 1990-07-26
PH22417A (en) 1988-09-12
CA1187087A (en) 1985-05-14
NO156940B (no) 1987-09-14
US5061722A (en) 1991-10-29
DD219480A5 (de) 1985-03-06
NZ202378A (en) 1988-01-08
AU586316B2 (en) 1989-07-06
SU1277895A3 (ru) 1986-12-15
PH21175A (en) 1987-08-07
JO1224B1 (en) 1985-04-20
IE822636L (en) 1983-05-05
ES8307746A1 (es) 1983-08-01
DK114492D0 (da) 1992-09-17

Similar Documents

Publication Publication Date Title
KR840002354A (ko) 시스, 엔도-2-아자비사이클로-[3.3.0]-옥탄-3-카복실산 유도체의 제조방법
KR840002810A (ko) 2환성 아미노산 유도체의 제조방법
KR830006219A (ko) 아미노산 유도체의 제조방법
KR840004071A (ko) 2환성 아미노산 유도체의 제조방법
KR840001169A (ko) 항비루스성 화합물의 제조방법
ES8705415A1 (es) Procedimiento para la preparacion de nuevos acetales opticamente activos
GR3031823T3 (en) Water soluble camptothecin analogues, processes and methods.
GB1433817A (en) N-heteroarylmethyl-benzomorphane derivatives
ES8600734A1 (es) Un nuevo proceso para la preparacion de &-6-deoxi-tetraciclinas
KR840004113A (ko) 7-아실아미노-3-세펨-4- 카르복실산 유도체의 제조방법
KR840001173A (ko) 테트라히드로푸란 카르복실산 유도체의 제조방법
PT86401A (de) Verfahren zur herstellung von (<)-biotin
KR830005090A (ko) 3,7,11,15-테트라메틸-2,4,6,10,14-헥사데카펜타엔 산(酸)
KR840005122A (ko) 메틸플라본 유도체의 제조방법
KR850004743A (ko) 티아졸일 아세트산 유도체의 제조방법
KR830010048A (ko) α-할로알킬아미드의 제조방법
BG48694A3 (en) Method for preparing alkandiol- dicarboxilates
Dyke et al. Cytochalasan synthesis: total synthesis of cytochalasin G
ATE137232T1 (de) Verfahren zur herstellung von 6-hydroxy-2,5,7,8- tetraalkyl-2-(4-aminophenoxymethyl)chromanen
IN159806B (ko)
GB1366664A (en) 3 - /3 - cyanopropyl/ - cyclopenta /f/ /1/ benzopyrans and the preparation thereof
GB1497992A (en) Production of carboxy-alkane-phosphonic acids and carboxy-alkyl-phosphinic acids
KR850006177A (ko) 신남산 유도체의 제조방법
KR830002714A (ko) 테트라이이드로 이소퀴놀린 화합물의 제조방법
JPS57193437A (en) Amino acid derivative