KR840004113A - 7-아실아미노-3-세펨-4- 카르복실산 유도체의 제조방법 - Google Patents
7-아실아미노-3-세펨-4- 카르복실산 유도체의 제조방법 Download PDFInfo
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- KR840004113A KR840004113A KR1019830000930A KR830000930A KR840004113A KR 840004113 A KR840004113 A KR 840004113A KR 1019830000930 A KR1019830000930 A KR 1019830000930A KR 830000930 A KR830000930 A KR 830000930A KR 840004113 A KR840004113 A KR 840004113A
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- carboxy
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (4)
- (1) 하구 구조식(Ⅱ)의 화합물 또는 아미노기에서의 반응 유도체 또는 그의 염을 하기 구조식(Ⅲ)의 화합물 또는 카르복시기에서의 반응유도체 또는 그의 염을 반응시켜 화합물(Ⅰ) 또는 그의 염을 제조하거나, (2) 하기 구조식(I-a)의 화합물 또는 그의 염을 R2a에서의 카르복시-보호기의 제거반응에 도입하여 하기 구조식(I-b)의 화합물 또는 그의 염을 얻거나, (3) 하기 구조식(I-c)의 화합물 또는 그의 염을 R4a에 대한 카르복시-보호기의 제거반응에 도입하여 하기 구조식(I-d)의 화합물 또는 그의 염을 제조하는 것을 특징으로 하는 하기 구조식(Ⅰ)의 화합물 또는 그의 염을 제조하는 방법.상기에서, R1은 티아디졸릴이고, R2는 카르복시(저급)알킬 또는 보호된 카르복시(저급)알킬이며, R3는 수소, 할로겐 또는 저급 알케닐이며, R4는 카르복시 또는 보호된 카르복시이고, R2a는 보호된 카르복시(저급)알킬이며, R2b는 카르복시(저급)알킬이고, R4a는 보호된 카르복시기이다.
- 제1항에 있어서, 하기 구조식(Ⅱ)의 화합물, 또는 아미노기에서의 그 반응유도체 또는 그의 염을 하기 구조식(Ⅲ) 또는 카르복시기에서의 그 반응유도체 또는 그의 염을 반응시켜 하기 구조식(Ⅰ) 또는 그의 염을 제조하는 방법.상기에서, R1은 타아디아졸릴이고, R2는 카르복시(저급)알킬 또는 보호된 카르복시(저급)알킬이며, R3는 수소, 할로겐 또는 저급 알케닐이며, R4는 카르복시 또는 보호된 카르복시이다.
- 제1항에 있어서, 하기 구조식(I-a)의 화합물 또는 그의 염을 R2a에 대한 카르복시-보호기의 제거반응에 도입하여 하기 구조식(I-b)의 화합물 또는 그의 염을 제조하는 방법.상기에서, R1은 타아디아졸릴이고, R2a는 보호된 카르복시(저급)알킬이고, R2b는 카르복시알킬이고, R3는 수소, 할로겐 또는 저급 알케닐이며, R4는 카르복시 또는 보호된 카르복시이다.
- 제1항에 있어서, 하기 구조식(I-c)의 화합물 또는 그의 염을 R4a에 대한 카르복시-보호기의 제거반응에 도입하여 하기 구조식(I-d)의 화합물 또는 그의 염을 제조하는 방법.상기에서, R1은 타아디아졸릴이고, R2는 카르복시(저급)알킬 또는 보호된 카르복시(저급)알킬이며, R3는 수소, 할로겐 또는 저급 알케닐이며, R4a는 보호된 카르복시기이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/355,339 US4464369A (en) | 1977-03-14 | 1982-03-08 | 7-Acylamino-3-cephem-4-carboxylic acid derivatives and pharmaceutical compositions |
US355339 | 1982-03-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR840004113A true KR840004113A (ko) | 1984-10-06 |
Family
ID=23397090
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019830000930A KR840004113A (ko) | 1982-03-08 | 1983-03-08 | 7-아실아미노-3-세펨-4- 카르복실산 유도체의 제조방법 |
Country Status (7)
Country | Link |
---|---|
US (1) | US4464369A (ko) |
EP (1) | EP0088385A3 (ko) |
JP (1) | JPS58164594A (ko) |
KR (1) | KR840004113A (ko) |
CA (1) | CA1197234A (ko) |
DK (1) | DK63683A (ko) |
ES (1) | ES520364A0 (ko) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4609730A (en) * | 1982-11-22 | 1986-09-02 | Fujisawa Pharmaceutical Co., Ltd. | 7-[substituted imino-2-(2-aminothiazol-4-yl)-acetamido]-3(2,2-dihalovinyl or ethynyl)-3-cephem-4-carboxylic acid (syn isomers), having antimicrobial activities |
US4874856A (en) * | 1985-06-24 | 1989-10-17 | Bristol-Myers Company | 3-(substituted)propenyl-7-(aminothiazolylacetamido) ceph-3-em-4-carboxylic acids and esters thereof |
US4708955A (en) * | 1985-06-24 | 1987-11-24 | Bristol-Myers Company | 3-(substituted)propenyl-7-aminothiazol-ylcephalosporanic acids and esters thereof |
CN100524371C (zh) * | 2003-03-10 | 2009-08-05 | 迪布尔特有限公司 | 现金分发自动银行机的存物接收系统和方法 |
CN101153045B (zh) * | 2006-09-30 | 2010-06-02 | 山东轩竹医药科技有限公司 | 新型头孢菌素化合物 |
WO2013036783A2 (en) | 2011-09-09 | 2013-03-14 | Cubist Pharmaceuticals, Inc. | Methods for treating intrapulmonary infections |
US8809314B1 (en) | 2012-09-07 | 2014-08-19 | Cubist Pharmacueticals, Inc. | Cephalosporin compound |
US8476425B1 (en) | 2012-09-27 | 2013-07-02 | Cubist Pharmaceuticals, Inc. | Tazobactam arginine compositions |
US9320740B2 (en) | 2013-03-15 | 2016-04-26 | Merck Sharp & Dohme Corp. | Ceftolozane-tazobactam pharmaceutical compositions |
US9872906B2 (en) | 2013-03-15 | 2018-01-23 | Merck Sharp & Dohme Corp. | Ceftolozane antibiotic compositions |
PE20160048A1 (es) | 2013-03-15 | 2016-02-12 | Merck Sharp & Dohme | Composiciones antibioticas de ceftolozano |
AU2014233637A1 (en) | 2013-09-09 | 2015-03-26 | Merck Sharp & Dohme Corp. | Treating infections with ceftolozane/tazobactam in subjects having impaired renal function |
US8906898B1 (en) | 2013-09-27 | 2014-12-09 | Calixa Therapeutics, Inc. | Solid forms of ceftolozane |
CN106866704B (zh) * | 2017-02-08 | 2019-06-14 | 河北科技大学 | 催化氢化脱除对硝基苄酯以制备7-acca的方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3971778A (en) * | 1972-05-12 | 1976-07-27 | Glaxo Laboratories Limited | Cephalosporins having (α-etherified oximino)acylamido groups at the 7-position |
GB1592149A (en) * | 1976-10-08 | 1981-07-01 | Fujisawa Pharmaceutical Co | 3 7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for preparation thereof |
PH17188A (en) * | 1977-03-14 | 1984-06-14 | Fujisawa Pharmaceutical Co | New cephem and cepham compounds and their pharmaceutical compositions and method of use |
US4399133A (en) * | 1977-03-14 | 1983-08-16 | Fujisawa Pharmaceutical Company, Limited | Cephem compounds |
FR2387235A1 (fr) * | 1978-01-23 | 1978-11-10 | Fujisawa Pharmaceutical Co | Procede de preparation de composes d'acide 3,7-disubstitue-3-cephem-4-carboxylique et nouveaux produits ainsi obtenus, ayant une forte activite antibacterienne |
GB2025933B (en) * | 1978-06-13 | 1982-10-27 | Fujisawa Pharmaceutical Co | Cephem and cepham compounds |
ZA806977B (en) * | 1979-11-19 | 1981-10-28 | Fujisawa Pharmaceutical Co | 7-acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof |
-
1982
- 1982-03-08 US US06/355,339 patent/US4464369A/en not_active Expired - Fee Related
-
1983
- 1983-02-14 DK DK63683A patent/DK63683A/da not_active Application Discontinuation
- 1983-03-04 EP EP83102105A patent/EP0088385A3/en not_active Withdrawn
- 1983-03-07 CA CA000422967A patent/CA1197234A/en not_active Expired
- 1983-03-07 JP JP58038103A patent/JPS58164594A/ja active Granted
- 1983-03-07 ES ES520364A patent/ES520364A0/es active Granted
- 1983-03-08 KR KR1019830000930A patent/KR840004113A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ES8404360A1 (es) | 1984-04-16 |
JPH0526792B2 (ko) | 1993-04-19 |
EP0088385A2 (en) | 1983-09-14 |
US4464369A (en) | 1984-08-07 |
CA1197234A (en) | 1985-11-26 |
JPS58164594A (ja) | 1983-09-29 |
EP0088385A3 (en) | 1984-12-05 |
ES520364A0 (es) | 1984-04-16 |
DK63683A (da) | 1983-09-09 |
DK63683D0 (da) | 1983-02-14 |
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