FR2746394B1 - Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant - Google Patents

Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant

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Publication number
FR2746394B1
FR2746394B1 FR9603437A FR9603437A FR2746394B1 FR 2746394 B1 FR2746394 B1 FR 2746394B1 FR 9603437 A FR9603437 A FR 9603437A FR 9603437 A FR9603437 A FR 9603437A FR 2746394 B1 FR2746394 B1 FR 2746394B1
Authority
FR
France
Prior art keywords
medicaments
intermediates
application
pharmaceutical compositions
preparation process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR9603437A
Other languages
English (en)
Other versions
FR2746394A1 (fr
Inventor
Serge Bernard
Denis Carniato
Jean Francois Gourvest
Jean Georges Teutsch
Jochen Knolle
Hans Ulrich Stilz
Volker Wehner
C Sarah Bodary
R Thomas Gadek
S Robert Mcdowell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR9603437A priority Critical patent/FR2746394B1/fr
Priority to ARP970101095A priority patent/AR006317A1/es
Priority to HR9603437A priority patent/HRP970163A2/hr
Priority to ZA9702393A priority patent/ZA972393B/xx
Priority to APAP/P/1998/001342A priority patent/AP806A/en
Priority to ES97915519T priority patent/ES2164337T3/es
Priority to NZ331778A priority patent/NZ331778A/en
Priority to EA199800837A priority patent/EA002271B1/ru
Priority to JP53320897A priority patent/JP4091983B2/ja
Priority to SI9720021A priority patent/SI9720021A/sl
Priority to KR1019980707434A priority patent/KR20000064710A/ko
Priority to BR9708231A priority patent/BR9708231A/pt
Priority to EP97915519A priority patent/EP0888292B1/fr
Priority to AU22966/97A priority patent/AU728852B2/en
Priority to AT97915519T priority patent/ATE207889T1/de
Priority to TR1998/01846T priority patent/TR199801846T2/xx
Priority to SK1249-98A priority patent/SK282894B6/sk
Priority to CA002249471A priority patent/CA2249471A1/fr
Priority to GEAP19974530A priority patent/GEP20012516B/en
Priority to EE9800317A priority patent/EE9800317A/xx
Priority to US09/155,063 priority patent/US6221907B1/en
Priority to CN97194806A priority patent/CN1090178C/zh
Priority to CZ982888A priority patent/CZ288898A3/cs
Priority to IL12610697A priority patent/IL126106A0/xx
Priority to PCT/FR1997/000487 priority patent/WO1997034865A1/fr
Priority to PT97915519T priority patent/PT888292E/pt
Priority to DE69707843T priority patent/DE69707843T2/de
Priority to HU9902495A priority patent/HUP9902495A3/hu
Priority to PL97329034A priority patent/PL329034A1/xx
Priority to DK97915519T priority patent/DK0888292T3/da
Priority to TW086113848A priority patent/TW458963B/zh
Publication of FR2746394A1 publication Critical patent/FR2746394A1/fr
Priority to LVP-98-209A priority patent/LV12207B/lv
Application granted granted Critical
Publication of FR2746394B1 publication Critical patent/FR2746394B1/fr
Priority to YU40898A priority patent/YU40898A/sh
Priority to BG102778A priority patent/BG63569B1/bg
Priority to NO19984352A priority patent/NO312459B1/no
Priority to OA9800175A priority patent/OA11603A/fr
Priority to LT98-145A priority patent/LT4535B/lt
Priority to CN02141265A priority patent/CN1401621A/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/12—Nitrogen atoms not forming part of a nitro radical
    • C07D239/18—Nitrogen atoms not forming part of a nitro radical with hetero atoms attached to said nitrogen atoms, except nitro radicals, e.g. hydrazine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/06—Compounds containing any of the groups, e.g. semicarbazides
    • C07C281/08—Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones
    • C07C281/12—Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones the carbon atom being part of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
    • C07C331/02—Thiocyanates
    • C07C331/04—Thiocyanates having sulfur atoms of thiocyanate groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
    • C07C331/02—Thiocyanates
    • C07C331/10—Thiocyanates having sulfur atoms of thiocyanate groups bound to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
    • C07C331/02—Thiocyanates
    • C07C331/12—Thiocyanates having sulfur atoms of thiocyanate groups bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
    • C07C331/02—Thiocyanates
    • C07C331/14—Thiocyanates having sulfur atoms of thiocyanate groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C337/00—Derivatives of thiocarbonic acids containing functional groups covered by groups C07C333/00 or C07C335/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C337/06—Compounds containing any of the groups, e.g. thiosemicarbazides
    • C07C337/08—Compounds containing any of the groups, e.g. thiosemicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. thiosemicarbazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/516—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of nitrogen-containing compounds to >C = O groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/52—Nitrogen atoms not forming part of a nitro radical with hetero atoms directly attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
FR9603437A 1996-03-20 1996-03-20 Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant Expired - Lifetime FR2746394B1 (fr)

Priority Applications (38)

Application Number Priority Date Filing Date Title
FR9603437A FR2746394B1 (fr) 1996-03-20 1996-03-20 Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
HR9603437A HRP970163A2 (en) 1996-03-20 1997-03-19 Novel tricyclic compounds, process for the preparation and intermediates thereof, the application thereof as medicaments ans pharmaceutical preparations containing them
ZA9702393A ZA972393B (en) 1996-03-20 1997-03-19 Tricyclic compounds, their preparation process and the intermediates of this process, their use a medicaments and the pharmaceutical compositions containing them.
ARP970101095A AR006317A1 (es) 1996-03-20 1997-03-19 Compuestos triciclicos, su procedimiento de preparacion y los intermedios de este procedimiento, su aplicacion a titulo de medicamentos y lascomposiciones farmaceuticas que los contienen
IL12610697A IL126106A0 (en) 1996-03-20 1997-03-20 Tricyclic compounds having activity specific for integrins particularly alpha vbeta3 integrins method for preparing same intermediates therefor use of said compounds as drugs and pharmaceutical compounds containing same
NZ331778A NZ331778A (en) 1996-03-20 1997-03-20 Tricyclic compounds having activity specific for integrins, particularly avb3 integrins, method for preparing same, intermediates therefore, use of said compounds as drugs, and pharmaceutical compositions containing same
EA199800837A EA002271B1 (ru) 1996-03-20 1997-03-20 ТРИЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ, ОБЛАДАЮЩИЕ АКТИВНОСТЬЮ В ОТНОШЕНИИ ИНТЕГРИНОВ, В ЧАСТНОСТИ В ОТНОШЕНИИ ИНТЕГРИНА АЛЬФАvБЕТА 3, СПОСОБ ИХ ПОЛУЧЕНИЯ И ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ, ИСПОЛЬЗУЕМЫЕ В ЭТОМ СПОСОБЕ, ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ МЕДИКАМЕНТОВ И СОДЕРЖАЩИЕ ИХ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ
JP53320897A JP4091983B2 (ja) 1996-03-20 1997-03-20 新規な三環式化合物、それらの製造方法及びこの方法の中間体、それらの薬剤としての使用並びにそれらを含有する製薬組成物
SI9720021A SI9720021A (sl) 1996-03-20 1997-03-20 Triciklične spojine s specifično aktivnostjo za integrine, zlasti za integrine alfavbeta3, postopki za njihovo pripravo in intermediati teh postopkov, njihova aplikacija kot zdravila in farmacevtski sestavki, ki jih vsebujejo
KR1019980707434A KR20000064710A (ko) 1996-03-20 1997-03-20 인테그린, 특히 ανβ3 인테그린에 대하여 특이 활성을갖는 3환식 화합물, 그 제조방법 및 그 제조를 위한 중간체, 의약으로서의 그 용도 및 그를 포함한 약제 조성물
BR9708231A BR9708231A (pt) 1996-03-20 1997-03-20 Compostos tricíclicos que têm uma atividade face a integrinas principalmente face à integrina alfavbeta3 seu processo de preparação e os intermediários desse processo sua aplicação a título de medicamentos e composiçóes farmacêuticas que os contêm
EP97915519A EP0888292B1 (fr) 1996-03-20 1997-03-20 COMPOSES TRICYCLIQUES AYANT UNE ACTIVITE VIS-A-VIS DES INTEGRINES NOTAMMENT VIS-A-VIS DE L'INTEGRINE ALPHA vBETA3, LEUR PROCEDE DE PREPARATION ET LES INTERMEDIAIRES DE CE PROCEDE, LEUR APPLICATION A TITRE DE MEDICAMENTS ET LES COMPOSITIONS PHARMACEUTIQUES LES RENFERMANT
AU22966/97A AU728852B2 (en) 1996-03-20 1997-03-20 Tricyclic compounds having an activity vis-a-vis integrins in particular vis-a-vis alphavbeta3 integrins, their preparation process and inttermediates of this process, their use as medicaments and the pharmaceutical compositions containing them
AT97915519T ATE207889T1 (de) 1996-03-20 1997-03-20 Trizyclische verbindungen mit wirkung auf integrine, besonders auf das alphavbeta3-integrin,verfahren zur ihrer herstellung und zwischenprodukte des verfahrens, ihre verwendung als arzneimittel und sie enthaltende pharmazeutische zusammensetzungen
TR1998/01846T TR199801846T2 (xx) 1996-03-20 1997-03-20 �ntegrinlere �zg� aktiviteye sahip trisiklik bile�ikler.
SK1249-98A SK282894B6 (sk) 1996-03-20 1997-03-20 Tricyklické zlúčeniny, spôsob ich prípravy a medziprodukty tohto spôsobu, ich použitie ako liečiv a farmaceutické zmesi, ktoré ich obsahujú
CA002249471A CA2249471A1 (fr) 1996-03-20 1997-03-20 Composes tricycliques ayant une activite vis-a-vis des integrines notamment vis-a-vis de l'integrine alphavbeta3, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
GEAP19974530A GEP20012516B (en) 1996-03-20 1997-03-20 Tricyclic Compounds Having Activity Specific for Integring, Particularly , avB3 Integrins, Method for Preparation the Same as Drugs and Pharmaceutical Composition Containing Same
EE9800317A EE9800317A (et) 1996-03-20 1997-03-20 Integriinide, eriti avß3-integriinide suhtes spetsiifilise aktiivsusega tritsüklilised ühendid, nende valmistamismeetod ja vaheühendid, nende kasutamine ravimitena ning neid sisaldavad farmatseutilised kompositsioonid
US09/155,063 US6221907B1 (en) 1996-03-20 1997-03-20 Tricyclic compounds having activity specific for integrins, particularly alphanubeta3 integrins, method for preparing same, intermediates therefor, use of said compounds as drugs, and pharmaceutical compositions containing same
APAP/P/1998/001342A AP806A (en) 1996-03-20 1997-03-20 Tricyclic compounds having activity specific for integrins, particularly avB3 integrins, method for preparing same, intermediates therefor, use of said compounds as drugs, and pharmaceutical compositions containing same.
CZ982888A CZ288898A3 (cs) 1996-03-20 1997-03-20 Nové tricyklické sloučeniny, způsob jejich přípravy a meziprodukty tohoto způsobu, jejich použití jako léčiv a farmaceutické směsi, které je obsahují
ES97915519T ES2164337T3 (es) 1996-03-20 1997-03-20 Compuestos triciclicos que tienen actividad frente a integrinas, especialmente frente a la integrina alfa vbeta3, su procedimiento de preparacion y los productos intermedios de este procedimiento, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen.
PCT/FR1997/000487 WO1997034865A1 (fr) 1996-03-20 1997-03-20 COMPOSES TRICYCLIQUES AYANT UNE ACTIVITE VIS-A-VIS DES INTEGRINES NOTAMMENT VIS-A-VIS DE L'INTEGRINE ALPHA vBETA3, LEUR PROCEDE DE PREPARATION ET LES INTERMEDIAIRES DE CE PROCEDE, LEUR APPLICATION A TITRE DE MEDICAMENTS ET LES COMPOSITIONS PHARMACEUTIQUES LES RENFERMANT
PT97915519T PT888292E (pt) 1996-03-20 1997-03-20 Compostos triciclicos tendo uma actividade em relacao as integrinas em especial em relacao a integrina alfavbeta3 processo para a sua preparacao e os intermediarios deste processo sua aplicacao como medicamentos e composicoes farmaceuticas que os contem
DE69707843T DE69707843T2 (de) 1996-03-20 1997-03-20 TRIZYCLISCHE VERBINDUNGEN MIT WIRKUNG AUF INTEGRINE, BESONDERS AUF DAS ALPHAvBETA3-INTEGRIN, VERFAHREN ZUR IHRER HERSTELLUNG UND ZWISCHENPRODUKTE DES VERFAHRENS, IHRE VERWENDUNG ALS ARZNEIMITTEL UND SIE ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN
HU9902495A HUP9902495A3 (en) 1996-03-20 1997-03-20 Tricyclic compounds, method for preparing same, intermediates therefor, and pharmaceutical compositions
PL97329034A PL329034A1 (en) 1996-03-20 1997-03-20 Novel tricyclic compounds, method of obtaining them
DK97915519T DK0888292T3 (da) 1996-03-20 1997-03-20 Tricykliske forbindelser med virkning over for integriner, især alphavbeta3 integriner, fremgangsmåde til deres fremstilling, mellemprodukter deraf, deres anvendelse som lægemidler og farmaceutiske præparater med indhold deraf
CN97194806A CN1090178C (zh) 1996-03-20 1997-03-20 对整联蛋白,特别是ανβ3整联蛋白具有特异性活性的三环化合物,它们的制备方法和这种方法的中间体，它们作为药物的用途以及含有它们的药物组合物
TW086113848A TW458963B (en) 1996-03-20 1997-09-23 2,3,5,6-tetrahydro-benz[e]azulen derivatives inhibiting the binding of vitronectin receptor Α v β3 or other integrins having vitronectin as ligand to their natural ligand, their preparation process and the pharmaceutical compositions
LVP-98-209A LV12207B (lv) 1996-03-20 1998-01-07 Tricikliski savienojumi
YU40898A YU40898A (sh) 1996-03-20 1998-09-18 TRICIKLIČNA JEDINJENJA KOJA POSEDUJU SPECIFIČNU AKTIVNOST ZA INTEGRINE, NAROČITO αγβ3 INTEGRINE, POSTUPAK ZA NJIHOVO DOBIJANJE NJIHOVI INTERMEDIJERI NJIHOVA PRIMENA KAO LEKOVA, FARMACEUTSKI PREPARATI KOJI IH SADRŽE
OA9800175A OA11603A (fr) 1996-03-20 1998-09-18 Composés tricycliques ayant une activité vis-à-visdes intégrines notamment vis-à-vis de l'intégrine ALPHAvBETA3, leur procédé de préparation et les i ntermédiaires de ce procédé, leur application à titre de médicaments et les compositions pharmaceutiques les renfermant.
NO19984352A NO312459B1 (no) 1996-03-20 1998-09-18 Trisykliske forbindelser med aktivitet spesifikk for integriner, i s¶rdeleshet <alfa>v<beta>3-integriner, fremgangsmåtefor fremstilling av disse, mellomprodukter ved fremgangsmåten,anvendelse av forbindelsene for fremstilling av legemidler og
BG102778A BG63569B1 (bg) 1996-03-20 1998-09-18 Трициклени съединения с активност спрямо интегрини, по-специално спрямо алфаvбета3 интегрини, методза получаването им, използването им като лекарствени средства и фармацевтични състави, които ги съдържат
LT98-145A LT4535B (lt) 1996-03-20 1998-10-15 Tricikliai junginiai, pasižymintys specifiniu aktyvumu integrinams, būtent 3 integrinui, jų gavimo būdas, tarpiniai jungiai šiems junginiams gauti, jų panaudojimas vaistams ir farmacinės kompozicijos, į kurias įeina šie junginiai
CN02141265A CN1401621A (zh) 1996-03-20 2002-06-27 用于制备三环化合物的中间体以及该中间体的制备方法

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HR (1) HRP970163A2 (fr)
HU (1) HUP9902495A3 (fr)
IL (1) IL126106A0 (fr)
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DE3044236A1 (de) 1980-11-25 1982-06-16 Hoechst Ag, 6000 Frankfurt Aminosaeurederivate und verfahren zu ihrer herstellung
FR2503155A2 (fr) 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2487829A2 (fr) 1979-12-07 1982-02-05 Science Union & Cie Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
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FR2492381A1 (fr) 1980-10-21 1982-04-23 Science Union & Cie Nouveaux acides aza bicyclo alcane carboxyliques substitues leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
DE3174844D1 (en) 1980-10-23 1986-07-24 Schering Corp Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
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DE3246503A1 (de) 1982-12-16 1984-06-20 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(5.3.0)-decan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
DE3643012A1 (de) 1986-12-17 1988-06-30 Hoechst Ag 2,3-disubstituierte isoxazolidine, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
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JPH10504825A (ja) * 1994-08-22 1998-05-12 スミスクライン・ビーチャム・コーポレイション 二環式化合物
FR2731217B1 (fr) 1995-03-03 1997-06-13 Roussel Uclaf Nouveaux derives tricycliques, leur preparation, leur application a la preparation de la colchicine et de la thiocolchicine optiquement actives ou racemiques et d'analogues ou derives et intermediaires

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PT888292E (pt) 2002-04-29
LT98145A (en) 1999-03-25
AR006317A1 (es) 1999-08-25
OA11603A (fr) 2004-08-11
IL126106A0 (en) 1999-05-09
CZ288898A3 (cs) 1999-03-17
PL329034A1 (en) 1999-03-01
HRP970163A2 (en) 1998-08-31
HUP9902495A3 (en) 2001-07-30
TR199801846T2 (xx) 1998-12-21
ES2164337T3 (es) 2002-02-16
FR2746394A1 (fr) 1997-09-26
HUP9902495A2 (hu) 1999-11-29
LT4535B (lt) 1999-08-25
ZA972393B (en) 1998-03-19
CN1219165A (zh) 1999-06-09
CN1090178C (zh) 2002-09-04
TW458963B (en) 2001-10-11
YU40898A (sh) 1999-09-27
CN1401621A (zh) 2003-03-12

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