FR2745570B1 - Nouveaux derives soufres comportant une liaison retroamide, leur procede et intermediaires de preparation, leur application a titre de medicaments, et les compositions pharmaceutiques les renfermant - Google Patents

Nouveaux derives soufres comportant une liaison retroamide, leur procede et intermediaires de preparation, leur application a titre de medicaments, et les compositions pharmaceutiques les renfermant

Info

Publication number
FR2745570B1
FR2745570B1 FR9602674A FR9602674A FR2745570B1 FR 2745570 B1 FR2745570 B1 FR 2745570B1 FR 9602674 A FR9602674 A FR 9602674A FR 9602674 A FR9602674 A FR 9602674A FR 2745570 B1 FR2745570 B1 FR 2745570B1
Authority
FR
France
Prior art keywords
retroamide
medicaments
intermediates
binding
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9602674A
Other languages
English (en)
Other versions
FR2745570A1 (fr
Inventor
Pierre Deprez
Jacques Dumas
Jacques Guillaume
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9602674A priority Critical patent/FR2745570B1/fr
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to IL12596197A priority patent/IL125961A0/xx
Priority to AU19307/97A priority patent/AU722680B2/en
Priority to KR1019980706913A priority patent/KR19990087485A/ko
Priority to PCT/FR1997/000369 priority patent/WO1997032849A1/fr
Priority to CN97194386A priority patent/CN1217713A/zh
Priority to EP97907159A priority patent/EP0888299A1/fr
Priority to TR1998/01750T priority patent/TR199801750T2/xx
Priority to PL97328705A priority patent/PL328705A1/xx
Priority to CA002248188A priority patent/CA2248188A1/fr
Priority to US09/142,288 priority patent/US6420341B1/en
Priority to BR9707908A priority patent/BR9707908A/pt
Priority to RU98118188/14A priority patent/RU2215526C2/ru
Priority to JP9531513A priority patent/JP2000506156A/ja
Publication of FR2745570A1 publication Critical patent/FR2745570A1/fr
Application granted granted Critical
Publication of FR2745570B1 publication Critical patent/FR2745570B1/fr
Priority to NO984048A priority patent/NO984048L/no
Priority to US10/052,416 priority patent/US20020161030A1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
FR9602674A 1996-03-04 1996-03-04 Nouveaux derives soufres comportant une liaison retroamide, leur procede et intermediaires de preparation, leur application a titre de medicaments, et les compositions pharmaceutiques les renfermant Expired - Fee Related FR2745570B1 (fr)

Priority Applications (16)

Application Number Priority Date Filing Date Title
FR9602674A FR2745570B1 (fr) 1996-03-04 1996-03-04 Nouveaux derives soufres comportant une liaison retroamide, leur procede et intermediaires de preparation, leur application a titre de medicaments, et les compositions pharmaceutiques les renfermant
US09/142,288 US6420341B1 (en) 1996-03-04 1997-03-03 Sulphur derivatives with a retroamide bond as endothelin-converting enzyme inhibitors
KR1019980706913A KR19990087485A (ko) 1996-03-04 1997-03-03 엔도텔린 전환 효소 억제제로서 레트로아미드 결합을 가진 황유도체
PCT/FR1997/000369 WO1997032849A1 (fr) 1996-03-04 1997-03-03 Derives soufres comportant une liaison retroamide comme inhibiteurs d'enzymes de conversion d'endotheline
CN97194386A CN1217713A (zh) 1996-03-04 1997-03-03 用作内皮素转化酶抑制剂的含逆向酰胺键的硫衍生物
EP97907159A EP0888299A1 (fr) 1996-03-04 1997-03-03 Derives soufres comportant une liaison retroamide comme inhibiteurs d'enzymes de conversion d'endotheline
TR1998/01750T TR199801750T2 (xx) 1996-03-04 1997-03-03 Retroamid ba�l� k�k�rt t�revleri.
PL97328705A PL328705A1 (en) 1996-03-04 1997-03-03 Novel sulphuric derivatives containing retroamide bonds, method of obtaining them, their application as drugs and pharmaceutic agents containing such derivatives
IL12596197A IL125961A0 (en) 1996-03-04 1997-03-03 Sulphur derivatives with a retroamide bond as endothelin-converting enzyme inhibitors
AU19307/97A AU722680B2 (en) 1996-03-04 1997-03-03 Sulphur derivatives with a retroamide bond as endothelin-coating enzyme inhibitors
BR9707908A BR9707908A (pt) 1996-03-04 1997-03-03 Derivados sulfurados que contêm uma ligação retroamida como inibidores de enzimas de conversão de endotelina
RU98118188/14A RU2215526C2 (ru) 1996-03-04 1997-03-03 Серосодержащие производные с ретроамидной связью в качестве ингибиторов эндотелинпревращающих ферментов
JP9531513A JP2000506156A (ja) 1996-03-04 1997-03-03 エンドセリン転化酵素の阻害剤としてのレトロアミド結合を含有する新規の硫黄誘導体
CA002248188A CA2248188A1 (fr) 1996-03-04 1997-03-03 Derives soufres comportant une liaison retroamide comme inhibiteurs d'enzymes de conversion d'endotheline
NO984048A NO984048L (no) 1996-03-04 1998-09-03 Svovelderivater med en retroamidbinding som endotelinomdannende enzyminhibitorer
US10/052,416 US20020161030A1 (en) 1996-03-04 2002-01-16 Sulpur derivatives containing a retroamide bond as inhibitors of endothelin-converting enzymes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9602674A FR2745570B1 (fr) 1996-03-04 1996-03-04 Nouveaux derives soufres comportant une liaison retroamide, leur procede et intermediaires de preparation, leur application a titre de medicaments, et les compositions pharmaceutiques les renfermant

Publications (2)

Publication Number Publication Date
FR2745570A1 FR2745570A1 (fr) 1997-09-05
FR2745570B1 true FR2745570B1 (fr) 1998-06-19

Family

ID=9489807

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9602674A Expired - Fee Related FR2745570B1 (fr) 1996-03-04 1996-03-04 Nouveaux derives soufres comportant une liaison retroamide, leur procede et intermediaires de preparation, leur application a titre de medicaments, et les compositions pharmaceutiques les renfermant

Country Status (15)

Country Link
US (2) US6420341B1 (fr)
EP (1) EP0888299A1 (fr)
JP (1) JP2000506156A (fr)
KR (1) KR19990087485A (fr)
CN (1) CN1217713A (fr)
AU (1) AU722680B2 (fr)
BR (1) BR9707908A (fr)
CA (1) CA2248188A1 (fr)
FR (1) FR2745570B1 (fr)
IL (1) IL125961A0 (fr)
NO (1) NO984048L (fr)
PL (1) PL328705A1 (fr)
RU (1) RU2215526C2 (fr)
TR (1) TR199801750T2 (fr)
WO (1) WO1997032849A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19745151A1 (de) * 1997-10-14 1999-04-15 Basf Ag Neue Verbindungen zur Behandlung von Krankheiten, die mit der biologischen Wirkung von Endothelin assoziiert sind
IL138688A0 (en) * 1998-04-23 2001-10-31 Novartis Ag Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme
US6426354B1 (en) 1998-04-23 2002-07-30 Novartis Ag Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme
US6423727B1 (en) 1998-04-23 2002-07-23 Novartis Ag Certain thiol inhibitors of endothelin-converting enzyme
JP2006511562A (ja) * 2002-12-20 2006-04-06 バイエル・ヘルスケア・アクチェンゲゼルシャフト 泌尿器系疾患の処置のための置換２，５−ジアミドインドール類の使用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1298307C (fr) * 1984-04-02 1992-03-31 Norma G. Delaney Inhibiteurs de l'encephalinase
CA1337400C (fr) * 1987-06-08 1995-10-24 Norma G. Delaney Inhibiteurs de l'endopeptidase neutre
CA2043741C (fr) * 1990-06-07 2003-04-01 Kiyofumi Ishikawa Derives de peptides antagonistes d'endotheline
IT1266571B1 (it) * 1993-07-30 1997-01-09 Zambon Spa Derivati della beta-mercapto-propanammide utili nel trattamento delle malattie cardiovascolari

Also Published As

Publication number Publication date
NO984048L (no) 1998-11-03
US6420341B1 (en) 2002-07-16
RU2215526C2 (ru) 2003-11-10
IL125961A0 (en) 1999-04-11
US20020161030A1 (en) 2002-10-31
BR9707908A (pt) 1999-07-27
FR2745570A1 (fr) 1997-09-05
AU1930797A (en) 1997-09-22
KR19990087485A (ko) 1999-12-27
AU722680B2 (en) 2000-08-10
CN1217713A (zh) 1999-05-26
WO1997032849A1 (fr) 1997-09-12
CA2248188A1 (fr) 1997-09-12
PL328705A1 (en) 1999-02-15
NO984048D0 (no) 1998-09-03
EP0888299A1 (fr) 1999-01-07
TR199801750T2 (xx) 1999-02-22
JP2000506156A (ja) 2000-05-23

Similar Documents

Publication Publication Date Title
EE03263B1 (et) Erütromütsiini derivaadid, nende valmistamismeetod, farmatseutiline kompositsioon ja vaheühendid
EE9500064A (et) Asendatud 1H-imidasoolid, nende valmistamismeetodid ja farmatseutilised kompositsioonid
FR2727411B1 (fr) Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent
HUP0102307A3 (en) Bispidine derivatives, process for their preparation, pharmaceutical compositions thereof and intermediates
MA26433A1 (fr) Derives de pyridylpyrrole, procede pour leur preparation et compositions pharmaceutiques les contenant
MA26558A1 (fr) Derives nouveaux de 6-0-methylerythromycine a, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2796644B1 (fr) Nouveaux derives de beta-carboline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EE9900112A (et) 2-tsüanoiminoimidasooli derivaadid, nende valmistamismeetod, kasutamine ja farmatseutilised kompositsioonid
MA26501A1 (fr) Derives de quinoleine nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
FI950625A (fi) Polysubstituoituja 3-asyyliamino-5-fenyyli-1,4-bentsodiatsepiini-2-onijohdannaisia, menetelmä niiden valmistamiseksi ja niitä sisältäviä farmaseuttisia koostumuksia
FR2757166B1 (fr) Derives du pyrrole, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2720397B1 (fr) Nouveaux oxathiolanes, leur procédé de préparation et les compositions pharmaceutiques qui en renferment.
FR2750988B1 (fr) Nouveaux derives de 2-(1h)-quinoleinone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2747680B1 (fr) Nouveaux steroides, leur application a titre de medicaments, leur procede de preparation, les intermediaires de ce procede et les compositions pharmaceutiques les renfermant
FR2745570B1 (fr) Nouveaux derives soufres comportant une liaison retroamide, leur procede et intermediaires de preparation, leur application a titre de medicaments, et les compositions pharmaceutiques les renfermant
FR2772761B1 (fr) Nouveaux derives de n-phenylamide et n-pyridylamide, leur procede de preparation et compositions pharmaceutiques les contenant
MA26441A1 (fr) Derives de pyrrolidinyl- et pyrrolinyl- ethylamine, procede pour leur preparation et compositions pharmaceutiques les contenant
MA26583A1 (fr) Derives de benzamide nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2691459B1 (fr) Nouveaux derives de la phenothiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2733498B1 (fr) Nouveaux composes cyclohexaniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2761992B1 (fr) Nouveaux steroides 4-halogenes, leur procede et intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
EE200000336A (et) Ehhinokandiini derivaadid, nende valmistamismeetod, vaheühendid ja farmatseutilised kompositsioonid
FR2740135B1 (fr) Nouveaux derives de pyrazoles acides, leur procede de preparation, leur application a titre de medicaments, leur nouvelle utilisation et les compositions pharmaceutiques les renfermant
FR2772766B1 (fr) Nouveaux composes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2723947B1 (fr) Nouveaux composes tetrahydropyraniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Legal Events

Date Code Title Description
TP Transmission of property
TP Transmission of property
ST Notification of lapse