NO984048L - Svovelderivater med en retroamidbinding som endotelinomdannende enzyminhibitorer - Google Patents

Svovelderivater med en retroamidbinding som endotelinomdannende enzyminhibitorer

Info

Publication number
NO984048L
NO984048L NO984048A NO984048A NO984048L NO 984048 L NO984048 L NO 984048L NO 984048 A NO984048 A NO 984048A NO 984048 A NO984048 A NO 984048A NO 984048 L NO984048 L NO 984048L
Authority
NO
Norway
Prior art keywords
endothelin
converting enzyme
enzyme inhibitors
sulfur derivatives
retroamide
Prior art date
Application number
NO984048A
Other languages
English (en)
Other versions
NO984048D0 (no
Inventor
Pierre Deprez
Jacques Dumas
Jacques Guillaume
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of NO984048D0 publication Critical patent/NO984048D0/no
Publication of NO984048L publication Critical patent/NO984048L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)

Abstract

Produkter av formel (I) HS¿(CH,)n.-------'----NH ¿C----\----(NH)n2------A (I), O n © hvori R! i særdeleshet er fenyl eller bifenyl eventuelt substituert med halo- gen, HJ og n2 er O eller l, R2 er i sær- deleshet hydrogen eller metyl substitu- ert med fenyl, som i sin tur kan være substituert, og A er i særdeleshet karboksy eller alkyl substituert i sær- deleshet med fenoksy, så vel som alle isomerer og organiske og uorganiske baseaddisjonssalter derav, er be- skrevet.
NO984048A 1996-03-04 1998-09-03 Svovelderivater med en retroamidbinding som endotelinomdannende enzyminhibitorer NO984048L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9602674A FR2745570B1 (fr) 1996-03-04 1996-03-04 Nouveaux derives soufres comportant une liaison retroamide, leur procede et intermediaires de preparation, leur application a titre de medicaments, et les compositions pharmaceutiques les renfermant
PCT/FR1997/000369 WO1997032849A1 (fr) 1996-03-04 1997-03-03 Derives soufres comportant une liaison retroamide comme inhibiteurs d'enzymes de conversion d'endotheline

Publications (2)

Publication Number Publication Date
NO984048D0 NO984048D0 (no) 1998-09-03
NO984048L true NO984048L (no) 1998-11-03

Family

ID=9489807

Family Applications (1)

Application Number Title Priority Date Filing Date
NO984048A NO984048L (no) 1996-03-04 1998-09-03 Svovelderivater med en retroamidbinding som endotelinomdannende enzyminhibitorer

Country Status (15)

Country Link
US (2) US6420341B1 (no)
EP (1) EP0888299A1 (no)
JP (1) JP2000506156A (no)
KR (1) KR19990087485A (no)
CN (1) CN1217713A (no)
AU (1) AU722680B2 (no)
BR (1) BR9707908A (no)
CA (1) CA2248188A1 (no)
FR (1) FR2745570B1 (no)
IL (1) IL125961A0 (no)
NO (1) NO984048L (no)
PL (1) PL328705A1 (no)
RU (1) RU2215526C2 (no)
TR (1) TR199801750T2 (no)
WO (1) WO1997032849A1 (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19745151A1 (de) * 1997-10-14 1999-04-15 Basf Ag Neue Verbindungen zur Behandlung von Krankheiten, die mit der biologischen Wirkung von Endothelin assoziiert sind
US6423727B1 (en) 1998-04-23 2002-07-23 Novartis Ag Certain thiol inhibitors of endothelin-converting enzyme
US6426354B1 (en) 1998-04-23 2002-07-30 Novartis Ag Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme
PT1080104E (pt) * 1998-04-23 2005-06-30 Novartis Ag Certos tiois heteroarilo substituidos inibidores da enzima conversora da endotelina
EP1578418A2 (en) * 2002-12-20 2005-09-28 Bayer HealthCare AG Use of substituted 2,5-diamidoindoles for the treatment of urological diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE30415T1 (de) * 1984-04-02 1987-11-15 Squibb & Sons Inc Enkephalinas-inhibitoren.
CA1337400C (en) * 1987-06-08 1995-10-24 Norma G. Delaney Inhibitors of neutral endopeptidase
CA2043741C (en) * 1990-06-07 2003-04-01 Kiyofumi Ishikawa Endothelin antagonistic peptide derivatives
IT1266571B1 (it) * 1993-07-30 1997-01-09 Zambon Spa Derivati della beta-mercapto-propanammide utili nel trattamento delle malattie cardiovascolari

Also Published As

Publication number Publication date
FR2745570B1 (fr) 1998-06-19
AU1930797A (en) 1997-09-22
TR199801750T2 (xx) 1999-02-22
NO984048D0 (no) 1998-09-03
CA2248188A1 (fr) 1997-09-12
RU2215526C2 (ru) 2003-11-10
EP0888299A1 (fr) 1999-01-07
US6420341B1 (en) 2002-07-16
JP2000506156A (ja) 2000-05-23
AU722680B2 (en) 2000-08-10
KR19990087485A (ko) 1999-12-27
CN1217713A (zh) 1999-05-26
BR9707908A (pt) 1999-07-27
US20020161030A1 (en) 2002-10-31
FR2745570A1 (fr) 1997-09-05
WO1997032849A1 (fr) 1997-09-12
PL328705A1 (en) 1999-02-15
IL125961A0 (en) 1999-04-11

Similar Documents

Publication Publication Date Title
NO179142C (no) 3-benzyliden-1-karbamoyl-2-pyrrolidon-analoger
EP0513387A4 (en) Active oxygen inhibitor
ES2213831T3 (es) Inhibidores de cisteina-proteasa.
DE69814375D1 (de) Fungizide trifluoromethylalkylamino-triazolopyrimidine-derivate
TW349843B (en) Substituted 1-arylpyrazoles
DE68913930D1 (de) Serotonin- und Norepinephrin-Aufnahme-Inhibitoren.
DK51986D0 (da) Heterocycliske forbindelser, deres fremstilling og anvendelse som insecticide midler
ATE158288T1 (de) Antiatherosklerotische und antithrombotische 1- benzopyran-4-on- und 2-amino-1,3-benzoxazin-4-on- derivate
BR0001569A (pt) Inibidores da uroquinase do tipo 2-piridinilguanidina
DK0518558T3 (da) 1-methylcarbapenemderivater, deres fremstilling og deres anvendelse som antibiotika
NO984048L (no) Svovelderivater med en retroamidbinding som endotelinomdannende enzyminhibitorer
DE69024397T2 (de) Diaminoethylen-Verbindungen
CA2289787A1 (en) Fungicidal mixtures
DK592688A (da) Benz(thi)amidderivater, deres fremstilling og anvendelse som fungicider
ES2013035A6 (es) Un metodo para preparar derivados de acilfenol.
DE68920717D1 (de) Reaktivfarbstoffe.
MX9701949A (es) Derivados de distamicina substituidos con bis-(2-haloetil) aminofenilo como agentes antitumorales y antivirales.
DE69122812D1 (de) Glutathionderivat
PL290676A1 (en) Method of obtaining novel derivatives of 2-aminoalkyl-5-diaryl-alkyl-1.3-dioxane
DE69303350D1 (de) Aromatische Amine Derivate von 2,5-Dimercapto-1,3,4-Thiadiazolen.
DK0719760T3 (da) Naphthalenderivater og deres anvendelse som PGE2-agonister og -antagonister
ATE110378T1 (de) Heterocyclische nitromethanderivate.
CO5011097A1 (es) Derivados de 8-azabiciclo [3.2.1]octan-3-metanamina .
NO954769L (no) 3-(indol-3-yl)propensyrederivater som NMDA-antagonister
EA200000681A1 (ru) Фунгицидная смесь на базе амидных соединений и производных пиридина