CN1090178C - 对整联蛋白,特别是ανβ3整联蛋白具有特异性活性的三环化合物,它们的制备方法和这种方法的中间体,它们作为药物的用途以及含有它们的药物组合物 - Google Patents
对整联蛋白,特别是ανβ3整联蛋白具有特异性活性的三环化合物,它们的制备方法和这种方法的中间体,它们作为药物的用途以及含有它们的药物组合物 Download PDFInfo
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- CN1090178C CN1090178C CN97194806A CN97194806A CN1090178C CN 1090178 C CN1090178 C CN 1090178C CN 97194806 A CN97194806 A CN 97194806A CN 97194806 A CN97194806 A CN 97194806A CN 1090178 C CN1090178 C CN 1090178C
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- 159000000000 sodium salts Chemical class 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
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- 238000012109 statistical procedure Methods 0.000 description 1
- QTENRWWVYAAPBI-YCRXJPFRSA-N streptomycin sulfate Chemical compound OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](N=C(N)N)[C@H](O)[C@@H](N=C(N)N)[C@H](O)[C@H]1O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](N=C(N)N)[C@H](O)[C@@H](N=C(N)N)[C@H](O)[C@H]1O QTENRWWVYAAPBI-YCRXJPFRSA-N 0.000 description 1
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- XJDNKRIXUMDJCW-UHFFFAOYSA-J titanium tetrachloride Chemical compound Cl[Ti](Cl)(Cl)Cl XJDNKRIXUMDJCW-UHFFFAOYSA-J 0.000 description 1
- 238000004454 trace mineral analysis Methods 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 108091007466 transmembrane glycoproteins Proteins 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
- WJKHJLXJJJATHN-UHFFFAOYSA-N triflic anhydride Chemical compound FC(F)(F)S(=O)(=O)OS(=O)(=O)C(F)(F)F WJKHJLXJJJATHN-UHFFFAOYSA-N 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- WRECIMRULFAWHA-UHFFFAOYSA-N trimethyl borate Chemical compound COB(OC)OC WRECIMRULFAWHA-UHFFFAOYSA-N 0.000 description 1
- UCPYLLCMEDAXFR-UHFFFAOYSA-N triphosgene Chemical compound ClC(Cl)(Cl)OC(=O)OC(Cl)(Cl)Cl UCPYLLCMEDAXFR-UHFFFAOYSA-N 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N tryptophan Chemical compound C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical group NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
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- 201000011531 vascular cancer Diseases 0.000 description 1
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- 239000000080 wetting agent Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
- C07D239/18—Nitrogen atoms not forming part of a nitro radical with hetero atoms attached to said nitrogen atoms, except nitro radicals, e.g. hydrazine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/06—Compounds containing any of the groups, e.g. semicarbazides
- C07C281/08—Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones
- C07C281/12—Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones the carbon atom being part of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
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- C07C331/02—Thiocyanates
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- C07C331/02—Thiocyanates
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- C07C337/06—Compounds containing any of the groups, e.g. thiosemicarbazides
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- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
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- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
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- C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
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- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/52—Nitrogen atoms not forming part of a nitro radical with hetero atoms directly attached to said nitrogen atoms
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- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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FR9603437A FR2746394B1 (fr) | 1996-03-20 | 1996-03-20 | Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
FR96/03437 | 1996-03-20 |
Related Child Applications (1)
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CN02141265A Division CN1401621A (zh) | 1996-03-20 | 2002-06-27 | 用于制备三环化合物的中间体以及该中间体的制备方法 |
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Publication Number | Publication Date |
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CN1219165A CN1219165A (zh) | 1999-06-09 |
CN1090178C true CN1090178C (zh) | 2002-09-04 |
Family
ID=9490337
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Application Number | Title | Priority Date | Filing Date |
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CN97194806A Expired - Fee Related CN1090178C (zh) | 1996-03-20 | 1997-03-20 | 对整联蛋白,特别是ανβ3整联蛋白具有特异性活性的三环化合物,它们的制备方法和这种方法的中间体,它们作为药物的用途以及含有它们的药物组合物 |
CN02141265A Pending CN1401621A (zh) | 1996-03-20 | 2002-06-27 | 用于制备三环化合物的中间体以及该中间体的制备方法 |
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CN02141265A Pending CN1401621A (zh) | 1996-03-20 | 2002-06-27 | 用于制备三环化合物的中间体以及该中间体的制备方法 |
Country Status (16)
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CN (2) | CN1090178C (fr) |
AR (1) | AR006317A1 (fr) |
CZ (1) | CZ288898A3 (fr) |
ES (1) | ES2164337T3 (fr) |
FR (1) | FR2746394B1 (fr) |
HR (1) | HRP970163A2 (fr) |
HU (1) | HUP9902495A3 (fr) |
IL (1) | IL126106A0 (fr) |
LT (1) | LT4535B (fr) |
OA (1) | OA11603A (fr) |
PL (1) | PL329034A1 (fr) |
PT (1) | PT888292E (fr) |
TR (1) | TR199801846T2 (fr) |
TW (1) | TW458963B (fr) |
YU (1) | YU40898A (fr) |
ZA (1) | ZA972393B (fr) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996006087A1 (fr) * | 1994-08-22 | 1996-02-29 | Smithkline Beecham Corporation | Composes bicycliques |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2937779A1 (de) | 1979-09-19 | 1981-04-09 | Hoechst Ag, 6000 Frankfurt | Aminosaeurederivate und verfahren zu ihrer herstellung |
DE3044236A1 (de) | 1980-11-25 | 1982-06-16 | Hoechst Ag, 6000 Frankfurt | Aminosaeurederivate und verfahren zu ihrer herstellung |
FR2503155A2 (fr) | 1980-10-02 | 1982-10-08 | Science Union & Cie | Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
FR2487829A2 (fr) | 1979-12-07 | 1982-02-05 | Science Union & Cie | Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
US4350704A (en) | 1980-10-06 | 1982-09-21 | Warner-Lambert Company | Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids |
EP0278530A3 (fr) | 1980-08-30 | 1989-08-02 | Hoechst Aktiengesellschaft | Dérivés amino-acides, leur procédé de préparation, les agents les contenant et leur emploi |
US4344949A (en) | 1980-10-03 | 1982-08-17 | Warner-Lambert Company | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
FR2492381A1 (fr) | 1980-10-21 | 1982-04-23 | Science Union & Cie | Nouveaux acides aza bicyclo alcane carboxyliques substitues leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
EP0050800B2 (fr) | 1980-10-23 | 1995-06-07 | Schering Corporation | Dipeptides carboxyalcoyliques, procédés pour les préparer et compositions pharmaceutiques les contenant |
US4374847A (en) | 1980-10-27 | 1983-02-22 | Ciba-Geigy Corporation | 1-Carboxyalkanoylindoline-2-carboxylic acids |
DE3226768A1 (de) | 1981-11-05 | 1983-05-26 | Hoechst Ag, 6230 Frankfurt | Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung |
IE55867B1 (en) | 1981-12-29 | 1991-02-14 | Hoechst Ag | New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation |
DE3210496A1 (de) | 1982-03-23 | 1983-10-06 | Hoechst Ag | Neue derivate bicyclischer aminsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung |
DE3211397A1 (de) | 1982-03-27 | 1983-11-10 | Hoechst Ag, 6230 Frankfurt | Spiro (4.(3+n))-2-aza-3-carbonsaeure-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung |
DE3211676A1 (de) | 1982-03-30 | 1983-10-06 | Hoechst Ag | Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung |
DE3227055A1 (de) | 1982-07-20 | 1984-01-26 | Hoechst Ag, 6230 Frankfurt | Neue derivate der 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure als zwischenstufe und verfahren zu deren herstellung |
DE3242151A1 (de) | 1982-11-13 | 1984-05-17 | Hoechst Ag, 6230 Frankfurt | Neue derivate tricyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung, sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung |
DE3246503A1 (de) | 1982-12-16 | 1984-06-20 | Hoechst Ag, 6230 Frankfurt | Derivate der cis, endo-2-azabicyclo-(5.3.0)-decan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung |
DE3643012A1 (de) | 1986-12-17 | 1988-06-30 | Hoechst Ag | 2,3-disubstituierte isoxazolidine, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung |
DE3818850A1 (de) | 1988-06-03 | 1989-12-07 | Hoechst Ag | Oligopeptide mit zyklischen prolin-analogen aminosaeuren |
FR2731217B1 (fr) | 1995-03-03 | 1997-06-13 | Roussel Uclaf | Nouveaux derives tricycliques, leur preparation, leur application a la preparation de la colchicine et de la thiocolchicine optiquement actives ou racemiques et d'analogues ou derives et intermediaires |
-
1996
- 1996-03-20 FR FR9603437A patent/FR2746394B1/fr not_active Expired - Lifetime
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1997
- 1997-03-19 ZA ZA9702393A patent/ZA972393B/xx unknown
- 1997-03-19 HR HR9603437A patent/HRP970163A2/hr not_active Application Discontinuation
- 1997-03-19 AR ARP970101095A patent/AR006317A1/es unknown
- 1997-03-20 PL PL97329034A patent/PL329034A1/xx unknown
- 1997-03-20 TR TR1998/01846T patent/TR199801846T2/xx unknown
- 1997-03-20 HU HU9902495A patent/HUP9902495A3/hu unknown
- 1997-03-20 IL IL12610697A patent/IL126106A0/xx unknown
- 1997-03-20 CZ CZ982888A patent/CZ288898A3/cs unknown
- 1997-03-20 ES ES97915519T patent/ES2164337T3/es not_active Expired - Lifetime
- 1997-03-20 PT PT97915519T patent/PT888292E/pt unknown
- 1997-03-20 CN CN97194806A patent/CN1090178C/zh not_active Expired - Fee Related
- 1997-09-23 TW TW086113848A patent/TW458963B/zh not_active IP Right Cessation
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1998
- 1998-09-18 YU YU40898A patent/YU40898A/sh unknown
- 1998-09-18 OA OA9800175A patent/OA11603A/fr unknown
- 1998-10-15 LT LT98-145A patent/LT4535B/lt not_active IP Right Cessation
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2002
- 2002-06-27 CN CN02141265A patent/CN1401621A/zh active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996006087A1 (fr) * | 1994-08-22 | 1996-02-29 | Smithkline Beecham Corporation | Composes bicycliques |
Also Published As
Publication number | Publication date |
---|---|
HRP970163A2 (en) | 1998-08-31 |
CZ288898A3 (cs) | 1999-03-17 |
OA11603A (fr) | 2004-08-11 |
LT4535B (lt) | 1999-08-25 |
HUP9902495A2 (hu) | 1999-11-29 |
FR2746394B1 (fr) | 1998-05-29 |
HUP9902495A3 (en) | 2001-07-30 |
LT98145A (en) | 1999-03-25 |
ZA972393B (en) | 1998-03-19 |
PL329034A1 (en) | 1999-03-01 |
ES2164337T3 (es) | 2002-02-16 |
CN1219165A (zh) | 1999-06-09 |
TW458963B (en) | 2001-10-11 |
AR006317A1 (es) | 1999-08-25 |
FR2746394A1 (fr) | 1997-09-26 |
TR199801846T2 (xx) | 1998-12-21 |
CN1401621A (zh) | 2003-03-12 |
IL126106A0 (en) | 1999-05-09 |
YU40898A (sh) | 1999-09-27 |
PT888292E (pt) | 2002-04-29 |
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