ES8600734A1 - Un nuevo proceso para la preparacion de &-6-deoxi-tetraciclinas - Google Patents

Un nuevo proceso para la preparacion de &-6-deoxi-tetraciclinas

Info

Publication number
ES8600734A1
ES8600734A1 ES535223A ES535223A ES8600734A1 ES 8600734 A1 ES8600734 A1 ES 8600734A1 ES 535223 A ES535223 A ES 535223A ES 535223 A ES535223 A ES 535223A ES 8600734 A1 ES8600734 A1 ES 8600734A1
Authority
ES
Spain
Prior art keywords
deoxy
sio3
tetracyclines
alpha
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES535223A
Other languages
English (en)
Other versions
ES535223A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hovione Inter AG
Original Assignee
Hovione Inter AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PT77210A external-priority patent/PT77210A/pt
Priority claimed from PT7833484A external-priority patent/PT78334A/pt
Application filed by Hovione Inter AG filed Critical Hovione Inter AG
Publication of ES8600734A1 publication Critical patent/ES8600734A1/es
Publication of ES535223A0 publication Critical patent/ES535223A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE BAB-6-DEOXITETRACICLINAS.CONSISTE EN LA HIDROGENACION HETEROGENEA ESTEREOSELECTIVA DE UNA 6-DEMETIL-6-DEOXI-6-METILENO-TETRACICLINA O UNA SAL ACIDA DE LA MISMA, EN PRESENCIA DE UNA FOSFINA TERCIARIA. LA HIDROGENACION SE EFECTUA A UNA PRESION COMPRENDIDA ENTRE 0,1 Y 20 KG/CM, EN UN DISOLVENTE INERTE A UNA TEMPERATURA ENTRE 50JC Y 100JC, EN PRESENCIA DE UN CATALIZADOR DE UNA SAL DE RODIO UNIDO A UNAMINOPOLISILOSANO.TAMBIEN SE PUEDE REALIZAR LA DESHALOGENACION E HIDROGENACION ESTEREOSELECTIVA SIMULTANEAS DE UNA 11A-HALO-6-DEMETIL-6-DEOXI-6-METILENO-TETRACICLINA O UNA SAL ACIDA DE LA MISMA.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO ANTIBIOTICOS, PARA EL TRATAMIENTO DE INFECCIONES.
ES535223A 1983-08-17 1984-08-16 Un nuevo proceso para la preparacion de &-6-deoxi-tetraciclinas Granted ES535223A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PT77210A PT77210A (fr) 1983-08-17 1983-08-17 Nouveau procede pour preparation de alpha-6-deoxy-tetracyclines
PT7833484A PT78334A (en) 1984-03-29 1984-03-29 Preparation of the alpha-6-deoxy-tetracyclines new process

Publications (2)

Publication Number Publication Date
ES8600734A1 true ES8600734A1 (es) 1985-11-01
ES535223A0 ES535223A0 (es) 1985-11-01

Family

ID=26653438

Family Applications (1)

Application Number Title Priority Date Filing Date
ES535223A Granted ES535223A0 (es) 1983-08-17 1984-08-16 Un nuevo proceso para la preparacion de &-6-deoxi-tetraciclinas

Country Status (11)

Country Link
US (1) US4597904A (es)
EP (1) EP0137661B1 (es)
KR (1) KR870001142B1 (es)
AU (1) AU548771B2 (es)
CA (1) CA1242704A (es)
DE (1) DE3480339D1 (es)
DK (1) DK386784A (es)
ES (1) ES535223A0 (es)
FR (1) FR2550788B1 (es)
HK (1) HK70090A (es)
NZ (1) NZ209262A (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4743699A (en) * 1982-01-19 1988-05-10 Plurichemie Anstalt Homogeneous catalytic system and a process for the preparation of same
HU198173B (en) * 1987-09-18 1989-08-28 Chinoin Gyogyszer Es Vegyeszet Process for producing doxycycline
US4987242A (en) * 1988-10-28 1991-01-22 Jagmohan Khanna Hydrogenation catalyst useful in the production of alpha-6-deoxytetracyclines
US4902447A (en) * 1988-10-28 1990-02-20 Ranbaxy Laboratories Limited Process for the production of alpha-6-deoxytetracyclines and hydrogenation catalyst useful therein
EP0452412A4 (en) * 1989-01-04 1992-06-03 Houba, Inc. Process for the production of alpha-6-deoxytetracyclines
US5049683A (en) * 1989-01-04 1991-09-17 Houba, Inc. Process for the production of alpha-6-deoxytetracyclines
DE68900339D1 (de) * 1989-04-03 1991-11-21 Ranbaxy Lab Ltd Verfahren zur herstellung von alpha-6-deoxytetracyclinen.
CN103040773A (zh) * 2003-07-25 2013-04-17 沃纳奇尔科特有限责任公司 多西环素金属络合物固体剂型
AU2005244988C1 (en) 2004-05-21 2012-06-28 President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
SG158869A1 (en) * 2005-01-21 2010-02-26 Warner Chilcott Co Llc A tetracycline metal complex in a solid dosage form
AU2007235279B2 (en) * 2006-04-07 2012-12-06 President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
EP3056487B1 (en) 2006-10-11 2018-02-21 President and Fellows of Harvard College Synthesis of enone intermediate
US9073829B2 (en) 2009-04-30 2015-07-07 President And Fellows Of Harvard College Synthesis of tetracyclines and intermediates thereto
CA3039133A1 (en) * 2016-10-27 2018-05-03 Vanadis Diagnostics Method for processing rolling circle amplification products
CN107098825B (zh) * 2017-04-10 2019-05-31 广东中农联生物制药有限公司 一种强力霉素的高效制备方法
CN107056641B (zh) * 2017-04-10 2019-05-17 河南师范大学 一种强力霉素的制备方法
CN113248397B (zh) * 2021-07-01 2021-11-05 山东国邦药业有限公司 一种盐酸多西环素的制备方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA668581A (en) * 1963-08-13 R. D. Mccormick Jerry Process for the catalytic reduction of 6-hydroxy hydronaphthacenes
FR1430859A (es) * 1960-05-23 1966-05-25
US3484483A (en) * 1966-10-31 1969-12-16 Pfizer & Co C Process for producing alpha-6-deoxytetracyclines
US3444198A (en) * 1967-02-13 1969-05-13 Pfizer & Co C Process for producing alpha-6-deoxytetracyclines
US3397231A (en) * 1967-04-12 1968-08-13 Pfizer & Co C Refining of alpha-6-deoxy-5-oxytetracycline
US3442943A (en) * 1967-08-16 1969-05-06 American Cyanamid Co Process for preparing 6-deoxytetracyclines
AU2940371A (en) * 1970-06-12 1972-11-30 Societa Farmaceutici Italia 6-deoxy-5-oxytetracycline-5-esters
US4061676A (en) * 1970-07-03 1977-12-06 Ivan Villax Recovery of doxycycline and products thereof
CA942743A (en) * 1970-07-03 1974-02-26 Ivan Villax Process for producing 6-methylenetetracyclines and 6-deoxytetracyclines
US3795707A (en) * 1970-12-28 1974-03-05 Rachelle Labor Italia Spa Manufacture of alpha-6-deoxytetracyclines
US4207258A (en) * 1972-02-24 1980-06-10 Ankerfarm S.P.A. Process for the preparatin of α-6-deoxytetracyclines
SE435619C (sv) * 1973-02-01 1985-11-18 Pfizer Forfarande for framstellning av en 6alfa-deoxitetracyklin
US3954862A (en) * 1973-04-20 1976-05-04 Pfizer Inc. Process for producing α-6-deoxytetracyclines
HU167250B (es) * 1973-06-08 1975-09-27
GB1459861A (en) * 1973-06-21 1976-12-31 Pfizer Process for 11a-dehalogenation of 11a-halotetracyclines
DK501574A (es) * 1973-09-28 1975-05-26 Ankerfarm Spa
US3907890A (en) * 1974-05-28 1975-09-23 Pfizer Preparation of alpha-6-deoxy-5-hydroxytetracycline
AR208347A1 (es) * 1974-12-19 1976-12-20 Pfizer Mejora en la produccion de alfa-6-deoxitetraciclinas
US4001321A (en) * 1975-06-26 1977-01-04 Pfizer Inc. Preparation of α-6-deoxytetracyclines
US3962131A (en) * 1975-01-28 1976-06-08 Pfizer Inc. Rhodium containing catalyst and use thereof in preparation of 6-deoxy-5-oxytetracycline
GB1593927A (en) * 1978-05-15 1981-07-22 Pliva Pharm & Chem Works T-butyl derivatives of 5-hydroxy-tetracycline and a process for preparing the same
IT1198342B (it) * 1980-07-10 1988-12-21 Carbo Biochimica Srl Processo per la produzione di alfa-6-desossi-tetracicline
DE3131954C2 (de) * 1981-08-13 1984-10-31 Degussa Ag, 6000 Frankfurt Metallkomplexe von polymeren, gegebenenfalls vernetzten Organosiloxanaminen, Verfahren zu ihrer Herstellung und Verwendung
US4500458A (en) * 1982-01-19 1985-02-19 Plurichemie Anstalt Process for the preparation of α-6-deoxytetracyclines

Also Published As

Publication number Publication date
DK386784A (da) 1985-02-18
EP0137661A2 (en) 1985-04-17
CA1242704A (en) 1988-10-04
NZ209262A (en) 1987-07-31
US4597904A (en) 1986-07-01
DK386784D0 (da) 1984-08-10
AU3197984A (en) 1985-02-21
EP0137661A3 (en) 1987-08-19
EP0137661B1 (en) 1989-11-02
DE3480339D1 (en) 1989-12-07
KR850001897A (ko) 1985-04-10
ES535223A0 (es) 1985-11-01
FR2550788B1 (fr) 1989-11-17
KR870001142B1 (ko) 1987-06-11
AU548771B2 (en) 1986-01-02
FR2550788A1 (fr) 1985-02-22
HK70090A (en) 1990-09-14

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20050705