ATE115962T1 - Verfahren für umwandlung von menschlichem insulin-vorläufer in menschliches insulin. - Google Patents

Verfahren für umwandlung von menschlichem insulin-vorläufer in menschliches insulin.

Info

Publication number
ATE115962T1
ATE115962T1 AT87309011T AT87309011T ATE115962T1 AT E115962 T1 ATE115962 T1 AT E115962T1 AT 87309011 T AT87309011 T AT 87309011T AT 87309011 T AT87309011 T AT 87309011T AT E115962 T1 ATE115962 T1 AT E115962T1
Authority
AT
Austria
Prior art keywords
human insulin
conversion
precursor
insulin precursor
human
Prior art date
Application number
AT87309011T
Other languages
English (en)
Inventor
Bruce Hill Frank
Richard Eugene Heiney
Walter Francis Prouty
Mark Robert Walden
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE115962T1 publication Critical patent/ATE115962T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT87309011T 1986-10-14 1987-10-13 Verfahren für umwandlung von menschlichem insulin-vorläufer in menschliches insulin. ATE115962T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91793986A 1986-10-14 1986-10-14

Publications (1)

Publication Number Publication Date
ATE115962T1 true ATE115962T1 (de) 1995-01-15

Family

ID=25439543

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87309011T ATE115962T1 (de) 1986-10-14 1987-10-13 Verfahren für umwandlung von menschlichem insulin-vorläufer in menschliches insulin.

Country Status (26)

Country Link
US (1) US5457066A (de)
EP (1) EP0264250B1 (de)
JP (1) JP2634176B2 (de)
KR (1) KR970003519B1 (de)
CN (1) CN1029131C (de)
AR (1) AR243608A1 (de)
AT (1) ATE115962T1 (de)
AU (1) AU595934B2 (de)
CA (1) CA1339955C (de)
CY (1) CY1830A (de)
DE (1) DE3750897T2 (de)
DK (1) DK175266B1 (de)
EG (1) EG18520A (de)
ES (1) ES2065321T3 (de)
GR (1) GR3015143T3 (de)
HK (1) HK39495A (de)
HU (1) HU204572B (de)
IE (1) IE65972B1 (de)
IL (1) IL84110A (de)
MX (1) MX168305B (de)
NZ (1) NZ222082A (de)
PH (1) PH26471A (de)
PT (1) PT85892B (de)
RU (1) RU1829939C (de)
SG (1) SG14795G (de)
ZA (1) ZA877505B (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5130236A (en) * 1989-12-07 1992-07-14 Eli Lilly And Company Process for producing des(64,65)-proinsulin
FI103805B1 (fi) 1990-09-05 1999-09-30 Hoechst Ag Menetelmä preproinsuliinien hydroloimiseksi
TW224471B (de) * 1991-11-26 1994-06-01 Lilly Co Eli
IL107536A0 (en) * 1992-11-13 1994-02-27 Lilly Co Eli Expression vectors for bovine trypsin and trypsinogen and host cells transformed therewith
US6001604A (en) * 1993-12-29 1999-12-14 Bio-Technology General Corp. Refolding of proinsulins without addition of reducing agents
US6068993A (en) * 1997-07-02 2000-05-30 Biobras Sa Vector for expression of heterologous protein and methods for extracting recombinant protein and for purifying isolated recombinant insulin
US6087558A (en) * 1998-07-22 2000-07-11 Prodigene, Inc. Commercial production of proteases in plants
WO2000047236A1 (en) 1999-02-12 2000-08-17 Biostream, Inc. Matrices for drug delivery and methods for making and using the same
US7169889B1 (en) 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
US20020164712A1 (en) * 2000-12-11 2002-11-07 Tonghua Gantech Biotechnology Ltd. Chimeric protein containing an intramolecular chaperone-like sequence
WO2002051428A1 (fr) * 2000-12-25 2002-07-04 Shiseido Company, Ltd. Composition de parfum stimulant le systeme sympathique
US7060675B2 (en) 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US6867183B2 (en) 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6713452B2 (en) * 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828305B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7166571B2 (en) 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7196059B2 (en) 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US6913903B2 (en) 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7312192B2 (en) 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
RU2376379C2 (ru) * 2001-11-19 2009-12-20 Ново Нордиск А/С Способ получения инсулиновых соединений
DE60334912D1 (de) * 2002-05-24 2010-12-23 Medtronic Inc Polypeptid-spaltungsprozess
EP1572720A4 (de) * 2002-05-24 2008-12-24 Nps Allelix Corp Verfahren zur enzymatischen herstellung von glp-2-(1-33)- und glp-2-(1-34)-peptiden
WO2003099853A2 (en) * 2002-05-24 2003-12-04 Restoragen, Inc. Petide amidation process
AU2003236521A1 (en) * 2002-06-13 2003-12-31 Nobex Corporation Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
DE10235168A1 (de) 2002-08-01 2004-02-12 Aventis Pharma Deutschland Gmbh Verfahren zur Reinigung von Preproinsulin
PL1704234T3 (pl) * 2003-11-21 2012-06-29 Nps Pharma Inc Wytwarzanie glukagonopodobnego peptydu 2 i analogów
DE602004025192D1 (de) * 2003-12-05 2010-03-11 Roche Diagnostics Gmbh Rekombinante Carboxypeptidase B und ihre Aufreinigung
CA2580313C (en) * 2004-07-19 2016-03-15 Biocon Limited Insulin-oligomer conjugates, formulations and uses thereof
JP5868594B2 (ja) 2007-10-16 2016-02-24 バイオコン・リミテッドＢｉｏｃｏｎ Ｌｉｍｉｔｅｄ 経口投与可能な固形医薬組成物及びそのプロセス
MX2011001408A (es) * 2008-08-07 2011-05-02 Biocon Ltd Proceso para la preparacion de compuestos de insulina.
WO2012104099A1 (en) * 2011-02-04 2012-08-09 Glucometrix Ag Process for the production of recombinant trypsin
WO2012115640A1 (en) 2011-02-23 2012-08-30 Elona Biotechnologies Liquid insulin- containing compositions and methods of making the same
US20180291077A1 (en) * 2015-09-24 2018-10-11 Hanmi Pharm. Co., Ltd Method of insulin production
KR20200080747A (ko) * 2018-12-27 2020-07-07 주식회사 폴루스 인슐린 전구체의 인슐린 효소 전환용 조성물 및 이를 이용하여 인슐린 전구체를 인슐린으로 전환하는 방법
TW202409070A (zh) 2022-05-18 2024-03-01 美商普羅托莫科技公司 芳族含硼化合物及相關胰島素類似物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5756878A (en) * 1980-09-22 1982-04-05 Sharp Corp Cleaning device
DK149824C (da) * 1982-01-22 1987-03-16 Carlsberg Biotechnology Ltd Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyrer i insuliner

Also Published As

Publication number Publication date
EP0264250A3 (en) 1990-03-21
SG14795G (en) 1995-06-16
HUT46363A (en) 1988-10-28
HU204572B (en) 1992-01-28
AU7952887A (en) 1988-04-21
CY1830A (en) 1995-12-01
EG18520A (en) 1993-04-30
GR3015143T3 (en) 1995-05-31
IL84110A0 (en) 1988-03-31
HK39495A (en) 1995-03-24
RU1829939C (ru) 1993-07-23
CA1339955C (en) 1998-07-14
ZA877505B (en) 1989-05-30
JP2634176B2 (ja) 1997-07-23
AU595934B2 (en) 1990-04-12
PT85892B (pt) 1990-07-31
DK528487A (da) 1988-04-15
CN87107019A (zh) 1988-04-27
CN1029131C (zh) 1995-06-28
KR970003519B1 (ko) 1997-03-18
MX168305B (es) 1993-05-17
PT85892A (en) 1987-11-01
IE872743L (en) 1988-04-14
DK528487D0 (da) 1987-10-09
JPS63105695A (ja) 1988-05-10
AR243608A1 (es) 1993-08-31
DE3750897D1 (de) 1995-02-02
DK175266B1 (da) 2004-08-02
EP0264250B1 (de) 1994-12-21
DE3750897T2 (de) 1995-05-18
IL84110A (en) 1992-11-15
EP0264250A2 (de) 1988-04-20
PH26471A (en) 1992-07-27
US5457066A (en) 1995-10-10
KR880005262A (ko) 1988-06-28
ES2065321T3 (es) 1995-02-16
NZ222082A (en) 1989-08-29
IE65972B1 (en) 1995-11-29

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee