ATE115962T1 - Verfahren für umwandlung von menschlichem insulin-vorläufer in menschliches insulin. - Google Patents

Verfahren für umwandlung von menschlichem insulin-vorläufer in menschliches insulin.

Info

Publication number
ATE115962T1
ATE115962T1 AT87309011T AT87309011T ATE115962T1 AT E115962 T1 ATE115962 T1 AT E115962T1 AT 87309011 T AT87309011 T AT 87309011T AT 87309011 T AT87309011 T AT 87309011T AT E115962 T1 ATE115962 T1 AT E115962T1
Authority
AT
Austria
Prior art keywords
human insulin
conversion
precursor
insulin precursor
human
Prior art date
Application number
AT87309011T
Other languages
English (en)
Inventor
Bruce Hill Frank
Richard Eugene Heiney
Walter Francis Prouty
Mark Robert Walden
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE115962T1 publication Critical patent/ATE115962T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT87309011T 1986-10-14 1987-10-13 Verfahren für umwandlung von menschlichem insulin-vorläufer in menschliches insulin. ATE115962T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91793986A 1986-10-14 1986-10-14

Publications (1)

Publication Number Publication Date
ATE115962T1 true ATE115962T1 (de) 1995-01-15

Family

ID=25439543

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87309011T ATE115962T1 (de) 1986-10-14 1987-10-13 Verfahren für umwandlung von menschlichem insulin-vorläufer in menschliches insulin.

Country Status (26)

Country Link
US (1) US5457066A (de)
EP (1) EP0264250B1 (de)
JP (1) JP2634176B2 (de)
KR (1) KR970003519B1 (de)
CN (1) CN1029131C (de)
AR (1) AR243608A1 (de)
AT (1) ATE115962T1 (de)
AU (1) AU595934B2 (de)
CA (1) CA1339955C (de)
CY (1) CY1830A (de)
DE (1) DE3750897T2 (de)
DK (1) DK175266B1 (de)
EG (1) EG18520A (de)
ES (1) ES2065321T3 (de)
GR (1) GR3015143T3 (de)
HK (1) HK39495A (de)
HU (1) HU204572B (de)
IE (1) IE65972B1 (de)
IL (1) IL84110A (de)
MX (1) MX168305B (de)
NZ (1) NZ222082A (de)
PH (1) PH26471A (de)
PT (1) PT85892B (de)
RU (1) RU1829939C (de)
SG (1) SG14795G (de)
ZA (1) ZA877505B (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5130236A (en) * 1989-12-07 1992-07-14 Eli Lilly And Company Process for producing des(64,65)-proinsulin
CZ283234B6 (cs) 1990-09-05 1998-02-18 Hoechst Aktiengesellschaft Enymatický způsob konverse preproinsulinů na insuliny
ZA928916B (en) * 1991-11-26 1994-05-18 Lilly Co Eli Tri-arginine insulins
IL107536A0 (en) * 1992-11-13 1994-02-27 Lilly Co Eli Expression vectors for bovine trypsin and trypsinogen and host cells transformed therewith
US6001604A (en) * 1993-12-29 1999-12-14 Bio-Technology General Corp. Refolding of proinsulins without addition of reducing agents
US6068993A (en) * 1997-07-02 2000-05-30 Biobras Sa Vector for expression of heterologous protein and methods for extracting recombinant protein and for purifying isolated recombinant insulin
US6087558A (en) * 1998-07-22 2000-07-11 Prodigene, Inc. Commercial production of proteases in plants
US6395299B1 (en) 1999-02-12 2002-05-28 Biostream, Inc. Matrices for drug delivery and methods for making and using the same
US7169889B1 (en) * 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
US20020164712A1 (en) * 2000-12-11 2002-11-07 Tonghua Gantech Biotechnology Ltd. Chimeric protein containing an intramolecular chaperone-like sequence
KR20030005204A (ko) * 2000-12-25 2003-01-17 가부시키가이샤 시세이도 교감신경 활성화 향료 조성물
US6867183B2 (en) 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7060675B2 (en) 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6713452B2 (en) * 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828305B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7312192B2 (en) 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6913903B2 (en) 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7196059B2 (en) 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7166571B2 (en) 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
CA2464616C (en) 2001-11-19 2012-07-24 Are Bogsnes Process for preparing insulin compounds
DE60334912D1 (de) * 2002-05-24 2010-12-23 Medtronic Inc Polypeptid-spaltungsprozess
WO2003099853A2 (en) * 2002-05-24 2003-12-04 Restoragen, Inc. Petide amidation process
WO2003099854A2 (en) * 2002-05-24 2003-12-04 Nps Allelix Corp. Method for enzymatic production of glp-2(1-33) and glp-2-(1-34) peptides
AU2003236521A1 (en) * 2002-06-13 2003-12-31 Nobex Corporation Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
DE10235168A1 (de) 2002-08-01 2004-02-12 Aventis Pharma Deutschland Gmbh Verfahren zur Reinigung von Preproinsulin
ME01366B (me) * 2003-11-21 2013-12-20 Nps Allelix Corp POSTUPAK ZA PROIZVODNJU PEPTIDA 2 NALIK NA GLUKAGON l NJIHOVIH ANALOGA
DE602004025192D1 (de) * 2003-12-05 2010-03-11 Roche Diagnostics Gmbh Rekombinante Carboxypeptidase B und ihre Aufreinigung
EP2626368B1 (de) 2004-07-19 2016-12-21 Biocon Limited Insulinoligomerkonjugate, Formulierungen und Verwendungen davon
AU2008313248B2 (en) 2007-10-16 2012-04-26 Biocon Limited An orally administerable solid pharmaceutical composition and a process thereof
EP2307441B1 (de) * 2008-08-07 2016-03-23 Biocon Limited Verfahren zur herstellung von insulinverbindungen
WO2012104099A1 (en) * 2011-02-04 2012-08-09 Glucometrix Ag Process for the production of recombinant trypsin
WO2012115640A1 (en) 2011-02-23 2012-08-30 Elona Biotechnologies Liquid insulin- containing compositions and methods of making the same
CN108473548A (zh) * 2015-09-24 2018-08-31 韩美药品股份有限公司 胰岛素生产方法
KR20200080747A (ko) * 2018-12-27 2020-07-07 주식회사 폴루스 인슐린 전구체의 인슐린 효소 전환용 조성물 및 이를 이용하여 인슐린 전구체를 인슐린으로 전환하는 방법
WO2023225534A1 (en) 2022-05-18 2023-11-23 Protomer Technologies Inc. Aromatic boron-containing compounds and related insulin analogs

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5756878A (en) * 1980-09-22 1982-04-05 Sharp Corp Cleaning device
DK149824C (da) * 1982-01-22 1987-03-16 Carlsberg Biotechnology Ltd Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyrer i insuliner

Also Published As

Publication number Publication date
CN1029131C (zh) 1995-06-28
IE872743L (en) 1988-04-14
JPS63105695A (ja) 1988-05-10
SG14795G (en) 1995-06-16
KR880005262A (ko) 1988-06-28
JP2634176B2 (ja) 1997-07-23
DE3750897D1 (de) 1995-02-02
ZA877505B (en) 1989-05-30
HU204572B (en) 1992-01-28
AU595934B2 (en) 1990-04-12
PT85892B (pt) 1990-07-31
DK175266B1 (da) 2004-08-02
PT85892A (en) 1987-11-01
RU1829939C (ru) 1993-07-23
MX168305B (es) 1993-05-17
DE3750897T2 (de) 1995-05-18
AR243608A1 (es) 1993-08-31
GR3015143T3 (en) 1995-05-31
AU7952887A (en) 1988-04-21
PH26471A (en) 1992-07-27
CA1339955C (en) 1998-07-14
HUT46363A (en) 1988-10-28
DK528487D0 (da) 1987-10-09
IE65972B1 (en) 1995-11-29
EP0264250A3 (en) 1990-03-21
CY1830A (en) 1995-12-01
DK528487A (da) 1988-04-15
IL84110A (en) 1992-11-15
NZ222082A (en) 1989-08-29
EP0264250A2 (de) 1988-04-20
IL84110A0 (en) 1988-03-31
HK39495A (en) 1995-03-24
KR970003519B1 (ko) 1997-03-18
EG18520A (en) 1993-04-30
EP0264250B1 (de) 1994-12-21
CN87107019A (zh) 1988-04-27
US5457066A (en) 1995-10-10
ES2065321T3 (es) 1995-02-16

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee