CY1830A - Process for transforming a human insulin precursor to human insulin - Google Patents
Process for transforming a human insulin precursor to human insulinInfo
- Publication number
- CY1830A CY1830A CY183095A CY183095A CY1830A CY 1830 A CY1830 A CY 1830A CY 183095 A CY183095 A CY 183095A CY 183095 A CY183095 A CY 183095A CY 1830 A CY1830 A CY 1830A
- Authority
- CY
- Cyprus
- Prior art keywords
- human insulin
- transforming
- precursor
- insulin precursor
- human
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91793986A | 1986-10-14 | 1986-10-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1830A true CY1830A (en) | 1995-12-01 |
Family
ID=25439543
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY183095A CY1830A (en) | 1986-10-14 | 1995-12-01 | Process for transforming a human insulin precursor to human insulin |
Country Status (26)
Country | Link |
---|---|
US (1) | US5457066A (de) |
EP (1) | EP0264250B1 (de) |
JP (1) | JP2634176B2 (de) |
KR (1) | KR970003519B1 (de) |
CN (1) | CN1029131C (de) |
AR (1) | AR243608A1 (de) |
AT (1) | ATE115962T1 (de) |
AU (1) | AU595934B2 (de) |
CA (1) | CA1339955C (de) |
CY (1) | CY1830A (de) |
DE (1) | DE3750897T2 (de) |
DK (1) | DK175266B1 (de) |
EG (1) | EG18520A (de) |
ES (1) | ES2065321T3 (de) |
GR (1) | GR3015143T3 (de) |
HK (1) | HK39495A (de) |
HU (1) | HU204572B (de) |
IE (1) | IE65972B1 (de) |
IL (1) | IL84110A (de) |
MX (1) | MX168305B (de) |
NZ (1) | NZ222082A (de) |
PH (1) | PH26471A (de) |
PT (1) | PT85892B (de) |
RU (1) | RU1829939C (de) |
SG (1) | SG14795G (de) |
ZA (1) | ZA877505B (de) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5130236A (en) * | 1989-12-07 | 1992-07-14 | Eli Lilly And Company | Process for producing des(64,65)-proinsulin |
NZ239652A (en) * | 1990-09-05 | 1992-09-25 | Hoechst Ag | Hydrolysis of preproinsulin to insulin and analogues using clostripain and optionally carboxypeptidase |
CZ342492A3 (en) * | 1991-11-26 | 1993-06-16 | Lilly Co Eli | Derivatives of tri-arginine insulin, process of their preparation and a pharmaceutical composition in which said derivatives are comprised |
IL107536A0 (en) * | 1992-11-13 | 1994-02-27 | Lilly Co Eli | Expression vectors for bovine trypsin and trypsinogen and host cells transformed therewith |
US6001604A (en) * | 1993-12-29 | 1999-12-14 | Bio-Technology General Corp. | Refolding of proinsulins without addition of reducing agents |
US6068993A (en) * | 1997-07-02 | 2000-05-30 | Biobras Sa | Vector for expression of heterologous protein and methods for extracting recombinant protein and for purifying isolated recombinant insulin |
US6087558A (en) * | 1998-07-22 | 2000-07-11 | Prodigene, Inc. | Commercial production of proteases in plants |
AU772153B2 (en) | 1999-02-12 | 2004-04-08 | Molecular Insight Pharmaceuticals, Inc. | Matrices for drug delivery and methods for making and using the same |
US7169889B1 (en) | 1999-06-19 | 2007-01-30 | Biocon Limited | Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin |
US20020164712A1 (en) * | 2000-12-11 | 2002-11-07 | Tonghua Gantech Biotechnology Ltd. | Chimeric protein containing an intramolecular chaperone-like sequence |
CN1406131A (zh) * | 2000-12-25 | 2003-03-26 | 株式会社资生堂 | 活化交感神经的香料组合物 |
US7060675B2 (en) | 2001-02-15 | 2006-06-13 | Nobex Corporation | Methods of treating diabetes mellitus |
US6867183B2 (en) | 2001-02-15 | 2005-03-15 | Nobex Corporation | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
US6858580B2 (en) * | 2001-06-04 | 2005-02-22 | Nobex Corporation | Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6828305B2 (en) | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US7713932B2 (en) | 2001-06-04 | 2010-05-11 | Biocon Limited | Calcitonin drug-oligomer conjugates, and uses thereof |
US6835802B2 (en) * | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
US6828297B2 (en) | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6713452B2 (en) * | 2001-06-04 | 2004-03-30 | Nobex Corporation | Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US7166571B2 (en) | 2001-09-07 | 2007-01-23 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
US7196059B2 (en) | 2001-09-07 | 2007-03-27 | Biocon Limited | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
US7312192B2 (en) | 2001-09-07 | 2007-12-25 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
US6913903B2 (en) | 2001-09-07 | 2005-07-05 | Nobex Corporation | Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
BR0213583A (pt) * | 2001-11-19 | 2004-08-24 | Novo Nordisk As | Processo para preparar um composto de insulina, e, composto de insulina |
WO2003099853A2 (en) * | 2002-05-24 | 2003-12-04 | Restoragen, Inc. | Petide amidation process |
AU2003243316A1 (en) * | 2002-05-24 | 2003-12-12 | Nps Allelix Corp. | Method for enzymatic production of glp-2(1-33) and glp-2-(1-34) peptides |
DE60334912D1 (de) * | 2002-05-24 | 2010-12-23 | Medtronic Inc | Polypeptid-spaltungsprozess |
US7601688B2 (en) * | 2002-06-13 | 2009-10-13 | Biocon Limited | Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus |
DE10235168A1 (de) | 2002-08-01 | 2004-02-12 | Aventis Pharma Deutschland Gmbh | Verfahren zur Reinigung von Preproinsulin |
SI1704234T1 (sl) * | 2003-11-21 | 2012-08-31 | Nps Pharma Inc | Proizvodnja glukagonu podobnih peptidov 2 in analogov |
JP4411192B2 (ja) * | 2003-12-05 | 2010-02-10 | エフ.ホフマン−ラ ロシュ アーゲー | 組換えで発現されるカルボキシペプチダーゼbおよびその精製 |
UA103758C2 (ru) | 2004-07-19 | 2013-11-25 | Биокон Лимитед | Конъюгаты олигомеров инсулина, их композиции и применение |
BRPI0818004B8 (pt) | 2007-10-16 | 2021-05-25 | Biocon Ltd | composição farmacêutica sólida administrável por via oral e o processo da mesma. |
BRPI0823004B8 (pt) * | 2008-08-07 | 2021-05-25 | Biocon Ltd | processo para preparação de compostos de insulina |
WO2012104099A1 (en) * | 2011-02-04 | 2012-08-09 | Glucometrix Ag | Process for the production of recombinant trypsin |
WO2012115640A1 (en) | 2011-02-23 | 2012-08-30 | Elona Biotechnologies | Liquid insulin- containing compositions and methods of making the same |
US20180291077A1 (en) * | 2015-09-24 | 2018-10-11 | Hanmi Pharm. Co., Ltd | Method of insulin production |
KR20200080747A (ko) * | 2018-12-27 | 2020-07-07 | 주식회사 폴루스 | 인슐린 전구체의 인슐린 효소 전환용 조성물 및 이를 이용하여 인슐린 전구체를 인슐린으로 전환하는 방법 |
TW202409070A (zh) | 2022-05-18 | 2024-03-01 | 美商普羅托莫科技公司 | 芳族含硼化合物及相關胰島素類似物 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5756878A (en) * | 1980-09-22 | 1982-04-05 | Sharp Corp | Cleaning device |
DK149824C (da) * | 1982-01-22 | 1987-03-16 | Carlsberg Biotechnology Ltd | Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyrer i insuliner |
-
1987
- 1987-10-06 IL IL84110A patent/IL84110A/xx not_active IP Right Cessation
- 1987-10-06 ZA ZA877505A patent/ZA877505B/xx unknown
- 1987-10-06 CA CA000548665A patent/CA1339955C/en not_active Expired - Fee Related
- 1987-10-07 NZ NZ222082A patent/NZ222082A/xx unknown
- 1987-10-08 PH PH35908A patent/PH26471A/en unknown
- 1987-10-09 MX MX008788A patent/MX168305B/es unknown
- 1987-10-09 PT PT85892A patent/PT85892B/pt not_active IP Right Cessation
- 1987-10-09 DK DK198705284A patent/DK175266B1/da not_active IP Right Cessation
- 1987-10-09 AU AU79528/87A patent/AU595934B2/en not_active Ceased
- 1987-10-11 EG EG584/87A patent/EG18520A/xx active
- 1987-10-12 HU HU874603A patent/HU204572B/hu not_active IP Right Cessation
- 1987-10-13 ES ES87309011T patent/ES2065321T3/es not_active Expired - Lifetime
- 1987-10-13 KR KR1019870011305A patent/KR970003519B1/ko not_active IP Right Cessation
- 1987-10-13 CN CN87107019A patent/CN1029131C/zh not_active Expired - Fee Related
- 1987-10-13 RU SU874203477A patent/RU1829939C/ru active
- 1987-10-13 AT AT87309011T patent/ATE115962T1/de not_active IP Right Cessation
- 1987-10-13 EP EP87309011A patent/EP0264250B1/de not_active Expired - Lifetime
- 1987-10-13 DE DE3750897T patent/DE3750897T2/de not_active Expired - Fee Related
- 1987-10-13 JP JP62258166A patent/JP2634176B2/ja not_active Expired - Fee Related
- 1987-10-13 IE IE274387A patent/IE65972B1/en not_active IP Right Cessation
- 1987-10-14 AR AR87308958A patent/AR243608A1/es active
-
1992
- 1992-05-11 US US07/882,189 patent/US5457066A/en not_active Expired - Lifetime
-
1995
- 1995-01-27 SG SG14795A patent/SG14795G/en unknown
- 1995-02-22 GR GR950400363T patent/GR3015143T3/el unknown
- 1995-03-16 HK HK39495A patent/HK39495A/xx not_active IP Right Cessation
- 1995-12-01 CY CY183095A patent/CY1830A/xx unknown
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